메뉴 건너뛰기




Volumn 289, Issue 2-3, 2011, Pages 74-82

Hypermethylation of estrogen receptor promoter region in adult testis of rats exposed neonatally to bisphenol A

Author keywords

Bisphenol a; DNA methylation; Estrogen receptor; Neonatal exposure

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; DNA; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA;

EID: 80052737714     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2011.07.011     Document Type: Article
Times cited : (148)

References (57)
  • 1
    • 20344385787 scopus 로고    scopus 로고
    • Epigenetic transgenerational actions of endocrine disruptors and male fertility
    • Anway D., Cupp S., Uzumcu M., Skinner M. Epigenetic transgenerational actions of endocrine disruptors and male fertility. Science 2005, 308:1466-1469.
    • (2005) Science , vol.308 , pp. 1466-1469
    • Anway, D.1    Cupp, S.2    Uzumcu, M.3    Skinner, M.4
  • 2
    • 33750607327 scopus 로고    scopus 로고
    • Transgenerational effect of the endocrine disruptor vinclozolin on male spermatogenesis
    • Anway D., Memon A., Uzumcu M., Skinner M. Transgenerational effect of the endocrine disruptor vinclozolin on male spermatogenesis. J. Androl. 2006, 27:868-879.
    • (2006) J. Androl. , vol.27 , pp. 868-879
    • Anway, D.1    Memon, A.2    Uzumcu, M.3    Skinner, M.4
  • 3
    • 67749129297 scopus 로고    scopus 로고
    • Epigenetics and environmental chemicals
    • Baccarelli A., Bollati V. Epigenetics and environmental chemicals. Curr. Opin. Pediatr. 2009, 21:243-251.
    • (2009) Curr. Opin. Pediatr. , vol.21 , pp. 243-251
    • Baccarelli, A.1    Bollati, V.2
  • 5
    • 67649648228 scopus 로고    scopus 로고
    • Hypermethylation of HOXA10 by in utero diethylstilbestrol exposure: an epigenetic mechanism for altered developmental programming
    • Bromer J., Wu J., Zhou Y., Taylor H. Hypermethylation of HOXA10 by in utero diethylstilbestrol exposure: an epigenetic mechanism for altered developmental programming. Endocrinology 2009, 150:3376-3382.
    • (2009) Endocrinology , vol.150 , pp. 3376-3382
    • Bromer, J.1    Wu, J.2    Zhou, Y.3    Taylor, H.4
  • 6
    • 77953090055 scopus 로고    scopus 로고
    • Bisphenol-A exposure in utero leads to epigenetic alterations in the developmental programming of uterine estrogen response
    • Bromer J., Zhou Y., Taylor M., Doherty L., Taylor H. Bisphenol-A exposure in utero leads to epigenetic alterations in the developmental programming of uterine estrogen response. FASEB J. 2010, 24:2273-2280.
    • (2010) FASEB J. , vol.24 , pp. 2273-2280
    • Bromer, J.1    Zhou, Y.2    Taylor, M.3    Doherty, L.4    Taylor, H.5
  • 9
    • 70350323691 scopus 로고    scopus 로고
    • Estrogen regulates DNA methyltransferase 3B expression in Ishikawa endometrial adenocarcinoma cells
    • Cui M., Wen Z., Yang Z., Chen J., Wang F. Estrogen regulates DNA methyltransferase 3B expression in Ishikawa endometrial adenocarcinoma cells. Mol. Biol. Rep. 2009, 36:2201-2207.
    • (2009) Mol. Biol. Rep. , vol.36 , pp. 2201-2207
    • Cui, M.1    Wen, Z.2    Yang, Z.3    Chen, J.4    Wang, F.5
  • 10
    • 33750503417 scopus 로고    scopus 로고
    • Estrogen effects on fetal and neonatal testicular development
    • Delbes C., Levacher C., Habert R. Estrogen effects on fetal and neonatal testicular development. Reproduction 2006, 132:527-538.
    • (2006) Reproduction , vol.132 , pp. 527-538
    • Delbes, C.1    Levacher, C.2    Habert, R.3
  • 11
    • 0001019698 scopus 로고
    • Synthetic estrogenic agents without the phenanthrene nucleus
    • Dodds E., Lawson W. Synthetic estrogenic agents without the phenanthrene nucleus. Nature 1936, 137:996-997.
    • (1936) Nature , vol.137 , pp. 996-997
    • Dodds, E.1    Lawson, W.2
  • 12
    • 34548715144 scopus 로고    scopus 로고
    • Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development
    • Dolinoy D., Huang D., Jirtle R. Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development. Proc. Natl. Acad. Sci. U.S.A. 2007, 32:13056-13061.
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.32 , pp. 13056-13061
    • Dolinoy, D.1    Huang, D.2    Jirtle, R.3
  • 13
    • 34247109637 scopus 로고    scopus 로고
    • Epigenetic gene regulation: linking early developmental environment to adult disease
    • Dolinoy D., Weidman J., Jirtle R. Epigenetic gene regulation: linking early developmental environment to adult disease. Reprod. Toxicol. 2007, 23:297-307.
    • (2007) Reprod. Toxicol. , vol.23 , pp. 297-307
    • Dolinoy, D.1    Weidman, J.2    Jirtle, R.3
  • 14
    • 0029969771 scopus 로고    scopus 로고
    • Targeted disruption of the estrogen receptor gene in male mice causes alteration of spermatogenesis and infertility
    • Eddy E., Washburn T., Bunch D., Goulding E., Gladen B., Lubahn D., Korach K. Targeted disruption of the estrogen receptor gene in male mice causes alteration of spermatogenesis and infertility. Endocrinology 1996, 11:4796-4805.
    • (1996) Endocrinology , vol.11 , pp. 4796-4805
    • Eddy, E.1    Washburn, T.2    Bunch, D.3    Goulding, E.4    Gladen, B.5    Lubahn, D.6    Korach, K.7
  • 15
    • 18244368449 scopus 로고    scopus 로고
    • Epigenetic alteration by the chemical substances, food and environmental factors
    • Fukata H., Mori C. Epigenetic alteration by the chemical substances, food and environmental factors. Reprod. Med. Biol. 2004, 3(2004):115-121.
    • (2004) Reprod. Med. Biol. , vol.3 , Issue.2004 , pp. 115-121
    • Fukata, H.1    Mori, C.2
  • 16
    • 0141995080 scopus 로고    scopus 로고
    • Expression analysis of DNA methyltransferases 1, 3A, and 3B in sporadic breast carcinomas
    • Girault I., Tozlu S., Lidereau R., Bièche I. Expression analysis of DNA methyltransferases 1, 3A, and 3B in sporadic breast carcinomas. Clin. Cancer Res. 2003, 9:4415-4422.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 4415-4422
    • Girault, I.1    Tozlu, S.2    Lidereau, R.3    Bièche, I.4
  • 17
    • 0038513527 scopus 로고    scopus 로고
    • Neonatal estrogen exposure of male rats alters reproductive functions at adulthood
    • Goyal H., Robateau A., Braden T., Williams C., Srivastava K., Ali K. Neonatal estrogen exposure of male rats alters reproductive functions at adulthood. Biol. Reprod. 2003, 68:2081-2091.
    • (2003) Biol. Reprod. , vol.68 , pp. 2081-2091
    • Goyal, H.1    Robateau, A.2    Braden, T.3    Williams, C.4    Srivastava, K.5    Ali, K.6
  • 18
    • 74549139049 scopus 로고    scopus 로고
    • Occupational exposure levels of bisphenol A among Chinese workers
    • He Y., Miao M., Wu C., Yuan W., Gao E., Zhou Z., Li D.K. Occupational exposure levels of bisphenol A among Chinese workers. J. Occup. Health. 2009, 51:432-436.
    • (2009) J. Occup. Health. , vol.51 , pp. 432-436
    • He, Y.1    Miao, M.2    Wu, C.3    Yuan, W.4    Gao, E.5    Zhou, Z.6    Li, D.K.7
  • 19
    • 33745246032 scopus 로고    scopus 로고
    • Developmental exposure to estradiol and bisphenol A increases susceptibility to prostate carcinogenesis and epigenetically regulates phosphodiesterase type 4 variant 4
    • Ho S., Tang W., Belmsonte, Frausto J., Prins G. Developmental exposure to estradiol and bisphenol A increases susceptibility to prostate carcinogenesis and epigenetically regulates phosphodiesterase type 4 variant 4. Cancer Res. 2006, 11:5624-5632.
    • (2006) Cancer Res. , vol.11 , pp. 5624-5632
    • Ho, S.1    Tang, W.2    Belmsonte Frausto, J.3    Prins, G.4
  • 20
    • 12844277281 scopus 로고    scopus 로고
    • Transcriptional regulation of the human DNA methyltransferase 3A and 3B genes by Sp3 and Sp1 zinc finger proteins
    • Jinawanth A., Miyake S., Yanagisawa Y., Akiyama Y., Yuasa Y. Transcriptional regulation of the human DNA methyltransferase 3A and 3B genes by Sp3 and Sp1 zinc finger proteins. Biochem. J. 2005, 15:557-564.
    • (2005) Biochem. J. , vol.15 , pp. 557-564
    • Jinawanth, A.1    Miyake, S.2    Yanagisawa, Y.3    Akiyama, Y.4    Yuasa, Y.5
  • 21
    • 33947310031 scopus 로고    scopus 로고
    • Environmental epigenomics and disease susceptibility
    • Jirtle R., Skinner M. Environmental epigenomics and disease susceptibility. Nat. Rev. Genet. 2007, 8:253-262.
    • (2007) Nat. Rev. Genet. , vol.8 , pp. 253-262
    • Jirtle, R.1    Skinner, M.2
  • 22
    • 0034522699 scopus 로고    scopus 로고
    • Exposure of newborn male and female rats to environmental estrogens: delayed and sustained hyperprolactinemia and alterations in estrogen receptor expression
    • Khurana S., Ranmal S., Ben-Jonathan N. Exposure of newborn male and female rats to environmental estrogens: delayed and sustained hyperprolactinemia and alterations in estrogen receptor expression. Endocrinology 2000, 141:4512-4517.
    • (2000) Endocrinology , vol.141 , pp. 4512-4517
    • Khurana, S.1    Ranmal, S.2    Ben-Jonathan, N.3
  • 23
    • 0035870282 scopus 로고    scopus 로고
    • P16(INK4a) and histology-specific methylation of CpG islands by exposure to tobacco smoke in non-small cell lung cancer
    • Kim D., Nelson H., Wiencke J., Zheng S., Christiani D., Wain J., Mark E., Kelsey K. p16(INK4a) and histology-specific methylation of CpG islands by exposure to tobacco smoke in non-small cell lung cancer. Cancer Res. 2001, 15:3419-3424.
    • (2001) Cancer Res. , vol.15 , pp. 3419-3424
    • Kim, D.1    Nelson, H.2    Wiencke, J.3    Zheng, S.4    Christiani, D.5    Wain, J.6    Mark, E.7    Kelsey, K.8
  • 24
    • 0027222826 scopus 로고
    • Bisphenol-A: an estrogenic substance is released from polycarbonate flasks during autoclaving
    • Krishnan A., Stathis P., Permuth S., Tokes L., Feldman D. Bisphenol-A: an estrogenic substance is released from polycarbonate flasks during autoclaving. Endocrinology 1993, 132:2279-2286.
    • (1993) Endocrinology , vol.132 , pp. 2279-2286
    • Krishnan, A.1    Stathis, P.2    Permuth, S.3    Tokes, L.4    Feldman, D.5
  • 25
    • 0036733675 scopus 로고    scopus 로고
    • Chromatin modification and epigenetic reprogramming in mammalian development
    • Li E. Chromatin modification and epigenetic reprogramming in mammalian development. Nat. Rev. Genet. 2002, 3:662-673.
    • (2002) Nat. Rev. Genet. , vol.3 , pp. 662-673
    • Li, E.1
  • 26
    • 0030817594 scopus 로고    scopus 로고
    • Developmental exposure to diethylstilbestrol elicits demethylation of estrogen-responsive lactoferrin gene in mouse uterus
    • Li S., Washburn K., Moore R., Uno T., Teng C., Newbold R., McLachlan J., Negishi M. Developmental exposure to diethylstilbestrol elicits demethylation of estrogen-responsive lactoferrin gene in mouse uterus. Cancer Res. 1997, 57:4356-4359.
    • (1997) Cancer Res. , vol.57 , pp. 4356-4359
    • Li, S.1    Washburn, K.2    Moore, R.3    Uno, T.4    Teng, C.5    Newbold, R.6    McLachlan, J.7    Negishi, M.8
  • 27
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta DeltaC(T)) method
    • Livak K., Schmittgen T. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta DeltaC(T)) method. Methods 2001, 25:402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.1    Schmittgen, T.2
  • 28
    • 33745899960 scopus 로고    scopus 로고
    • Endocrine disruptors and reproductive health: the case of bisphenol-A
    • Maffini M., Rubin B., Sonnenschein C., Soto A. Endocrine disruptors and reproductive health: the case of bisphenol-A. Mol. Cell. Endocrinol. 2006, 25:179-186.
    • (2006) Mol. Cell. Endocrinol. , vol.25 , pp. 179-186
    • Maffini, M.1    Rubin, B.2    Sonnenschein, C.3    Soto, A.4
  • 29
    • 1642332240 scopus 로고    scopus 로고
    • Estrogen signaling: a subtle balance between ERα and ERβ
    • Matthews J., Gustafsson J. Estrogen signaling: a subtle balance between ERα and ERβ. Mol. Interv. 2003, 3:281-292.
    • (2003) Mol. Interv. , vol.3 , pp. 281-292
    • Matthews, J.1    Gustafsson, J.2
  • 30
    • 0035102123 scopus 로고    scopus 로고
    • In vitro and in vivo interactions of bisphenol A and its metabolite, bisphenol Aglucuronide, with estrogen receptors alpha and beta
    • Matthews J., Twomey K., Zacharewski T. In vitro and in vivo interactions of bisphenol A and its metabolite, bisphenol Aglucuronide, with estrogen receptors alpha and beta. Chem. Res. Toxicol. 2001, 14:149-157.
    • (2001) Chem. Res. Toxicol. , vol.14 , pp. 149-157
    • Matthews, J.1    Twomey, K.2    Zacharewski, T.3
  • 31
    • 0035283201 scopus 로고    scopus 로고
    • Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia
    • Mizuno S., Chijiwa T., Okamura T., Akashi K., Fukumaki Y., Niho Y., Sasaki H. Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia. Blood 2001, 97:1172-1179.
    • (2001) Blood , vol.97 , pp. 1172-1179
    • Mizuno, S.1    Chijiwa, T.2    Okamura, T.3    Akashi, K.4    Fukumaki, Y.5    Niho, Y.6    Sasaki, H.7
  • 32
    • 33646821720 scopus 로고    scopus 로고
    • Adverse effects of the model environmental estrogen diethylstilbestrol are transmitted to subsequent generations
    • Newbold R., Padilla-Banks E., Jefferson W. Adverse effects of the model environmental estrogen diethylstilbestrol are transmitted to subsequent generations. Endocrinology 2006, 147:S11-S17.
    • (2006) Endocrinology , vol.147
    • Newbold, R.1    Padilla-Banks, E.2    Jefferson, W.3
  • 33
    • 0004320263 scopus 로고    scopus 로고
    • NTP, National Toxicology Program's Report of the Endocrine Disruptors Low Dose Peer Review
    • Research Triangle Park, NC.
    • NTP, 2001. National Toxicology Program's Report of the Endocrine Disruptors Low Dose Peer Review. National Toxicology Program, Research Triangle Park, NC.
    • (2001) National Toxicology Program
  • 34
    • 64049114766 scopus 로고    scopus 로고
    • NTP, NTP-CERHRMonographonthe PotentialHumanReproductive and Developmental Effects of Bisphenol A
    • NTP-08-5994. Research Triangle Park, NC.
    • NTP, 2008.NTP-CERHRMonographonthe PotentialHumanReproductive and Developmental Effects of Bisphenol A. NTP-08-5994. Research Triangle Park, NC.
    • (2008)
  • 37
    • 65049087847 scopus 로고    scopus 로고
    • Effect of tamoxifen treatment on global and insulin-like growth factor 2-H19 locus-specific DNA methylation in rat spermatozoa and its association with embryo loss
    • Pathak S., Kedia-Mokashi N., Saxena M., D'Souza R., Maitra A., Parte P., Gill-Sharma M., Balasinor N. Effect of tamoxifen treatment on global and insulin-like growth factor 2-H19 locus-specific DNA methylation in rat spermatozoa and its association with embryo loss. Fertil. Steril. 2009, 91:2253-2263.
    • (2009) Fertil. Steril. , vol.91 , pp. 2253-2263
    • Pathak, S.1    Kedia-Mokashi, N.2    Saxena, M.3    D'Souza, R.4    Maitra, A.5    Parte, P.6    Gill-Sharma, M.7    Balasinor, N.8
  • 38
    • 0035839126 scopus 로고    scopus 로고
    • Epigenetic reprogramming in mammalian development
    • Reik W., Dean W., Walter J. Epigenetic reprogramming in mammalian development. Science 2001, 293:1089-1093.
    • (2001) Science , vol.293 , pp. 1089-1093
    • Reik, W.1    Dean, W.2    Walter, J.3
  • 39
    • 29144436510 scopus 로고    scopus 로고
    • Methylation of estrogen receptor β promoter correlates with loss of ER-β expression in mammary carcinoma and is an early indication marker in premalignant lesions
    • Rody A., Holtrich U., Solbach C., Kourtis K., Minckwitz G., Engels K., Kissler S., Gätje R., Karn T., Kaufmann M. Methylation of estrogen receptor β promoter correlates with loss of ER-β expression in mammary carcinoma and is an early indication marker in premalignant lesions. Endocr. Relat. Cancer 2005, 12:903-916.
    • (2005) Endocr. Relat. Cancer , vol.12 , pp. 903-916
    • Rody, A.1    Holtrich, U.2    Solbach, C.3    Kourtis, K.4    Minckwitz, G.5    Engels, K.6    Kissler, S.7    Gätje, R.8    Karn, T.9    Kaufmann, M.10
  • 40
    • 70349984500 scopus 로고    scopus 로고
    • Neonatal exposure of male rats to Bisphenol A impairs fertility and expression of sertoli cell junctional proteins in the testis
    • Salian S., Doshi T., Vanage G. Neonatal exposure of male rats to Bisphenol A impairs fertility and expression of sertoli cell junctional proteins in the testis. Toxicology 2009, 12:56-67.
    • (2009) Toxicology , vol.12 , pp. 56-67
    • Salian, S.1    Doshi, T.2    Vanage, G.3
  • 41
    • 70449108111 scopus 로고    scopus 로고
    • Perinatal exposure of rats to bisphenol A affects the fertility of male offspring
    • Salian S., Doshi T., Vanage G. Perinatal exposure of rats to bisphenol A affects the fertility of male offspring. Life Sci. 2009, 18:742-752.
    • (2009) Life Sci. , vol.18 , pp. 742-752
    • Salian, S.1    Doshi, T.2    Vanage, G.3
  • 42
    • 33745621608 scopus 로고    scopus 로고
    • Neonatal exposure to diethylstilbestrol alters the expression of DNA methyltransferases and methylation of genomic DNA in the epididymis of mice
    • Sato K., Fukata H., Kogo Y., Ohgane J., Shiota K., Mori C. Neonatal exposure to diethylstilbestrol alters the expression of DNA methyltransferases and methylation of genomic DNA in the epididymis of mice. Endocr. J. 2006, 53:331-337.
    • (2006) Endocr. J. , vol.53 , pp. 331-337
    • Sato, K.1    Fukata, H.2    Kogo, Y.3    Ohgane, J.4    Shiota, K.5    Mori, C.6
  • 43
    • 62549142309 scopus 로고    scopus 로고
    • Neonatal exposure to diethylstilbestrol alters expression of DNA methyltransferases and methylation of genomic DNA in the mouse uterus
    • Sato K., Fukata H., Kogo Y., Ohgane J., Shiota K., Mori C. Neonatal exposure to diethylstilbestrol alters expression of DNA methyltransferases and methylation of genomic DNA in the mouse uterus. Endocr. J. 2009, 56:131-139.
    • (2009) Endocr. J. , vol.56 , pp. 131-139
    • Sato, K.1    Fukata, H.2    Kogo, Y.3    Ohgane, J.4    Shiota, K.5    Mori, C.6
  • 44
    • 0033564902 scopus 로고    scopus 로고
    • DNA methylation
    • Singal R., Ginder G. DNA methylation. Blood 1999, 9:4059-4070.
    • (1999) Blood , vol.9 , pp. 4059-4070
    • Singal, R.1    Ginder, G.2
  • 45
    • 68349091505 scopus 로고    scopus 로고
    • The early life environment and the epigenome
    • Szyf M. The early life environment and the epigenome. Biochim. Biophys. Acta 2009, 1790:878-885.
    • (2009) Biochim. Biophys. Acta , vol.1790 , pp. 878-885
    • Szyf, M.1
  • 46
    • 0037462288 scopus 로고    scopus 로고
    • Exposure to the environmental estrogen bisphenol A differentially modulated estrogen receptor-α and -β immunoreactivity and mRNA in male mouse testis
    • Takao T., Nanamiya W., Nazarloo H., Matsumoto R., Asaba K., Hashimoto K. Exposure to the environmental estrogen bisphenol A differentially modulated estrogen receptor-α and -β immunoreactivity and mRNA in male mouse testis. Life Sci. 2003, 72:1159-1169.
    • (2003) Life Sci. , vol.72 , pp. 1159-1169
    • Takao, T.1    Nanamiya, W.2    Nazarloo, H.3    Matsumoto, R.4    Asaba, K.5    Hashimoto, K.6
  • 48
    • 13444269673 scopus 로고    scopus 로고
    • Effects of neonatal administration of 17beta-estradiol, beta-estradiol 3-benzoate, or bisphenol A on mouse and rat spermatogenesis
    • Toyama Y., Yuasa S. Effects of neonatal administration of 17beta-estradiol, beta-estradiol 3-benzoate, or bisphenol A on mouse and rat spermatogenesis. Reprod. Toxicol. 2004, 19:181-188.
    • (2004) Reprod. Toxicol. , vol.19 , pp. 181-188
    • Toyama, Y.1    Yuasa, S.2
  • 52
    • 53149087398 scopus 로고    scopus 로고
    • Genome-wide analysis of epigenomic alterations in fetal mouse forebrain after exposure to low doses of bisphenol A
    • Yaoi T., Itoh K., Nakamura K., Ogi H., Fujiwara Y., Fushiki S. Genome-wide analysis of epigenomic alterations in fetal mouse forebrain after exposure to low doses of bisphenol A. Biochem. Biophys. Res. Commun. 2008, 21:563-567.
    • (2008) Biochem. Biophys. Res. Commun. , vol.21 , pp. 563-567
    • Yaoi, T.1    Itoh, K.2    Nakamura, K.3    Ogi, H.4    Fujiwara, Y.5    Fushiki, S.6
  • 53
    • 61449106828 scopus 로고    scopus 로고
    • Epigenetic modifications of the estrogen receptor beta gene in epithelial ovarian cancer cells
    • Yap O., Bhat G., Liu L., Tollefsbol T. Epigenetic modifications of the estrogen receptor beta gene in epithelial ovarian cancer cells. Anticancer Res. 2009, 29:139-144.
    • (2009) Anticancer Res. , vol.29 , pp. 139-144
    • Yap, O.1    Bhat, G.2    Liu, L.3    Tollefsbol, T.4
  • 54
    • 0034522739 scopus 로고    scopus 로고
    • Distinct mechanisms of loss of estrogen receptor alpha gene expression in human breast cancer: methylation of the gene and alteration of trans-acting factors
    • Yoshida T., Eguchi H., Nakachi K., Tanimoto K., Higashi Y., Suemasu K., Iino Y., Morishita Y., Hayashi S. Distinct mechanisms of loss of estrogen receptor alpha gene expression in human breast cancer: methylation of the gene and alteration of trans-acting factors. Carcinogenesis 2000, 21:2193-2201.
    • (2000) Carcinogenesis , vol.21 , pp. 2193-2201
    • Yoshida, T.1    Eguchi, H.2    Nakachi, K.3    Tanimoto, K.4    Higashi, Y.5    Suemasu, K.6    Iino, Y.7    Morishita, Y.8    Hayashi, S.9
  • 55
    • 0028318783 scopus 로고
    • Methylation of the estrogen receptor gene CpG island marks loss of estrogen receptor expression in human breast cancer cells
    • Ottaviano Y.L., Issa J.P., Parl F.F., Smith H.S., Baylin S.B., Davidson N.E. Methylation of the estrogen receptor gene CpG island marks loss of estrogen receptor expression in human breast cancer cells. Cancer Res. 1994, 54:2552-2555.
    • (1994) Cancer Res. , vol.54 , pp. 2552-2555
    • Ottaviano, Y.L.1    Issa, J.P.2    Parl, F.F.3    Smith, H.S.4    Baylin, S.B.5    Davidson, N.E.6
  • 56
    • 70349313124 scopus 로고    scopus 로고
    • Fetal and neonatal exposure to the endocrine disruptor methoxychlor causes epigenetic alterations in adult ovarian genes
    • Zama A., Uzumcu M. Fetal and neonatal exposure to the endocrine disruptor methoxychlor causes epigenetic alterations in adult ovarian genes. Endocrinology 2009, 150:4681-4691.
    • (2009) Endocrinology , vol.150 , pp. 4681-4691
    • Zama, A.1    Uzumcu, M.2
  • 57
    • 2442676740 scopus 로고    scopus 로고
    • Dynamic regulation of estrogen receptor-beta expression by DNA methylation during prostate cancer development and metastasis
    • Zhu X., Leav I., Leung Y., Wu M., Liu Q., Gao Y., McNeal J., Ho S. Dynamic regulation of estrogen receptor-beta expression by DNA methylation during prostate cancer development and metastasis. Am. J. Pathol. 2004, 164:2003-2012.
    • (2004) Am. J. Pathol. , vol.164 , pp. 2003-2012
    • Zhu, X.1    Leav, I.2    Leung, Y.3    Wu, M.4    Liu, Q.5    Gao, Y.6    McNeal, J.7    Ho, S.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.