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Volumn 14, Issue 5, 2013, Pages 435-441

β3-receptor agonists for overactive bladder - New frontier or more of the same?

Author keywords

Adverse effect profile; Antimuscarinics; Clinical efficacy; Mechanisms of action; Mirabegron

Indexed keywords

5 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL] 1,3 BENZODIOXOLE 2,2 DICARBOXYLIC ACID; BETA 3 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; DARIFENACIN; FESOTERODINE; FLAVOXATE; MIRABEGRON; MOXIFLOXACIN; MUSCARINIC RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; OXYBUTYNIN; PLACEBO; PROPIVERINE; SOLIFENACIN; TOLTERODINE; TROSPIUM CHLORIDE;

EID: 84886782472     PISSN: 15272737     EISSN: 15346285     Source Type: Journal    
DOI: 10.1007/s11934-013-0335-8     Document Type: Article
Times cited : (10)

References (53)
  • 1
    • 84868700750 scopus 로고    scopus 로고
    • Diagnosis and treatment of overactive bladder (non-neurogenic) in adults:AUA/SUFU guideline. American Urological Association; Society of Urodynamics, Female Pelvic Medicine & Urogenital Reconstruction
    • 23098785 10.1016/j.juro.2012.09.079
    • Gormley EA, Lightner DJ, Burgio KL, et al. Diagnosis and treatment of overactive bladder (non-neurogenic) in adults:AUA/SUFU guideline. American Urological Association; Society of Urodynamics, Female Pelvic Medicine & Urogenital Reconstruction. J Urol. 2012;188(6 Suppl):2455-63.
    • (2012) J Urol , vol.188 , Issue.6 SUPPL. , pp. 2455-2463
    • Gormley, E.A.1    Lightner, D.J.2    Burgio, K.L.3
  • 2
    • 84868559568 scopus 로고    scopus 로고
    • EAU guidelines on assessment and nonsurgical management of urinary incontinence
    • 22985745 10.1016/j.eururo.2012.08.047
    • Lucas MG, Bosch RJ, Burkhard FC, et al. EAU guidelines on assessment and nonsurgical management of urinary incontinence. Eur Urol. 2012;62(6):1130-42.
    • (2012) Eur Urol , vol.62 , Issue.6 , pp. 1130-1142
    • Lucas, M.G.1    Bosch, R.J.2    Burkhard, F.C.3
  • 3
    • 47949098266 scopus 로고    scopus 로고
    • The effects of antimuscarinic treatments in overactive bladder: An update of a systematic review and meta-analysis
    • 18599186 10.1016/j.eururo.2008.06.047 1:CAS:528:DC%2BD1cXhtFKisb%2FK
    • Chapple CR, Khullar V, Gabriel Z, et al. The effects of antimuscarinic treatments in overactive bladder: an update of a systematic review and meta-analysis. Eur Urol. 2008;54(3):543-62.
    • (2008) Eur Urol , vol.54 , Issue.3 , pp. 543-562
    • Chapple, C.R.1    Khullar, V.2    Gabriel, Z.3
  • 4
    • 50849116095 scopus 로고    scopus 로고
    • Systematic review and meta-analysis of randomized controlled trials with antimuscarinic drugs for overactive bladder
    • 18632201 10.1016/j.eururo.2008.06.080 1:CAS:528:DC%2BD1cXhtlGgu77F
    • Novara G, Galfano A, Secco S, et al. Systematic review and meta-analysis of randomized controlled trials with antimuscarinic drugs for overactive bladder. Eur Urol. 2008;54(4):740-63.
    • (2008) Eur Urol , vol.54 , Issue.4 , pp. 740-763
    • Novara, G.1    Galfano, A.2    Secco, S.3
  • 5
    • 84927174200 scopus 로고    scopus 로고
    • Pharmacological treatment of urinary incontinence
    • Incontinence. ed by AbramsP, Cardozo L, Khoury A, Wein A Paris February 2012, ICUD-EAU Up-to-date review of current treatments
    • •• Andersson KE, Chapple CR, Cardozo L, et al. Pharmacological treatment of urinary incontinence. In: Incontinence. ed by AbramsP, Cardozo L, Khoury A, Wein A. 5th International Consultation on Incontinence, Paris February 2012, ICUD-EAU 2013:625-728. Up-to-date review of current treatments.
    • (2013) 5th International Consultation on Incontinence , pp. 625-728
    • Andersson, K.E.1    Chapple, C.R.2    Cardozo, L.3
  • 6
    • 84883771990 scopus 로고    scopus 로고
    • Selective β3-Adrenoceptor Agonists in the Treatment of the Overactive Bladder
    • Feb 28. [Epub ahead of print]
    • Andersson KE, Martin N, Nitti V. Selective β3-Adrenoceptor Agonists in the Treatment of the Overactive Bladder. J Urol. 2013b Feb 28. [Epub ahead of print]
    • (2013) J Urol.
    • Andersson, K.E.1    Martin, N.2    Nitti, V.3
  • 7
    • 61349178824 scopus 로고    scopus 로고
    • The beta3-adrenoceptor as a therapeutic target: Current perspectives
    • 19429463 10.1016/j.phrs.2009.01.002 1:CAS:528:DC%2BD1MXivVWls7Y%3D
    • Ursino MG, Vasina V, Raschi E, Crema F, De Ponti F. The beta3-adrenoceptor as a therapeutic target: current perspectives. Pharmacol Res. 2009;59(4):221-34.
    • (2009) Pharmacol Res , vol.59 , Issue.4 , pp. 221-234
    • Ursino, M.G.1    Vasina, V.2    Raschi, E.3    Crema, F.4    De Ponti, F.5
  • 8
    • 79952241104 scopus 로고    scopus 로고
    • Muscarinic acetylcholine receptors in the urinary tract
    • 21290234 10.1007/978-3-642-16499-6-16 1:CAS:528:DC%2BC3MXntVClsLc%3D
    • Andersson KE. Muscarinic acetylcholine receptors in the urinary tract. Handb Exp Pharmacol. 2011;202:319-44.
    • (2011) Handb Exp Pharmacol , vol.202 , pp. 319-344
    • Andersson, K.E.1
  • 9
    • 35148841097 scopus 로고    scopus 로고
    • Muscarinic receptor antagonists for overactive bladder
    • 17922784 10.1111/j.1464-410X.2007.07205.x 1:CAS:528:DC%2BD2sXhtlGgur7M
    • Abrams P, Andersson KE. Muscarinic receptor antagonists for overactive bladder. BJU Int. 2007;100(5):987-1006.
    • (2007) BJU Int , vol.100 , Issue.5 , pp. 987-1006
    • Abrams, P.1    Andersson, K.E.2
  • 10
    • 79551485468 scopus 로고    scopus 로고
    • Antimuscarinic mechanisms and the overactive detrusor: An update
    • 21168951 10.1016/j.eururo.2010.11.040 1:CAS:528:DC%2BC3MXht1ylsbk%3D
    • Andersson KE. Antimuscarinic mechanisms and the overactive detrusor: an update. Eur Urol. 2011;59(3):377-86.
    • (2011) Eur Urol , vol.59 , Issue.3 , pp. 377-386
    • Andersson, K.E.1
  • 11
    • 70349269052 scopus 로고    scopus 로고
    • A refocus on the bladder as the originator of storage lower urinary tract symptoms: A systematic review of the latest literature
    • 19683859 10.1016/j.eururo.2009.07.044
    • Roosen A, Chapple CR, Dmochowski RR, et al. A refocus on the bladder as the originator of storage lower urinary tract symptoms: a systematic review of the latest literature. Eur Urol. 2009;56(5):810-9.
    • (2009) Eur Urol , vol.56 , Issue.5 , pp. 810-819
    • Roosen, A.1    Chapple, C.R.2    Dmochowski, R.R.3
  • 12
    • 84871937932 scopus 로고    scopus 로고
    • Common theme for drugs effective in overactive bladder treatment: Inhibition of afferent signaling from the bladder
    • 23072271 10.1111/j.1442-2042.2012.03196.x 1:CAS:528: DC%2BC3sXjs1Ckug%3D%3D
    • Hood B, Andersson KE. Common theme for drugs effective in overactive bladder treatment: Inhibition of afferent signaling from the bladder. Int J Urol. 2013;20(1):21-7.
    • (2013) Int J Urol , vol.20 , Issue.1 , pp. 21-27
    • Hood, B.1    Andersson, K.E.2
  • 13
    • 1342299961 scopus 로고    scopus 로고
    • The autonomous bladder: A view of the origin of bladder overactivity and sensory urge
    • 15008713 10.1111/j.1464-410X.2003.04667.x 1:STN:280: DC%2BD2c3jtFSksA%3D%3D
    • Gillespie JI. The autonomous bladder: a view of the origin of bladder overactivity and sensory urge. BJU Int. 2004;93(4):478-83.
    • (2004) BJU Int , vol.93 , Issue.4 , pp. 478-483
    • Gillespie, J.I.1
  • 14
    • 77949336457 scopus 로고    scopus 로고
    • Bladder afferent signaling: Recent findings
    • 20171668 10.1016/j.juro.2009.12.060 1:CAS:528:DC%2BC3cXkvFOnur8%3D
    • Kanai A, Andersson KE. Bladder afferent signaling: recent findings. J Urol. 2010;183(4):1288-95.
    • (2010) J Urol , vol.183 , Issue.4 , pp. 1288-1295
    • Kanai, A.1    Andersson, K.E.2
  • 15
    • 84878491899 scopus 로고    scopus 로고
    • Urothelial signaling
    • 23589830 10.1152/physrev.00030.2012 1:CAS:528:DC%2BC3sXnsVWrtb8%3D
    • Birder L, Andersson KE. Urothelial signaling. Physiol Rev. 2013;93(2):653-80.
    • (2013) Physiol Rev , vol.93 , Issue.2 , pp. 653-680
    • Birder, L.1    Andersson, K.E.2
  • 16
    • 3142617911 scopus 로고
    • Tension receptors in the stomach and the urinary bladder
    • 13243351 1:STN:280:DyaG2M7gsFKitw%3D%3D
    • Iggo A. Tension receptors in the stomach and the urinary bladder. J Physiol. 1955;128(3):593-607.
    • (1955) J Physiol , vol.128 , Issue.3 , pp. 593-607
    • Iggo, A.1
  • 17
    • 33750891388 scopus 로고    scopus 로고
    • The effects of a new selective beta3-adrenoceptor agonist (GW427353) on spontaneous activity and detrusor relaxation in human bladder
    • 17026593 10.1111/j.1464-410X.2006.06564.x 1:CAS:528: DC%2BD2sXktlarsw%3D%3D
    • Biers SM, Reynard JM, Brading AF. The effects of a new selective beta3-adrenoceptor agonist (GW427353) on spontaneous activity and detrusor relaxation in human bladder. BJU Int. 2006;98(6):1310-4.
    • (2006) BJU Int , vol.98 , Issue.6 , pp. 1310-1314
    • Biers, S.M.1    Reynard, J.M.2    Brading, A.F.3
  • 18
    • 34247205378 scopus 로고    scopus 로고
    • Effect of (R)-2-(2-aminothiazol-4-yl)-4'-{2-[(2-hydroxy-2-phenylethyl) amino]ethyl} acetanilide (YM178), a novel selective beta3-adrenoceptor agonist, on bladder function
    • 17293563 10.1124/jpet.106.115840 1:CAS:528:DC%2BD2sXltFehur0%3D
    • Takasu T, Ukai M, Sato S, et al. Effect of (R)-2-(2-aminothiazol-4-yl)- 4'-{2-[(2-hydroxy-2-phenylethyl)amino]ethyl} acetanilide (YM178), a novel selective beta3-adrenoceptor agonist, on bladder function. J Pharmacol Exp Ther. 2007;321(2):642-7.
    • (2007) J Pharmacol Exp Ther , vol.321 , Issue.2 , pp. 642-647
    • Takasu, T.1    Ukai, M.2    Sato, S.3
  • 19
    • 84871875830 scopus 로고    scopus 로고
    • The novel β(3)-adrenoceptor agonist mirabegron reduces carbachol-induced contractile activity in detrusor tissue from patients with bladder outflow obstruction with or without detrusor overactivity
    • 23246623
    • Svalø J, Nordling J, Bouchelouche K, et al. The novel β(3)-adrenoceptor agonist mirabegron reduces carbachol-induced contractile activity in detrusor tissue from patients with bladder outflow obstruction with or without detrusor overactivity. Eur J Pharmacol. 2012;699(1-3):101-5.
    • (2012) Eur J Pharmacol , vol.699 , Issue.1-3 , pp. 101-105
    • Svalø, J.1    Nordling, J.2    Bouchelouche, K.3
  • 20
    • 84886788691 scopus 로고    scopus 로고
    • In vitro and in vivo pharmacological profile of the selective β(3)-adrenoceptor agonistmirabegron in rats
    • Dec 14. [Epub ahead of print]
    • Hatanaka T, Ukai M, Watanabe M, et al. In vitro and in vivo pharmacological profile of the selective β(3)-adrenoceptor agonistmirabegron in rats. Naunyn Schmiedebergs Arch Pharmacol. 2012 Dec 14. [Epub ahead of print]
    • (2012) Naunyn Schmiedebergs Arch Pharmacol.
    • Hatanaka, T.1    Ukai, M.2    Watanabe, M.3
  • 21
    • 84872353497 scopus 로고    scopus 로고
    • Effect of mirabegron, a novel β(3)-adrenoceptor agonist, on bladder function during storage phase in rats
    • 23224420 10.1007/s00210-012-0814-3 1:CAS:528:DC%2BC3sXjtVWqtw%3D%3D
    • Hatanaka T, Ukai M, Watanabe M, et al. Effect of mirabegron, a novel β(3)-adrenoceptor agonist, on bladder function during storage phase in rats. Naunyn Schmiedebergs Arch Pharmacol. 2013;386(1):71-8.
    • (2013) Naunyn Schmiedebergs Arch Pharmacol , vol.386 , Issue.1 , pp. 71-78
    • Hatanaka, T.1    Ukai, M.2    Watanabe, M.3
  • 22
    • 84863551967 scopus 로고    scopus 로고
    • Modulation of non-voiding activity by the muscarinergic antagonist tolterodine and the β(3)-adrenoceptor agonist mirabegron in conscious rats with partial outflow obstruction
    • 22734512 10.1111/j.1464-410X.2012.11240.x 1:CAS:528:DC%2BC38XhtFOmsrjN
    • Gillespie JI, Palea S, Guilloteau V, et al. Modulation of non-voiding activity by the muscarinergic antagonist tolterodine and the β(3)-adrenoceptor agonist mirabegron in conscious rats with partial outflow obstruction. BJU Int. 2012;110(2 Pt 2):E132-42.
    • (2012) BJU Int , vol.110 , Issue.2 PART 2
    • Gillespie, J.I.1    Palea, S.2    Guilloteau, V.3
  • 23
    • 77955557104 scopus 로고    scopus 로고
    • Effects of CL316,243, a β3 adrenoreceptor agonist, and intravesical prostaglandin E2 on the primary bladder afferent activity of the rat
    • 19816919 10.1002/nau.20826 1:CAS:528:DC%2BC3cXpslOls7g%3D
    • Aizawa N, Igawa Y, Nishizawa O, Wyndaele JJ. Effects of CL316,243, a β3 adrenoreceptor agonist, and intravesical prostaglandin E2 on the primary bladder afferent activity of the rat. Neurourol Urodyn. 2010;29:771-6.
    • (2010) Neurourol Urodyn , vol.29 , pp. 771-776
    • Aizawa, N.1    Igawa, Y.2    Nishizawa, O.3    Wyndaele, J.J.4
  • 24
    • 84868556806 scopus 로고    scopus 로고
    • Effects of mirabegron, a novel β3-adrenoceptor agonist, on primary bladder afferent activity and bladder microcontractions in rats compared with the effects of oxybutynin
    • 22981677 10.1016/j.eururo.2012.08.056 1:CAS:528:DC%2BC38XhtlGnsLjP Nice demonstration of mirabegron effects on bladder Aδ - and C-fiber afferents
    • • Aizawa N, Homma Y, Igawa Y. Effects of mirabegron, a novel β3-adrenoceptor agonist, on primary bladder afferent activity and bladder microcontractions in rats compared with the effects of oxybutynin. Eur Urol. 2012;62(6):1165-73. Nice demonstration of mirabegron effects on bladder Aδ - and C-fiber afferents.
    • (2012) Eur Urol , vol.62 , Issue.6 , pp. 1165-1173
    • Aizawa, N.1    Homma, Y.2    Igawa, Y.3
  • 25
    • 0344944933 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of drugs used to treat urge incontinence
    • 14606931 10.2165/00003088-200342140-00004 1:CAS:528:DC%2BD2cXps1ej
    • Guay DR. Clinical pharmacokinetics of drugs used to treat urge incontinence. Clin Pharmacokinet. 2003;42(14):1243-85.
    • (2003) Clin Pharmacokinet , vol.42 , Issue.14 , pp. 1243-1285
    • Guay, D.R.1
  • 26
    • 57749110417 scopus 로고    scopus 로고
    • Urothelial effects of oral agents for overactive bladder
    • 18947510 10.1007/s11934-008-0079-z
    • Andersson KE, Fullhase C, Soler R. Urothelial effects of oral agents for overactive bladder. Curr Urol Rep. 2008;9(6):459-64.
    • (2008) Curr Urol Rep , vol.9 , Issue.6 , pp. 459-464
    • Andersson, K.E.1    Fullhase, C.2    Soler, R.3
  • 27
    • 84867345500 scopus 로고    scopus 로고
    • Single dose pharmacokinetics and absolute bioavailibility of mirabegron, a β3-adrenoceptor agonist for treatment of overactive bladder
    • 22943933 10.5414/CP201782 1:CAS:528:DC%2BC3sXkvFeltg%3D%3D
    • Eltink C, Lee J, Schaddelee M, et al. Single dose pharmacokinetics and absolute bioavailibility of mirabegron, a β3-adrenoceptor agonist for treatment of overactive bladder. Int J Clin Pharmacol Ther. 2012;50(11):838-50.
    • (2012) Int J Clin Pharmacol Ther , vol.50 , Issue.11 , pp. 838-850
    • Eltink, C.1    Lee, J.2    Schaddelee, M.3
  • 28
    • 84867344252 scopus 로고    scopus 로고
    • Pharmacokinetic Properties of Mirabegron, a β(3)-Adrenoceptor Agonist: Results from Two Phase I, Randomized, Multiple-Dose Studies in Healthy Young and Elderly Men and Women
    • 23063375 10.1016/j.clinthera.2012.09.010 1:CAS:528:DC%2BC38XhsFSlsrjL
    • Krauwinkel W, van Dijk J, Schaddelee M, et al. Pharmacokinetic Properties of Mirabegron, a β(3)-Adrenoceptor Agonist: Results From Two Phase I, Randomized, Multiple-Dose Studies in Healthy Young and Elderly Men and Women. Clin Ther. 2012;34(10):2144.
    • (2012) Clin Ther , vol.34 , Issue.10 , pp. 2144
    • Krauwinkel, W.1    Van Dijk, J.2    Schaddelee, M.3
  • 29
    • 80052071598 scopus 로고    scopus 로고
    • Beta3-adrenoceptors in the rat sacral spinal cord and their functional relevance in micturition under normal conditions and in a model of partial urethral obstruction
    • 21661032
    • Füllhase C, Soler R, Westerling-Andersson K, Andersson KE. Beta3-adrenoceptors in the rat sacral spinal cord and their functional relevance in micturition under normal conditions and in a model of partial urethral obstruction. Neurourol Urodyn. 2011;30(7):1382-7.
    • (2011) Neurourol Urodyn , vol.30 , Issue.7 , pp. 1382-1387
    • Füllhase, C.1    Soler, R.2    Westerling-Andersson, K.3    Andersson, K.E.4
  • 30
    • 84863364985 scopus 로고    scopus 로고
    • Absorption, metabolism and excretion of [(14)C]mirabegron (YM178), a potent and selective β(3)-adrenoceptor agonist, after oral administration to healthy male volunteers
    • 22269146 10.1124/dmd.111.043588 1:CAS:528:DC%2BC38XkvVOhsbc%3D
    • Takusagawa S, van Lier JJ, Suzuki K, et al. Absorption, metabolism and excretion of [(14)C]mirabegron (YM178), a potent and selective β(3)-adrenoceptor agonist, after oral administration to healthy male volunteers. Drug Metab Dispos. 2012;40(4):815.
    • (2012) Drug Metab Dispos , vol.40 , Issue.4 , pp. 815
    • Takusagawa, S.1    Van Lier, J.J.2    Suzuki, K.3
  • 31
    • 84865852131 scopus 로고    scopus 로고
    • Identification of human cytochrome P450 isoforms and esterases involved in the metabolism of mirabegron, a potent and selective β(3)-adrenoceptor agonist
    • Apr 18. [Epub ahead of print]
    • Takusagawa S, Yajima K, Miyashita A, et al. Identification of human cytochrome P450 isoforms and esterases involved in the metabolism of mirabegron, a potent and selective β(3)-adrenoceptor agonist. Xenobiotica. 2012 Apr 18. [Epub ahead of print]
    • (2012) Xenobiotica
    • Takusagawa, S.1    Yajima, K.2    Miyashita, A.3
  • 32
    • 84868627009 scopus 로고    scopus 로고
    • In vitro inhibition and induction of human cytochrome P450 enzymes by mirabegron, a potent and selective β3-adrenoceptor agonist
    • Jul 27. [Epub ahead of print]
    • Takusagawa S, Miyashita A, Iwatsubo T, Usui T. In vitro inhibition and induction of human cytochrome P450 enzymes by mirabegron, a potent and selective β3-adrenoceptor agonist. Xenobiotica. 2012 Jul 27. [Epub ahead of print]
    • (2012) Xenobiotica
    • Takusagawa, S.1    Miyashita, A.2    Iwatsubo, T.3    Usui, T.4
  • 33
    • 50949091878 scopus 로고    scopus 로고
    • A review of adherence to drug therapy in patients with overactive bladder
    • 18616691 10.1111/j.1464-410X.2008.07769.x
    • Basra RK, Wagg A, Chapple C, Cardozo L, Castro-Diaz D, et al. A review of adherence to drug therapy in patients with overactive bladder. BJU Int. 2008;102(7):774-9.
    • (2008) BJU Int , vol.102 , Issue.7 , pp. 774-779
    • Basra, R.K.1    Wagg, A.2    Chapple, C.3    Cardozo, L.4    Castro-Diaz, D.5
  • 34
    • 76049121846 scopus 로고    scopus 로고
    • Overactive bladder medication adherence when medication is free to patients
    • 20092838 10.1016/j.juro.2009.11.026
    • Sears CL, Lewis C, Noel K, Albright TS, Fischer JR. Overactive bladder medication adherence when medication is free to patients. J Urol. 2010;183:1077-81.
    • (2010) J Urol , vol.183 , pp. 1077-1081
    • Sears, C.L.1    Lewis, C.2    Noel, K.3    Albright, T.S.4    Fischer, J.R.5
  • 35
    • 84870912754 scopus 로고    scopus 로고
    • Persistence with prescribed antimuscarinic therapy for overactive bladder: A UK experience
    • 22409769 10.1111/j.1464-410X.2012.11023.x 1:CAS:528:DC%2BC38XhvVSqurfE
    • Wagg A, Compion G, Fahey A, Siddiqui E. Persistence with prescribed antimuscarinic therapy for overactive bladder: a UK experience. BJU Int. 2012;110(11):1767-74.
    • (2012) BJU Int , vol.110 , Issue.11 , pp. 1767-1774
    • Wagg, A.1    Compion, G.2    Fahey, A.3    Siddiqui, E.4
  • 36
    • 84864286232 scopus 로고    scopus 로고
    • Comparative adherence to oxybutynin or tolterodine among older patients
    • 21710237 10.1007/s00228-011-1090-8 1:CAS:528:DC%2BC38XksVWitg%3D%3D
    • Gomes T, Juurlink DN, Mamdani MM. Comparative adherence to oxybutynin or tolterodine among older patients. Eur J Clin Pharmacol. 2012;68(1):97-9.
    • (2012) Eur J Clin Pharmacol , vol.68 , Issue.1 , pp. 97-99
    • Gomes, T.1    Juurlink, D.N.2    Mamdani, M.M.3
  • 37
    • 80051885471 scopus 로고    scopus 로고
    • Symptom change after discontinuation of successful antimuscarinic treatment in patients with overactive bladder symptoms: A randomised, multicentre trial
    • 21849011 10.1111/j.1742-1241.2011.02728.x
    • Lee YS, Choo MS, Lee JY, Oh SJ, Lee KS. Symptom change after discontinuation of successful antimuscarinic treatment in patients with overactive bladder symptoms: a randomised, multicentre trial. Int J Clin Pract. 2011;65(9):997-1004.
    • (2011) Int J Clin Pract , vol.65 , Issue.9 , pp. 997-1004
    • Lee, Y.S.1    Choo, M.S.2    Lee, J.Y.3    Oh, S.J.4    Lee, K.S.5
  • 38
    • 84885935828 scopus 로고    scopus 로고
    • Why anticholinergics fail: Oxybutynin and fesoterodine induce a shift from muscarinergic to purinergic transmission in the rat bladder
    • 10.1016/S1569-9056(13)60925-2 Interesting preliminary report suggestion tolerance development to muscarinic receptor blockade
    • •• Uvin P, Boudes M, Franken J, et al. Why anticholinergics fail: Oxybutynin and fesoterodine induce a shift from muscarinergic to purinergic transmission in the rat bladder. Eur Urol Suppl. 2013;12:e441. Interesting preliminary report suggestion tolerance development to muscarinic receptor blockade.
    • (2013) Eur Urol Suppl , vol.12 , pp. 441
    • Uvin, P.1    Boudes, M.2    Franken, J.3
  • 39
    • 84880788904 scopus 로고    scopus 로고
    • A phase II dose-ranging study of mirabegron in patients with overactive bladder
    • On behalf of the Dragon Investigator Group Mar 8. [Epub ahead of print]
    • Chapple CR, Dvorak V, Radziszewski P, et al. On behalf of the Dragon Investigator Group. A phase II dose-ranging study of mirabegron in patients with overactive bladder. Int Urogynecol J. 2013 Mar 8. [Epub ahead of print]
    • (2013) Int Urogynecol J.
    • Chapple, C.R.1    Dvorak, V.2    Radziszewski, P.3
  • 40
    • 84886394357 scopus 로고    scopus 로고
    • A proof-of-concept study: Mirabegron, a new therapy for overactive bladder
    • On behalf of the Dragon Investigator Group Feb 19. [Epub ahead of print]
    • Chapple CR, Dvorak V, Radziszewski P, et al. On behalf of the Dragon Investigator Group. A proof-of-concept study: Mirabegron, a new therapy for overactive bladder. Neurourol Urodyn. 2013 Feb 19. [Epub ahead of print]
    • (2013) Neurourol Urodyn.
    • Chapple, C.R.1    Dvorak, V.2    Radziszewski, P.3
  • 41
    • 84875953225 scopus 로고    scopus 로고
    • Results of a Randomized Phase III Trial of Mirabegron in Patients with Overactive Bladder
    • 23079373 10.1016/j.juro.2012.10.017 1:CAS:528:DC%2BC3sXisVOmu7s%3D
    • Nitti VW, Auerbach S, Martin N, et al. Results of a Randomized Phase III Trial of Mirabegron in Patients with Overactive Bladder. J Urol. 2013;189(4):1388-95.
    • (2013) J Urol , vol.189 , Issue.4 , pp. 1388-1395
    • Nitti, V.W.1    Auerbach, S.2    Martin, N.3
  • 42
    • 84871925684 scopus 로고    scopus 로고
    • Efficacy and Tolerability of Mirabegron, a β(3)-Adrenoceptor Agonist, in Patients with Overactive Bladder: Results from a Randomised European-Australian Phase 3 Trial
    • 23182126 10.1016/j.eururo.2012.10.016 1:CAS:528:DC%2BC38XhslSmtLnJ
    • Khullar V, Amarenco G, Angulo JC, et al. Efficacy and Tolerability of Mirabegron, a β(3)-Adrenoceptor Agonist, in Patients with Overactive Bladder: Results from a Randomised European-Australian Phase 3 Trial. Eur Urol. 2013;63(2):283-95.
    • (2013) Eur Urol , vol.63 , Issue.2 , pp. 283-295
    • Khullar, V.1    Amarenco, G.2    Angulo, J.C.3
  • 44
    • 84871920033 scopus 로고    scopus 로고
    • Randomized double-blind, active-controlled phase 3 study to assess 12-month safety and efficacy of mirabegron, a β(3)-adrenoceptor agonist, in overactive bladder
    • 23195283 10.1016/j.eururo.2012.10.048 1:CAS:528:DC%2BC38XhslCrsrvP The first long-term study of mirabegron with a toterodine treatment arm
    • •• Chapple CR, Kaplan SA, Mitcheson D, et al. Randomized double-blind, active-controlled phase 3 study to assess 12-month safety and efficacy of mirabegron, a β(3)-adrenoceptor agonist, in overactive bladder. Eur Urol. 2013;63(2):296-305. The first long-term study of mirabegron with a toterodine treatment arm.
    • (2013) Eur Urol , vol.63 , Issue.2 , pp. 296-305
    • Chapple, C.R.1    Kaplan, S.A.2    Mitcheson, D.3
  • 45
    • 31544474458 scopus 로고    scopus 로고
    • Which anticholinergic drug for overactive bladder symptoms in adults
    • CD005429
    • Madhuvrata P, Cody JD, Ellis G, et al. Which anticholinergic drug for overactive bladder symptoms in adults. Cochrane Database Syst Rev. 2012;18:1. CD005429.
    • (2012) Cochrane Database Syst Rev , vol.18 , pp. 1
    • Madhuvrata, P.1    Cody, J.D.2    Ellis, G.3
  • 46
    • 79952034846 scopus 로고    scopus 로고
    • Adverse event assessment of antimuscarinics for treating overactive bladder: A network meta-analytic approach
    • 21373193 10.1371/journal.pone.0016718 1:CAS:528:DC%2BC3MXivVymtLY%3D
    • Kessler TM, Bachmann LM, Minder C, et al. Adverse event assessment of antimuscarinics for treating overactive bladder: a network meta-analytic approach. PLoS One. 2011;6(2):e16718.
    • (2011) PLoS One , vol.6 , Issue.2 , pp. 16718
    • Kessler, T.M.1    Bachmann, L.M.2    Minder, C.3
  • 47
    • 35148812233 scopus 로고    scopus 로고
    • Treating patients with overactive bladder syndrome with antimuscarinics: Heart rate considerations
    • Andersson KE, Olshansky B. Treating patients with overactive bladder syndrome with antimuscarinics: heart rate considerations. BJU Int. 2007;100(5):1007-14.
    • (2007) BJU Int. , vol.100 , Issue.5 , pp. 1007-1014
    • Andersson, K.E.1    Olshansky, B.2
  • 48
    • 79960188172 scopus 로고    scopus 로고
    • Cardiac effects of muscarinic receptor antagonists used for voiding dysfunction
    • 10.1111/j.1365-2125.2010.03813.x 1:CAS:528:DC%2BC3MXhtV2qtr3M
    • Andersson KE, Campeau L, Olshansky B. Cardiac effects of muscarinic receptor antagonists used for voiding dysfunction. Br J Clin Pharm. 2011;72:186-96.
    • (2011) Br J Clin Pharm , vol.72 , pp. 186-196
    • Andersson, K.E.1    Campeau, L.2    Olshansky, B.3
  • 49
    • 84877914090 scopus 로고    scopus 로고
    • Randomized, multicenter phase II study evaluating the urodynamic safety of mirabegron in males with lower urinary tract symptoms (LUTS) and bladder outlet
    • 10.1016/j.juro.2012.02.2023
    • Nitti V, Rosenberg S, Mitcheson HD, et al. Randomized, multicenter phase II study evaluating the urodynamic safety of mirabegron in males with lower urinary tract symptoms (LUTS) and bladder outlet. J Urol. 2012;187(4 suppl):e756.
    • (2012) J Urol , vol.187 , Issue.4 SUPPL. , pp. 756
    • Nitti, V.1    Rosenberg, S.2    Mitcheson, H.D.3
  • 50
    • 84886773851 scopus 로고    scopus 로고
    • Accessed 1 May 2013
    • Mirabegron prescribing information. http://www.us.astellas.com/docs/ myrbetriq-full-pi.pdf. Accessed 1 May 2013.
    • Mirabegron Prescribing Information
  • 51
    • 84869491480 scopus 로고    scopus 로고
    • Proarrhythmic Safety of Repeat Doses of Mirabegron in Healthy Subjects: A Randomized, Double-Blind, Placebo-, and Active-Controlled Thorough QT Study
    • 23149929 10.1038/clpt.2012.181 1:CAS:528:DC%2BC38Xhs12is7fJ Important documentation of cardiac effects of mirabegron
    • • Malik M, van Gelderen EM, Lee JH, et al. Proarrhythmic Safety of Repeat Doses of Mirabegron in Healthy Subjects: A Randomized, Double-Blind, Placebo-, and Active-Controlled Thorough QT Study. Clin Pharmacol Ther. 2012;92(6):696. Important documentation of cardiac effects of mirabegron.
    • (2012) Clin Pharmacol Ther , vol.92 , Issue.6 , pp. 696
    • Malik, M.1    Van Gelderen, E.M.2    Lee, J.H.3
  • 52
    • 84886779829 scopus 로고    scopus 로고
    • 3-adrenoceptor agonists on contractions induced by electrical field stimulation of rat isolated urinary bladder strips
    • 10.1016/S1569-9056(13)60924-0
    • 3-adrenoceptor agonists on contractions induced by electrical field stimulation of rat isolated urinary bladder strips. Eur Urol Suppl. 2013;12:e440.
    • (2013) Eur Urol Suppl , vol.12 , pp. 440
    • Rekik, M.1    Rouget, C.2    Palea, S.3
  • 53
    • 84885910064 scopus 로고    scopus 로고
    • Combination treatment with mirabegron and solifenacin in patients with overactive bladder (OAB) - Efficacy results from a phase 2 study (Symphony)
    • 10.1016/j.juro.2013.02.2377
    • Abrams P, Kelleher C, Staskin D, et al. Combination treatment with mirabegron and solifenacin in patients with overactive bladder (OAB) - Efficacy results from a phase 2 study (Symphony). J Urol Suppl. 2013;189(4S):e803.
    • (2013) J Urol Suppl , vol.189 , Issue.4 , pp. 803
    • Abrams, P.1    Kelleher, C.2    Staskin, D.3


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