Analysis of the global methylation status of human spermatozoa and its association with the tendency of these cells to enter apoptosis

Andrologia

Volumn 45, Issue 6, 2013, Pages 424-429

  Barzideh, J ^a,b,c   Scott, R J ^b,c   Aitken, R J ^a  

^a UNIVERSITY OF NEWCASTLE   (Australia)

^b UNIVERSITY OF NEWCASTLE   (Australia)

^c JOHN HUNTER HOSPITAL   (Australia)

Author keywords

Annexin V binding; Apoptosis; Methylation; Spermatozoa

Indexed keywords

5 METHYLCYTOSINE; LIPOCORTIN 5;

APOPTOSIS; ARTICLE; CELL DENSITY; CHROMATIN; CONTROLLED STUDY; CROSS REACTION; DNA METHYLATION; FLOW CYTOMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MALE; MITOCHONDRIAL GENOME; PROTEIN BINDING; SENESCENCE; SPERM; SPERMATOGENESIS; SPERMATOZOON;

ANNEXIN V BINDING; APOPTOSIS; METHYLATION; SPERMATOZOA;

5-METHYLCYTOSINE; ANNEXIN A5; APOPTOSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA METHYLATION; FLOW CYTOMETRY; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; SPERMATOZOA; YOUNG ADULT;

EID: 84886771966     PISSN: 03034569     EISSN: 14390272     Source Type: Journal    
DOI: 10.1111/and.12033     Document Type: Article

References (24)

1. Aitken RJ, Ryan AL, Curry BJ, Baker MA (2003) Multiple forms of redox activity in populations of human spermatozoa. Mol Hum Reprod 9:645-661.
2. Aitken RJ, Baker MA, O'Bryan M (2004) Shedding light on chemiluminescence: the application of chemiluminescence in diagnostic andrology. J Androl 25:455-465.
3. Amor DJ, Halliday J (2009) A review of known imprinting syndromes and their association with assisted reproduction technologies. Hum Reprod 23:2826-2834.
4. Benchaib M, Braun V, Ressnikof D, Lornage J, Durand P, Niveleau A, Guérin JF (2005) Influence of global sperm DNA methylation on IVF results. Hum Reprod 20:768-773.
5. Boissonnas CC, Abdalaoui HE, Haelewyn V, Fauque P, Dupont JM, Gut I, Vaiman D, Jouannet P, Tost J, Jammes H (2010) Specific epigenetic alterations of IGF2-H19 locus in spermatozoa from infertile men. Eur J Hum Genet 18:73-80.
6. Chorbov VM, Todorov AA, Lynskey MT, Cicero TJ (2011) Elevated levels of DNA methylation at the OPRM1 promoter in blood and sperm from male opioid addicts. J Opioid Manag 7:258-264.
7. Doshi T, Mehta SS, Dighe V, Balasinor N, Vanage G (2011) Hypermethylation of estrogen receptor promoter region in adult testis of rats exposed neonatally to bisphenol A. Toxicology 289:74-82.
8. El Hajj N, Zechner U, Schneider E, Tresch A, Gromoll J, Hahn T, Schorsch M, Haaf T (2011) Methylation status of imprinted genes and repetitive elements in sperm DNA from infertile males. Sex Dev 5:60-69.
9. Hammoud SS, Purwar J, Pflueger C, Cairns BR, Carrell DT (2010) Alterations in sperm DNA methylation patterns at imprinted loci in two classes of infertility. Fertil Steril 94:1728-1733.
10. Hammoud SS, Nix DA, Hammoud AO, Gibson M, Cairns BR, Carrell DT (2011) Genome-wide analysis identifies changes in histone retention and epigenetic modifications at developmental and imprinted gene loci in the sperm of infertile men. Hum Reprod 26:2558-2569.
11. Houshdaran S, Cortessis VK, Siegmund K, Yang A, Laird PW, Sokol RZ (2007) Widespread epigenetic abnormalities suggest a broad DNA methylation erasure defect in abnormal human sperm. PLoS ONE 2:e1289.
12. Koppers AJ, Mitchell LA, Wang P, Lin M, Aitken RJ (2011) Phosphoinositide 3-kinase signalling pathway involvement in a truncated apoptotic cascade associated with motility loss and oxidative DNA damage in human spermatozoa. Biochem J 436:687-698.
13. Manipalviratn S, DeCherney A, Segars JI (2009) Imprinting disorders and assisted reproductive technology. Fertil Steril 91:305-315.
14. Marques CJ, Costa P, Vaz B, Carvalho F, Fernandes S, Barros A, Sousa M (2008) Abnormal methylation of imprinted genes in human sperm is associated with oligozoospermia. Mol Hum Reprod 14:67-74.
15. Marques CJ, João Pinho M, Carvalho F, Bièche I, Barros A, Sousa M (2011) DNA methylation imprinting marks and DNA methyltransferase expression in human spermatogenic cell stages. Epigenetics 6:1354-1361.
16. Minor A, Chow V, Ma S (2011) Aberrant DNA methylation at imprinted genes in testicular sperm retrieved from men with obstructive azoospermia and undergoing vasectomy reversal. Reproduction 141:749-757.
17. Mitchell LA, De Iuliis GN, Aitken RJ (2011) The TUNEL assay consistently underestimates DNA damage in human spermatozoa and is influenced by DNA compaction and cell vitality: development of an improved methodology. Int J Androl 34:2-13.
18. Mossman D, Kim KT, Scott RJ (2010) Demethylation by 5-aza-2′-deoxycytidine in colorectal cancer cells targets genomic DNA whilst promoter CpG island methylation persists. BMC Cancer 10:366-376.
19. Nanassy L, Carrell DT (2011) Analysis of the methylation pattern of six gene promoters in sperm of men with abnormal protamination. Asian J Androl 13:342-346.
20. Navarro-Costa P, Nogueira P, Carvalho M, Leal F, Cordeiro I, Calhaz-Jorge C, Gonçalves J, Plancha CE (2010) Incorrect DNA methylation of the DAZL promoter CpG island associates with defective human sperm. Hum Reprod 25:2647-2654.
21. Poplinski A, Tüttelmann F, Kanber D, Horsthemke B, Gromoll J (2010) Idiopathic male infertility is strongly associated with aberrant methylation of MEST and IGF2/H19 ICR1. Int J Androl 33:642-649.
22. Rajender S, Avery K, Agarwal A (2011) Epigenetics, spermatogenesis and male infertility. Mutat Res 727:62-71.
23. Sawyer DE, Roman SD, Aitken RJ (2001) Relative susceptibilities of mitochondrial and nuclear DNA to damage induced by hydrogen peroxide in two mouse germ cell lines. Redox Rep 6:182-184.
24. Sutovsky P, Moreno RD, Ramalho-Santos J, Dominko T, Simerly C, Schatten G (2000) Ubiquitinated sperm mitochondria, selective proteolysis, and the regulation of mitochondrial inheritance in mammalian embryos. Biol Reprod 63:582-590.