Characterization of a soluble ternary complex formed between human interferon-β-1a and its receptor chains

Protein Science

Volumn 8, Issue 9, 1999, Pages 1867-1877

  Arduini, Robert M ^a   Strauch, Kathryn L ^a   Runkel, Laura A ^a   Carlson, Melissa M ^a   Hronowski, Xiaoping ^a   Foley, Susan F ^a   Young, Carmen N ^a   Cheng, Wenjie ^a   Hochman, Paula S ^a   Baker, Darren P ^a  

^a BIOGEN   (United States)

Author keywords

IFNAR1; IFNAR2; Interferon receptor complexes; Interferon 1a

Indexed keywords

BETA1A INTERFERON; INTERFERON RECEPTOR; SUCCINIMIDE DERIVATIVE;

ARTICLE; COMPLEX FORMATION; CROSS LINKING; HUMAN; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; STOICHIOMETRY; X RAY CRYSTALLOGRAPHY;

EID: 0032824502     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.8.9.1867     Document Type: Article

References (63)

1. Abramovitch C, Shulman LM, Ratoviski E, Harroch S, Tovey M, Eid P, Revel M. 1994. Differential tyrosine phosphorylation of the IFNAR chain of the type I interferon receptor and of an associated surface protein in response to IFN-α and IFN-β. EMBO J 13:5871-5877.
2. Baker DP, Whitty A, Zafari M, Olson DL, Hession CA, Miatkowski K, Avedissian LS, Foley SF, McKay ML, Benjamin CD, Burkly LC. 1998. The murine anti-human common gamma chain monoclonal antibody CP.B8 blocks the second step in the formation of the intermediate affinity IL-2 receptor. Biochemistry 37:14337-14349.
3. Bazan JF. 1990. Structural design and molecular evolution of a cytokine receptor superfamily. Proc Natl Acad Sci USA 87:6934-6938.
4. Bazer FW, Spencer TE, Ott TL. 1997. Interferon tau: A novel pregnancy recognition signal. Am J Reprod Immunol 37:412-420.
5. Belhumeur P, Lanoix J, Blais Y, Forget D, Steyaert A, Skup D. 1993. Action of spontaneously produced beta interferon in differentiation of embryonal carcinoma cells through an autoinduction mechanism. Mol Cell Biol 13:2846-2857.
6. Cali Cutrone E, Langer JA. 1997. Contributions of cloned type I interferon receptor subunits to differential ligand binding. FEBS Lett 404:197-202.
7. Cleary CM, Donnelly RJ, Soh J, Mariano TM, Petska S. 1994. Knockout and reconstitution of a functional human type I interferon receptor complex. J Biol Chem 269:18747-18749.
8. Cohen B, Novick D, Barak S, Rubinstein M. 1995. Ligand-induced association of the type I interferon receptor components. Mol Cell Biol 15:4208-4214.
9. tyk2 tyrosine kinase. Mol Cell Biol 14:8133-8142.
10. tyk2, an interferon-α-activated tyrosine kinase, is physically associated with an interferon-α receptor. J Biol Chem 269:3518-3522.
11. Constantinescu SN, Croze E, Murti A, Wang C, Basu L, Hollander D, Russell-Harde D, Betts M, Garcia-Martinez V, Mullersman JE, Pfeffer LM. 1995. Expression and signaling specificity of the IFNAR chain of the type I interferon receptor complex. Proc Natl Acad Sci USA 92:10487-10491.
12. Cook JR, Cleary CM, Mariano TM, Izotova L, Pestka S. 1996. Differential responsiveness of a splice variant of the human type I interferon receptor to interferons. J Biol Chem 271:13448-13453.
13. Cunningham BC, Ultsch M, De Vos AM, Mulkerrin MG, Clauser KR, Wells JA. 1991. Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone. Science 254:821-825.
14. Darnell JE, Kerr IM, Stark GR. 1994. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264:1415-1421.
15. Der SD, Zhou A, Williams BRG, Silverman RH. 1998. Identification of genes differentially regulated by interferon α, β, or γ using oligonucleotide arrays. Proc Natl Acad Sci USA 95:15623-15628.
16. De Vos AM, Ultsch M, Kossiakoff AA. 1992. Human growth hormone and extracellular domain of its receptor: Crystal structure of the complex. Science 255:306-312.
17. Diaz MO, Pomykala HM, Bohlander SK, Maltepe E, Malik K, Brownstein B, Olopade OI. 1994. Structure of the human type-I interferon gene cluster determined from a YAC clone contig. Genomics 22:540-552.
18. Domanski P, Witte M, Kellmun M, Rubinstein M, Hackett R, Pitha P, Colamonici OR. 1995. Cloning and expression of a long form of the β subunit of the interferon αβ receptor that is required for signaling. J Biol Chem 270:21606-21611.
19. Fuh G, Cunningham BC, Fukunaga R, Nagata S, Goeddel DV, Wells JA. 1992. Rational design of potent antagonists to the human growth hormone receptor. Science 256:1677-1680.
20. Garbe C, Krasagakis K. 1993. Effects of interferons and cytokines on melanoma cells. J Invest Dermatol 100:239S-244S.
21. Gill SC, von Hippel PH. 1989. Calculation of protein extinction coefficients from amino acid sequence data. Anal Biochem 182:319-326.
22. Goldman LA, Cali Cutrone E, Dang A, Hao X, Lim J-K, Langer JA. 1998. Mapping human interferon-alpha (IFN-α2) binding determinants of the type I interferon receptor subunit IFNAR-1 with human/bovine IFNAR-1 chimeras. Biochemistry 37:13003-13010.
23. Heldin C-H. 1995. Dimerization of cell surface receptors in signal transduction. Cell 80:213-223.
24. Hoffman RC, Castner BJ, Gerhart M, Gibson MG, Rasmussen BD, March CJ, Weatherbee J, Tsang M, Gustchina A, Schalk-Hihi C, et al. 1995. Direct evidence of a heterotrimeric complex of human interleukin-4 with its receptors. Protein Sci 4:382-386.
25. Hoffman RC, Castner BJ, Gerhart M, Gibson MG, Rasmussen BD, March CJ, Weatherbee J, Tsang M, Gustchina A, Schalk-Hihi C, et al. 1997. Erratum: Direct evidence of a heterotrimeric complex of human interleukin-4 with its receptors. Protein Sci 6:494.
26. John J, McKendry R, Pellegrini S, Flavell D, Kerr IM, Stark GR. 1991. Isolation and characterization of a new mutant human cell line unresponsive to alpha and beta interferons. Mol Cell Biol 11:4189-4195.
27. Karpusas M, Nolte M, Benton CB, Meier W, Lipscomb WN, Goelz S. 1997. The crystal structure of human interferon β at 2.2-Å resolution. Proc Natl Acad Sci USA 94:11813-11818.
28. Klaus W, Gsell B, Labhardt AM, Wipf B, Senn H. 1997. The three-dimensional high resolution structure of human interferon α-2a determined by heteronuclear NMR spectroscopy in solution. J Mol Biol 274:661-675.
29. Kotenko SV, Krause CD, Izotova LS, Pollack BP, Wu W, Petska S. 1997. Identification and functional characterization of a second chain of the interleukin-10 receptor complex. EMBO J 16:5894-5903.
30. Kruse N, Shen B-J, Arnold S, Tony H-P, Muller T, Sebald W. 1993. Two distinct functional sites of human interleukin 4 are identified by variants impaired in either receptor binding or receptor activation. EMBO J 12:5121-5129.
31. Lewerenz M, Mogensen KE, Uze G. 1998. Shared receptor components but distinct complexes for α and β interferons. J Mol Biol 282:585-599.
32. Li J, Roberts RM. 1994. Interferon-tau and interferon-alpha interact with the same receptors in bovine endometrium. Use of a readily iodinatable form of recombinant interferon-tau for binding studies. J Biol Chem 269:13544-13550.
33. Li X, Leung S, Kerr IM, Stark GR. 1997. Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling. Mol Cell Biol 17:2048-2056.
34. Ling LE, Zafari M, Reardon D, Brickelmaier M, Goelz SE, Benjamin CD. 1995. Human type I interferon receptor, IFNAR, is a heavily glycosylated 120-130 kD membrane protein. J Interferon Cytokine Res 15:55-61.
35. Livnah O, Stura EA, Middleton SA, Johnson DL, Jolliffe LK, Wilson IA. 1999. Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation. Science 283:987-990.
36. Lu J, Chuntharapai A, Beck J, Bass S, Ow A, De Vos AM, Gibbs V, Kim KJ. 1998. Structure-function study of the extracellular domain of the human IFN-α receptor (hIFNAR1) using blocking monoclonal antibodies: The role of domains 1 and 2. J Immunol 160:1782-1788.
37. Lutfalla G, Holland SJ, Cinato E, Monneron D, Reboul J, Rogers NC, Smith JM, Stark GR, Gardiner K, Mogensen KE, et al. 1995. Mutant U5A cells are complemented by an interferon-αβ receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster. EMBO J 14:5100-5108.
38. Novick D, Cohen B, Rubinstein M. 1994. The human Interferon α/β receptor: Characterization and molecular cloning. Cell 77:391-400.
39. Palmer H, Libby P. 1992. Interferon beta. A potential autocrine regulator of human vascular smooth muscle cell growth. Lab Invest 66:715-721.
40. Pellegrini S, John J, Shearer M, Ken IM, Stark GR. 1989. Use of a selectable marker regulated by alpha interferon to obtain mutations in the signaling pathway. Mol Cell Biol 9:4605-4612.
41. Pestka S. 1997a. The human interferon-alpha species and hybrid proteins. Semin Oncol S9:4-17.
42. Pestka S. 1997b. The interferon receptors. Semin Oncol S9:18-40.
43. Pfeffer LM, Basu L, Pfeffer SR, Yang CH, Murti A, Russell-Harde D, Croze E. 1997. The short form of the interferon α/β receptor chain 2 acts as a dominant negative for type I interferon action. J Biol Chem 272:11002-11005.
44. Platanias LC, Uddin S, Colamonici OR. 1994. Tyrosine phosphorylation of the α and β subunits of the type I interferon receptor. J Biol Chem 269:17761-17764.
45. Platanias LS, Uddin P, Domanski P, Colamonici OR. 1996. Differences in α and β signaling. J Biol Chem 271:23630-23633.
46. Ramaswamy R, Walter LJ, Hruza A, Reichert P, Trotta PP, Nagabhushan TL, Walter MR. 1996. Zinc mediated dimer of human interferon-α2b revealed by X-ray crystallography. Structure 4:1453-1463.
47. Rani MRS, Foster GR, Leung S, Leaman D, Stark GR, Ransohoff RM. 1996. Characterization of β-R1, a gene that is selectively induced by interferon β (IFN-β) compared with IFN-α. J Biol Chem 271:22878-22884.
48. Remy I, Wilson IA, Michnick SW. 1999. Erythropoietin receptor activation by a ligand-induced conformational change. Science 283:990-993.
49. Runkel L, Meier W, Pepinsky RB, Karpusas M, Whitty A, Kimball K, Brickelmaier M, Muldowney C, Jones W, Goelz SE. 1998. Structural and functional differences between glycosylated and non-glycosylated forms of human interferon-β (IFN-β). Pharmacol Res 15:641-649.
50. Sen G, Lengyel P. 1992. The interferon system: A bird's eye view of its biochemistry. J Biol Chem 267:5017-5020.
51. Seto MH, Harkins RN, Adler M, Whitlow M, Church WB, Croze E. 1995. Homology model of human interferon-α8 and its receptor complex. Protein Sci 4:655-670.
52. Soh J, Donnelly RJ, Kotenko S, Mariano TM, Cook JR, Wang N, Schwartz B, Miki T, Petska S. 1994. Identification and sequence of an accessory factor required for activation of the human interferon gamma receptor. Cell 76:793-802.
53. Stewart WEI. 1979. The interferon system. New York: Springer-Verlag.
54. Thoreau E, Petridou B, Kelly PA, Djiane J, Mornon JP. 1991. Structural symmetry of the extracellular domain of the cytokine/growth hormone/prolactin receptor family and interferon receptors revealed by hydrophobic cluster analysis. FEBS Lett 282:26-31.
55. Tyring SK. 1995. Interferons: Biochemistry and mechanisms of action. Am J Obstet Gynecol 172:1350-1353.
56. Uze G, Lutfalla G, Bandu M-T, Proudhon D, Mogensen KE. 1992. Behavior of a cloned murine interferon α/β receptor expressed in homospecific or heterospecific background. Proc Natl Acad Sci USA 89:4774-4778.
57. Uze G, Lutfalla G, Gresser I. 1990. Genetic transfer of a functional human interferon a receptor into mouse cells: Cloning and expression of its cDNA. Cell 60:225-234.
58. Uze G, Lutfalla G, Mogensen KE. 1995. α and β interferons and their receptors and their friends and relations. J Interferon Cytokine Res 15:3-26.
59. Velazquez L, Fellous M, Stark GR, Pellegrini S. 1992. A protein tyrosine kinase in the interferon α/β signaling pathway. Cell 70:313-322.
60. Walter MR, Windsor WT, Nagabhushan TL, Lundell DJ, Lunn CA, Zauodny PJ, Narula SK. 1995. Crystal structure of a complex between interferon-γ and its soluble high-affinity receptor. Nature 376:230-235.
61. Weissmann C, Weber H. 1986. The interferon genes. Prog Nucleic Acid Res 33:251-300.
62. Whitty A, Raskin N, Olson DL, Borysenko CW, Ambrose CM, Benjamin CD, Burkly LC. 1998. Interaction affinity between cytokine receptor components on the cell surface. Proc Natl Acad Sci USA 95:13165-13170.
63. Yang C-H, Shi W, Basu L, Murti A, Constantinescu SN, Blatte L, Croze E, Mullersman JE, Pfeffer LM. 1996. Direct association of STAT3 with the IFNAR-1 chain of the human type I interferon receptor. J Biol Chem 271:8057-8061.