Integrated optical microfluidic biosensor using a polycarbazole photodetector for point-of-care detection of hormonal compounds

Journal of Biomedical Optics

Volumn 18, Issue 9, 2013, Pages

  Pires, Nuno Miguel Matos ^a   Dong, Tao ^a   Hanke, Ulrik ^a   Hoivik, Nils ^a  

^a UNIVERSITY OF SOUTH EASTERN NORWAY   (Norway)

Author keywords

chemiluminescence; hormones; immunosensing; integrated optics; Microfluidics; point of care; polymer photodetector

Indexed keywords

CHEMILUMINESCENT IMMUNOASSAYS; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOSENSING; MICROFLUIDIC BIOSENSORS; POINT OF CARE; POINT-OF-CARE DIAGNOSTICS; POLY-3 ,4-ETHYLENEDIOXYTHIOPHENE; POLYMER PHOTODETECTORS;

CHEMICAL DETECTION; CHEMILUMINESCENCE; CONDUCTING POLYMERS; HETEROJUNCTIONS; HORMONES; INTEGRATED OPTICS; MICROFLUIDICS; OPTIMIZATION; PHOTODETECTORS; PHOTODIODES; PHOTONS; SENSORS;

BIOSENSORS;

HORMONE; IMMOBILIZED ANTIBODY; POLYMER; THYROTROPIN;

ADULT; CHEMICAL MODEL; CHEMISTRY; DEVICES; GENETIC PROCEDURES; HOSPITAL INFORMATION SYSTEM; HUMAN; METABOLISM; MICROFLUIDIC ANALYSIS; PROCEDURES; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; ARTICLE; EQUIPMENT; METHODOLOGY;

ADULT; ANTIBODIES, IMMOBILIZED; BIOSENSING TECHNIQUES; HORMONES; HUMANS; MICROFLUIDIC ANALYTICAL TECHNIQUES; MODELS, CHEMICAL; POINT-OF-CARE SYSTEMS; POLYMERS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; THYROTROPIN;

EID: 84886812402     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.JBO.18.9.097001     Document Type: Article

References (45)

1. F. S. Ligler, "Perspective on optical biosensors and integrated sensor systems," Anal. Chem. 81(2), 519-526 (2009).
2. A. Warsinke, "Point-of-care testing of proteins," Anal. Bioanal. Chem. 393(5), 1393-1405 (2009).
3. J. S. Ahn et al., "Development of a point-of-care assay system for high-sensitivity C-reactive protein in whole blood," Clin. Chim. Acta 332(1-2), 51-59 (2003). (Pubitemid 36577489)
4. P.-Y. Chung et al., "Amplification-free point of care immunosensor for detecting type V collagen at a concentration level of ngml," Proc. SPIE 8029, 80291C (2011).
5. V. Gubala et al., "Point of care diagnostics: status and future," Anal. Chem. 84(2), 487-515 (2012).
6. A. Bange, H. B. Halsall, and W. R. Heineman, "Microfluidic immunosensor systems," Biosens. Bioelectron. 20(12), 2488-2503 (2005). (Pubitemid 40602185)
7. N. M. M. Pires et al., "A mediator embedded micro-immunosensing unit for electrochemical detection on viruses within physiological saline media," J. Micromech. Microeng. 21(11), 115031 (2011).
8. F. B. Myers and L. P. Lee, "Innovations in optical microfluidic technologies for point-of-care diagnostics," Lab Chip 8(12), 2015-2031 (2008).
9. C. Monat, P. Domachuk, and B. J. Eggleton, "Integrated optofluidics: A new river of light," Nat. Photonics 1(2), 106-114 (2007).
10. M. Yang et al., "An automated point-of-care system for immunodetection of staphylococcal enterotoxin B," Anal. Biochem. 416(1), 74-81 (2011).
11. C. D. Chin, V. Linder, and S. K. Sia, "Commercialization of microfluidic point-of-care diagnostic devices," Lab Chip 12(12), 2118-2134 (2012).
12. A. Bhattacharyya and C. M. Klapperich, "Design and testing of a disposable microfluidic chemiluminescent immunoassay for disease biomarkers in human serum samples," Biomed. Microdevices 9(2), 245-251 (2007). (Pubitemid 46554132)
13. J. Yakovleva et al., "Microfluidic enzyme immunoassay using silicon microchip with immobilized antibodies and chemiluminescence detection," Anal. Chem. 74(13), 2994-3004 (2002). (Pubitemid 34759949)
14. M. Miyake et al., "Performance of an organic photodiode as an optical detector and its application to fluorometric flow-immunoassay for IgA," Talanta 96, 132-139 (2012).
15. X. Wang et al., "Integrated thin-film polymer/fullerene photodetectors for on-chip microfluidic chemiluminescence detection," Lab Chip 7(1), 58-63 (2007). (Pubitemid 44974595)
16. X. Huang and J. Ren, "On-line chemiluminescence detection for isoelectric focusing of heme proteins on microchips," Electrophoresis 26(19), 3595-3601 (2005). (Pubitemid 41512011)
17. C. Chandsawangbhuwana et al., "High-throughput optofluidic system for the laser microsurgery of oocytes," J. Biomed. Opt. 17(1), 015001 (2012).
18. T. Dong et al., "Integratable non-clogging microconcentrator based on counter-flow principle for continuous enrichment of CaSki cells sample," Microfluid. Nanofluid. 10(4), 855-865 (2011).
19. B. Kuswandi et al., "Optical sensing systems for microfluidic devices: A review," Anal. Chim. Acta 601(2), 141-155 (2007). (Pubitemid 47505229)
20. M. Granstrom et al., "Laminated fabrication of polymeric photovoltaic diodes," Nature 395(6699), 257-260 (1998). (Pubitemid 28447545)
21. E. Kraker et al., "Integrated organic electronic based optochemical sensors using polarization filters," Appl. Phys. Lett. 92(3), 033302 (2008).
22. O. Hofmann et al., "Thin-film organic photodiodes as integrated detectors for microscale chemiluminescence assays," Sens. Actuators B Chem. 106(2), 878-884 (2005). (Pubitemid 40557653)
23. J. R. Wojciechowski et al., "Organic photodiodes for biosensors miniaturization," Anal. Chem. 81(9), 3455-3461 (2009).
24. X. Wang et al., "Thin-film organic photodiodes for integrated on-chip chemiluminescence detection-application to antioxidant capacity screening," Sens. Actuators B Chem. 140(2), 643-648 (2009).
25. A. J. Heeger, "Semiconducting polymers: The Third Generation," Chem. Soc. Rev. 39(7), 2354-2371 (2010).
26. S. H. Park et al., "Bulk heterojunction solar cells with internal quantum efficiency approaching 100%," Nat. Photonics 3(5), 297-302 (2009).
27. K. K. H. Chan et al., "Charge injection and transport studies of poly(2,7-carbazole) copolymer PCDTBT and their relationship to solar cell performance," Org. Electron. 13(5), 850-855 (2012).
28. J. Nichols et al., "On-chip digital microfluidic architectures for enhanced actuation and sensing," J. Biomed. Opt. 17(6), 067005 (2012).
29. K. W. Kho et al., "Polymer-based microfluidics with surface-enhanced Raman-spectroscopy-active periodic metal nanostructures for biofluid analysis," J. Biomed. Opt. 13(5), 054026 (2008).
30. T. Dong et al., "A smart fully integrated micromachined separator with soft magnetic micro-pillar arrays for cell isolation," J. Micromech. Microeng. 20(11), 115021 (2010).
31. G. P. Chrousos, "Stress and disorders of the stress system," Nat. Rev. Endocrinol. 5(7), 374-381 (2009).
32. J. Wu and M. Gu, "Microfluidic sensing: state of the art fabrication and detection techniques," J. Biomed. Opt. 16(8), 080901 (2011).
33. E. Ouellet et al., "Novel carboxyl-amine bonding methods for poly (dimethylsiloxane)-based devices," Langmuir 26(14), 11609-11614 (2010).
34. B. Xiao et al., "Integrated micro Pirani gauge based hermetical package monitoring for uncooled VOx bolometer FPAs," Microsyst. Technol. 17(1), 115-124 (2011).
35. X. Zhao et al., "Compatible immune-NASBA LOC device for quantitative detection of waterborne pathogens: Design and validation," Lab Chip 12(3), 602-612 (2012).
36. J. Huang and J. deMello, "An introduction to organic photodetectors," Chapter 6 in Organic Electronics in Sensors and Biotechnology, R. Shinar and J. Shinar, Eds., pp. 193-263, McGraw-Hill, New York (2009).
37. B. Friedel et al., "Effect of layer thickness and annealing of PEDOT:PSS layers in organic photodetectors," Macromolecules 42(17), 6741-6747 (2009).
38. B. V. Andersson et al., "An optical spacer is no panacea for light collection in organic solar cells," Appl. Phys. Lett. 94(4), 043302 (2009).
39. A. J. Moulé and K. Meerholz, "Intensity-dependent photocurrent generation at the anode in bulk-heterojunction solar cells," Appl. Phys. B 92(2), 209-218 (2008).
40. T.-Y. Chu et al., "Highly efficient polycarbazole-based organic photovoltaic devices," Appl. Phys. Lett. 95(6), 063304 (2009).
41. A. G. Gianoukakis, N. Khadavi, and T. J. Smith, "Cytokines, Gravés disease, and thyroid-associated ophthalmopathy," Thyroid 18(9), 953-958 (2008).
42. L. Zhang and T. Dong, "A Si/SiGe quantum well based biosensor for direct analysis of exothermic biochemical reaction," J. Micromech. Microeng. 23(4), 045011 (2013).
43. P. Yager et al., "Microfluidic diagnostic technologies for global public health," Nature 442(7101), 412-418 (2006). (Pubitemid 44264785)
44. X. Zhao and T. Dong, "Multifunctional sample preparation kit and onchip quantitative nucleic acid sequence-based amplification tests for microbial detection," Anal. Chem. 84(20), 8541-8548 (2012).
45. T. Laksanasopin et al., "Microfluidic point-of-care diagnostics for resource-poor environments," Proc. SPIE 7318, 73180E (2009).