Synthesis and structure-activity relationships of amino acid conjugates of cholanic acid as antagonists of the EphA2 receptor

Molecules

Volumn 18, Issue 10, 2013, Pages 13043-13060

  Russo, Simonetta ^a   Incerti, Matteo ^a   Tognolini, Massimiliano ^a   Castelli, Riccardo ^a   Pala, Daniele ^a   Hassan Mohamed, Iftiin ^a   Giorgio, Carmine ^a   De Franco, Francesca ^b   Gioiello, Antimo ^c   Vicini, Paola ^a   Barocelli, Elisabetta ^a   Rivara, Silvia ^a   Mor, Marco ^a   Lodola, Alessio ^a  

^a UNIVERSITY OF PARMA   (Italy)

^b TES Pharma Srl   (Italy)

^c UNIVERSITY OF PERUGIA   (Italy)

Author keywords

Amino acid conjugates; Cholanic acid; EphA2 antagonists; Structure activity relationships

Indexed keywords

CHOLANIC ACID; CHOLIC ACID DERIVATIVE; EPHRIN RECEPTOR A1; EPHRIN RECEPTOR A2; PROTEIN BINDING;

ARTICLE; BINDING SITE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; HYDROGEN BOND; IC 50; METABOLISM; MOLECULAR DOCKING; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN PROCESSING; PROTEIN SECONDARY STRUCTURE; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; IC50;

BINDING SITES; CELL LINE, TUMOR; CHOLIC ACIDS; HUMANS; HYDROGEN BONDING; INHIBITORY CONCENTRATION 50; MOLECULAR DOCKING SIMULATION; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, SECONDARY; RECEPTOR, EPHA1; RECEPTOR, EPHA2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84886632939     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules181013043     Document Type: Article

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