Identification of novel small molecule inhibitors of centrosome clustering in cancer cells

Oncotarget

Volumn 4, Issue 10, 2013, Pages 1763-1776

  Kawamura, Eiko ^a   Fielding, Andrew B ^a,b   Kannan, Nagarajan ^c   Balgi, Aruna ^d   Eaves, Connie J ^c,d   Roberge, Michel ^d   Dedhar, Shoukat ^a,d  

^a BRITISH COLUMBIA CANCER AGENCY   (Canada)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

^c BRITISH COLUMBIA CANCER AGENCY   (Canada)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Cancer specific; Centrosome clustering; Multipolar mitosis; Small molecule; Spindle

Indexed keywords

ANTINEOPLASTIC AGENT; N2 (2 THIENYLMETHYL) 5 NITRO 2 FURAMIDE; N2 (3 PYRIDYLMETHYL) 5 NITRO 2 FURAMIDE; N2 BENZYL 5 NITRO 2 FURAMIDE; PACLITAXEL; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BREAST EPITHELIUM; CANCER CELL; CANCER CELL CULTURE; CANCER CELL DESTRUCTION; CANCER GROWTH; CANCER INHIBITION; CELL ASSAY; CELL DEATH; CELL SPECIFICITY; CELL VIABILITY; CENTROSOME; CLONOGENESIS; COLONY FORMING CELL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG STRUCTURE; HEMATOPOIETIC STEM CELL; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; MITOSIS INHIBITION; QUANTITATIVE ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

APOPTOSIS; BREAST NEOPLASMS; CELL DEATH; CELL LINE, TUMOR; CENTROSOME; FEMALE; HUMANS; MICROSCOPY, FLUORESCENCE; SMALL MOLECULE LIBRARIES; SPINDLE APPARATUS;

EID: 84886738066     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.1198     Document Type: Article

References (37)

1. Zyss D and Gergely F. Centrosome function in cancer: guilty or innocent? Trends Cell Biol. 2009, 19(7), 334-346.
2. Chan JY. A Clinical Overview of Centrosome Amplification in Human Cancers. Int J Biol Sci. 2011, 7(8), 1122-1144.
3. Fukasawa K. Oncogenes and tumour suppressors take on centrosomes. Nature Reviews Cancer. 2007, 7(12), 911-924.
4. Ganem NJ, Godinho SA and Pellman D. A mechanism linking extra centrosomes to chromosomal instability. Nature. 2009, 460(7252), 278-U146.
5. Quintyne NJ, Reing JE, Hoffelder DR, Gollin SM and Saunders WS. Spindle multipolarity is prevented by centrosomal clustering. Science. 2005, 307(5706), 127-129.
6. Kwon M, Godinho SA, Chandhok NS, Ganem NJ, Azioune A, Thery M and Pellman D. Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes. Gene Dev. 2008, 22(16), 2189-2203.
7. Leber B, Maier B, Fuchs F, Chi J, Riffel P, Anderhub S, Wagner L, Ho AD, Salisbury JL, Boutros M and Kramer A. Proteins Required for Centrosome Clustering in Cancer Cells. Science Translational Medicine. 2010, 2(33).
8. Fielding AB, Lim S, Montgomery K, Dobreva I and Dedhar S. A critical role of integrin-linked kinase, ch-TOG and TACC3 in centrosome clustering in cancer cells. Oncogene. 2011, 30(5), 521-534.
9. Jackson JR, Patrick DR, Dar MM and Huang PS. Targeted anti-mitotic therapies: can we improve on tubulin agents? Nat Rev Cancer. 2007, 7(2), 107-117.
10. Gergely F and Basto R. Multiple centrosomes: together they stand, divided they fall. Gene Dev. 2008, 22(17), 2291-2296.
11. Gascoigne KE and Taylor SS. How do anti-mitotic drugs kill cancer cells? Journal of Cell Science. 2009, 122(15), 2579-2585.
12. Rebacz B, Larsen TO, Clausen MH, Ronnest MH, Loffler H, Ho AD and Kramer A. Identification of griseofulvin as an inhibitor of centrosomal clustering in a phenotype-based screen. Cancer Research. 2007, 67(13), 6342-6350.
13. Raab MS, Breitkreutz I, Anderhub S, Ronnest MH, Leber B, Larsen TO, Weiz L, Konotop G, Hayden PJ, Podar K, Fruehauf J, Nissen F, Mier W, Haberkorn U, Ho AD, Goldschmidt H, et al. GF-15, a Novel Inhibitor of Centrosomal Clustering, Suppresses Tumor Cell Growth In Vitro and In Vivo. Cancer Research. 2012, 72(20), 5374-5385.
14. Chaudhuri AR and Luduena RF. Griseofulvin: A novel interaction with bovine brain tubulin. Biochem Pharmacol. 1996, 51(7), 903-909.
15. Sloboda RD, Vanblaricom G, Creasey WA, Rosenbaum JL and Malawista SE. Griseofulvin -Association with Tubulin and Inhibition of Invitro Microtubule Assembly. Biochem Bioph Res Co. 1982, 105(3), 882-888.
16. Rathinasamy K, Jindal B, Asthana J, Singh P, Balaji PV and Panda D. Griseofulvin stabilizes microtubule dynamics, activates p53 and inhibits the proliferation of MCF-7 cells synergistically with vinblastine. Bmc Cancer. 2010, 10.
17. Ho YS, Duh JS, Jeng JH, Wang YJ, Liang YC, Lin CH, Tseng CJ, Yu CF, Chen RJ and Lin JK. Griseofulvin potentiates antitumorigenesis effects of nocodazole through induction of apoptosis and G2/M cell cycle arrest in human colorectal cancer cells. Int J Cancer. 2001, 91(3), 393-401.
18. McDonald PC, Fielding AB and Dedhar S. Integrin-linked kinase -essential roles in physiology and cancer biology. Journal of Cell Science. 2008, 121(19), 3121-3132.
19. Fielding AB, Dobreva I, McDonald PC, Foster LJ and Dedhar S. Integrin-linked kinase localizes to the centrosome and regulates mitotic spindle organization. Journal of Cell Biology. 2008, 180(4), 681-689.
20. Anderson HJ, de Jong G, Vincent I and Roberge M. Flow cytometry of mitotic cells. Exp Cell Res. 1998, 238(2), 498-502.
21. Dranovsky A, Vincent I, Gregori L, Schwarzman A, Colflesh D, Enghild J, Strittmatter W, Davies P and Goldgaber D. Cdc2 phosphorylation of nucleolin demarcates mitotic stages and Alzheimer's disease pathology. Neurobiol Aging. 2001, 22(4), 517-528.
22. Franken NAP, Rodermond HM, Stap J, Haveman J and van Bree C. Clonogenic assay of cells in vitro. Nat Protoc. 2006, 1(5), 2315-2319.
23. Pessina A, Albella B, Bayo M, Bueren J, Brantom P, Casati S, Croera C, Gagliardi G, Foti P, Parchment R, Parent-Massin D, Schoeters G, Sibiril Y, Van den Heuvel R and Gribaldo L. Application of the CFU-GM assay to predict acute drug-induced neutropenia: An international blind trial to validate a prediction model for the maximum tolerated dose (MTD) of myelosuppressive xenobiotics. Toxicol Sci. 2003, 75(2), 355-367.
24. Lawo S, Bashkurov M, Mullin M, Ferreria MG, Kittler R, Habermann B, Tagliaferro A, Poser I, Hutchins JRA, Hegemann B, Pinchev D, BuchholZ F, Peters JM, Hyman AA, Gingras AC and Pelletier L. HAUS, the 8-Subunit Human Augmin Complex, Regulates Centrosome and Spindle Integrity. Current Biology. 2009, 19(10), 816-826.
25. De Luca M, Brunetto L, Asteriti IA, Giubettini M, Lavia P and Guarguaglini G. Aurora-A and ch-TOG act in a common pathway in control of spindle pole integrity. Oncogene. 2008, 27(51), 6539-6549.
26. Carvajal RD, Tse A and Schwartz GK. Aurora kinases: New targets for cancer therapy. Clinical Cancer Research. 2006, 12(23), 6869-6875.
27. Wu Q, He R, Zhou H, Yu AC, Zhang B, Teng J and Chen J. Cep57, a NEDD1-binding pericentriolar material component, is essential for spindle pole integrity. Cell Res. 2012.
28. Momotani K, Khromov AS, Miyake T, Stukenberg RT and Somlyo AV. Cep57, a multidomain protein with unique microtubule and centrosomal localization domains. Biochem J. 2008, 412, 265-273.
29. Kleylein-Sohn J, Pollinger B, Ohmer M, Hofmann F, Nigg EA, Hemmings BA and Wartmann M. Acentrosomal spindle organization renders cancer cells dependent on the kinesin HSET. Journal of Cell Science. 2012, 125(22), 5391-5402.
30. Thein KH, Kleylein-Sohn J, Nigg EA and Gruneberg U. Astrin is required for the maintenance of sister chromatid cohesion and centrosome integrity. Journal of Cell Biology. 2007, 178(3), 345-354.
31. Nakamura A, Arai H and Fujita N. Centrosomal Aki1 and cohesin function in separase-regulated centriole disengagement. Journal of Cell Biology. 2009, 187(5), 607-614.
32. Imbalzano KM, Tatarkova I, Imbalzano AN and Nickerson JA. Increasingly transformed MCF-10A cells have a progressively tumor-like phenotype in three-dimensional basement membrane culture. Cancer Cell Int. 2009, 9.
33. Eirew P, Stingl J, Raouf A, Turashvili G, Aparicio S, Emerman JT and Eaves CJ. A method for quantifying normal human mammary epithelial stem cells with in vivo regenerative ability. Nat Med. 2008, 14(12), 1384-1389.
34. Kannan N, Huda N, Tu L, Droumeva R, Aubert G, Chavez E, Brinkman RR, Lansdorp P, Emerman J, Abe S, Eaves C and Gilley D. The Luminal Progenitor Compartment of the Normal Human Mammary Gland Constitutes a Unique Site of Telomere Dysfunction. Stem Cell Reports. 2013, 1(1), 28-37.
35. Raouf A, Zhao Y, To K, Stingl J, Delaney A, Barbara M, Iscove N, Jones S, McKinney S, Emerman J, Aparicio S, Marra M and Eaves C. Transcriptome analysis of the normal human mammary cell commitment and differentiation process. Cell Stem Cell. 2008, 3(1), 109-118.
36. Dobreva I, Fielding A, Foster LJ and Dedhar S. Mapping the integrin-linked kinase interactome using SILAC. Journal of Proteome Research. 2008, 7(4), 1740-1749.
37. Chen M, Gallipoli P, DeGeer D, Sloma I, Forrest DL, Chan M, Lai DM, Jorgensen H, Ringrose A, Wang HM, Lambie K, Nakamoto H, Saw KM, Turhan A, Arlinghaus R, Paul J, et al. Targeting Primitive Chronic Myeloid Leukemia Cells by Effective Inhibition of a New AHI-1BCR-ABL-JAK2 Complex. Jnci-J Natl Cancer I. 2013, 105(6), 405-423.