A novel pH-sensitive interferon-β (INF-β) oral delivery system for application in multiple sclerosis

International Journal of Pharmaceutics

Volumn 456, Issue 2, 2013, Pages 459-472

  Kondiah, Pierre P D ^a   Tomar, Lomas K ^a   Tyagi, Charu ^a   Choonara, Yahya E ^a   Modi, Girish ^a   Du Toit, Lisa C ^a   Kumar, Pradeep ^a   Pillay, Viness ^a  

^a UNIVERSITY OF THE WITWATERSRAND   (South Africa)

Author keywords

Box Behnken experimental design; Copolymeric microparticulate system; Insulin; Interferon (INF ); Oral delivery system; pH responsive

Indexed keywords

BETA INTERFERON; CHITOSAN; INSULIN; METHACRYLIC ACID; POLY(ETHYLENE GLYCOL)DIMETHACRYLATE; POLYMER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG HALF LIFE; DRUG RELEASE; IN VITRO STUDY; INSULIN RELEASE; MORPHOLOGY; MUCOADHESION; MULTIPLE SCLEROSIS; NONHUMAN; PARTICLE SIZE; PH; POLYMERIZATION; PRIORITY JOURNAL; TABLET FORMULATION; TABLET POROSITY; ZETA POTENTIAL;

BOX-BEHNKEN EXPERIMENTAL DESIGN; COPOLYMERIC MICROPARTICULATE SYSTEM; INSULIN; INTERFERON-Β (INF-Β); ORAL DELIVERY SYSTEM; PH-RESPONSIVE;

ADMINISTRATION, ORAL; ANIMALS; CHEMISTRY, PHARMACEUTICAL; DRUG DELIVERY SYSTEMS; HUMANS; HYDROGEN-ION CONCENTRATION; INTERFERON-BETA; MULTIPLE SCLEROSIS; PARTICLE SIZE; RABBITS;

EID: 84886719997     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.08.038     Document Type: Article

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