High-throughput bioanalysis of bile acids and their conjugates using UHPLC coupled to HRMS

Bioanalysis

Volumn 5, Issue 20, 2013, Pages 2481-2494

  Ding, Jie ^a   Lund, Eric T ^a   Zulkoski, John ^a   Lindsay, John P ^a   McKenzie, Donald L ^a  

^a 206 Carnegie Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; BILE ACID CONJUGATE;

ANALYTICAL EQUIPMENT; ANALYTICAL PARAMETERS; ARTICLE; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG RESEARCH; FEASIBILITY STUDY; HIGH THROUGHPUT SCREENING; MASS SPECTROMETRY; PROCESS OPTIMIZATION; QUANTITATIVE ANALYSIS; REPRODUCIBILITY; SPECTROMETER; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

ANIMALS; BILE ACIDS AND SALTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HAPLORHINI; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; LIMIT OF DETECTION; MASS SPECTROMETRY; RATS; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS;

EID: 84886556168     PISSN: 17576180     EISSN: 17576199     Source Type: Journal    
DOI: 10.4155/bio.13.215     Document Type: Article

References (25)

1. Chiang JYL. Bile acids: regulation of synthesis. J. Lipid Res. 50, 1955-1966 (2009).
2. Kramer W, Wess G, Schubert G et al. Liver-specifc drug targeting by coupling to bile acids. J. Biol. Chem. 267, 18598-18604 (1992).
3. St-Pierre MV, Kullak-Ublick GA, Hagenbuch B, Meier PJ. Transport of bile acids in hepatic and non-hepatic tissues. J. Exp. Biol. 204, 1673-1686 (2001)
4. Trauner M, Boyer JL. Bile salt transporters: molecular characterization, function, and regulation. Physiol. Rev. 83, 633-671 (2003).
5. Morgan RE, Trauner M, Staden CJ et al. Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicol. Sci. 118, 485-500 (2010).
6. Ruben AT, Berge-Henegouwen GP. A simple reverse-phase high pressure liquid chromatographic determination of conjugated bile acids in serum and bile using a novel radial compression separation system. Clin. Chim. Acta 119, 41-50 (1982).
7. Setchell KDR, Vestal CH. Thermospray ionization liquid chromatography mass spectrometry: a new and highly specifc technique for the ana lysis of bile acids. J. Lipid Res. 30, 1459-1469 (1989).
8. Perwaiz S, Tuchweber B, Mignault D, Gilat T, Yousef IM. Determination of bile acids in biological fuids by liquid chromatography-electrospray tandem mass spectrometry. J. Lipid Res. 42, 114-119 (2001).
9. Alnouti Y, Csanaky IL, Klaassen CD. Quantitative-profling of bile acids and their conjugates in mouse liver, bile, plasma, and urine using LC-MS/MS. J. Chromatogr. B 873, 209-217 (2008).
10. Janzen N, Sander S, Terhardt M et al. Rapid quantifcation of conjugated and unconjugated bile acids and C27 precursors in dried blood spots and small volumes of serum. J. Lipid Res. 51, 1591-1598 (2010).
11. Steiner C, von Eckardstein A, Rentsch KM. Quantifcation of the 15 major human bile acids and their precursor 7a-hydroxy-4-cholesten-3-one in serum by liquid chromatography-tandem mass spectrometry. J. Chromatogr. B 8782870-2880 (2010).
12. Qiao X, Ye M, Pan DL et al. Differentiation of various traditional Chinese medicines derived from animal bile and gallstone: simultaneous determination of bile acids by liquid chromatography coupled with triple quadrupole mass spectrometry. J. Chromatogr. A 1218, 107-117 (2011).
13. Sharma KR. Review on bile acid ana lysis. Int. J. Pharm. Biomed. Sci. 3, 28-34 (2012).
14. Sergi M, Montesano C, Napoletano S et al. Analysis of bile acids profle in human serum by ultrafltration clean-up and LC-MS/MS. Chromatographia 75, 479-489 (2012).
15. Scherer M, Gnewuch C, Schwitz G, Liebisch G. Rapid quantifcation of bile acids and their conjugates in serum by liquid chromatography-tandem mass spectrometry. J. Chromatogr. B 877, 3920-3925 (2009).
16. United States Pharmacopoeia. USP30-NF25. United States Pharmacopoeia Convention, Rockville, MD, USA 3439 (2007).
17. Makishima M, Lu TT, Xie W et al. Vitamin D receptor as an intestinal bile acid sensor. Science 296, 1313-1316 (2002).
18. Russell DH, Edmondson RD. High-resolution mass spectrometry and accurate mass measurements with emphasis on the characterization of peptides and proteins by matrix-assisted laser desorption/ionization time-of-fight mass spectrometry. J. Mass Spectrom. 32, 263-276 (1997).
19. Michalski A, Damoc E, Hauschild JP et al. Mass spectrometry-based proteomics using Q Exactive, a high-performance benchtop quadrupole orbitrap mass spectrometer. Mol. Cell. Proteomics 10, 1-11 (2011).
20. Xia YQ, Lau J, Olah T, Jemal M. Targeted quantitative bioana lysis in plasma using liquid chromatography/high-resolution accurate mass spectrometry: an evaluation of global selectivity as a function of mass resolving power and extraction window, with comparison of centroid and profle modes. Rapid Commun. Mass Spectrom. 25, 2863-2878 (2011).
21. Ramanathan R, Korfmacher W. The emergence of high-resolution MS as the premier analytical tool in the pharmaceutical bioanalysis arena. Bioanalysis 4(5), 467-469 (2012).
22. Rousu T, Tolonen A. Comparison of unit resolution SRM and TOF-MS at 12, 000 mass resolution for quantitative bioana lysis of 11 steroids from human plasma quantitative bioana lysis of 11 steroids from human plasma. Bioanalysis 4(5), 555-563 (2012).
23. Dillen L, Cools W, Vereyken L et al. Comparison of triple quadrupole and high-resolution TOF-MS for quantifcation of peptides. Bioanalysis 4(5), 565-579 (2012).
24. Xie C, Zhong D, Yu K, Chen X. Recent advances in metabolite identifcation and quantitative bioana lysis by LC-Q-TOF MS. Bioanalysis 4(8), 937-959 (2012).
25. Rochat B, Kottelat E, McMullen J. The future key role of LC-high-resolution-MS analyses in clinical laboratories: a focus on quantifcation. Bioanalysis 4(24), 2939-2958 (2012).