The E693Δ (Osaka) mutation in amyloid precursor protein potentiates cholesterol-mediated intracellular amyloid β toxicity via its impaired cholesterol efflux

Journal of Neuroscience Research

Volumn 91, Issue 12, 2013, Pages 1541-1550

  Nomura, Sachiko ^a,b   Umeda, Tomohiro ^a,b   Tomiyama, Takami ^a,b   Mori, Hiroshi ^a,b  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Alzheimer's disease; Amyloid (A ); Cholesterol; Mitochondria; Reactive oxygen species (ROS)

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CHOLESTEROL; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL MEMBRANE; CHOLESTEROL TRANSPORT; EFFUSION; ENDOPLASMIC RETICULUM; ENDOSOME; GOLGI COMPLEX; HUMAN; HUMAN CELL; INTERNALIZATION; LYSOSOME; MUTATION; NONHUMAN; PRIORITY JOURNAL; WILD TYPE;

ALZHEIMER'S DISEASE; AMYLOID Β (AΒ); CHOLESTEROL; MITOCHONDRIA; REACTIVE OXYGEN SPECIES (ROS);

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; CHOLESTEROL; HEK293 CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SPACE; MUTATION; PROTEIN TRANSPORT; TRANSFECTION;

EID: 84886641409     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.23278     Document Type: Article

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