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Volumn 48, Issue 5, 2013, Pages 705-710

Late-onset myasthenia gravis: A review when incidence in older adults keeps increasing

Author keywords

Late onset; Myasthenia gravis; Older adults; Thymectomy; Treatment

Indexed keywords

AZATHIOPRINE; CYCLOPHOSPHAMIDE; CYCLOSPORIN; IMMUNOGLOBULIN G; LIVE VACCINE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PLACEBO; PREDNISOLONE; PROTEIN TYROSINE KINASE; PYRIDOSTIGMINE; RITUXIMAB; TACROLIMUS;

EID: 84886740529     PISSN: 0148639X     EISSN: 10974598     Source Type: Journal    
DOI: 10.1002/mus.23964     Document Type: Article
Times cited : (69)

References (64)
  • 1
    • 0016298143 scopus 로고
    • Age groups in American society and rise of young-old
    • Neugarten B. Age groups in American society and rise of young-old. Ann Am Acad Polit Soc Sci 1974;415:187-198.
    • (1974) Ann Am Acad Polit Soc Sci , vol.415 , pp. 187-198
    • Neugarten, B.1
  • 2
    • 0018943586 scopus 로고
    • Clinical, pathological, HLA antigen and immunological evidence for disease heterogeneity in myasthenia gravis
    • Compston DA, Vincent A, Newsom-Davis J, Batchelor JR. Clinical, pathological, HLA antigen and immunological evidence for disease heterogeneity in myasthenia gravis. Brain 1980;103:579-601.
    • (1980) Brain , vol.103 , pp. 579-601
    • Compston, D.A.1    Vincent, A.2    Newsom-Davis, J.3    Batchelor, J.R.4
  • 3
    • 45249092352 scopus 로고    scopus 로고
    • Myasthenia gravis in the elderly: is it different?
    • Aarli JA. Myasthenia gravis in the elderly: is it different? Ann NY Acad Sci 2008;1132:238-243.
    • (2008) Ann NY Acad Sci , vol.1132 , pp. 238-243
    • Aarli, J.A.1
  • 5
    • 0025830647 scopus 로고
    • Epidemiology of myasthenia gravis in Denmark. A longitudinal and comprehensive population survey
    • Somnier FE, Keiding N, Paulson OB. Epidemiology of myasthenia gravis in Denmark. A longitudinal and comprehensive population survey. Arch Neurol 1991;48:733-739.
    • (1991) Arch Neurol , vol.48 , pp. 733-739
    • Somnier, F.E.1    Keiding, N.2    Paulson, O.B.3
  • 6
  • 7
    • 33845212622 scopus 로고    scopus 로고
    • Comparison of the histological and immunohistochemical features of the thymus in young- and elderly-onset myasthenia gravis without thymoma
    • Ishii W, Matsuda M, Hanyuda M, Momose M, Nakayama J, Ehara T, et al. Comparison of the histological and immunohistochemical features of the thymus in young- and elderly-onset myasthenia gravis without thymoma. J Clin Neurosci 2007;14:110-115.
    • (2007) J Clin Neurosci , vol.14 , pp. 110-115
    • Ishii, W.1    Matsuda, M.2    Hanyuda, M.3    Momose, M.4    Nakayama, J.5    Ehara, T.6
  • 8
    • 79955492922 scopus 로고    scopus 로고
    • Increasing incidence of myasthenia gravis among elderly in British Columbia, Canada
    • Pakzad Z, Aziz T, Oger J. Increasing incidence of myasthenia gravis among elderly in British Columbia, Canada. Neurology 2011;76:1526-1528.
    • (2011) Neurology , vol.76 , pp. 1526-1528
    • Pakzad, Z.1    Aziz, T.2    Oger, J.3
  • 9
    • 0141593150 scopus 로고
    • A historical review of myasthenia gravis from 1672 to 1900
    • Viets HR. A historical review of myasthenia gravis from 1672 to 1900. JAMA 1953;153:1273-1280.
    • (1953) JAMA , vol.153 , pp. 1273-1280
    • Viets, H.R.1
  • 11
    • 0016777427 scopus 로고
    • Diseases of the central nervous system. Myasthenia gravis
    • Havard CW. Diseases of the central nervous system. Myasthenia gravis. BMJ 1975;4:152-154.
    • (1975) BMJ , vol.4 , pp. 152-154
    • Havard, C.W.1
  • 12
    • 0014603679 scopus 로고
    • Epidemiology of myasthenia gravis in Finland
    • Hokkanen E. Epidemiology of myasthenia gravis in Finland. J Neurol Sci 1969;9:463-478.
    • (1969) J Neurol Sci , vol.9 , pp. 463-478
    • Hokkanen, E.1
  • 13
    • 0141816347 scopus 로고
    • Sex and age in myasthenia gravis as critical factors in incidence and remission
    • Schwab RS, Leland CC. Sex and age in myasthenia gravis as critical factors in incidence and remission. JAMA 1953;153:1270-1273.
    • (1953) JAMA , vol.153 , pp. 1270-1273
    • Schwab, R.S.1    Leland, C.C.2
  • 14
    • 33746232420 scopus 로고    scopus 로고
    • A systematic review of diagnostic studies in myasthenia gravis
    • Benatar M. A systematic review of diagnostic studies in myasthenia gravis. Neuromuscul Disord 2006;16:459-467.
    • (2006) Neuromuscul Disord , vol.16 , pp. 459-467
    • Benatar, M.1
  • 15
    • 0035105784 scopus 로고    scopus 로고
    • Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies
    • Hoch W, McConville J, Helms S, Newsom-Davis J, Melms A, Vincent A. Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies. Nat Med 2001;7:365-368.
    • (2001) Nat Med , vol.7 , pp. 365-368
    • Hoch, W.1    McConville, J.2    Helms, S.3    Newsom-Davis, J.4    Melms, A.5    Vincent, A.6
  • 16
    • 79959324658 scopus 로고    scopus 로고
    • Anti-MuSK antibody myasthenia gravis: clinical findings and response to treatment in two large cohorts
    • Guptill JG, Sanders DB, Evoli A. Anti-MuSK antibody myasthenia gravis: clinical findings and response to treatment in two large cohorts. Muscle Nerve 2011;44:36-40.
    • (2011) Muscle Nerve , vol.44 , pp. 36-40
    • Guptill, J.G.1    Sanders, D.B.2    Evoli, A.3
  • 17
    • 84859939384 scopus 로고    scopus 로고
    • Autoantibodies to lipoprotein-related protein 4 in patients with double-seronegative myasthenia gravis
    • Zhang B, Tzartos JS, Belimezi M, Ragheb S, Bealmear B, Lewis RA, et al. Autoantibodies to lipoprotein-related protein 4 in patients with double-seronegative myasthenia gravis. Arch Neurol 2012;69:445-451.
    • (2012) Arch Neurol , vol.69 , pp. 445-451
    • Zhang, B.1    Tzartos, J.S.2    Belimezi, M.3    Ragheb, S.4    Bealmear, B.5    Lewis, R.A.6
  • 19
    • 0028779203 scopus 로고
    • Myasthenia gravis
    • Drachman DB. Myasthenia gravis. N Engl J Med 1994;330:1797-1810.
    • (1994) N Engl J Med , vol.330 , pp. 1797-1810
    • Drachman, D.B.1
  • 20
    • 79955702892 scopus 로고    scopus 로고
    • Characteristics of myasthenia gravis according to onset-age: Japanese nationwide survey
    • Murai H, Yamashita N, Watanabe M, Nomura Y, Motomura M, Yoshikawa H, et al. Characteristics of myasthenia gravis according to onset-age: Japanese nationwide survey. J Neurol Sci 2011;305:97-102.
    • (2011) J Neurol Sci , vol.305 , pp. 97-102
    • Murai, H.1    Yamashita, N.2    Watanabe, M.3    Nomura, Y.4    Motomura, M.5    Yoshikawa, H.6
  • 21
    • 0033067712 scopus 로고    scopus 로고
    • Efficacy and safety of extended thymectomy for elderly patients with myasthenia gravis
    • Tsuchida M, Yamato Y, Souma T, Yoshiya K, Watanabe T, Aoki T, et al. Efficacy and safety of extended thymectomy for elderly patients with myasthenia gravis. Ann Thorac Surg 1999;67:1563-1567.
    • (1999) Ann Thorac Surg , vol.67 , pp. 1563-1567
    • Tsuchida, M.1    Yamato, Y.2    Souma, T.3    Yoshiya, K.4    Watanabe, T.5    Aoki, T.6
  • 22
    • 1142275269 scopus 로고    scopus 로고
    • Age-related changes in lymphocyte development and function
    • Linton PJ, Dorshkind K. Age-related changes in lymphocyte development and function. Nat Immunol 2004;5:133-139.
    • (2004) Nat Immunol , vol.5 , pp. 133-139
    • Linton, P.J.1    Dorshkind, K.2
  • 23
    • 0020670095 scopus 로고
    • Anti-acetylcholine receptor antibodies in myasthenia gravis. Part 1. Relation to clinical parameters in 250 patients
    • Limburg PC, The TH, Hummel-Tappel E, Oosterhuis HJ. Anti-acetylcholine receptor antibodies in myasthenia gravis. Part 1. Relation to clinical parameters in 250 patients. J Neurol Sci 1983;58:357-370.
    • (1983) J Neurol Sci , vol.58 , pp. 357-370
    • Limburg, P.C.1    The, T.H.2    Hummel-Tappel, E.3    Oosterhuis, H.J.4
  • 26
    • 78650987466 scopus 로고    scopus 로고
    • Clinical and immunological differences between early and late-onset myasthenia gravis in Japan
    • Suzuki S, Utsugisawa K, Nagane Y, Satoh T, Kuwana M, Suzuki N. Clinical and immunological differences between early and late-onset myasthenia gravis in Japan. J Neuroimmunol 2011;230:148-152.
    • (2011) J Neuroimmunol , vol.230 , pp. 148-152
    • Suzuki, S.1    Utsugisawa, K.2    Nagane, Y.3    Satoh, T.4    Kuwana, M.5    Suzuki, N.6
  • 27
    • 84867332830 scopus 로고    scopus 로고
    • Characteristics of late-onset myasthenia gravis
    • Zivkovic SA, Clemens PR, Lacomis D. Characteristics of late-onset myasthenia gravis. J Neurol 2012;259:2167-2171.
    • (2012) J Neurol , vol.259 , pp. 2167-2171
    • Zivkovic, S.A.1    Clemens, P.R.2    Lacomis, D.3
  • 28
    • 84861460473 scopus 로고    scopus 로고
    • Three types of striational antibodies in myasthenia gravis
    • Suzuki S, Utsugisawa K, Nagane Y, Suzuki N. Three types of striational antibodies in myasthenia gravis. Autoimmune Dis 2011;2011:740583.
    • (2011) Autoimmune Dis , vol.2011 , pp. 740583
    • Suzuki, S.1    Utsugisawa, K.2    Nagane, Y.3    Suzuki, N.4
  • 29
    • 0034129733 scopus 로고    scopus 로고
    • Muscle autoantibodies in subgroups of myasthenia gravis patients
    • Romi F, Skeie GO, Aarli JA, Gilhus NE. Muscle autoantibodies in subgroups of myasthenia gravis patients. J Neurol 2000;247:369-375.
    • (2000) J Neurol , vol.247 , pp. 369-375
    • Romi, F.1    Skeie, G.O.2    Aarli, J.A.3    Gilhus, N.E.4
  • 30
    • 0033751724 scopus 로고    scopus 로고
    • The severity of myasthenia gravis correlates with the serum concentration of titin and ryanodine receptor antibodies
    • Romi F, Skeie GO, Aarli JA, Gilhus NE. The severity of myasthenia gravis correlates with the serum concentration of titin and ryanodine receptor antibodies. Arch Neurol 2000;57:1596-1600.
    • (2000) Arch Neurol , vol.57 , pp. 1596-1600
    • Romi, F.1    Skeie, G.O.2    Aarli, J.A.3    Gilhus, N.E.4
  • 33
    • 0027788344 scopus 로고
    • Ocular myasthenia gravis. A critical review of clinical and pathophysiological aspects
    • Sommer N, Melms A, Weller M, Dichgans J. Ocular myasthenia gravis. A critical review of clinical and pathophysiological aspects. Doc Ophthalmol 1993;84:309-333.
    • (1993) Doc Ophthalmol , vol.84 , pp. 309-333
    • Sommer, N.1    Melms, A.2    Weller, M.3    Dichgans, J.4
  • 34
    • 39749125211 scopus 로고    scopus 로고
    • Electrophysiological signs and the prevalence of adverse effects of acetylcholinesterase inhibitors in patients with myasthenia gravis
    • Punga AR, Sawada M, Stalberg EV. Electrophysiological signs and the prevalence of adverse effects of acetylcholinesterase inhibitors in patients with myasthenia gravis. Muscle Nerve 2008;37:300-307.
    • (2008) Muscle Nerve , vol.37 , pp. 300-307
    • Punga, A.R.1    Sawada, M.2    Stalberg, E.V.3
  • 35
    • 0021329141 scopus 로고
    • Long-term corticosteroid treatment of myasthenia gravis: report of 116 patients
    • Pascuzzi RM, Coslett HB, Johns TR. Long-term corticosteroid treatment of myasthenia gravis: report of 116 patients. Ann Neurol 1984;15:291-298.
    • (1984) Ann Neurol , vol.15 , pp. 291-298
    • Pascuzzi, R.M.1    Coslett, H.B.2    Johns, T.R.3
  • 38
    • 0031747483 scopus 로고    scopus 로고
    • A randomized double-blind trial of prednisolone alone or with azathioprine in myasthenia gravis
    • Palace J, Newsom-Davis J, Lecky B. A randomized double-blind trial of prednisolone alone or with azathioprine in myasthenia gravis. Neurology 1998;50:1778-1783.
    • (1998) Neurology , vol.50 , pp. 1778-1783
    • Palace, J.1    Newsom-Davis, J.2    Lecky, B.3
  • 39
    • 0026407985 scopus 로고
    • Azathioprine in myasthenia gravis: observations in 41 patients and a review of literature
    • Kuks JB, Djojoatmodjo S, Oosterhuis HJ. Azathioprine in myasthenia gravis: observations in 41 patients and a review of literature. Neuromuscul Disord 1991;1:423-431.
    • (1991) Neuromuscul Disord , vol.1 , pp. 423-431
    • Kuks, J.B.1    Djojoatmodjo, S.2    Oosterhuis, H.J.3
  • 41
    • 0023118848 scopus 로고
    • Preliminary results of a double-blind, randomized, placebo-controlled trial of cyclosporine in myasthenia gravis
    • Tindall RS, Rollins JA, Phillips JT, Greenlee RG, Wells L, Belendiuk G. Preliminary results of a double-blind, randomized, placebo-controlled trial of cyclosporine in myasthenia gravis. N Engl J Med 1987;316:719-724.
    • (1987) N Engl J Med , vol.316 , pp. 719-724
    • Tindall, R.S.1    Rollins, J.A.2    Phillips, J.T.3    Greenlee, R.G.4    Wells, L.5    Belendiuk, G.6
  • 42
  • 43
    • 49049115186 scopus 로고    scopus 로고
    • A trial of mycophenolate mofetil with prednisone as initial immunotherapy in myasthenia gravis
    • Muscle Study Group
    • Muscle Study Group. A trial of mycophenolate mofetil with prednisone as initial immunotherapy in myasthenia gravis. Neurology 2008;71:394-399.
    • (2008) Neurology , vol.71 , pp. 394-399
  • 44
  • 46
    • 84861822103 scopus 로고    scopus 로고
    • Therapeutic plasma exchange in the elderly: experience at a tertiary center
    • Abdel-Rahman EM, Hayes J, Balogun RA. Therapeutic plasma exchange in the elderly: experience at a tertiary center. J Clin Apher 2012;27:108-111.
    • (2012) J Clin Apher , vol.27 , pp. 108-111
    • Abdel-Rahman, E.M.1    Hayes, J.2    Balogun, R.A.3
  • 47
    • 4844221605 scopus 로고    scopus 로고
    • Thromboembolic events as an emerging adverse effect during high-dose intravenous immunoglobulin therapy in elderly patients: a case report and discussion of the relevant literature
    • Hefer D, Jaloudi M. Thromboembolic events as an emerging adverse effect during high-dose intravenous immunoglobulin therapy in elderly patients: a case report and discussion of the relevant literature. Ann Hematol 2004;83:661-665.
    • (2004) Ann Hematol , vol.83 , pp. 661-665
    • Hefer, D.1    Jaloudi, M.2
  • 50
    • 0019743687 scopus 로고
    • Comparison of the results of transsternal simple, transcervical simple, and extended thymectomy
    • Masaoka A, Monden Y. Comparison of the results of transsternal simple, transcervical simple, and extended thymectomy. Ann NY Acad Sci 1981;377:755-765.
    • (1981) Ann NY Acad Sci , vol.377 , pp. 755-765
    • Masaoka, A.1    Monden, Y.2
  • 51
    • 85027936584 scopus 로고    scopus 로고
    • Robot-aided thoracoscopic thymectomy for early-stage thymoma: a multicenter European study
    • Marulli G, Rea F, Melfi F, Schmid TA, Ismail M, Fanucchi O, et al. Robot-aided thoracoscopic thymectomy for early-stage thymoma: a multicenter European study. J Thorac Cardiovasc Surg 2012;144:1125-1130.
    • (2012) J Thorac Cardiovasc Surg , vol.144 , pp. 1125-1130
    • Marulli, G.1    Rea, F.2    Melfi, F.3    Schmid, T.A.4    Ismail, M.5    Fanucchi, O.6
  • 54
    • 0016612676 scopus 로고
    • The thymus gland in elderly patients with myasthenia gravis
    • Perlo VP, Arnason B, Castleman B. The thymus gland in elderly patients with myasthenia gravis. Neurology 1975;25:294-295.
    • (1975) Neurology , vol.25 , pp. 294-295
    • Perlo, V.P.1    Arnason, B.2    Castleman, B.3
  • 55
    • 0035957071 scopus 로고    scopus 로고
    • In myasthenia gravis cells from atrophic thymus secrete acetylcholine receptor antibodies
    • Katzberg HD, Aziz T, Oger J. In myasthenia gravis cells from atrophic thymus secrete acetylcholine receptor antibodies. Neurology 2001;56:572-573.
    • (2001) Neurology , vol.56 , pp. 572-573
    • Katzberg, H.D.1    Aziz, T.2    Oger, J.3
  • 56
    • 70149103802 scopus 로고    scopus 로고
    • Pharmacokinetics and drug metabolism in the elderly
    • Klotz U. Pharmacokinetics and drug metabolism in the elderly. Drug Metab Rev 2009;41:67-76.
    • (2009) Drug Metab Rev , vol.41 , pp. 67-76
    • Klotz, U.1
  • 60
    • 0026327429 scopus 로고
    • Prognosis of myasthenia gravis: a multicenter follow-up study of 844 patients
    • Beghi E, Antozzi C, Batocchi AP, Cornelio F, Cosi V, Evoli A, et al. Prognosis of myasthenia gravis: a multicenter follow-up study of 844 patients. J Neurol Sci 1991;106:213-220.
    • (1991) J Neurol Sci , vol.106 , pp. 213-220
    • Beghi, E.1    Antozzi, C.2    Batocchi, A.P.3    Cornelio, F.4    Cosi, V.5    Evoli, A.6
  • 61
    • 0025730448 scopus 로고
    • Actuarial analysis of the occurrence of remissions following thymectomy for myasthenia gravis in 400 patients
    • Durelli L, Maggi G, Casadio C, Ferri R, Rendine S, Bergamini L. Actuarial analysis of the occurrence of remissions following thymectomy for myasthenia gravis in 400 patients. J Neurol Neurosurg Psychiatry 1991;54:406-411.
    • (1991) J Neurol Neurosurg Psychiatry , vol.54 , pp. 406-411
    • Durelli, L.1    Maggi, G.2    Casadio, C.3    Ferri, R.4    Rendine, S.5    Bergamini, L.6
  • 63
  • 64
    • 34547844246 scopus 로고    scopus 로고
    • Nonthymoma early-onset- and late-onset-generalized myasthenia gravis-a retrospective hospital-based study
    • Chan KH, Cheung RT, Mak W, Ho SL. Nonthymoma early-onset- and late-onset-generalized myasthenia gravis-a retrospective hospital-based study. Clin Neurol Neurosurg 2007;109:686-691.
    • (2007) Clin Neurol Neurosurg , vol.109 , pp. 686-691
    • Chan, K.H.1    Cheung, R.T.2    Mak, W.3    Ho, S.L.4


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