Glutamate changes in healthy young adulthood

European Neuropsychopharmacology

Volumn 23, Issue 11, 2013, Pages 1484-1490

  Marsman, Anouk ^a   Mandl, René C W ^a   van den Heuvel, Martijn P ^a   Boer, Vincent O ^b   Wijnen, Jannie P ^b   Klomp, Dennis W J ^b   Luijten, Peter R ^b   Hilleke E , Hulshoff Pol ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Aging; Glutamate; Magnetic resonance spectroscopy

Indexed keywords

GLUTAMIC ACID;

ADULT; ARTICLE; BRAIN REGION; CENTRAL NERVOUS SYSTEM; COGNITION; FEMALE; FRONTAL CORTEX; GRAY MATTER; HUMAN; MALE; NEUROANATOMY; NEUROIMAGING; NORMAL HUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; WHITE MATTER;

AGING; GLUTAMATE; MAGNETIC RESONANCE SPECTROSCOPY;

ADOLESCENT; ADULT; AGING; CROSS-SECTIONAL STUDIES; FEMALE; FRONTAL LOBE; FUNCTIONAL NEUROIMAGING; GLUTAMIC ACID; HEALTH; HEALTHY VOLUNTEERS; HUMANS; MALE; NERVE FIBERS, MYELINATED; NERVE FIBERS, UNMYELINATED; YOUNG ADULT;

EID: 84886779860     PISSN: 0924977X     EISSN: 18737862     Source Type: Journal    
DOI: 10.1016/j.euroneuro.2012.11.003     Document Type: Article

References (56)

1. Anderton B.H. Ageing of the brain. Mech. Ageing Dev. 2002, 123:811-817.
2. Antuono P.G., Jones J.L., Wang Y., Li S.J. Decreased glutamate+glutamine in Alzheimer's disease detected in vivo with (1)H-MRS at 0.5T. Neurology 2001, 56:737-742.
3. Banay-Schwartz M., Lajtha A., Palkovits M. Changes with aging in the levels of amino acids in rat CNS structural elements. I. Glutamate and related amino acids. Neurochem. Res. 1989, 14:555-562.
4. Boer V.O., van Lier A.L., Hoogduin J.M., Wijnen J.P., Luijten P.R., Klomp D.W. 7-T (1) H MRS with adiabatic refocusing at short TE using radiofrequency focusing with a dual-channel volume transmit coil. NMR Biomed. 2011, 24:1038-1046.
5. Boumezbeur F., Mason G.F., De Graaf R.A., Behar K.L., Cline G.W., Shulman G.I., Rothman D.L., Petersen K.F. Altered brain mitochondrial metabolism in healthy aging as assessed by in vivo magnetic resonance spectroscopy. J. Cereb. Blood Flow Metab. 2009, 30:211-221.
6. Bourgeois J.P., Rakic P. Changes of synaptic density in the primary visual cortex of the macaque monkey from fetal to adult stage. J. Neurosci. 1993, 13:2801-2820.
7. Brans R.G.H., Kahn R.S., Schnack H.G., van Baal G.C., Posthuma D., Van Haren N.E.M., Lepage C., Lerch J.P., Collins D.L., Evans A.C., Boomsma D.I., Hulshoff Pol H.E. Brain plasticity and intellectual ability are influenced by shared genes. J. Neurosci. 2010, 30:5519-5524.
8. Brooks J.C.W., Roberts N., Kemp G.J., Gosney M.A., Lye M., Whitehouse G.H. A proton magnetic resonance spectroscopy study of age-related changes in frontal lobe metabolite concentrations. Cereb. Cortex 2001, 11:598-605.
9. Bustillo J.R., Chen H., Gasparovic C., Mullins P., Caprihan A., Qualls C., Apfeldorf W., Lauriello J., Posse S. Glutamate as a marker of cognitive function in schizophrenia: a proton spectroscopic imaging study at 4T. Biol. Psychiatry 2011, 69:19-27.
10. Chang L., Ernst T., Poland R.E., Jenden D.J. In vivo proton magnetic resonance spectroscopy of the normal aging human brain. Life Sci. 1996, 58:2049-2056.
11. Chang L., Jiang C.S., Ernst T. Effects of age and sex on brain glutamate and other metabolites. Magn. Reson. Imaging 2009, 27:142-145.
12. Cobo M., Mora F. Acidic amino acids and self-stimulation of the prefrontal cortex in the rat: a pharmacological study. Eur. J. Neurosci. 1991, 3:531-538.
13. Cotman C.W., Monaghan D.T., Ganong A.H. Excitatory amino acid neurotransmission: NMDA receptors and Hebb-type synaptic plasticity. Annu. Rev. Neurosci. 1988, 11:61-80.
14. Craik F.I., Bialystok E. Cognition through the lifespan: mechanisms of change. Trends Cogn. Sci. 2006, 10:131-138.
15. Danbolt N.C. Glutamate uptake. Prog. Neurobiol. 2001, 65:1-105.
16. De Graaf R.A., Nicolay K. Adiabatic water suppression using frequency slective excitation. Magn. Reson. Med. 1998, 40:690-696.
17. Fonnum F. Glutamate: a neurotransmitter in mammalian brain. J. Neurochem. 1984, 42:1-11.
18. Fonnum F. Regulation of the synthesis of the transmitter glutamate pool. Prog. Biophys. Mol. Biol. 1993, 60:47-57.
19. Fornieles F., Petnado J.M., Mora F. Endogenous levels of amino acid neurotransmitters in different regions of frontal and temporal cortex of the rat during the normal process of aging. Neurosci. Lett. 1986, Suppl. 26:150.
20. Gong G., Rosa-Neto P., Carbonell F., Chen Z.J., He Y., Evans A.C. Age- and gender-related differences in the cortical anatomical network. J. Neurosci. 2009, 29:15684-15693.
21. Grachev I.D., Apkarian A.V. Chemical heterogeneity of the living human brain: a proton MR spectroscopy study on the effects of sex, age, and brain region. Neuroimage 2000, 11:554-563.
22. Grachev I.D., Apkarian A.V. Aging alters regional multichemical profile of the human brain: an in vivo1H-MRS study of young versus middle-aged subjects. J. Neurochem. 2001, 76:582-593.
23. Grachev I.D., Swarnkar A., Szeverenyi N.M., Ramachandran T.S., Apkarian A.V. Aging alters the multichemical networking profile of the human brain: an in vivo1H-MRS study of young versus middle-aged subjects. J. Neurochem. 2001, 77:292-303.
24. Greenamyre J.T. Glutamate-dopamine interactions in the basal ganglia: relationship to Parkinson's disease. J. Neural Transm. Gen. Sect. 1993, 91:255-269.
25. Gruetter R. Automatic, localized in vivo adjustment of all first- and second-order shim coils. Magn Reson. Med. 1993, 29:804-811.
26. Gruetter R., Boesch C. Fast, non-iterative shimming on spatially localized signals: in vivo analysis of the magnetic field along axes. J. Magn. Reson. 1992, 96:323-334.
27. Hedman A.M., van Haren N.E., Schnack H.G., Kahn R.S., Hulshoff Pol H.E. Human brain changes across the life span: a review of 56 longitudinal magnetic resonance imaging studies. Hum. Brain Mapp. 2012, 33:1987-2002.
28. Hulshoff Pol H.E., Schnack H.G., Mandl R.C., Van Haren N.E.M., Koning H., Collins D.L., Evans A.C., Kahn R.S. Focal gray matter density changes in schizophrenia. Arch. Gen. Psychiatry 2001, 58:1118-1125.
29. Kaiser L.G., Schuff N., Cashdollar N., Weiner M.W. Age-related glutamate and glutamine concentration changes in normal human brain: 1H MR spectroscopy study at 4T. Neurobiol. Aging 2005, 26:665-672.
30. Kreis R., Slotboom J., Hofmann L., Boesch C. Integrated data acquisition and processing to determine metabolite contents, relaxation times, and macromolecule baseline in single examinations of individual subjects. Magn. Reson. Med. 2005, 54:761-768.
31. Krystal J.H., Karper L.P., Seibyl J.P., Freeman G.K., Delaney R., Bremner J.D., Heninger G.R., Bowers M.B., Charney D.S. Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses. Arch. Gen. Psychiatry 1994, 51:199-214.
32. Lo C.Y., He Y., Lin C.P. Graph theoretical analysis of human brain structural networks. Rev. Neurosci. 2011, 22:551-563.
33. Marsman A., van den Heuvel M.P., Klomp D.W.J., Kahn R.S., Luijten P.R., Hulshoff Pol H.E. Glutamate in schizophrenia: a focused review and meta-analysis of 1H-MRS studies. Schizophr. Bull, in press 2011.
34. Maudsley A.A., Domenig C., Govind V., Darkazanli A., Studholme C., Arheart K., Bloomer C. Mapping of brain metabolite distributions by volumetric proton MR spectroscopic imaging (MRSI). Magn. Reson. Med. 2009, 61:548-559.
35. Mora F., Cobo M. The neurobiological basis of prefrontal cortex self-stimulation: a review and an integrative hypothesis. Prog. Brain Res. 1990, 85:419-431.
36. Mufson E.J., Stein D.G. Degeneration in the spinal cord of old rats. Exp. Neurol. 1980, 70:179-186.
37. Nedergaard M., Takano T., Hansen A.J. Beyond the role of glutamate as a neurotransmitter. Nat. Rev. Neurosci. 2002, 3:748-755.
38. Olney J.W., Farber N.B. Glutamate receptor dysfunction and schizophrenia. Arch. Gen. Psychiatry 1995, 52:998-1007.
39. Olney J.W., Newcomer J.W., Farber N.B. NMDA receptor hypofunction model of schizophrenia. J. Psychiatr. Res. 1999, 33:523-533.
40. Petersen C., Cotman C.W. Strain-dependent decrease in glutamate binding to N-methyl-d-aspartic acid receptor during aging. Neurosci. Lett. 1989, 104:313.
41. Pioro E.P., Majors A.W., Mitsumoto H., Nelson D.R., Ng T.C. 1H-MRS evidence of neurodegeneration and excess glutamate glutamine in ALS medulla. Neurology 1999, 53:71.
42. Poullet J.B., Sima D.M., Simonetti A.W., De N.B., Vanhamme L., Lemmerling P., Van H.S. An automated quantitation of short echo time MRS spectra in an open source software environment: AQSES. NMR Biomed. 2007, 20:493-504.
43. R Development Core Team R: A Language and Environment for Statistical Computing 2006, R Foundation for Statistical Computing, Vienna, Austria.
44. Raininko R., Mattsson P. Metabolite concentrations in supraventricular white matter from teenage to early old age: a short echo time 1H magnetic resonance spectroscopy (MRS) study. Acta Radiol. 2010, 51:309-315.
45. Sawa A. Cortical development and glutamatergic dysregulation in schizophrenia. Biol. Psychiatry 2009, 66:530-532.
46. Schmidt W.J., Bubser M., Hauber W. Behavioural pharmacology of glutamate in the basal ganglia. J. Neural Transm. Suppl. 1992, 38:65-89.
47. Segovia G., Porras A., Del Arco A., Mora F. Glutamatergic neurotransmission in aging: a critical perspective. Mech. Ageing Dev. 2001, 122:1-29.
48. Stoneham E.T., Sanders E.M., Sanyal M., Dumas T.C. Rules of engagement: factors that regulate activity-dependent synaptic plasticity during neural network development. Biol. Bull. 2010, 219:81-99.
49. van den Heuvel M.P., Stam C.J., Kahn R.S., Hulshoff Pol H.E. Efficiency of functional brain networks and intellectual performance. J. Neurosci. 2009, 29:7619-7624.
50. Van Vliet, I.M., Leroy, H., Van Megen, H.J.G.M., 2000. M.I.N.I. Plus: M.I.N.I. International Neuropsychiatric Interview. Dutch Version 5.0.0.
51. Versluis M.J., Kan H.E., van Buchem M.A., Webb A.G. Improved signal to noise in proton spectroscopy of the human calf muscle at 7T using localized B1 calibration. Magn. Reson. Med. 2010, 63:207-211.
52. Wallace D.R., Dawson R.J. Ammonia regulation of phosphate-activated glutaminase displays regional variation and impairment in the brain of aged rat. Neurochem. Res. 1992, 17:1122.
53. Wallace D.R., Dawson R.J. Regional differences in glutamate activation by phosphate and calcium in rat brain: impairment in aged rats and implications for regional glutaminase isozymes. Neurochem. Res. 1993, 18:1279.
54. Wen W., Zhu W., He Y., Kochan N.A., Reppermund S., Slavin M.J., Brodaty H., Crawford J., Xia A., Sachdev P. Discrete neuroanatomical networks are associated with specific cognitive abilities in old age. J. Neurosci. 2011, 31:1204-1212.
55. Westall F.C., Hawkins A., Ellison G.W., Myers L.W. Abnormal glutamic acid metabolism in multiple sclerosis. J. Neurol. Sci. 1980, 47:353-364.
56. Zahr N.M., Mayer D., Pfefferbaum A., Sullivan E.V. Low striatal glutamate levels underlie cognitive decline in the elderly: evidence from in vivo molecular spectroscopy. Cerebr. Cortex 2008, 18:2241-2250.