On-chip digital microfluidic architectures for enhanced actuation and sensing

Journal of Biomedical Optics

Volumn 17, Issue 6, 2012, Pages

  Nichols, Jacqueline ^a   Collier, Christopher M ^a   Landry, Emily L ^a   Wiltshire, Michael ^a   Born, Brandon ^a   Holzman, Jonathan F ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Digital microfluidic device; Electrowetting; Integrated optics; Lab on a chip; Optical sensing; Refractometry

Indexed keywords

GLASS; POLYMER; WATER;

ANIMAL; ARTICLE; CHEMISTRY; COMPUTER SIMULATION; ELECTRODE; EQUIPMENT DESIGN; HUMAN; LAB ON A CHIP; METHODOLOGY; MICROFLUIDIC ANALYSIS; MICROFLUIDICS; MOTION; OPTICS; REFRACTOMETRY;

ANIMALS; COMPUTER SIMULATION; ELECTRODES; EQUIPMENT DESIGN; GLASS; HUMANS; LAB-ON-A-CHIP DEVICES; MICROFLUIDIC ANALYTICAL TECHNIQUES; MICROFLUIDICS; MOTION; OPTICS AND PHOTONICS; POLYMERS; REFRACTOMETRY; WATER;

EID: 84868651935     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.JBO.17.6.067005     Document Type: Article

References (39)

1. H.-C. Lin, Y.-J. Liu, and D.-J. Yao, "DNA litigation using coplanar electrodes electro-wetting-on-dielectric (EWOD) device," in Proc. 4th IEEE Int. Conf. Nano/Micro Engineered and Molecular Systems, pp. 385-389, IEEE Computer Society, Washington, DC, USA (2009).
2. T. H. Schulte, R. L. Bardell, and B. H. Weigl, "Microfluidic technologies in clinical diagnostics," Clin. Chem. Acta 321(1-2), 1-10 (2002). (Pubitemid 34597045)
3. C. Neils et al., "Combinatorial mixing of microfluidic streams," Lab Chip 4(4), 342-350 (2004). (Pubitemid 39150236)
4. M. Brivio, W. Verbroom, and D. N. Reinhoudt, "Miniaturized continuous flow reaction vessels: influence on chemical reactions," Lab Chip 6(3), 329-244 (2006).
5. J. P. Urbanski et al., "Digital microfluidics using soft lithography," Lab Chip 6(1), 96-104 (2006).
6. J. Lee et al., "Electrowetting and electrowetting-on-dielectric for microscale liquid handling," Sensor. Actuator A 95(2), 259-268 (2002). (Pubitemid 34061315)
7. T. Xu et al., "Automated design on pin-constrained digital microfluidic biochips under droplet-interference constraints," ACM J. Emerg. Tech. 3(3), 14:1-14:23 (2007).
8. V. Srinivasan, V. K. Pamula, and R. B. Fair, "An integrated digital microfluidic lab-on-a-chip for clinical diagnostics on human physiological fluids," Lab Chip 4(4), 310-315 (2004). (Pubitemid 39150230)
9. M. G. Pollack, R. B. Fair, and A. D. Shenderov, "Electrowetting- based actuation of liquid droplets for microfluidic applications," Appl. Phys. Lett. 77(11), 1725-1726 (2000).
10. K. Bohringer, "Modeling and controlling parallel tasks in droplet-based microfluidic systems," IEEE Trans. CAD 25(2), 329-339 (2006). (Pubitemid 43146090)
11. J. Berthier, Microdrops and Digital Microfluidics, William Andrew Inc., Norwhich, NY (2008).
12. M. J. Jebrail and A. R.Wheeler, "Let's get digital: digitizing chemical biology with microfluidics," Curr. Opin. Chem. Biol. 14(5), 574-581 (2010).
13. P. Paik, V. K. Pamula, and R. B. Fair, "Rapid droplet mixers for digital microfluidic systems," Lab Chip 3(4), 253-259 (2003). (Pubitemid 41646532)
14. J. Gong and C.-J. Kim, "Direct-referencing two-dimensional-array digital microfluidics using multi-layer printed circuit board," J. MEMS 17(2), 257-264 (2008).
15. C. M. Collier et al., "Nonlinear dual-phase multiplexing in digital microfluidic architectures," Micromachines 2(4), 369-384 (2011).
16. Y. Li et al., "Anodic Ta2O5 for CMOS compatible low voltage electrowetting-on-dielectric device fabrication," Solid-State Electron. 52(9), 1382-1387 (2008).
17. M. J. Madou and R. Cubicciotti, "Scaling issues in chemical and biological sensors," Proc. IEEE 91(6), 830-838 (2003).
18. A. Ahmadi et al., "In situ characterization of microdroplet interfacial properties in digital microfluidic systems," Lab Chip 10(11), 1429-1435 (2010).
19. M. Han, F. Guo, and Y. Lu, "Optical fiber refractometer based on cladding-mode Bragg grating," Opt. Lett. 35(3), 399-401 (2010).
20. B. Born, E. L. Landry, and J. F. Holzman, "Electro-dispensing of micro-spheroids for lateral refractive and reflective photonic elements," IEEE Photon. J. 2(6), 873-883 (2010).
21. E. Maftei, P. Pop, and J. Madsen, "Tabu search-based synthesis of digital microfluidic biochips with dynamically reconfigurable nonrectangular devices," Des. Autom. Embed. Syst. 14(3), 287-307 (2010).
22. D. Davids et al., "Multiple fault diagnosis in digital microfluidic biochips," ACM J. Emerg. Tech. 2(4), 262-276 (2006). (Pubitemid 46192920)
23. Z. Xiao and E. F. Young, "CrossRouter: a droplet router for crossreferencing digital microfluidic biochips," in Proc. 15th Asia South Pacific Design Automation Conf., pp. 269-274, IEEE Press, Piscataway, NJ, USA (2010).
24. M. Cho and D. Z. Pan, "A high-performance droplet routing algorithm for digital microfluidic biochips," IEEE Trans. Comput. Aided Des. 27(10), 1714-1724 (2008).
25. T. Zhu and K. Chakrabarty, "A droplet-manipulation method for achieving high-throughput in cross-referencing-based digital microfluidic biochips," IEEE Trans. Comput. Aided Des. 27(11), 1905-1917 (2008).
26. R. Renaudot et al., "Optimization of liquid dielectrophoresis (LDEP) digital microfluidic transduction for biomedical applications," Micromachines 2(2), 258-273 (2011).
27. A. Dolatabadi, K. Mohseni, and A. Arzpeyma, "Behaviour of a moving droplet under electrowetting actuation: numerical simulation," Can. J. Chem. Eng. 84(1), 17-21 (2006). (Pubitemid 43989158)
28. F. Su, W. Hwang, and K. Chakrabarty, "Droplet routing in the synthesis of digital microfluidic biochips," in Proc. Des. Autom. Test Eur., Munich, Germany, pp. 323-328 (March 6-10 2006).
29. C.-T. Ho et al., "Micromachined electrochemical T-switches for cell sorting applications," Lab Chip 5(11), 1248-1258 (2005). (Pubitemid 41626180)
30. A. P. Chandrakasan, N. Verma, and D. C. Daly, "Ultralow-power electronics for biomedical applications," Annu. Rev. Biomed. Eng. 10(1), 247-274 (2008).
31. R. H. W. Lam, M.-C. Kim, and T. Thorsen, "Culturing aerobic and anaerobic bacteria and mammalian cells with a microfluidic differential oxygenator," Anal. Chem. 81(14), 5918-5924 (2009).
32. H. Moon et al., "Low voltage electrowetting-on-dielectric," J. Appl. Phys. 92(7), 4080-4087 (2002).
33. A. Ahmadi et al., "Digital implementations for integrated microfluidic sensing," Proc. SPIE 7318, 73181C (2009).
34. C. Monat, P. Domachuk, and B. J. Eggleton, "Integrated optofluidics: a new river of light," Nat. Photon. 1(2), 106-114 (2007).
35. C. Elbuken et al., "Detection of microdroplet size and speed using capacitive sensors," Sensor Actuator A 171(2), 55-62 (2011).
36. J. L. Cruz-Campa et al., "Microlens rapid prototyping technique with capability for wide variation in lens diameter and focal length," Microelectron. Eng. 87(11), 2376-2381 (2010).
37. G. Ladam et al., "Protein adsorption onto auto-assembled polyelectrolyte films," Langmuir 17(2-6), 878-882 (2001). (Pubitemid 32873078)
38. W. B. Li et al., "Determination of the temperature and concentration dependence of the refractive index of a liquid mixture," J. Chem. Phys. 101(6), 5058-5069 (1994).
39. F. Mugele and J. C. Baret, "Electrowetting: from basics to applications," J. Phys.: Condens. Matter 17(28), R705-R774 (2005). (Pubitemid 40970543)