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Volumn 13, Issue 10, 2013, Pages 1099-1105

Elderly patients with glioblastoma: The treatment challenge

Author keywords

elderly patients; glioblastoma; radiochemotherapy; surgery; temozolomide

Indexed keywords

TEMOZOLOMIDE;

EID: 84886876599     PISSN: 14737175     EISSN: 17448360     Source Type: Journal    
DOI: 10.1586/14737175.2013.840419     Document Type: Review
Times cited : (9)

References (48)
  • 2
    • 84870804437 scopus 로고    scopus 로고
    • Treatment decision in elderly patients with glioblastoma
    • Brandes AA, Bartolotti M. Treatment decision in elderly patients with glioblastoma. Nat. Rev. Neurol. 8, 664-665 (2012).
    • (2012) Nat. Rev. Neurol. , vol.8 , pp. 664-665
    • Brandes, A.A.1    Bartolotti, M.2
  • 3
    • 84865548432 scopus 로고    scopus 로고
    • Glioblastoma therapy in the elderly: One age does not fit all
    • Nghiemphu PL, Cloughesy T. Glioblastoma therapy in the elderly: one age does not fit all. Lancet Oncol. 13, 857-858 (2012).
    • (2012) Lancet Oncol. , vol.13 , pp. 857-858
    • Nghiemphu, P.L.1    Cloughesy, T.2
  • 5
    • 80054989813 scopus 로고    scopus 로고
    • Treatment of glioblastoma in 'elderly' patients
    • Yovino S, Grossman SA. Treatment of glioblastoma in 'elderly' patients. Curr. Treat. Opin. Oncol. 12, 253-262 (2011).
    • (2011) Curr. Treat. Opin. Oncol. , vol.12 , pp. 253-262
    • Yovino, S.1    Grossman, S.A.2
  • 6
    • 68549111220 scopus 로고    scopus 로고
    • Glioblastoma in elderly: The Memorial-Sloan Kettering Cancer Center experience (1997-2007)
    • Iwamoto FM, Cooper AR, Reiner AS et al. Glioblastoma in elderly: the Memorial-Sloan Kettering Cancer Center experience (1997-2007). Cancer 115(16), 3758-3766 (2009).
    • (2009) Cancer , vol.115 , Issue.16 , pp. 3758-3766
    • Iwamoto, F.M.1    Cooper, A.R.2    Reiner, A.S.3
  • 8
    • 84880273376 scopus 로고    scopus 로고
    • Impact of age and co-morbidities in patients with newly diagnosed glioblastoma: A pooled data analysis of three prospective mono-institutional Phase II studies
    • Balducci M, Fiorentino A, De Bonis P et al. Impact of age and co-morbidities in patients with newly diagnosed glioblastoma: a pooled data analysis of three prospective mono-institutional Phase II studies. Med. Oncol. 29(5), 3478-3483 (2012).
    • (2012) Med. Oncol. , vol.29 , Issue.5 , pp. 3478-3483
    • Balducci, M.1    Fiorentino, A.2    De Bonis, P.3
  • 9
    • 84880301548 scopus 로고    scopus 로고
    • Comorbidity assessment and adjuvant radiochemotherapy in elderly affected by glioblastoma
    • Fiorentino A, Caivano R, Chiumento C et al. Comorbidity assessment and adjuvant radiochemotherapy in elderly affected by glioblastoma. Med. Oncol. 29(5), 3467-3471 (2012).
    • (2012) Med. Oncol. , vol.29 , Issue.5 , pp. 3467-3471
    • Fiorentino, A.1    Caivano, R.2    Chiumento, C.3
  • 12
    • 79959795966 scopus 로고    scopus 로고
    • Glioblastoma multiforme of the elderly: The prognostic effect of resection on survival
    • Ewelt C, Goeppert M, Rapp M, Steiger HJ, Stummer W, Sabel M. Glioblastoma multiforme of the elderly: the prognostic effect of resection on survival. J. Neurooncol. 103(3), 611-618 (2011).
    • (2011) J. Neurooncol. , vol.103 , Issue.3 , pp. 611-618
    • Ewelt, C.1    Goeppert, M.2    Rapp, M.3    Steiger, H.J.4    Stummer, W.5    Sabel, M.6
  • 13
    • 84863091424 scopus 로고    scopus 로고
    • Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: The NOA-08 randomised Phase 3 trial
    • Wick W, Platten M, Meisner C et al. Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, Phase 3 trial. Lancet Oncol. 13, 707-715 (2012).
    • (2012) Lancet Oncol. , vol.13 , pp. 707-715
    • Wick, W.1    Platten, M.2    Meisner, C.3
  • 14
  • 17
    • 2442659387 scopus 로고    scopus 로고
    • Abbreviated course of radiation therapy in older patients with glioblastoma multiforme: A prospective randomized clinical trial
    • Roa W, Brasher PM, Bauman G et al. Abbreviated course of radiation therapy in older patients with glioblastoma multiforme: a prospective randomized clinical trial. J. Clin. Oncol. 22(9), 1593-1598 (2004).
    • (2004) J. Clin. Oncol. , vol.22 , Issue.9 , pp. 1593-1598
    • Roa, W.1    Brasher, P.M.2    Bauman, G.3
  • 19
    • 0034024340 scopus 로고    scopus 로고
    • Chemotherapy for high-grade gliomas
    • Galanis E, Buckner J. Chemotherapy for high-grade gliomas. Br. J. Cancer 82, 1371-1380 (2000). (Pubitemid 30175900)
    • (2000) British Journal of Cancer , vol.82 , Issue.8 , pp. 1371-1380
    • Galanis, E.1    Buckner, J.2
  • 20
    • 0027516695 scopus 로고
    • Meta-analysis of radiation therapy with and without adjuvant chemotherapy for malignant gliomas in adults
    • Fine HA, Dear KBG, Loeffler JS, Black PM, Canellos GP. Meta-analysis of radiation therapy with and without adjuvant chemotherapy for malignant gliomas in adults. Cancer 71, 2585-2597 (1993). (Pubitemid 23100496)
    • (1993) Cancer , vol.71 , Issue.8 , pp. 2585-2597
    • Fine, H.A.1    Dear, K.B.G.2    Loeffler, J.S.3    Black, P.M.4    Canellos, G.P.5
  • 21
    • 0037161024 scopus 로고    scopus 로고
    • Chemotherapy in adult high-grade glioma: A systematic review and meta-analysis of individual patient data from 12 randomised trials
    • DOI 10.1016/S0140-6736(02)08091-1
    • Stewart LA. Chemotherapy in adult high-grade glioma: a systematic review and meta-analysis of individual patient data from 12 randomised trials. Lancet 359, 1011-1018 (2002). (Pubitemid 34286538)
    • (2002) Lancet , vol.359 , Issue.9311 , pp. 1011-1018
    • Stewart, L.A.1
  • 22
    • 0035266245 scopus 로고    scopus 로고
    • 2/M arrest and the fate of temozolomide-treated human glioblastoma cells
    • Hirose Y, Berger MS, Pieper RO. P53 effects both the duration of G2/M arrest and the fate of temozolomide-treated human glioblastoma cells. Cancer. Res. 61, 1957-1963 (2001). (Pubitemid 32692013)
    • (2001) Cancer Research , vol.61 , Issue.5 , pp. 1957-1963
    • Hirose, Y.1    Berger, M.S.2    Pieper, R.O.3
  • 23
    • 33947200238 scopus 로고    scopus 로고
    • A pilot study of primary temozolomide chemotherapy and deferred radiotherapy in elderly patients with glioblastoma
    • DOI 10.1007/s11060-006-9269-z
    • Chamberlain MC, Chalmers L. A pilot study of primary temozolomide chemotherapy and deferred radiotherapy in elderly patients with glioblastoma. J. Neurooncol. 82, 207-209 (2007). (Pubitemid 46431867)
    • (2007) Journal of Neuro-Oncology , vol.82 , Issue.2 , pp. 207-209
    • Chamberlain, M.C.1    Chalmers, L.2
  • 25
    • 1042297227 scopus 로고    scopus 로고
    • Phase II study of temozolomide without radiotherapy in newly diagnosed glioblastoma multiforme in an elderly populations
    • Chinot OL, Barrie M, Barrie M et al. Phase II study of temozolomide without radiotherapy in newly diagnosed glioblastoma multiforme in an elderly populations. Cancer 100(10), 2208-2214 (2004).
    • (2004) Cancer , vol.100 , Issue.10 , pp. 2208-2214
    • Chinot, O.L.1    Barrie, M.2    Barrie, M.3
  • 26
    • 80051659072 scopus 로고    scopus 로고
    • Temozolomide in elderly patients with newly diagnosed glioblastoma and poor performance status: An ANOCEF Phase II trial
    • Gallego-Perez-Larraya J, Ducray F, Chinot O et al. Temozolomide in elderly patients with newly diagnosed glioblastoma and poor performance status: an ANOCEF Phase II trial. J. Clin. Oncol. 29, 3050-3055(2011).
    • (2011) J. Clin. Oncol. , vol.29 , pp. 3050-3055
    • Gallego-Perez-Larraya, J.1    Ducray, F.2    Chinot, O.3
  • 27
    • 84867203245 scopus 로고    scopus 로고
    • Treatment of elderly patients with glioblastoma: From clinical evidence to molecular highlights
    • Chargari C, Feuvret L, Bauduceau O et al. Treatment of elderly patients with glioblastoma: from clinical evidence to molecular highlights. Cancer Treat. Rev. 38, 988-995 (2012).
    • (2012) Cancer Treat. Rev. , vol.38 , pp. 988-995
    • Chargari, C.1    Feuvret, L.2    Bauduceau, O.3
  • 28
    • 0037403996 scopus 로고    scopus 로고
    • Temozolomide as an alternative to irradiation for elderly patients with newly diagnosed malignant gliomas
    • DOI 10.1002/cncr.11323
    • Glantz M, Chamberlain M, Liu Q et al. Temozolomide as an alternative to irradiation for elderly patients with new diagnosed malignant gliomas. Cancer 97(9), 2262-2266 (2003). (Pubitemid 36444070)
    • (2003) Cancer , vol.97 , Issue.9 , pp. 2262-2266
    • Glantz, M.1    Chamberlain, M.2    Liu, Q.3    Litofsky, N.S.4    Recht, L.D.5
  • 29
    • 84865558322 scopus 로고    scopus 로고
    • Temozolomide versus standard 6-week radiotherapy versus hypofractionated radiotherapy in patients older than 60 years with glioblastoma: The Nordic randomised Phase 3 trial
    • Malmstrom A, Gronberg BH, Marosi C et al. Temozolomide versus standard 6-week radiotherapy versus hypofractionated radiotherapy in patients older than 60 years with glioblastoma: the Nordic randomised, Phase 3 trial. Lancet Oncol. 13, 916-926 (2012).
    • (2012) Lancet Oncol. , vol.13 , pp. 916-926
    • Malmstrom, A.1    Gronberg, B.H.2    Marosi, C.3
  • 31
    • 65349121788 scopus 로고    scopus 로고
    • Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised Phase III study: 5-year analysis of the EORTC-NCIC trial
    • Stupp R, Hegi ME, Mason WP et al. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised Phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol. 10, 459-466 (2009).
    • (2009) Lancet Oncol. , vol.10 , pp. 459-466
    • Stupp, R.1    Hegi, M.E.2    Mason, W.P.3
  • 32
    • 84878275261 scopus 로고    scopus 로고
    • Hypofractionated radiotherapy and stereotactic boost with concurrent and adjuvant temozolomide for glioblastoma in glioblastoma status elderly patients-early results of a phase II trial
    • Floyd SR, Kasper EM, Uhlmann EJ et al. Hypofractionated radiotherapy and stereotactic boost with concurrent and adjuvant temozolomide for glioblastoma in glioblastoma status elderly patients-early results of a phase II trial. Front Oncol. 2, 122 (2012).
    • (2012) Front Oncol. , vol.2 , Issue.122
    • Floyd, S.R.1    Kasper, E.M.2    Uhlmann, E.J.3
  • 33
    • 84973470134 scopus 로고    scopus 로고
    • Can elderly patients with newly diagnosed glioblastoma be enrolled in radiochemotherapy trials?
    • doi:10.1097/COC.0b013e3182868ea2 Epub ahead of print
    • Fiorentino A, Balducci M, De Bonis P et al. Can elderly patients with newly diagnosed glioblastoma be enrolled in radiochemotherapy trials? Am. J. Clin. Oncol. doi:10.1097/COC.0b013e3182868ea2 (2013) (Epub ahead of print).
    • (2013) Am. J. Clin. Oncol.
    • Fiorentino, A.1    Balducci, M.2    De Bonis, P.3
  • 34
    • 84884798553 scopus 로고    scopus 로고
    • Adjuvant radiochemotherapy in the elderly affected by glioblastoma: Single-institution experience and literature review
    • Fiorentino A, Chiumento C, Caivano R et al. Adjuvant radiochemotherapy in the elderly affected by glioblastoma: single-institution experience and literature review. Radiol. Med. 118(5), 870-881 (2012).
    • (2012) Radiol. Med. , vol.118 , Issue.5 , pp. 870-881
    • Fiorentino, A.1    Chiumento, C.2    Caivano, R.3
  • 36
    • 42349090207 scopus 로고    scopus 로고
    • Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma in elderly patients
    • Minniti G, De Sanctis V, Muni R et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma in elderly patients. J. Neurooncol. 88, 97-103 (2008).
    • (2008) J. Neurooncol. , vol.88 , pp. 97-103
    • Minniti, G.1    De Sanctis, V.2    Muni, R.3
  • 37
    • 68149182696 scopus 로고    scopus 로고
    • Temozolomide concomitant and adjuvant to radiotherapy in elderly patients with glioblastoma: Correlation with MGMT promoter methylation status
    • Brandes AA, Franceschi E, Tosoni A et al. Temozolomide concomitant and adjuvant to radiotherapy in elderly patients with glioblastoma: correlation with MGMT promoter methylation status. Cancer 115, 3512-3518 (2009).
    • (2009) Cancer , vol.115 , pp. 3512-3518
    • Brandes, A.A.1    Franceschi, E.2    Tosoni, A.3
  • 38
    • 78651476882 scopus 로고    scopus 로고
    • Postoperative radiotherapy and concomitant temozolomide for elderly patients with glioblastoma
    • Gerstein J, Franz K, Steinbach JP et al. Postoperative radiotherapy and concomitant temozolomide for elderly patients with glioblastoma. Radiother. Oncol. 97(3), 382-386 (2010).
    • (2010) Radiother. Oncol. , vol.97 , Issue.3 , pp. 382-386
    • Gerstein, J.1    Franz, K.2    Steinbach, J.P.3
  • 39
    • 77953289751 scopus 로고    scopus 로고
    • Glioblastoma in elderly patients: Safety and efficacy of adjuvant radiotherapy with concomitant temozolomide
    • Fiorica F, Berretta M, Colosimo C et al. Glioblastoma in elderly patients: safety and efficacy of adjuvant radiotherapy with concomitant temozolomide. Arch. Gerontol. Geriatr. 51(1), 31-35 (2010).
    • (2010) Arch. Gerontol. Geriatr. , vol.51 , Issue.1 , pp. 31-35
    • Fiorica, F.1    Berretta, M.2    Colosimo, C.3
  • 40
    • 77953355373 scopus 로고    scopus 로고
    • Concurrent temozolomide and radiation, a reasonable option for elderly patients with glioblastoma multiforme?
    • Kimple RJ, Grabowski S, Papez M, Collichio F, Ewend MG, Morris DE. Concurrent temozolomide and radiation, a reasonable option for elderly patients with glioblastoma multiforme? Am. J. Clin. Oncol. 33, 265-270 (2010).
    • (2010) Am. J. Clin. Oncol. , vol.33 , pp. 265-270
    • Kimple, R.J.1    Grabowski, S.2    Papez, M.3    Collichio, F.4    Ewend, M.G.5    De, M.6
  • 41
    • 84886726767 scopus 로고    scopus 로고
    • Radiotherapy with or without temozolomide in elderly glioblastoma patients: Treatment results and prognostic factor
    • Dirier A, Abacioglu MU, Okkan S et al. Radiotherapy with or without temozolomide in elderly glioblastoma patients: treatment results and prognostic factor. J. Clin. Oncol. 28, 15s (2010).
    • (2010) J. Clin. Oncol. , vol.28
    • Dirier, A.1    Abacioglu, M.U.2    Okkan, S.3
  • 42
    • 84859827804 scopus 로고    scopus 로고
    • Phase II study of short-course radiotherapy plus concomitant and adjuvant temozolomide in elderly patients with glioblastoma
    • Minniti G, Lanzetta G, Scaringi C et al. Phase II study of short-course radiotherapy plus concomitant and adjuvant temozolomide in elderly patients with glioblastoma. Int. J. Radiat. Oncol. Biol. Phys. 83, 93-99 (2012).
    • (2012) Int. J. Radiat. Oncol. Biol. Phys. , vol.83 , pp. 93-99
    • Minniti, G.1    Lanzetta, G.2    Scaringi, C.3
  • 43
    • 84863560794 scopus 로고    scopus 로고
    • Hypofractionated radiotherapy with or without concurrent temozolomide in elderly patients with glioblastoma multiforme: A review of ten-year single institutional experience
    • Cao JQ, Fisher BJ, Bauman GS, Megyesi JF, Watling CJ, Macdonald DR. Hypofractionated radiotherapy with or without concurrent temozolomide in elderly patients with glioblastoma multiforme: a review of ten-year single institutional experience. J. Neurooncol. 107, 395-405 (2012).
    • (2012) J. Neurooncol. , vol.107 , pp. 395-405
    • Cao, J.Q.1    Fisher, B.J.2    Bauman, G.S.3    Megyesi, J.F.4    Watling, C.J.5    MacDonald, D.R.6
  • 46
    • 84856244319 scopus 로고    scopus 로고
    • Low-dose fractionated radiotherapy and concomitant chemotherapy in glioblastoma multiforme with poor prognosis: A feasibility study
    • Balducci M, Chiesa S, Diletto B et al. Low-dose fractionated radiotherapy and concomitant chemotherapy in glioblastoma multiforme with poor prognosis: a feasibility study. Neuro. Oncol. 14(1), 79-86 (2012).
    • (2012) Neuro. Oncol. , vol.14 , Issue.1 , pp. 79-86
    • Balducci, M.1    Chiesa, S.2    Diletto, B.3
  • 47
    • 84879118353 scopus 로고    scopus 로고
    • Elderlyrsquo; Patients with newly diagnosed glioblastoma deserve optimal care
    • Holdhoff M, Rosner GL, Alcorn S, Grossman SA. 'Elderlyrsquo; patients with newly diagnosed glioblastoma deserve optimal care. J. Neurooncol. 113(2), 343-344 (2013).
    • (2013) J. Neurooncol. , vol.113 , Issue.2 , pp. 343-344
    • Holdhoff, M.1    Rosner, G.L.2    Alcorn, S.3    Grossman, S.A.4
  • 48
    • 84872739670 scopus 로고    scopus 로고
    • Elderly patients affected by glioblastoma treated with radiotherapy: The role of serum hemoglobin level
    • Fiorentino A, Fusco V. Elderly patients affected by glioblastoma treated with radiotherapy: the role of serum hemoglobin level. Int. J. Neurosci. 123(2), 133-137 (2013).
    • (2013) Int. J. Neurosci. , vol.123 , Issue.2 , pp. 133-137
    • Fiorentino, A.1    Fusco, V.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.