Crystal structures of the LsrR proteins complexed with phospho-AI-2 and two signal-interrupting analogues reveal distinct mechanisms for ligand recognition

Journal of the American Chemical Society

Volumn 135, Issue 41, 2013, Pages 15526-15535

  Ha, Jung Hye ^a,b   Eo, Yumi ^a,b   Grishaev, Alexander ^c   Guo, Min ^d   Smith, Jacqueline A I ^d   Sintim, Herman O ^d   Kim, Eun Hee ^a   Cheong, Hae Kap ^a   Bentley, William E ^e,f   Ryu, Kyoung Seok ^a,b  

^a Korea Basic Science Institute (KBSI)   (South Korea)

^b University of Science and Technology (UST)   (South Korea)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^d University of Maryland   (United States)

^e UNIVERSITY OF MARYLAND   (United States)

^f UNIVERSITY OF MARYLAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOFILM FORMATION; CELL-TO-CELL COMMUNICATION; DOWNSTREAM PROCESS; LIGAND RECOGNITION; REGULATORY MECHANISM; STRUCTURAL PERTURBATION; TETRAMERIC STRUCTURES; TRANSCRIPTIONAL REGULATOR;

BINDING ENERGY; CARBOXYLATION; HYDRATION; KETONES;

MOLECULES;

PEPTIDES AND PROTEINS; PROTEN LSRR; S RIBOSYLHOMOCYSTEINASE; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; HYDROGEN BOND; QUORUM SENSING;

AMINO ACID SEQUENCE; CRYSTALLIZATION; ESCHERICHIA COLI PROTEINS; HOMOSERINE; LACTONES; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; QUORUM SENSING; REPRESSOR PROTEINS; SEQUENCE ALIGNMENT;

EID: 84886871261     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja407068v     Document Type: Article

References (36)

1. Fuqua, W. C.; Winans, S. C.; Greenberg, E. P. J. Bacteriol. 1994, 176, 269-75
2. Waters, C. M.; Bassler, B. L. Annu. Rev. Cell Dev. Biol. 2005, 21, 319-46
3. Imperi, F.; Massai, F.; Facchini, M.; Frangipani, E.; Visaggio, D.; Leoni, L.; Bragonzi, A.; Visca, P. Proc. Natl. Acad. Sci. U.S.A. 2013, 110, 7458-63
4. Njoroge, J.; Sperandio, V. EMBO Mol. Med. 2009, 1, 201-10
5. Gospodarek, E.; Bogiel, T.; Zalas-Wiecek, P. Pol. J. Microbiol. 2009, 58, 191-8
6. Parker, C. T.; Sperandio, V. Cell Microbiol. 2009, 11, 363-9
7. Chen, X.; Schauder, S.; Potier, N.; Van Dorsselaer, A.; Pelczer, I.; Bassler, B. L.; Hughson, F. M. Nature 2002, 415, 545-9
8. Hu, M.; Zhang, C.; Mu, Y.; Shen, Q.; Feng, Y. Indian J. Microbiol 2010, 50, 362-8
9. Xavier, K. B.; Bassler, B. L. Nature 2005, 437, 750-3
10. Li, J.; Attila, C.; Wang, L.; Wood, T. K.; Valdes, J. J.; Bentley, W. E. J. Bacteriol. 2007, 189, 6011-20
11. Wang, L.; Li, J.; March, J. C.; Valdes, J. J.; Bentley, W. E. J. Bacteriol. 2005, 187, 8350-60
12. Meijler, M. M.; Hom, L. G.; Kaufmann, G. F.; McKenzie, K. M.; Sun, C.; Moss, J. A.; Matsushita, M.; Janda, K. D. Angew. Chem., Int. Ed. 2004, 43, 2106-8
13. Roy, V.; Adams, B. L.; Bentley, W. E. Enzyme Microb. Technol. 2011, 49, 113-23
14. Roy, V.; Meyer, M. T.; Smith, J. A.; Gamby, S.; Sintim, H. O.; Ghodssi, R.; Bentley, W. E. Appl. Microbiol. Biotechnol. 2013, 97, 2627-38
15. Byrd, C. M.; Bentley, W. E. Cell Res. 2009, 19, 1229-30
16. Zhu, P.; Li, M. Curr. Med. Chem. 2012, 19, 174-86
17. Ganin, H.; Tang, X.; Meijler, M. M. Bioorg. Med. Chem. Lett. 2009, 19, 3941-4
18. Smith, J. A.; Wang, J.; Nguyen-Mau, S. M.; Lee, V.; Sintim, H. O. Chem. Commun. (Cambridge, U.K.) 2009, 7033-5
19. Peng, H.; Cheng, Y.; Ni, N.; Li, M.; Choudhary, G.; Chou, H. T.; Lu, C. D.; Tai, P. C.; Wang, B. Chem. Med. Chem. 2009, 4, 1457-68
20. Lowery, C. A.; Abe, T.; Park, J.; Eubanks, L. M.; Sawada, D.; Kaufmann, G. F.; Janda, K. D. J. Am. Chem. Soc. 2009, 131, 15584-5
21. Gamby, S.; Roy, V.; Guo, M.; Smith, J. A.; Wang, J.; Stewart, J. E.; Wang, X.; Bentley, W. E.; Sintim, H. O. ACS Chem. Biol. 2012, 7, 1023-30
22. Roy, V.; Smith, J. A.; Wang, J.; Stewart, J. E.; Bentley, W. E.; Sintim, H. O. J. Am. Chem. Soc. 2010, 132, 11141-50
23. Wu, M.; Tao, Y.; Liu, X.; Zang, J. J. Biol. Chem. 2013, 288, 15878-87
24. de Sanctis, D.; McVey, C. E.; Enguita, F. J.; Carrondo, M. A. J. Mol. Biol. 2009, 387, 759-70
25. Harpaz, Y.; Gerstein, M.; Chothia, C. Structure 1994, 2, 641-9
26. Diaz, Z.; Xavier, K. B.; Miller, S. T. PLoS One 2009, 4, e6820
27. Miller, S. T.; Xavier, K. B.; Campagna, S. R.; Taga, M. E.; Semmelhack, M. F.; Bassler, B. L.; Hughson, F. M. Mol. Cell 2004, 15, 677-87
28. Globisch, D.; Lowery, C. A.; McCague, K. C.; Janda, K. D. Angew. Chem., Int. Ed. 2012, 51, 4204-8
29. Muraoka, S.; Okumura, R.; Ogawa, N.; Nonaka, T.; Miyashita, K.; Senda, T. J. Mol. Biol. 2003, 328, 555-66
30. Mortensen, U. H.; Breddam, K. Protein Sci. 1994, 3, 838-42
31. Langkilde, A.; Kristensen, S. M.; Lo Leggio, L.; Molgaard, A.; Jensen, J. H.; Houk, A. R.; Navarro Poulsen, J. C.; Kauppinen, S.; Larsen, S. Acta Crystallogr., Sect. D Biol. Crystallogr. 2008, D64, 851-63
32. Torshin, I. Y.; Weber, I. T.; Harrison, R. W. Protein Eng. 2002, 15, 359-63
33. Xue, T.; Zhao, L.; Sun, H.; Zhou, X.; Sun, B. Cell Res. 2009, 19, 1258-68
34. Zorrilla, S.; Doan, T.; Alfonso, C.; Margeat, E.; Ortega, A.; Rivas, G.; Aymerich, S.; Royer, C. A.; Declerck, N. Biophys. J. 2007, 92, 3215-27
35. Bennett, B. D.; Kimball, E. H.; Gao, M.; Osterhout, R.; Van Dien, S. J.; Rabinowitz, J. D. Nat. Chem. Biol. 2009, 5, 593-9
36. Rezacova, P.; Kozisek, M.; Moy, S. F.; Sieglova, I.; Joachimiak, A.; Machius, M.; Otwinowski, Z. Mol. Microbiol. 2008, 69, 895-910