Structural analysis of the novel influenza A (H7N9) viral Neuraminidase interactions with current approved neuraminidase inhibitors Oseltamivir, Zanamivir, and Peramivir in the presence of mutation R289K

BMC Bioinformatics

Volumn 14, Issue SUPPL16, 2013, Pages

  Tran To Su, Chinh ^a   Ouyang, Xuchang ^a   Zheng, Jie ^a,b   Kwoh, Chee Keong ^a  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^b GENOME INSTITUTE OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

AVIAN INFLUENZA A; BINDING CAVITY; CONFORMATIONAL CHANGE; GLOBAL HEALTH; MOLECULAR DOCKING; MOLECULAR DYNAMICS SIMULATIONS; NEURAMINIDASE INHIBITORS; STABLE COMPLEXES;

ANTIVIRAL AGENTS; HYDROGEN BONDS; MOLECULAR DYNAMICS;

VIRUSES;

ANTIVIRUS AGENT; CYCLOPENTANE DERIVATIVE; ENZYME INHIBITOR; GUANIDINE DERIVATIVE; OSELTAMIVIR; PERAMIVIR; SIALIDASE; VIRUS PROTEIN; ZANAMIVIR;

ANTIVIRAL RESISTANCE; ARTICLE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENETICS; INFLUENZA VIRUS A H7N9; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MUTATION;

ANTIVIRAL AGENTS; CYCLOPENTANES; DRUG RESISTANCE, VIRAL; ENZYME INHIBITORS; GUANIDINES; INFLUENZA A VIRUS, H7N9 SUBTYPE; MOLECULAR DOCKING SIMULATION; MOLECULAR DYNAMICS SIMULATION; MUTATION; NEURAMINIDASE; OSELTAMIVIR; VIRAL PROTEINS; ZANAMIVIR;

EID: 84886799435     PISSN: None     EISSN: 14712105     Source Type: Journal    
DOI: 10.1186/1471-2105-14-S16-S7     Document Type: Article

References (28)

1. Uyeki TM, Cox NJ. Global concerns regarding novel influenza A (H7N9) virus infections. The New England Journal of Medicine 2013
2. iJet Update: Emergence of Avian Influenza A (H7N9) in Eastern China. 2013, In. 910F Bestgate Road, Annapolis, MD 21401, iJet.
3. World Health Organization (WHO). Human Infection with Influenza A (H7N9) virus in China - update. http://www.who.int/csr/don/2013_04_16/en/index.html
4. Why the WHO is calling H7N9 one of the "most lethal" flu viruses so far. http://globalnews.ca/news/511395/why-the-who-is-calling-h7n9-one-of-the-most-lethal-flu-viruses-so-far
5. Gao R, Cao B, Hu Y, Feng Z, Wang D, Hu W, Chen J, Jie Z, Qiu H, Xu K, et al. Human Infection with a novel avian-origin influenza A (H7N9) virus. The New England Journal of Medicine 2013
6. Corman V, Erickmann M, Landt O, Bleicker T, Brunink S, Eschbach-Bludau M, Matrosovich M, Becker S, Drosten C. Specific detection by real-time reverse-transcription PCR assays of a novel avian influenza A (H7N9) strain associated with human spillover infections in China. Euro Surveil 2013, 18(16):pii-20461.
7. Wu S, Wu F, He J. Emerging risk of H7N9 influenza in China. The Lancet 2013, (13):60767-60769.
8. Wen Y-M, Klenk H-D. H7N9 avian influenza virus - search and re-search. Emerging Microbes and Infections 2013, 2(e18).
9. Matrosovich M, Matrosovich T, Gray T, Roberts N, Klenk H. Human and avian influenza viruses target different cell types in cultures of human airway epithelium. Proc Natl Acad Sci USA 2004, 101:4620-4624. 10.1073/pnas.0308001101, 384796, 15070767.
10. JianZhong S, GuoHua D, PeiHong L, JinPing Z, LiZheng G, WenHui L, XuYong L, Jing Z, GuoJun G, Jun F, et al. Isolation and characterization of H7N9 viruses from live poultry markets - Implication of the source of current H7N9 infection in humans. Chinese Science Bulletin 2013
11. Abed Y, Boivin G. Treatment of respiratiory virus infections. Antiviral Research 2006, 70:1-16. 10.1016/j.antiviral.2006.01.006, 16513187.
12. Baz M, Abed Y, Simon P, Hamelin M-E, Boivin G. Effect of the Neuraminidase Mutation H274Y conferring resistance to Oseltamivir on the Replicative Capacity and Virulence of old and recent Human Influenza A (H1N1) viruses. The journal of Infectious Diseases 2010, 201:740-745. 10.1086/650464, 20100088.
13. Hurt AC, Holien JK, Parker MW, Barr IG. Oseltamivir resistance and the H274Y Neuraminidase mutation in seasonal, pandemic and highly pathogenic influenza viruses. Drugs 2009, 69(18):2523-2531. 10.2165/11531450-000000000-00000, 19943705.
14. Aoki F, Boivin G, Roberts N. Influenza virus susceptibility and resistance to oseltamivir. Antivir Ther 2007, 12:603-616.
15. Russell RJ, Haire LF, Stevens DL, Collins PJ, Lin YP, Blackburn GM, Hay AJ, Gamblin SJ, Skehel JJ. The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design. Nature 2006, 443:45-49. 10.1038/nature05114, 16915235.
16. Wang M, Tai C, Mendel D. Mechanism by which mutations at His 274 alter sensitivity of influenza A virus N1 neuraminidase to oseltamivir carboxylate and zanamivir. Antimicrob Agents Chemother 2002, 46:3809-3816. 10.1128/AAC.46.12.3809-3816.2002, 132783, 12435681.
17. Kageyama T, Fujisaki S, Takashita E, Xu H, Yamada S, Uchida Y, Neumann G, Saito T, Kawaoka Y, Tashiro M. Genetic analysis of novel avian A (H7N9) influenza viruses isolated from patients in China, February to April 2013. Euro Surveil 2013, 18(15). pii=20453.
18. Matsuoka Y, Swayne D, Thomas C, Rameix-Welti M, Naffakh N, Warnes C, Altholtz M, Donis R, Subbarao K. Neuraminidase stalk length and additional glycosylation of the hemagglutinin influence the virulence of influenza H5N1 viruses for mice. Journal of Virology 2009, 83(9):4704-4708. 10.1128/JVI.01987-08, 2668507, 19225004.
19. Tamiflu resistance gene in H7N9 bird flu spurs drug tests. http://www.bloomberg.com/news/2013-04-11/tamiflu-resistance-gene-in-h7n9-bird-flu-spurs-drug-tests.html
20. Varghese JN, Smith PW, Sollis SL, Blick TJ, Sahasrabudhe A, McKimm-Breschkin JL, Colman PM. Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase. Structure 1998, 6:735-746. 10.1016/S0969-2126(98)00075-6, 9655825.
21. Morris G, Huey R, Lindstrom W, Sanner MF, Belew RK, Goodsell DS, Olson AJ. Autodock4 and AutoDockTools4: automated docking with selective receptor flexibility. Chemistry 2009, 16:2785-2791.
22. Salomon-Ferrer R, Case DA, Walker RC. An overview of the Amber biomolecular simulation package. WIREs Comput Mol Sci 2012
23. Guex N, Peitsch MC. Swiss-Model and the Swiss-Pdb Viewer: An environment for comparative protein modelling. Electrophoresis 1997, 18:2714-2723. 10.1002/elps.1150181505, 9504803.
24. National Center for Biotechnology Information. http://www.ncbi.nlm.nih.gov
25. RCSB Protein Data Bank. http://www.pdb.org
26. Zhang Y. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics 2008, 9(40).
27. Hernandez M, Ghersi D, Sanchez R. SiteHound-web: a server for ligand binding site identification in protein structures. Nucleic Acids Res 2009, 37(Web Server):W413-W416. 10.1093/nar/gkp281, 2703923, 19398430.
28. Case DA, CheathamIII TE, Darden T, Gohlke H, Luo R, Merz KM, Onufriev A, Simmerling S, Wang B, Woods R. The Amber biomolecular simulation programs. J Computat Chem 2005, 26:1668-1688.