Chimerism of allogeneic mesenchymal cells in bone marrow, liver, and spleen after mesenchymal stem cells infusion

Pediatric Transplantation

Volumn 17, Issue 8, 2013, Pages

  Meleshko, Alexander ^a   Prakharenia, Irina ^a   Kletski, Semen ^b   Isaikina, Yanina ^a  

^a Belarusian Research Center for Pediatric Oncology Hematology and Immunology   (Belarus)

^b Municipal Bureau of Clinical Pathology   (Belarus)

Author keywords

bone marrow transplantation; chimerism; mesenchymal stem cells; mesenchymal stem cells homing

Indexed keywords

ADOLESCENT; ALLOGENIC BONE MARROW TRANSPLANTATION; ARTICLE; BONE MARROW CELL; CASE REPORT; CHILD; CHIMERA; ENGRAFTMENT; FEMALE; GENE TARGETING; HEMATOLOGIC DISEASE; HUMAN; INFECTION COMPLICATION; LIVER CELL; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; SCHOOL CHILD; SPLEEN CELL; SRY GENE;

BONE MARROW TRANSPLANTATION; CHIMERISM; MESENCHYMAL STEM CELLS; MESENCHYMAL STEM CELLS HOMING;

ADOLESCENT; BONE MARROW CELLS; CELLS, CULTURED; CHILD; CHIMERISM; FEMALE; HUMANS; LIVER; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; PARAFFIN; REAL-TIME POLYMERASE CHAIN REACTION; SPLEEN; TRANSPLANTATION, HOMOLOGOUS;

EID: 84886812174     PISSN: 13973142     EISSN: 13993046     Source Type: Journal    
DOI: 10.1111/petr.12168     Document Type: Article

References (30)

1. Uccelli A, Moretta L, Pistoia V,. Mesenchymal stem cells in health and disease. Nat Rev Immunol 2008: 8: 726-736.
2. Koç ON, Gerson SL, Cooper BW, et al. Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy. J Clin Oncol 2000: 18: 307-316.
3. Lazarus HM, Haynesworth SE, Gerson SL, Rosenthal NS, Caplan AI,. Ex vivo expansion and subsequent infusion of human bone marrow-derived stromal progenitor cells (mesenchymal progenitor cells): Implications for therapeutic use. Bone Marrow Transplant 1995: 16: 557-564.
4. Ringden O, Uzunel M, Rasmusson I, et al. Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease. Transplantation 2006: 81: 1390-1397.
5. Tolar J, Nauta AJ, Osborn MJ, et al. Sarcoma derived from cultured mesenchymal stem cells. Stem Cells 2007: 25: 371-379.
6. le Blanc K, Samuelsson H, Gustafsson B, et al. Transplantation of mesenchymal stem cells to enhance engraftment of hematopoietic stem cells. Leukemia 2007: 21: 1733-1738.
7. Gonzalo-Daganzo R, Regidor C, Martín-Donaire T, et al. Results of a pilot study on the use of third-party donor mesenchymal stromal cells in cord blood transplantation in adults. Cytotherapy 2009: 11: 278-288.
8. di Nicola M, Carlo-Stella C, Magni M, et al. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 2002: 99: 3838-3843.
9. Bartholomew A, Sturgeon C, Siatskas M, et al. Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Exp Hematol 2002: 30: 42-48.
10. Abumaree M, Al Jumah M, Pace RA, Kalionis B,. Immunosuppressive properties of mesenchymal stem cells. Stem Cell Rev 2012: 8: 375-392.
11. Ghannam S, Bouffi C, Djouad F, Jorgensen C, Noël D,. Immunosuppression by mesenchymal stem cells: Mechanisms and clinical applications. Stem Cell Res Ther 2010: 1: 2.
12. Rieger K, Marinets O, Fietz T, et al. Mesenchymal stem cells remain of host origin even a long time after allogeneic peripheral blood stem cell or bone marrow transplantation. Exp Hematol 2005: 33: 605-611.
13. Cilloni D, Carlo-Stella C, Falzetti F, et al. Limited engraftment capacity of bone marrow-derived mesenchymal cells following T-cell-depleted hematopoietic stem cell transplantation. Blood 2000: 96: 3637-3643.
14. Bartsch K, Al-Ali H, Reinhardt A, et al. Mesenchymal stem cells remain host-derived independent of the source of the stem-cell graft and conditioning regimen used. Transplantation 2009: 87: 217-221.
15. Dickhut A, Schwerdtfeger R, Kuklick L, et al. Mesenchymal stem cells obtained after bone marrow transplantation or peripheral blood stem cell transplantation originate from host tissue. Ann Hematol 2005: 84: 722-727.
16. Koç ON, Day J, Nieder M, Gerson SL, Lazarus HM, Krivit W,. Allogeneic mesenchymal stem cell infusion for treatment of metachromatic leukodystrophy (MLD) and Hurler syndrome (MPS-IH). Bone Marrow Transplant 2002: 30: 215-222.
17. Lazarus HM, Koc ON, Devine SM, et al. Cotransplantation of HLA-identical sibling culture expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients. Biol Blood Marrow Transplant 2005: 11: 389-398.
18. Fouillard L, Bensidhoum M, Bories D, et al. Engraftment of allogeneic mesenchymal stem cells in the bone marrow of a patient with severe idiopathic aplastic anemia improves stroma. Leukemia 2003: 17: 474-476.
19. Ten Hove WR, Verspaget HW, Barge R, Lamers CB, Van Hoek B,. Liver chimerism after allogeneic blood stem cell transplantation. Transplant Proc 2007: 39: 231-236.
20. Quantitative analysis of chimerism after allogeneic stem cell transplantation using multiplex PCR amplification of short tandem repeat markers and fluorescence detection. Leukemia 2001: 15: 303-306.
21. van der Velden VH, Cazzaniga G, Schrauder A, et al. Analysis of minimal residual disease by Ig/TCR gene rearrangements: Guidelines for interpretation of real-time quantitative PCR data. Leukemia 2007: 21: 604-611.
22. Pikor LA, Enfield KS, Cameron H, Lam WL,. DNA extraction from paraffin embedded material for genetic and epigenetic analyses. J Vis Exp 2011: 49: e2763.
23. Pongers-Willemse MJ, Verhagen OJ, Tibbe GJ, et al. Real-time quantitative PCR for the detection of minimal residual disease in acute lymphoblastic leukemia using junctional region specific TaqMan probes. Leukemia 1998: 12: 2006-2014.
24. Otsuru S, Gordon PL, Shimono K, et al. Transplanted bone marrow mononuclear cells and MSCs impart clinical benefit to children with osteogenesis imperfecta through different mechanisms. Blood 2012: 120: 1933-1941.
25. Vosough M, Moslem M, Pournasr B, Baharvand H,. Cell-based therapeutics for liver disorder. Br Med Bull 2011: 100: 157-172.
26. Maijenburg MW, van der Schoot CE, Voermans C,. Mesenchymal stromal cell migration: Possibilities to improve cellular therapy. Stem Cells Dev 2012: 21: 19-29.
27. Ortiz LA, Gambelli F, McBride C, et al. Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects. Proc Natl Acad Sci U S A 2003: 100: 8407-8411.
28. Devine SM, Cobbs C, Jennings M, Bartholomew A, Hoffman R,. Mesenchymal stem cells distribute to a wide range of tissues following systemic infusion into nonhuman primates. Blood 2003: 101: 2999-3001.
29. Minguell JJ, Erices A, Conget P,. Mesenchymal stem cells. Exp Biol Med (Maywood) 2001: 226: 507-520.
30. Isaikina Y, Kustanovich A, Svirnovski A,. Growth kinetics and self-renewal of human mesenchymal stem cells derived from bone marrow of children with oncohematological diseases during expansion in vitro. Exp Oncol 2006: 28: 146-151.