Downregulation of LIMK1 level inhibits migration of lung cancer cells and enhances sensitivity to chemotherapy drugs

Oncology Research

Volumn 20, Issue 11, 2013, Pages 491-498

  Chen, Qingyong ^a   Jiao, Demin ^a   Hu, Huizhen ^a   Song, Jia ^a   Yan, Jie ^a   Wu, Lijun ^a   Xu, Li Qun ^a  

^a The 117th Hospital of Chinese PLA   (China)

Author keywords

Cisplatin; Gemcitabine; LIM kinase 1 (LIMK1); Lung cancer; Migration

Indexed keywords

CISPLATIN; COFILIN; GEMCITABINE; LIM KINASE 1; SHORT HAIRPIN RNA;

ADULT; ARTICLE; CANCER CELL; CANCER GENE THERAPY; CANCER SIZE; CANCER STAGING; CELL MIGRATION; CHEMOSENSITIVITY; DOWN REGULATION; EXPRESSION VECTOR; FEMALE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOHISTOCHEMISTRY; LUNG NON SMALL CELL CANCER; LYMPH NODE METASTASIS; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CISPLATIN; DEOXYCYTIDINE; DRUG RESISTANCE, NEOPLASM; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIM KINASES; LUNG NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASM STAGING; RESPIRATORY MUCOSA; RNA, SMALL INTERFERING;

EID: 84886929416     PISSN: 09650407     EISSN: 15553906     Source Type: Journal    
DOI: 10.3727/096504013X13657689382699     Document Type: Article

References (21)

1. Coello, M. C.; Luketich, J. D.; Litle, V. R.; Godfrey, T. E. Prognostic significance of micrometastasis in nonsmall-cell lung cancer. Clin. Lung Cancer 5:214-225; 2004.
2. Wang, W.; Mouneimne, G.; Sidani, M.; Wyckoff, J.; Chen, X.; Makris, A.; Goswami, S.; Bresnick, A. R.; Condeelis, J. S. The activity status of cofilin is directly related to invasion, intravasation, and metastasis of mammary tumors. J. Cell Biol. 173:395-404; 2006.
3. Hornsby, P. J. Senescence and life span. Pflugers Arch. 459:291-299; 2010.
4. Okano, I.; Hiraoka, J.; Otera, H.; Nunoue, K.; Ohashi, K.; Iwashita, S.; Hirai, M.; Mizuno, K. Identification and characterization of a novel family of serine/threonine kinases containing two N-terminal LIM motifs. J. Biol. Chem. 270:31321-31330; 1995.
5. Davila, M.; Frost, A. R.; Grizzle, W. E.; Chakrabarti, R. LIM kinase 1 is essential for the invasive growth of prostate epithelial cells: Implications in prostate cancer. J. Biol. Chem. 278:36868-36875; 2003.
6. Yoshioka, K.; Foletta, V.; Bernard, O.; Itoh, K. A role for LIM kinase in cancer invasion. Proc. Natl. Acad. Sci. USA 100:7247-7252; 2003.
7. DesMarais, V.; Ghosh, M.; Eddy, R.; Condeelis, J. Cofilin takes the lead. J. Cell Sci. 118:19-26; 2005.
8. Moriyama, K.; Iida, K.; Yahara, I. Phosphorylation of Ser-3 of cofilin regulates its essential function on actin. Genes Cells 1:73-86; 1996.
9. Hotulainen, P.; Paunola, E.; Vartiainen, M. K.; Lappalainen, P. Actin-depolymerizing factor and cofilin-1 play overlapping roles in promoting rapid F-actin depolymerization in mammalian nonmuscle cells. Mol. Biol. Cell 16:649-664; 2005.
10. Mountain, C. F. Revisions in the international system for staging lung cancer. Chest 111:1710-1717; 1997.
11. Boyd, J. M.; Huang, L.; Xie, L.; Moe, B.; Gabos, S.; Li, X. F. A cell-microelectronic sensing technique for profiling cytotoxicity of chemicals. Anal. Chim. Acta 615:80-87; 2008.
12. Kim, S. Y.; Jung, S. H.; Kim, H. S. Curcumin is a potent broad spectrum inhibitor of matrix metalloproteinase gene expression in human astroglioma cells. Biochem. Biophys. Res. Commun. 337:510-516; 2005.
13. Ji, C.; Cao, C.; Lu, S.; Kivlin, R.; Amaral, A.; Kouttab, N.; Yang, H.; Chu, W.; Bi, Z.; Di, W.; Wan, Y. Curcumin attenuates EGF-induced AQP3 upregulation and cell migration in human ovarian cancer cells. Cancer Chemother. Pharmacol. 62:857-865; 2008.
14. Vlecken, D. H.; Bagowski, C. P. LIMK1 and LIMK2 are important for metastatic behavior and tumor cell-induced angiogenesis of pancreatic cancer cells. Zebrafish 6:433-439; 2009.
15. Mishima, T.; Naotsuka, M.; Horita, Y.; Sato, M.; Ohashi, K.; Mizuno, K. LIM-kinase is critical for the mesenchymalto- amoeboid cell morphological transition in 3D matrices. Biochem. Biophys. Res. Commun. 392:577-581; 2010.
16. Yamazaki, D.; Kurisu, S.; Takenawa, T. Regulation of cancer cell motility through actin reorganization. Cancer Sci. 96:379-386; 2005.
17. Sahai, E.; Olson, M. F.; Marshall, C. J. Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility. EMBO J. 20:755-766; 2001.
18. Ghosh, M.; Song, X.; Mouneimne, G.; Sidani, M.; Lawrence, D. S.; Condeelis, J. S. Cofilin promotes actin polymerization and defines the direction of cell motility. Science 304:743-746; 2004.
19. Higuchi, O.; Baeg, G. H.; Akiyama, T.; Mizuno, K. Suppression of fibroblast cell growth by overexpression of LIM-kinase 1. FEBS Lett. 396:81-86; 1996.
20. Dan, S.; Tsunoda, T.; Kitahara, O.; Yanagawa, R.; Zembutsu, H.; Katagiri, T.; Yamazaki, K.; Nakamura, Y.; Yamori, T. An integrated database of chemosensitivity to 55 anticancer drugs and gene expression profiles of 39 human cancer cell lines. Cancer Res. 62:1139-1147; 2002.
21. Zhou, F. F.; Yan, M.; Guo, G. F.; Wang, F.; Qiu, H. J.; Zheng, F. M.; Zhang, Y.; Liu, Q.; Zhu, X. F.; Xia, L. P. Knockdown of eIF4E suppresses cell growth and migration, enhances chemosensitivity and correlates with increase in Bax/Bcl-2 ratio in triple-negative breast cancer cells. Med. Oncol. 28: 1302-1307; 2011.