Characteristics of myasthenia gravis according to onset-age: Japanese nationwide survey

Journal of the Neurological Sciences

Volumn 305, Issue 1-2, 2011, Pages 97-102

  Murai, Hiroyuki ^a,b   Yamashita, Natsumi ^c   Watanabe, Makoto ^d,h   Nomura, Yoshiko ^e   Motomura, Masakatsu ^f   Yoshikawa, Hiroaki ^g   Nakamura, Yosikazu ^h   Kawaguchi, Naoki ⁱ   Onodera, Hiroshi ^j   Araga, Shigeru ^k   Isobe, Noriko ^a   Nagai, Masaki ^l   Kira, Jun Ichi ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b ASO IIZUKA HOSPITAL   (Japan)

^c KURUME UNIVERSITY   (Japan)

^d NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^e Segawa Neurological Clinic for Children   (Japan)

^f NAGASAKI UNIVERSITY   (Japan)

^g KANAZAWA UNIVERSITY   (Japan)

^h JICHI MEDICAL UNIVERSITY   (Japan)

ⁱ CHIBA UNIVERSITY   (Japan)

^j National Hospital Organization Sendai Nishitaga Hospital   (Japan)

^k Fujii Memorial Hospital   (Japan)

^l SAITAMA MEDICAL UNIVERSITY   (Japan)

more..

Author keywords

Epidemiology; Generalized additive model (GAM); Infantile onset; Myasthenia gravis; Nationwide survey; Onset age; Thymoma

Indexed keywords

CHOLINERGIC RECEPTOR ANTIBODY;

ADOLESCENT; ADULT; AGE DISTRIBUTION; AGED; ARTICLE; CHILD; CLINICAL ASSESSMENT; ELECTROMYOGRAPHY; FEMALE; GENERALIZED ADDITIVE MODEL; HEALTH SURVEY; HUMAN; HYPERPLASIA; INFANT; JAPANESE; MAJOR CLINICAL STUDY; MALE; MYASTHENIA GRAVIS; ONSET AGE; PRESCHOOL CHILD; PREVALENCE; PRIORITY JOURNAL; SCHOOL CHILD; STATISTICAL MODEL; THYMOMA;

ADOLESCENT; ADULT; AGE OF ONSET; AGED; AGING; ASIAN CONTINENTAL ANCESTRY GROUP; CHILD; CHILD, PRESCHOOL; COMORBIDITY; FEMALE; GENETIC HETEROGENEITY; HUMANS; INFANT; INFANT, NEWBORN; JAPAN; MALE; MIDDLE AGED; MYASTHENIA GRAVIS; PREVALENCE; YOUNG ADULT;

EID: 79955702892     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jns.2011.03.004     Document Type: Article

References (36)

1. Lewis RA, Selwa JF, Lisak RP. Myasthenia gravis: immunological mechanisms and immunotherapy. Ann Neurol 1995;37(Suppl 1):S51-62.
2. Alshekhlee A, Miles JD, Katirji B, Preston DC, Kaminski HJ. Incidence and mortality rates of myasthenia gravis and myasthenic crisis in US hospitals. Neurology 2009;72:1548-54.
3. Hoch W, McConville J, Helms S, Newsom-Davis J, Melms A, Vincent A. Autoantibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies. Nat Med 2001;7:365-8. (Pubitemid 32224355)
4. Oh SJ, Morgan MB, Lu L, Hatanaka Y, Hemmi S, Young A, et al. Racial differences in myasthenia gravis in Alabama. Muscle Nerve 2009;39:328-32.
5. Chiu HC, Vincent A, Newsom-Davis J, Hsieh KH, Hung T. Myasthenia gravis: population differences in disease expression and acetylcholine receptor antibody titers between Chinese and Caucasians. Neurology 1987;37:1854-7. (Pubitemid 18026365)
6. Wong V, Hawkins BR, Yu YL. Myasthenia gravis in Hong Kong Chinese. 2. Paediatric disease. Acta Neurol Scand 1992;86:68-72.
7. Zhang X, Yang M, Xu J, Zhang M, Lang B, Wang W, et al. Clinical and serological study of myasthenia gravis in HuBei Province, China. J Neurol Neurosurg Psychiatry 2007;78:386-90. (Pubitemid 46580547)
8. Chiang LM, Darras BT, Kang PB. Juvenile myasthenia gravis. Muscle Nerve 2009;39: 423-31.
9. Somnier FE. Increasing incidence of late-onset anti-AChR antibody-seropositive myasthenia gravis. Neurology 2005;65:928-30. (Pubitemid 41362144)
10. Aarli JA. Myasthenia gravis in the elderly: is it different? Ann NY Acad Sci 2008;1132:238-43.
11. Matsuda M, Dohi-Iijima N, Nakamura A, Sekijima Y, Morita H, Matsuzawa S, et al. Increase in incidence of elderly-onset patients with myasthenia gravis in Nagano Prefecture, Japan. Intern Med 2005;44:572-7. (Pubitemid 40932830)
12. Matsui N, Nakane S, Nakagawa Y, Kondo K, Mitsui T, Matsumoto T, et al. Increasing incidence of elderly onset patients with myasthenia gravis in a local area of Japan. J Neurol Neurosurg Psychiatry 2009;80:1168-71.
13. Jacobson DL, Gange SJ, Rose NR, Graham NM. Epidemiology and estimated population burden of selected autoimmune diseases in the United States. Clin Immunol Immunopathol 1997;84:223-43. (Pubitemid 27398022)
14. Cooper GS, Stroehla BC. The epidemiology of autoimmune diseases. Autoimmun Rev 2003;2:119-25. (Pubitemid 37443848)
15. Jimenez S, Cervera R, Font J, Ingelmo M. The epidemiology of systemic lupus erythematosus. Clin Rev Allergy Immunol 2003;25:3-12.
16. Hirayama M, Sugishita T, Uono K. Epidemiological study of myasthenia gravis ( in Japanese). Annual Report of Myasthenia Gravis Research Committee; 1974. p. 50-66.
17. Uono M. Clinical statistics of myasthenia gravis in Japan. Int J Neurol 1980;14: 87-99.
18. Takamori M, Igata A. Epidemiological study of myasthenia gravis (in Japanese). Annual Report of Neuroimmunological Disease Research Committee; 1988. p. 227-45.
19. Miura K, Nakagawa H, Morikawa Y, Sasayama S, Matsumori A, Hasegawa K, et al. Epidemiology of idiopathic cardiomyopathy in Japan: results from a nationwide survey. Heart 2002;87:126-30. (Pubitemid 34098371)
20. Jaretzki III A, Barohn RJ, Ernstoff RM, Kaminski HJ, Keesey JC, Penn AS, et al. Myasthenia gravis: recommendations for clinical research standards. Task Force of the Medical Scientific Advisory Board of the Myasthenia Gravis Foundation of America. Neurology 2000;55:16-23. (Pubitemid 30460991)
21. Wolfe GI, Herbelin L, Nations SP, Foster B, Bryan WW, Barohn RJ. Myasthenia gravis activities of daily living profile. Neurology 1999;52:1487-9. (Pubitemid 29190546)
22. Hashimoto S, Fukutomi K,Nagai M. Response bias in the nationwide epidemiological survey of an intractable disease in Japan. J Epidemiol 1991;1:27-30.
23. Osoegawa M, Kira J, Fukazawa T, Fujihara K, Kikuchi S, Matsui M, et al. Temporal changes and geographical differences in multiple sclerosis phenotypes in Japanese: nationwide survey results over 30 years. Mult Scler 2009;15:159-73.
24. Team RDC. R: a language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing; 2008.
25. Hastie TJ, Tibshirani RJ. Generalized additive models. New York: Chapman & Hall/CRC; 1990.
26. Meriggioli MN, Sanders DB. Autoimmune myasthenia gravis: emerging clinical and biological heterogeneity. Lancet Neurol 2009;8:475-90.
27. Hawkins BR, Chan-Lui WY, Choi EK, Ho AY. Strong association of HLA BW46 with juvenile onset myasthenia gravis in Hong Kong Chinese. J Neurol Neurosurg Psychiatry 1984;47:555-7. (Pubitemid 14145509)
28. Hawkins BR, Yu YL, Wong V, Woo E, Ip MS, Dawkins RL. Possible evidence for a variant of myasthenia gravis based on HLA and acetylcholine receptor antibody in Chinese patients. Q J Med 1989;70:235-41. (Pubitemid 19135598)
29. Chen WH, Chiu HC, Hseih RP. Association of HLA-Bw46DR9 combinationwith juvenile myasthenia gravis in Chinese. J Neurol Neurosurg Psychiatry 1993;56:382-5.
30. Matsuki K, Juji T, Tokunaga K, Takamizawa M, Maeda H, Soda M, et al. HLA antigens in Japanese patients with myasthenia gravis. J Clin Invest 1990;86:392-9. (Pubitemid 20271870)
31. Nomura Y, Ehara M, Matsuki K, Juji T, Segawa M. HLA haplotype in myasthenia gravis (MG) of Japanese children. Correlative studies between MG patients and their normal siblings and parents. Ann NY Acad Sci 1993;681:581-3.
32. Shinomiya N, Nomura Y, Segawa M. A variant of childhood-onset myasthenia gravis: HLA typing and clinical characteristics in Japan. Clin Immunol 2004;110:154-8. (Pubitemid 38296705)
33. Ashraf VV, Taly AB, Veerendrakumar M, Rao S. Myasthenia gravis in children: a longitudinal study. Acta Neurol Scand 2006;114:119-23. (Pubitemid 44034260)
34. Rodriguez M, Gomez MR, Howard Jr FM, Taylor WF. Myasthenia gravis in children: long-term follow-up. Ann Neurol 1983;13:504-10. (Pubitemid 13086668)
35. Evoli A, Batocchi AP, Bartoccioni E, Lino MM, Minisci C, Tonali P. Juvenile myasthenia gravis with prepubertal onset. Neuromuscul Disord 1998;8:561-7. (Pubitemid 28555738)
36. Morita MP, Gabbai AA, Oliveira AS, Penn AS. Myasthenia gravis in children: analysis of 18 patients. Arq Neuropsiquiatr 2001;59:681-5. (Pubitemid 32946374)