Transcriptome-Guided Functional Analyses Reveal Novel Biological Properties and Regulatory Hierarchy of Human Embryonic Stem Cell-Derived Ventricular Cardiomyocytes Crucial for Maturation

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Poon, Ellen ^a   Yan, Bin ^b   Zhang, Shaohong ^c,d   Rushing, Stephanie ^e   Keung, Wendy ^a   Ren, Lihuan ^a   Lieu, Deborah K ^e,f   Geng, Lin ^a   Kong, Chi Wing ^a   Wang, Jiaxian ^a,e   Wong, Hau San ^c   Boheler, Kenneth R ^a,g   Li, Ronald A ^a,e  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

^c CITY UNIVERSITY OF HONG KONG   (Hong Kong)

^d GUANGZHOU UNIVERSITY   (China)

^e MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM ION; POTASSIUM ION; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR HAND1; TRANSCRIPTION FACTOR NKX2.5; TRANSCRIPTION FACTOR PPARGC1A; TRANSCRIPTION FACTOR TCF8; TRANSCRIPTOME; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BIOLOGICAL FUNCTIONS; CALCIUM HOMEOSTASIS; CALCIUM METABOLISM; CALCIUM TRANSPORT; CELL CYCLE; CELL FUNCTION; CELL HYPOXIA; CELL MATURATION; CELL METABOLISM; CELL MIGRATION; CONTRACTILE GENE; CONTROLLED STUDY; EMBRYONIC STEM CELL; FETUS CELL; FUNCTIONAL ASSESSMENT; GENE; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC TRANSCRIPTION; HEART MUSCLE CELL; HEART VENTRICLE; HEART VENTRICLE CONTRACTION; HUMAN; HUMAN CELL; IN VITRO STUDY; METABOLIC GENE; POTASSIUM TRANSPORT; PROMOTER REGION; PROTEIN EXPRESSION; REGULATORY MECHANISM; REOXYGENATION; SYSTEMS BIOLOGY; TRANSCRIPTOMICS;

ADULT; ANIMALS; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; CELL PROLIFERATION; ELECTROPHYSIOLOGY; EMBRYONIC STEM CELLS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE REGULATORY NETWORKS; HEART VENTRICLES; HUMANS; MICE; MYOCYTES, CARDIAC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROMOTER REGIONS, GENETIC; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 84886889331     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0077784     Document Type: Article

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