Clarithromycin in rheumatoid arthritis: The addition to methotrexate and low-dose methylprednisolone induces a significant additive value - A 24-month single-blind pilot study

Rheumatology International

Volumn 33, Issue 11, 2013, Pages 2833-2838

  Saviola, Gianantonio ^a   Abdi Ali, Lul ^a   Campostrini, Lorella ^a   Sacco, Silvano ^a   Baiardi, Paola ^a   Manfredi, Mariangela ^b   Benucci, Maurizio ^b   Bucci, Mariarosaria ^c   Cirino, Giuseppe ^c  

^a IRCCS   (Italy)

^b S Giovanni di Dio Hospital   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Clarithromycin; Macrolide antibiotics; Methotrexate; Periodontopathic bacteria; Rheumatoid arthritis

Indexed keywords

CLARITHROMYCIN; METHOTREXATE; METHYLPREDNISOLONE;

ADD ON THERAPY; ADULT; AGED; ALOPECIA; ARTICLE; CLINICAL ARTICLE; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; DRUG WITHDRAWAL; FEMALE; FOLLOW UP; FRACTURE; HEART DISEASE; HUMAN; LOW DRUG DOSE; MALE; METALLIC TASTE; NAUSEA; NEOPLASM; NEUROLOGIC DISEASE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RHEUMATOID ARTHRITIS; SIDE EFFECT; SINGLE BLIND PROCEDURE; STOMACH PAIN; TREATMENT DURATION;

ADULT; AGED; AGED, 80 AND OVER; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; CLARITHROMYCIN; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; MALE; METHOTREXATE; METHYLPREDNISOLONE; MIDDLE AGED; PILOT PROJECTS; SINGLE-BLIND METHOD; TREATMENT OUTCOME;

EID: 84886725651     PISSN: 01728172     EISSN: 1437160X     Source Type: Journal    
DOI: 10.1007/s00296-013-2822-0     Document Type: Article

References (25)

1. Ianaro A, Ialenti A, Maffia P, Sautebin L, Rombolà L, Carnuccio R, et al. (2000) Anti-inflammatory activity of macrolide antibiotics. J Pharmacol Exp Ther 292:156-163
2. Saviola G, Abdi-Ali L, Rossini P, Campostini L, Coppini A, Gori M, et al. (2002) Clarithromycin in rheumatoid arthritis patients not responsive to disease-modifying anti-rheumatic drugs: an open uncontrolled pilot study. Clin Exp Rheum 20:373-378
3. Ogrendik M (2007) Effects of clarithromycin in patients with active rheumatoid arthritis. Curr Med Res Opin 23:515-522
4. Moskowitz R, Lesko M, Hooper M (2006) Open-label study of clarithromycin in patients with undifferentiated connective tissue disease. Semin Arthritis Rheum 36:82-87
5. Saviola G, Benucci M, Abdi Ali L, Baiardi P, Manfredi M, Bucci MR, et al. (2010) Clarithromycin in adult onset Still's disease. A study of 6 cases. Rheumatol Int 30(4):555-560. (Epub 2009 Dec 23)
6. Lequerré T, Quartier P, Roselini D, et al. (2008) Interleukin-1 receptor antagonist (anakinra) treatment in patients with systemic-onset juvenile idiopathic arthritis or adult onset Still disease: preliminary experience in France. Ann Rheum Dis 67:302-308
7. Saviola G, Abdi-Ali L, Shams-Eddin S, Davoli C, Taglietti M (2004) Clarithromycin in adult-onset Still's disease. Case report with 1 year follow-up. Clin Exp Rheumatol 22:379
8. Thanou-Stavraki A, Aberle T, Aksentijevich I, Bane BL, Harley JB (2011) Clarithromycin in adult-onset Still's disease: a potentially useful therapeutic. J Clin Rheumatol 17(7):373-376
9. Burrel RC, Walters JD (2008) Distribution of systemic clarithromycin to gingiva. J Periodontol 79:1712-1718
10. Schulz KF, Altman DG, Moher D (2010) CONSORT Group. CONSORT 2010 Statemen: updated guidelines for reporting parallel group randomised trials. J Clin Epidemiol 63(8):834-840
11. Stone M, Fortin PR, Pacheco-Tena C, Inman RD (2003) Should tetracycline treatment be used more extensively for rheumatoid arthritis? Metaanalysis demonstates clinical benefit with reduction in disease activity. J Rheumatol 30(10):2112-2122
12. Ogrendik M (2009) Rheumatoid arthritis is linked to oral bacteria. Mod Rheumatol 19(5):453-456. (Epub 2009 Jun 24, Review)
13. Tamaoki J, Kadota J, Takizawa H (2004) Clinical implications of the immunomodulatory effects of macrolides. Am J Med 117:5S-11S
14. Borszcz PD, Befus D, Moqbel R, Sin DD, Adamko DJ, Man SFP, et al. (2005) Effects of clarithromycin on inflammatory cell mediator release and survival. Chemotherapy 51:206-210
15. Simpson JL, Powell H, Boyle MJ, Scott RJ, Gibson PG (2008) Clarithromycin targets neutrophilic airway inflammation in refractory asthma. Am J Respir Crit Care 177:148-155
16. Giamarellos-Bourboulis EJ (2008) Immunomodulatory therapies for sepsis: unexpected effects with macrolides. Int J Antimicrob Agents 32(Suppl 1):S39-S43
17. Morris TC, Kettle PJ, Drake M, Jones FC, Hull DR, Boyd K, et al. (2008) Clarithromycin with low-dose dexamethasone and thalidomide is effective in relapsed/refractory myeloma. Br J Haematol 143(3):349-354. (Epub 2008 Aug 28)
18. Gay F, Rajkumar SV, Coleman M, Kumar S, Mark T, Dispenzieri A, Pearse R, et al. (2010) Clarithromycin (Biaxin)-lenalidomide-low-dose-dexamethasone (BiRd) versus Lenalidomide-low-dose dexamethasone (Rd) for newly diagnosed myeloma. Am J Hematol 85(9):664-669
19. Nakamura M, Kikukawa Y, Takeya M, Mitsuya H, Hata H (2010) Clarithromycin attenuates autophagy in myeloma cells. Int J Oncol 37(4):815-820
20. Saviola G, Benucci M, Cirino G (2007) Comments on: effects of clarithromycin in patients with active rheumatoid arthritis. Cur Med Res Opin 23:515-522
21. Rugter Persson G (2012) Rheumatoid Arthritis and periodontitis- inflammatory and infectious connections. Review of the literature. J Oral Microbiol. Epub 2012 Feb 12
22. Tanaka Y, Suzuki K, Saito K (2007) Efficacv of tacrolimus for joint destruction in rheumatoid arthritis. Clin Calcium 17(4):593-9. Review
23. Bruyn GA, Tate G, Caeiro F, Maldonado-Cocco J, Westhovens R, Tannenbaum H, et al. (2008) RADD Study Group. Everolimus in patients with rheumatoid arthritis receiving concomitant methotrexate: a 3-month, double blind, randomized, placebo-controlled, parallel-group, poof-of concept study. Ann Rheum Dis 67(8):1090-1095. (Epub 2007 Nov 23)
24. Sofroniadou S, Goldsmith D (2011) Mammalian target of rapamycin (mTOR) inhibitors: potential uses and a review of haematological adverse effects. Drug Saf 34(2):97-115
25. Coulston J, Balaratnam N (2005) Irreversible sensorineural hearing loss due to clarithromycin. Postgrad Med J 81:58-59