Control of energy balance by hypothalamic gene circuitry involving two nuclear receptors, neuron-derived orphan receptor 1 and glucocorticoid receptor

Molecular and Cellular Biology

Volumn 33, Issue 19, 2013, Pages 3826-3834

  Kim, Sun Gyun ^a   Lee, Bora ^a,b   Kim, Dae Hwan ^a   Kim, Juhee ^a   Lee, Seunghee ^c   Lee, Soo Kyung ^a,b   Lee, Jae W ^a,b,d  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c Seoul National University   (South Korea)

^d Pohang University of Science and Technology (POSTECH)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

AGOUTI RELATED PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; LEPTIN; NEUROPEPTIDE Y; NUCLEAR RECEPTOR NR4A3;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; ENERGY BALANCE; FEMALE; GENE EXPRESSION REGULATION; HYPOTHALAMUS; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WILD TYPE;

AGOUTI; MUS;

EID: 84886794481     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.00385-13     Document Type: Article

References (39)

1. Ellacott KL, Cone RD. 2004. The central melanocortin system and the integration of short- and long-term regulators of energy homeostasis. Recent Prog. Horm. Res. 59:395-408.
2. Seeley RJ, Drazen DL, Clegg DJ. 2004. The critical role of the melanocortin system in the control of energy balance. Annu. Rev. Nutr. 24:133- 149.
3. Bantubungi K, Prawitt J, Staels B. 2012. Control of metabolism by nutrient-regulated nuclear receptors acting in the brain. J. Steroid Biochem. Mol. Biol. 130:126-137.
4. Olofsson LE, Pierce AA, Xu AW. 2009. Functional requirement of AgRP and NPY neurons in ovarian cycle-dependent regulation of food intake. Proc. Natl. Acad. Sci. U. S. A. 106:15932-15937.
5. de Souza FS, Nasif S, López-Leal R, Levi DH, Low MJ, Rubinsten M. 2011. The estrogen receptor α colocalizes with proopiomelanocortin in hypothalamic neurons and binds to a conserved motif present in the neuron- specific enhancer nPE2. Eur. J. Pharmacol. 660:181-187.
6. Varela L, Martínez-Sánchez N, Gallego R, Vázquez MJ, Roa J, Gándara M, Schoenmakers E, Nogueiras R, Chatterjee K, Tena-Sempere M, Diéguez C, López M. 2012. Hypothalamic mTOR pathway mediates thyroid hormone-induced hyperphagia in hyperthyroidism. J. Pathol. 227:209-222.
7. Lee B, Kim SG, Kim J, Choi KY, Lee S, Lee SK, Lee JW. 2013. Brain-specific homeobox factor as a target selector for glucocorticoid receptor in energy balance. Mol. Cell. Biol. 33:2650-2658.
8. Pearen MA, Ryall JG, Maxwell MA, Ohkura N, Lynch GS, Muscat GE. 2006. The orphan nuclear receptor, NOR-1, is a target of beta-adrenergic signaling in skeletal muscle. Endocrinology 147:5217-5227.
9. Nilaweera KN, Ellis C, Barrett P, Mercer JG, Morgan PJ. 2002. Hypothalamic bHLH transcription factors are novel candidates in the regulation of energy balance. Eur. J. Neurosci. 15:644-650.
10. Castro DS, Hermanson E, Joseph B, Wallén A, Aarnisalo P, Heller A, Perlmann T. 2001. Induction of cell cycle arrest and morphological differentiation by Nurr1 and retinoids in dopamine MN9D cells. J. Biol. Chem. 276:43277-43284.
11. Thompson H, Barker D, Camand O, Erskine L. 2006. Slits contribute to the guidance of retinal ganglion cell axons in the mammalian optic tract. Dev. Biol. 296:476-484.
12. Fishilevich E, Domingos AI, Asahina K, Naef F, Vosshall LB, Louis M. 2005. Chemotaxis behavior mediated by single larval olfactory neurons in Drosophila. Curr. Biol. 15:2086-2096.
13. Nomiyama T, Nakamachi T, Gizard F, Heywood EB, Jones KL, Ohkura N, Kawamori R, Conneely OM, Bruemmer D. 2006. The NR4A orphan nuclear receptor NOR1 is induced by platelet-derived growth factor and mediates vascular smooth muscle cell proliferation. J. Biol. Chem. 281: 33467-33476.
14. Ponnio T, Burton Q, Pereira FA, Wu DK, Conneely OM. 2002. The nuclear receptor Nor-1 is essential for proliferation of the semicircular canals of the mouse inner ear. Mol. Cell. Biol. 22:935-945.
15. Martens C, Bilodeau S, Maira M, Yves Gauthier Y, Drouin J. 2005. Protein-protein interactions and transcriptional antagonism between the subfamily of NGFI-B/Nur77 orphan nuclear receptors and glucocorticoid receptor. Mol. Endocrinol. 19:885-897.
16. Kobayashi T, Deak M, Morrice N, Cohen P. 1999. Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid- induced protein kinase. Biochem. J. 344:189-197.
17. Catalano S, Giordano C, Rizza P, Gu G, Barone I, Bonofiglio D, Giordano F, Malivindi R, Gaccione D, Lanzino M, De Amicis F, Andò S. 2009. Evidence that leptin through STAT and CREB signaling enhances cyclin D1 expression and promotes human endometrial cancer proliferation. J. Cell. Physiol. 218:490-500.
18. Nduati V, Yan Y, Dalmasso G, Driss A, Sitaraman S, Merlin D. 2007. Leptin transcriptionally enhances peptide transporter (hPepT1) expression and activity via the cAMP-response element-binding protein and Cdx2 transcription factors. J. Biol. Chem. 282:1359-1373.
19. Duan J, Choi YH, Hartzell D, Della-Fera MA, Hamrick M, Baile CA. 2007. Effects of subcutaneous leptin injections on hypothalamic gene profiles in lean and ob/ob mice. Obesity (Silver Spring) 15:2624-2633.
20. Ohkubo T, Ohkura N, Maruyama K, Sasaki K, Nagasaki K, Hanzawa H, Tsukada T, Yamaguchi K. 2000. Early induction of the orphan nuclear receptor NOR-1 during cell death of the human breast cancer cell line MCF-7. Mol. Cell. Endocrinol. 162:151-156.
21. Rius J, Martínez-González J, Crespo J, Badimon L. 2004. Involvement of neuron-derived orphan receptor-1 (NOR-1) in LDL-induced mitogenic stimulus in vascular smooth muscle cells: role of CREB. Arterioscler. Thromb. Vasc. Biol. 24:697-702.
22. Stauber C, Altschmied J, Akerblom IE, Marron JL, Mellon PL. 1992. Mutual cross-interference between glucocorticoid receptor and CREB inhibits transactivation in placental cells. New Biol. 4:527-540.
23. Weng Z, Signore AP, Gao Y, Wang S, Zhang F, Hastings T, Yin XM, Chen J. 2007. Leptin protects against 6-hydroxydopamine-induced dopaminergic cell death via mitogen-activated protein kinase signaling. J. Biol. Chem. 282:34479-34491.
24. Makimura H, Mizuno TM, Isoda F, Beasley J, Silverstein JH, Mobbs CV. 2003. Role of glucocorticoids in mediating effects of fasting and diabetes on hypothalamic gene expression. BMC Physiol. 3:5. doi:10.1186 /1472-6793-3-5.
25. Savontaus E, Conwell IM, Wardlaw SL. 2002. Effects of adrenalectomy on AGRP, POMC, NPY and CART gene expression in the basal hypothalamus of fed and fasted rats. Brain Res. 958:130-138.
26. Dhillo WS, Small CJ, Gardiner JV, Bewick GA, Whitworth EJ, Jethwa PH, Seal LJ, Ghatei MA, Hinson JP, Bloom SR. 2003. Agouti-related protein has an inhibitory paracrine role in the rat adrenal gland. Biochem. Biophys. Res. Commun. 301:102-107.
27. Shimizu H, Arima H, Watanabe M, Goto M, Banno R, Sato I, Ozaki N, Nagasaki H, Oiso Y. 2008. Glucocorticoids increase neuropeptide Y and agouti-related peptide gene expression via adenosine monophosphateactivated protein kinase signaling in the arcuate nucleus of rats. Endocrinology 149:4544-4553.
28. Mohan HM, Aherne CM, Rogers AC, Baird AW, Winter DC, Murphy EP. 2012. Molecular pathways: the role of NR4A orphan nuclear receptors in cancer. Clin. Cancer Res. 18:3223-3228.
29. McEvoy AN, Murphy EA, Ponnio T, Conneely OM, Bresnihan B, FitzGerald O, Murphy EP. 2002. Activation of nuclear orphan receptor NURR1 transcription by NF-kappa B and cyclic adenosine 5=- monophosphate response element-binding protein in rheumatoid arthritis synovial tissue. J. Immunol. 168:2979-2987.
30. Chen X, Zachar V, Chang C, Ebbesen P, Liu X. 1998. Differential expression of Nur77 family members in human T-lymphotropic virus type 1-infected cells: transactivation of the TR3/nur77 gene by Tax protein. J. Virol. 72:6902-6906.
31. Ohkubo T, Sugawara Y, Sasaki K, Maruyama K, Ohkura N, Makuuchi M. 2002. Early induction of nerve growth factor-induced genes after liver resection-reperfusion injury. J. Hepatol. 36:210-217.
32. Klemm DJ, Roesler WJ, Boras T, Colton LA, Felder K, Reusch JE. 1998. Insulin stimulates cAMP-response element binding protein activity in HepG2 and 3T3-L1 cell lines. J. Biol. Chem. 273:917-923.
33. Wu X, Wang J, Cui X, Maianu L, Rhees B, Rosinski J, So WV, Willi SM, Osier MV, Hill HS, Page GP, Allison DB, Martin M, Garvey WT. 2007. The effect of insulin on expression of genes and biochemical pathways in human skeletal muscle. Endocrine 31:5-17.
34. Wauman J, Tavernier J. 2011. Leptin receptor signaling: Pathways to leptin resistance. Front. Biosci. (Landmark Ed.) 16:2771-2793.
35. Bouloumie A, Marumo T, Lafontan M, Busse R. 1999. Leptin induces oxidative stress in human endothelial cells. FASEB J. 13:1231-1238.
36. Gonzalez-Perez RR. 2010. Leptin upregulates VEGF in breast cancer via canonic and non-canonical signalling pathways and NFkappaB/HIF- 1alpha activation. Cell. Signal. 22:1350-1362.
37. Zhao Y, Howatt DA, Gizard F, Nomiyama T, Findeisen HM, Heywood EB, Jones KL, Conneely OM, Daugherty A, Bruemmer D. 2010. Deficiency of the NR4A orphan nuclear receptor NOR1 decreases monocyte adhesion and atherosclerosis. Circ. Res. 107:501-511.
38. Martorell L, Gentile M, Rius J, Rodríguez C, Crespo J, Badimon L, Martínez-González J. 2009. The hypoxia-inducible factor 1/NOR-1 axis regulates the survival response of endothelial cells to hypoxia. Mol. Cell. Biol. 29:5828-5842.
39. Zhang X, Zhang G, Zhang H, Karin M, Bai H, Cai D. 2008. Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell 135:61-73.