The circadian rhythm in adult attention-deficit/hyperactivity disorder: Current state of affairs

Expert Review of Neurotherapeutics

Volumn 13, Issue 10, 2013, Pages 1107-1116

  Kooij, Jj Sandra ^a   Bijlenga, Denise ^a  

^a PsyQ   (Netherlands)

Author keywords

ADHD; bright light therapy; cancer risk; chronic conditions; chronotype; circadian rhythm; delayed sleep phase syndrome; melatonin; metabolic syndrome; sleep hygiene; sleep onset insomnia

Indexed keywords

ALCOHOL; BENZODIAZEPINE DERIVATIVE; CANNABIS; CENTRAL STIMULANT AGENT; DOPAMINE; INSULIN RECEPTOR; MELATONIN; METHYLPHENIDATE; PER1 PROTEIN; PER2 PROTEIN; PLACEBO; PROTEIN BMAL1;

ACTIMETRY; ADULT; ALCOHOL CONSUMPTION; ATTENTION DEFICIT DISORDER; BODY MASS; BREAST CANCER; CANCER PATIENT; CHRONIC DISEASE; CIRCADIAN RHYTHM; CLINICAL TRIAL (TOPIC); DELAYED SLEEP PHASE SYNDROME; DIABETES MELLITUS; DISEASE ASSOCIATION; DISEASE SEVERITY; DROWSINESS; DRUG EFFICACY; DRUG MEGADOSE; DSM-IV; GENE EXPRESSION; HABITUATION; HEREDITY; HUMAN; HYGIENE; HYPERACTIVITY; HYPERTENSION; IMPULSIVENESS; INSOMNIA; LIBIDO; LIFESTYLE; LOW DRUG DOSE; META ANALYSIS; METABOLIC SYNDROME X; NEOPLASM; NONHUMAN; OBESITY; PHOTOTHERAPY; POLYSOMNOGRAPHY; PREVALENCE; PROSTATE CANCER; PSYCHOEDUCATION; REM SLEEP; REVIEW; REWARD; RHEUMATOID ARTHRITIS; RISK FACTOR; SIDE EFFECT; SLEEP DISORDER; SLEEP HYGIENE; SLEEP PATTERN; SLEEP TIME; SPERMATOZOON MOTILITY; SYMPTOM;

ADULT; ATTENTION; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CIRCADIAN RHYTHM; HUMANS; MELATONIN; SLEEP; SLEEP DISORDERS;

EID: 84886887385     PISSN: 14737175     EISSN: 17448360     Source Type: Journal    
DOI: 10.1586/14737175.2013.836301     Document Type: Review

References (109)

1. Roenneberg T, Kuehnle T, Juda M et al. Epidemiology of the human circadian clock. Sleep Med. Rev. 11(6), 429-438 (2007). (Pubitemid 350087711)
2. Lewy AJ. Melatonin and human chronobiology. Cold Spring Harb. Symp. Quant. Biol. 72, 623-636 (2007).
3. Zavada A, Gordijn MC, Beersma DG, Daan S, Roenneberg T. Comparison of the munich chronotype questionnaire with the Horne-Ostberg's morningness- eveningness score. Chronobiol. Int. 22(2), 267-278 (2005). (Pubitemid 40967232)
4. Roenneberg T, Wirz-Justice A, Merrow M. Life between clocks: daily temporal patterns of human chronotypes. J. Biol. Rhythms 18(1), 80-90 (2003). (Pubitemid 37187310)
5. Brown SA, Kunz D, Dumas A et al. Molecular insights into human daily behavior. Proc. Natl Acad. Sci. USA 105(5), 1602-1607 (2008). (Pubitemid 351346561)
6. Paine SJ, Gander PH, Travier N. The epidemiology of morningness/ eveningness: influence of age, gender, ethnicity, and socioeconomic factors in adults (30-49 years). J. Biol. Rhythms 21(1), 68-76 (2006). (Pubitemid 43113475)
7. Roenneberg T, Kuehnle T, Pramstaller PP et al. A marker for the end of adolescence. Curr. Biol. 14(24), R1038-1039 (2004). (Pubitemid 40033344)
8. Taillard J, Philip P, Chastang JF, Bioulac B. Validation of Horne and Ostberg morningness-eveningness questionnaire in a middle-aged population of French workers. J. Biol. Rhythms 19(1), 76-86 (2004). (Pubitemid 38084517)
9. Bijlenga D, van der Heijden KB, Breuk M et al. Associations between sleep characteristics, seasonal depressive symptoms, lifestyle, and ADHD symptoms in adults. J. Atten. Disord. 17(3), 261-274 (2013).
10. Dagan Y. Circadian rhythm sleep disorders (CRSD). Sleep Med. Rev. 6(1), 45-54 (2002).
11. Lee HJ, Rex KM, Nievergelt CM, Kelsoe JR, Kripke DF. Delayed sleep phase syndrome is related to seasonal affective disorder. J. Affect Disord. 133(3), 573-579 (2011).
12. Giglio LM, Magalhaes PV, Andersen ML, Walz JC, Jakobson L, Kapczinski F. Circadian preference in bipolar disorder. Sleep Breath 14(2), 153-155 (2010).
13. Wulff K, Dijk DJ, Middleton B, Foster RG, Joyce EM. Sleep and circadian rhythm disruption in schizophrenia. Br. J. Psychiatry 200(4), 308-316 (2012).
14. Giannotti F, Cortesi F, Sebastiani T, Ottaviano S. Circadian preference, sleep and daytime behaviour in adolescence. J. Sleep Res. 11(3), 191-199 (2002). (Pubitemid 35014003)
15. Hazama GI, Inoue Y, Kojima K, Ueta T, Nakagome K. The prevalence of probable delayed-sleep-phase syndrome in students from junior high school to university in Tottori, Japan. Tohoku. J. Exp. Med. 216(1), 95-98 (2008).
16. Yazaki M, Shirakawa S, Okawa M, Takahashi K. Demography of sleep disturbances associated with circadian rhythm disorders in Japan. Psychiatry Clin. Neurosci. 53(2), 267-268 (1999). (Pubitemid 29299929)
17. Schrader H, Bovim G, Sand T. The prevalence of delayed and advanced sleep phase syndromes. J. Sleep Res. 2(1), 51-55 (1993). (Pubitemid 23137511)
18. Ando K, Kripke DF, Ancoli-Israel S. Delayed and advanced sleep phase symptoms. Isr. J. Psychiatry Relat. Sci. 39(1), 11-18 (2002). (Pubitemid 44394783)
19. APA. Diagnostic and statistical manual of mental disorders (DSM-IV). American Psychiatric Association, Washington DC, USA (1994).
20. Pandi-Perumal SR, Smits M, Spence W et al. Dim light melatonin onset (DLMO): a tool for the analysis of circadian phase in human sleep and chronobiological disorders. Prog. Neuropsychopharmacol. Biol. Psychiatry 31(1), 1-11 (2007). (Pubitemid 46001487)
21. Lewy AJ, Bauer VK, Ahmed S et al. The human phase response curve (PRC) to melatonin is about 12 h out of phase with the PRC to light. Chronobiol. Int. 15(1), 71-83 (1998). (Pubitemid 28077919)
22. Lewy AJ. Circadian misalignment in mood disturbances. Curr. Psychiatry Rep. 11(6), 459-465 (2009).
23. Biederman J. Attention-deficit/hyperactivity disorder: a life-span perspective. J. Clin. Psychiatry 59(Suppl. 7), 4-16 (1998). (Pubitemid 28317217)
24. Faraone SV, Sergeant J, Gillberg C, Biederman J. The worldwide prevalence of ADHD: is it an American condition? World Psychiatry 2(2), 104-113 (2003).
25. Fayyad J, De Graaf R, Kessler R et al. Cross-national prevalence and correlates of adult attention-deficit hyperactivity disorder. Br. J. Psychiatry 190, 402-409 (2007). (Pubitemid 46706952)
26. Corkum P, Tannock R, Moldofsky H, Hogg-Johnson S, Humphries T. Actigraphy and parental ratings of sleep in children with attention-deficit/hyperactivity disorder (ADHD). Sleep 24(3), 303-312 (2001). (Pubitemid 32319352)
27. Gaultney JF, Terrell DF, Gingras JL. Parent-Reported Periodic Limb Movement, Sleep Disordered Breathing, Bedtime Resistance Behaviors, and ADHD. Behav. Sleep Med. 3(1), 32-43 (2005).
28. Konofal E, Lecendreux M, Bouvard MP, Mouren-Simeoni MC. High levels of nocturnal activity in children with attention-deficit hyperactivity disorder: a video analysis. Psychiatry Clin. Neurosci. 55(2), 97-103 (2001). (Pubitemid 32390663)
29. Lecendreux M, Cortese S. Sleep problems associated with ADHD: a review of current therapeutic options and recommendations for the future. Expert Rev. Neurother. 7(12), 1799-1806 (2007). (Pubitemid 350260676)
30. Sadeh A, Pergamin L, Bar-Haim Y. Sleep in children with attention-deficit hyperactivity disorder: a meta-analysis of polysomnographic studies. Sleep Med. Rev. 10(6), 381-398 (2006). (Pubitemid 44810064)
31. Yoon SYR, Jain U, Shapiro C. Sleep in attention-deficit/hyperactivity disorder in children and adults: past, present, and future. Sleep Med. Rev. 16(4), 371-388 (2012).
32. Wiebe S, Carrier J, Frenette S, Gruber R. Sleep and sleepiness in children with attention deficit/hyperactivity disorder and controls. J. Sleep Res. 22(1), 41-49. (2013).
33. Scott N, Blair PS, Emond AM et al. Sleep patterns in children with ADHD: a population-based cohort study from birth to 11 years. J. Sleep Res. 22(2), 121-128 (2013).
34. van der Heijden KB, Smits MG, Gunning WB. Sleep-related disorders in ADHD: a review. Clin. Pediatr. (Phila.) 44(3), 201-210 (2005). (Pubitemid 40547423)
35. van der Heijden KB, Smits MG, Van Someren EJ, Gunning WB. Idiopathic chronic sleep onset insomnia in attentiondeficit/hyperactivity disorder: a circadian rhythm sleep disorder. Chronobiol. Int. 22(3), 559-570 (2005). (Pubitemid 41140877)
36. Van Veen MM, Kooij JJS, Boonstra AM, Gordijn MC, Van Someren EJ. Delayed circadian rhythm in adults with attentiondeficit/hyperactivity disorder and chronic sleep-onset insomnia. Biol. Psychiatry 67(11), 1091-1096 (2010).
37. Kooij JJS, Middelkoop HA, van Gils K, Buitelaar JK. The effect of stimulants on nocturnal motor activity and sleep quality in adults with ADHD: An open-label casecontrol study. J. Clin. Psychiatry 62(12), 952-956 (2001). (Pubitemid 34007960)
38. Schredl M, Alm B, Sobanski E. Sleep quality in adult patients with attention deficit hyperactivity disorder (ADHD). Eur. Arch. Psychiatry Clin. Neurosci. 257(3), 164-168 (2007). (Pubitemid 46599130)
39. Shirayama M, Shirayama Y, Iida H et al. The psychological aspects of patients with delayed sleep phase syndrome (DSPS). Sleep Med. 4(5), 427-433 (2003). (Pubitemid 37193026)
40. Novakova M, Paclt I, Ptacek R, Kuzelova H , Hajek I, Sumova A. Salivary melatonin rhythm as a marker of the circadian system in healthy children and those with attention-deficit/hyperactivity disorder. Chronobiol. Int. 28(7), 630-637 (2011).
41. Mahajan N, Hong N, Wigal TL, Gehricke J-G. Hyperactive-impulsive symptoms associated with self-reported sleep quality in nonmedicated adults with ADHD. J. Atten. Disord. 14(2), 132-137 (2010).
42. Gau SS, Kessler RC, Tseng WL et al. Association between sleep problems and symptoms of attention-deficit/hyperactivity disorder in young adults. Sleep 30(2), 195-201 (2007).
43. Antle MC, van Diepen HC, Deboer T, Pedram P, Pereira RR, Meijer JH. Methylphenidate modifies the motion of the circadian clock. Neuropsychopharmacology 37(11), 2446-2455 (2012).
44. Corkum P, Panton R, Ironside S, Macpherson M, Williams T. Acute impact of immediate release methylphenidate administered three times a day on sleep in children with attention-deficit/hyperactivity disorder. J. Pediatr. Psychol. 33(4), 368-379 (2007).
45. Galland BC, Tripp EG, Taylor BJ. The sleep of children with attention deficit hyperactivity disorder on and off methylphenidate: A matched case-control study. J. Sleep Res. 19(2), 366-373 (2010).
46. Lee SH, Seox WS, Sung HM et al. Effect of methylphenidate on sleep parameters in children with ADHD. Psychiatry Invest. 9(4), 384-390 (2012).
47. Kent JD, Blader JC, Koplewicz HS, Abikoff H, Foley CA. Effects of late-afternoon methylphenidate administration on behavior and sleep in attention-deficit hyperactivity disorder. Pediatrics 96(2 Pt 1), 320-325 (1995).
48. Kim HW, Yoon IY, Cho SC et al. The effect of OROS methylphenidate on the sleep of children with attention-deficit/hyperactivity disorder. Int. Clin. Psychopharmacol. 25(2), 107-115 (2010).
49. Boonstra AM, Kooij JJS, Oosterlaan J, Sergeant JA, Buitelaar JK, Van Someren EJW. Hyperactive night and day? Actigraphy studies in adult ADHD: a baseline comparison and the effect of methylphenidate. Sleep 30(4), 433-442 (2007). (Pubitemid 46668700)
50. Sobanski E, Schredl M, Kettler N, Alm B. Sleep in adults with attention deficit hyperactivity disorder (ADHD) before and during treatment with methylphenidate: a controlled polysomnographic study. Sleep 31(3), 375-381 (2008). (Pubitemid 351536510)
51. Stratmann M, Schibler U. Properties, entrainment, and physiological functions of mammalian peripheral oscillators. J. Biol. Rhythms 21(6), 494-506 (2006). (Pubitemid 44706830)
52. Baird AL, Coogan AN, Siddiqui A, Donev RM, Thome J. Adult attention-deficit hyperactivity disorder is associated with alterations in circadian rhythms at the behavioural, endocrine and molecular levels. Mol. Psychiatry 17(10), 988-995 (2012).
53. Bijlenga D, Van Someren EJ, Gruber R et al. Body temperature, activity, and melatonin profiles in adults with attentiondeficit/hyperactivity syndrome and delayed sleep: a case-control study J. Sleep Res. doi:10.1111/jsr.12075 (2013) (Epub ahead of print).
54. Cortese S, Bernardina BD, Mouren MC. Attention-deficit/hyperactivity disorder (ADHD) and binge eating. Nutr. Rev. 65(9), 404-411 (2007). (Pubitemid 351804348)
55. Qin LQ, Li J, Wang Y, Wang J, Xu JY, Kaneko T. The effects of nocturnal life on endocrine circadian patterns in healthy adults. Life Sci. 73(19), 2467-2475 (2003). (Pubitemid 37101044)
56. Spiegel K, Leproult R, L'Hermite-Baleriaux M, Copinschi G, Penev PD, Van Cauter E. Leptin levels are dependent on sleep duration: relationships with sympathovagal balance, carbohydrate regulation, cortisol, and thyrotropin. J. Clin. Endocrinol. Metab. 89(11), 5762-5771 (2004). (Pubitemid 39518469)
57. Copinschi G. Metabolic and endocrine effects of sleep deprivation. Essent. Psychopharmacol. 6(6), 341-347 (2005).
58. Cappuccio FP, Taggart FM, Kandala NB et al. Meta-analysis of short sleep duration and obesity in children and adults. Sleep 31(5), 619-626 (2008). (Pubitemid 351694250)
59. Pinheiro SP, Schernhammer ES, Tworoger SS, Michels KB. A prospective study on habitual duration of sleep and incidence of breast cancer in a large cohort of women. Cancer Res. 66(10), 5521-5525 (2006). (Pubitemid 43844981)
60. Schernhammer ES, Berrino F, Krogh V et al. Urinary 6-sulfatoxymelatonin levels and risk of breast cancer in postmenopausal women. J. Natl Cancer Inst. 100(12), 898-905 (2008). (Pubitemid 351881952)
61. Viswanathan AN, Schernhammer ES. Circulating melatonin and the risk of breast and endometrial cancer in women. Cancer Lett. 281(1), 1-7 (2009).
62. Knutson KL, Van Cauter E. Associations between sleep loss and increased risk of obesity and diabetes. Ann. NY Acad. Sci. 1129, 287-304 (2008). (Pubitemid 351990301)
63. Gangwisch JE. Epidemiological evidence for the links between sleep, circadian rhythms and metabolism. Obes. Rev. 10(Suppl. 2), 37-45 (2009).
64. Fonken LK, Workman JL, Walton JC et al. Light at night increases body mass by shifting the time of food intake. Proc. Natl Acad. Sci. USA 107(43), 18664-18669 (2010).
65. Blask DE. Melatonin, sleep disturbance and cancer risk. Sleep Med. Rev. 13(4), 257-264 (2009).
66. Puttonen S, Harma M, Hublin C. Shift work and cardiovascular disease-pathways from circadian stress to morbidity. Scand. J. Work Environ. Health 36(2), 96-108 (2010).
67. Lauderdale DS, Knutson KL, Rathouz PJ, Yan LL, Hulley SB, Liu K. Cross-sectional and longitudinal associations between objectively measured sleep duration and body mass index: the CARDIA Sleep Study. Am. J. Epidemiol. 170(7), 805-813 (2009).
68. Fuemmeler BF, Ostbye T, Yang C, McClernon FJ, Kollins SH. Association between attention-deficit/hyperactivity disorder symptoms and obesity and hypertension in early adulthood: a population-based study. Int. J. Obes. (Lond.) 35(6), 852-862 (2010).
69. Altfas JR. Prevalence of attention deficit/hyperactivity disorder among adults in obesity treatment. BMC Psychiatry 2(1), 9 (2002).
70. Fleming JP, Levy LD, Levitan RD. Symptoms of attention deficit hyperactivity disorder in severely obese women. Eat. Weight Disord. 10(1) e10-e13 (2005). (Pubitemid 43098421)
71. Cortese S, Angriman M, Maffeis C et al. Attention-deficit/hyperactivity disorder (ADHD) and obesity: a systematic review of the literature. Crit. Rev. Food Sci. Nutrit. 48(6), 524-537 (2008). (Pubitemid 351883143)
72. Campbell BC, Eisenberg D. Obesity, attention deficit-hyperactivity disorder and the dopaminergic reward system. Coll. Antrop. 31(1), 33-38 (2007).
73. Liu LL, Li BM, Yang J, Wang YW. Does dopaminergic reward system contribute to explaining comorbidity obesity and ADHD? Med. Hypotheses 70(6), 1118-1120 (2008).
74. Kakizaki M, Kuriyama S, Sone T et al. Sleep duration and the risk of breast cancer: the Ohsaki Cohort Study. Br. J. Cancer 99(9), 1502-1505 (2008).
75. Stevens RG, Hansen J, Costa G et al. Considerations of circadian impact for defining 'shift work' in cancer studies: IARC Working Group Report. Occup. Environ. Med. 68(2), 154-162 (2011).
76. Schernhammer ES, Kroenke CH, Dowsett M, Folkerd E, Hankinson SE. Urinary 6-sulfatoxymelatonin levels and their correlations with lifestyle factors and steroid hormone levels. J. Pineal. Res. 40(2), 116-124 (2006).
77. Schernhammer ES, Rosner B, Willett WC, Laden F, Colditz GA, Hankinson SE. Epidemiology of urinary melatonin in women and its relation to other hormones and night work. Cancer Epidemiol. Biomarkers Prev. 13(6), 936-943 (2004). (Pubitemid 38756703)
78. Parent ME, El-Zein M, Rousseau MC, Pintos J, Siemiatycki J. Night work and the risk of cancer among men. Am. J. Epidemiol. 176(9), 751-759 (2012).
79. Sigurdardottir LG, Valdimarsdottir UA, Fall K et al. Circadian disruption, sleep loss, and prostate cancer risk: a systematic review of epidemiologic studies. Cancer Epidemiol. Biomarkers Prev. 21(7), 1002-1011 (2012).
80. Dopfel RP, Schulmeister K, Schernhammer ES. Nutritional and lifestyle correlates of the cancer-protective hormone melatonin. Cancer Detect. Prev. 31(2), 140-148 (2007). (Pubitemid 46680372)
81. Sliwinski T, Rozej W, Morawiec-Bajda A, Morawiec Z, Reiter R, Blasiak J. Protective action of melatonin against oxidative DNA damage: chemical inactivation versus base-excision repair. Mutat. Res. 634(1-2), 220-227 (2007). (Pubitemid 47634011)
82. Liu R, Fu A, Hoffman AE, Zheng T, Zhu Y. Melatonin enhances DNA repair capacity possibly by affecting genes involved in DNA damage responsive pathways. BMC Cell Biol. 14, 1 (2013).
83. Flynn-Evans EE, Stevens RG, Tabandeh H, Schernhammer ES, Lockley SW. Total visual blindness is protective against breast cancer. Cancer Causes Control 20(9), 1753-1756 (2009).
84. Anisimov VN, Vinogradova IA, Panchenko AV, Popovich IG, Zabezhinski MA. Light-at-night-induced circadian disruption, cancer, and aging. Curr. Aging Sci. 5(3), 170-177 (2012).
85. Bonde JP, Hansen J, Kolstad HA et al. Work at night and breast cancer-report on evidence-based options for preventive actions. Scand. J. Work Environ. Health 38(4), 380-390 (2012).
86. Chen ST, Choo KB, Hou MF, Yeh KT, Kuo SJ, Chang JG. Deregulated expression of the PER1, PER2 and PER3 genes in breast cancers. Carcinogenesis 26(7), 1241-1246 (2005).
87. Savvidis C, Koutsilieris M. Circadian rhythm disruption in cancer biology. Mol. Med. 18, 1249-1260 (2012).
88. Jones CR, Huang AL, Ptacek LJ, Fu YH. Genetic basis of human circadian rhythm disorders. Exp. Neurol. 243, 28-33 (2012).
89. Allebrandt KV, Teder-Laving M, Akyol M et al. CLOCK gene variants associate with sleep duration in two independent populations. Biol. Psychiatry 67(11), 1040-1047 (2010).
90. Archer SN, Robilliard DL, Skene DJ et al. A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference. Sleep 26(4), 413-415 (2003). (Pubitemid 39610658)
91. Hida A, Kitamura S, Mishima K. Pathophysiology and pathogenesis of circadian rhythm sleep disorders. J. Physiol. Anthropol. 31(1), 7 (2012).
92. Robilliard DL, Archer SN, Arendt J et al. The 3111 Clock gene polymorphism is not associated with sleep and circadian rhythmicity in phenotypically characterized human subjects. J. Sleep Res. 11(4), 305-312 (2002). (Pubitemid 35478074)
93. Osland TM, Bjorvatn BR, Steen VM, Pallesen S. Association study of a variable-number tandem repeat polymorphism in the clock gene PERIOD3 and chronotype in Norwegian university students. Chronobiol. Int. 28(9), 764-770 (2011).
94. Xu X, Breen G, Chen CK, Huang YS, Wu YY, Asherson P. Association study between a polymorphism at the 3́-untranslated region of CLOCK gene and attention deficit hyperactivity disorder. Behav. Brain Funct. 6, 48 (2010).
95. Benedetti F, Serretti A, Colombo C et al. Influence of CLOCK gene polymorphism on circadian mood fluctuation and illness recurrence in bipolar depression. Am. J. Med. Genet. B Neuropsychiatr. Genet. 123B(1), 23-26 (2003). (Pubitemid 37323259)
96. Chen PH, Kuo HY, Chueh KH. Sleep hygiene education: efficacy on sleep quality in working women. J. Nurs. Res. 18(4), 283-289 (2010).
97. Boivin DB, Boudreau P, Tremblay GM. Phototherapy and orange-tinted goggles for night-shift adaptation of police officers on patrol. Chronobiol. Int. 29(5), 629-640 (2012).
98. Romeijn N, Raymann RJ, Most E et al. Sleep, vigilance, and thermosensitivity. Pflugers Arch. 463(1), 169-176 (2012).
99. Ronkainen H, Vakkuri O, Kauppila A. Effects of physical exercise on the serum concentration of melatonin in female runners. Acta Obstet. Gynecol. Scand. 65(8), 827-829 (1986). (Pubitemid 17215556)
100. van der Heijden KB, Smits MG, Van Someren EJW, Ridderinkhof KR, Gunning WB. Effect of melatonin on sleep, behavior, and cognition in ADHD and chronic sleep-onset insomnia. J. Am. Acad. Child Adol. Psychiatry 46(2), 233-241 (2007). (Pubitemid 46148422)
101. Lewy AJ, Emens JS, Lefler BJ, Yuhas K, Jackman AR. Melatonin entrains free-running blind people according to a physiological dose-response curve. Chronobiol. Int. 22(6), 1093-1106 (2005). (Pubitemid 43062253)
102. van Geijlswijk IM, Korzilius HP, Smits MG. The use of exogenous melatonin in delayed sleep phase disorder: a meta-analysis. Sleep 33(12), 1605-1614 (2010).
103. Carrillo-Vico A, Reiter RJ, Lardone PJ et al. The modulatory role of melatonin on immune responsiveness. Curr. Opin. Invest. Drugs 7(5), 423-431 (2006). (Pubitemid 43772981)
104. Lewy AJ, Rough JN, Songer JB, Mishra N, Yuhas K, Emens JS. The phase shift hypothesis for the circadian component of winter depression. Dialogues Clin. Neurosci. 9(3), 291-300 (2007). (Pubitemid 350003872)
105. Crowley SJ, Eastman CI. Melatonin in the afternoons of a gradually advancing sleep schedule enhances the circadian rhythm phase advance. Psychopharmacology (Berl.) 225(4), 825-837 (2012).
106. Arns M, van der Heijden KB, Arnold LE, Kenemans JL. Geographic variation in the prevalence of attention-deficit/hyperactivity disorder: the sunny perspective. Biol. Psychiatry 74(8), 585-590 (2013).
107. Rosenthal NE, Joseph-Vanderpool JR, Levendosky AA et al. Phase-shifting effects of bright morning light as treatment for delayed sleep phase syndrome. Sleep 13(4), 354-361 (1990). (Pubitemid 20366853)
108. Paul MA, Gray GW, Lieberman HR et al. Phase advance with separate and combined melatonin and light treatment. Psychopharmacology (Berl.) 214(2), 515-523 (2011).
109. Kooij JJS. Adult ADHD: Diagnostic Assessment and Treatment. Springer, London (2013).