메뉴 건너뛰기




Volumn 154, Issue 11, 2013, Pages 4237-4248

Comparative inhibition of the GH/IGF-I axis obtained with either the targeted secretion inhibitor SXN101959 or the somatostatin analog octreotide in growing male rats

Author keywords

[No Author keywords available]

Indexed keywords

GHRELIN; GROWTH HORMONE; HORMONE ANTAGONIST; MESSENGER RNA; OCTREOTIDE; SNX 101959; SOMATOMEDIN C; UNCLASSIFIED DRUG;

EID: 84886534177     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2013-1427     Document Type: Article
Times cited : (7)

References (58)
  • 2
    • 0034129850 scopus 로고    scopus 로고
    • Ghrelin: A step forward in the understanding of somatotroph cell function and growth regulation
    • Dieguez C, Casanueva FF. Ghrelin: a step forward in the understanding of somatotroph cell function and growth regulation. Eur J Endocrinol. 2000;142: 413-417.
    • (2000) Eur J Endocrinol , vol.142 , pp. 413-417
    • Dieguez, C.1    Casanueva, F.F.2
  • 3
    • 33845491265 scopus 로고    scopus 로고
    • Medical progress: Acromegaly
    • Melmed S. Medical progress: acromegaly.NEngl J Med. 2006;355: 2558-2573.
    • (2006) NEngl J Med , vol.355 , pp. 2558-2573
    • Melmed, S.1
  • 4
    • 70449366466 scopus 로고    scopus 로고
    • Acromegaly pathogenesis and treatment
    • Melmed S. Acromegaly pathogenesis and treatment. J Clin Invest. 2009;119: 3189-3202.
    • (2009) J Clin Invest , vol.119 , pp. 3189-3202
    • Melmed, S.1
  • 5
    • 0036800303 scopus 로고    scopus 로고
    • Growth hormone receptor antagonists: Discovery, development, and use in patients with acromegaly
    • Kopchick JJ, Parkinson C, Stevens EC, Trainer PJ. Growth hormone receptor antagonists: discovery, development, and use in patients with acromegaly. Endocr Rev. 2002;23: 623-646.
    • (2002) Endocr Rev , vol.23 , pp. 623-646
    • Kopchick, J.J.1    Parkinson, C.2    Stevens, E.C.3    Trainer, P.J.4
  • 8
    • 70349199233 scopus 로고    scopus 로고
    • Pituitary gland: Medical therapy for acromegaly: Can we predict response?
    • Giustina A, Porcelli T. Pituitary gland: medical therapy for acromegaly: can we predict response? Nat Rev Endocrinol. 2009;5: 425-427.
    • (2009) Nat Rev Endocrinol , vol.5 , pp. 425-427
    • Giustina, A.1    Porcelli, T.2
  • 9
    • 80052517177 scopus 로고    scopus 로고
    • Endoscopic transsphenoidal surgery for acromegaly: Remission using modern criteria, complications, and predictors of outcome
    • Jane JA Jr, Starke RM, Elzoghby MA, et al. Endoscopic transsphenoidal surgery for acromegaly: remission using modern criteria, complications, and predictors of outcome. J Clin Endocrinol Metab. 2011;96: 2732-2740.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 2732-2740
    • Jane Jr., J.A.1    Starke, R.M.2    Elzoghby, M.A.3
  • 10
    • 79952097038 scopus 로고    scopus 로고
    • Targeted secretion inhibitors-innovative protein therapeutics
    • Keith F, John C. Targeted secretion inhibitors-innovative protein therapeutics. Toxins. 2010;2: 2795-2815.
    • (2010) Toxins , vol.2 , pp. 2795-2815
    • Keith, F.1    John, C.2
  • 11
    • 84865975652 scopus 로고    scopus 로고
    • A botulinum toxin-derived targeted secretion inhibitor downregulates the GH/IGF1 axis
    • Somm E, Bonnet N, Martinez A, et al. A botulinum toxin-derived targeted secretion inhibitor downregulates the GH/IGF1 axis. J Clin Invest. 2012;122: 3295-3306.
    • (2012) J Clin Invest , vol.122 , pp. 3295-3306
    • Somm, E.1    Bonnet, N.2    Martinez, A.3
  • 12
    • 0028127165 scopus 로고
    • Disproportional bone growth and reduced weight gain in gonadectomized male bovine growth hormone transgenic and normal mice
    • Sandstedt J, Ohlsson C, Norjavaara E, Nilsson J, Törnell J. Disproportional bone growth and reduced weight gain in gonadectomized male bovine growth hormone transgenic and normal mice. Endocrinology. 1994;135: 2574-2580.
    • (1994) Endocrinology , vol.135 , pp. 2574-2580
    • Sandstedt, J.1    Ohlsson, C.2    Norjavaara, E.3    Nilsson, J.4    Törnell, J.5
  • 13
    • 0029561679 scopus 로고
    • Effects of growth hormone overproduction on grip strength of transgenic mice
    • Wolf E, Wanke R, Schenck E, Hermanns W, Brem G. Effects of growth hormone overproduction on grip strength of transgenic mice. Eur J Endocrinol. 1995;133: 735-740.
    • (1995) Eur J Endocrinol , vol.133 , pp. 735-740
    • Wolf, E.1    Wanke, R.2    Schenck, E.3    Hermanns, W.4    Brem, G.5
  • 14
    • 0022500578 scopus 로고
    • Autoregulation of pituitary growth hormone messenger ribonucleic acid levels in rats bearing transplantable mammosomatotrophic pituitary tumors
    • Yamashita S, Slanina S, Kado H, Melmed S. Autoregulation of pituitary growth hormone messenger ribonucleic acid levels in rats bearing transplantable mammosomatotrophic pituitary tumors. Endocrinology. 1986;118: 915-918.
    • (1986) Endocrinology , vol.118 , pp. 915-918
    • Yamashita, S.1    Slanina, S.2    Kado, H.3    Melmed, S.4
  • 15
    • 84883142608 scopus 로고    scopus 로고
    • GHRH receptor-targeted botulinum neurotoxin selectively inhibits pulsatile GH secretion in male rats
    • Leggett J, Harper E, Waite E, Marks P, Martinez A, Lightman S. GHRH receptor-targeted botulinum neurotoxin selectively inhibits pulsatile GH secretion in male rats. Endocrinology. 2013;154(9): 3305-3318.
    • (2013) Endocrinology , vol.154 , Issue.9 , pp. 3305-3318
    • Leggett, J.1    Harper, E.2    Waite, E.3    Marks, P.4    Martinez, A.5    Lightman, S.6
  • 16
    • 0036773070 scopus 로고    scopus 로고
    • SOM230: A new somatostatin peptidomimetic with potent inhibitory effects on the growth hormone/insulin-like growth factor-I axis in rats, primates, and dogs
    • Weckbecker G, Briner U, Lewis I, Bruns C. SOM230: a new somatostatin peptidomimetic with potent inhibitory effects on the growth hormone/insulin-like growth factor-I axis in rats, primates, and dogs. Endocrinology. 2002;143: 4123-4130.
    • (2002) Endocrinology , vol.143 , pp. 4123-4130
    • Weckbecker, G.1    Briner, U.2    Lewis, I.3    Bruns, C.4
  • 17
    • 70350504344 scopus 로고    scopus 로고
    • Medical therapy of acromegaly: Efficacy and safety of somatostatin analogues
    • Feelders RA, Hofland LJ, van Aken MO, et al. Medical therapy of acromegaly: efficacy and safety of somatostatin analogues. Drugs. 2009;69: 2207-2226.
    • (2009) Drugs , vol.69 , pp. 2207-2226
    • Feelders, R.A.1    Hofland, L.J.2    Van Aken, M.O.3
  • 18
    • 2942730560 scopus 로고    scopus 로고
    • Quantification of bone microarchitecture with the structure model index
    • Hildebrand T, Rüegsegger P. Quantification of bone microarchitecture with the structure model index. Comput Methods Biomech Biomed Engin. 1997;1: 15-23.
    • (1997) Comput Methods Biomech Biomed Engin , vol.1 , pp. 15-23
    • Hildebrand, T.1    Rüegsegger, P.2
  • 19
    • 0035196410 scopus 로고    scopus 로고
    • The skeletal structure of insulinlike growth factor I-deficient mice
    • Bikle D, Majumdar S, Laib A, et al. The skeletal structure of insulinlike growth factor I-deficient mice. J Bone Miner Res. 2001;16: 2320-2329.
    • (2001) J Bone Miner Res , vol.16 , pp. 2320-2329
    • Bikle, D.1    Majumdar, S.2    Laib, A.3
  • 20
    • 78149366451 scopus 로고    scopus 로고
    • The GH/IGF-1 axis in growth and development: New insights derived from animal models
    • Cannata D, Vijayakumar A, Fierz Y, LeRoith D. The GH/IGF-1 axis in growth and development: new insights derived from animal models. Adv Pediatr. 2010;57: 331-351.
    • (2010) Adv Pediatr , vol.57 , pp. 331-351
    • Cannata, D.1    Vijayakumar, A.2    Fierz, Y.3    Leroith, D.4
  • 21
    • 41549083742 scopus 로고    scopus 로고
    • Clinical relevance of systemic and local IGF-I: Lessons from animal models
    • LeRoith D. Clinical relevance of systemic and local IGF-I: lessons from animal models. Pediatr Endocrinol Rev. 2008;5(suppl 2): 739-743.
    • (2008) Pediatr Endocrinol Rev , vol.5 , Issue.SUPPL. 2 , pp. 739-743
    • Leroith, D.1
  • 22
    • 0030774975 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor-I acutely inhibit surface translocation of growth hormone receptors in osteoblasts: A novel mechanism of growth hormone receptor regulation
    • Leung KC, Waters MJ, Markus I, Baumbach WR, Ho KK. Insulin and insulin-like growth factor-I acutely inhibit surface translocation of growth hormone receptors in osteoblasts: a novel mechanism of growth hormone receptor regulation. Proc Natl Acad Sci USA. 1997;94: 11381-11386.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 11381-11386
    • Leung, K.C.1    Waters, M.J.2    Markus, I.3    Baumbach, W.R.4    Ho, K.K.5
  • 23
    • 0020504087 scopus 로고
    • Growth hormone stimulates the proliferation of cultured chondrocytes from rabbit ear and rat rib growth cartilage
    • Madsen K, Friberg U, Roos P, Edén S, Isaksson O. Growth hormone stimulates the proliferation of cultured chondrocytes from rabbit ear and rat rib growth cartilage. Nature. 1983;304: 545-547.
    • (1983) Nature , vol.304 , pp. 545-547
    • Madsen, K.1    Friberg, U.2    Roos, P.3    Edén, S.4    Isaksson, O.5
  • 24
    • 68549092476 scopus 로고    scopus 로고
    • The role of liver-derived insulin-like growth factor-I
    • Ohlsson C, Mohan S, Sjögren K, et al. The role of liver-derived insulin-like growth factor-I. Endocr Rev. 2009;30: 494-535.
    • (2009) Endocr Rev , vol.30 , pp. 494-535
    • Ohlsson, C.1    Mohan, S.2    Sjögren, K.3
  • 25
    • 33646347639 scopus 로고    scopus 로고
    • A GH receptor antisense oligonucleotide inhibits hepaticGHreceptor expression, IGF-I production and body weight gain in normal mice
    • Tachas G, Lofthouse S, Wraight CJ, et al. A GH receptor antisense oligonucleotide inhibits hepaticGHreceptor expression, IGF-I production and body weight gain in normal mice. J Endocrinol. 2006; 189: 147-154.
    • (2006) J Endocrinol , vol.189 , pp. 147-154
    • Tachas, G.1    Lofthouse, S.2    Wraight, C.J.3
  • 26
    • 14544287701 scopus 로고    scopus 로고
    • Bone metabolism in relation to alterations in systemic growth hormone
    • Ueland T. Bone metabolism in relation to alterations in systemic growth hormone. Growth Horm IGF Res. 2004;14: 404-417.
    • (2004) Growth Horm IGF Res , vol.14 , pp. 404-417
    • Ueland, T.1
  • 27
    • 1542301428 scopus 로고    scopus 로고
    • Evidence supporting dual, IGF-I-independent and IGF-I-dependent, roles for GH in promoting longitudinal bone growth
    • Wang J, Zhou J, Cheng CM, Kopchick JJ, Bondy CA. Evidence supporting dual, IGF-I-independent and IGF-I-dependent, roles for GH in promoting longitudinal bone growth. J Endocrinol. 2004; 180: 247-255.
    • (2004) J Endocrinol , vol.180 , pp. 247-255
    • Wang, J.1    Zhou, J.2    Cheng, C.M.3    Kopchick, J.J.4    Bondy, C.A.5
  • 29
    • 4344649944 scopus 로고    scopus 로고
    • A mouse with targeted ablation of the growth hormone-releasing hormone gene: A new model of isolated growth hormone deficiency
    • Alba M, Salvatori R. A mouse with targeted ablation of the growth hormone-releasing hormone gene: a new model of isolated growth hormone deficiency. Endocrinology. 2004;145: 4134-4143.
    • (2004) Endocrinology , vol.145 , pp. 4134-4143
    • Alba, M.1    Salvatori, R.2
  • 30
    • 0347951038 scopus 로고    scopus 로고
    • Mechanisms for pituitary tumorigenesis: The plastic pituitary
    • Melmed S. Mechanisms for pituitary tumorigenesis: the plastic pituitary. J Clin Invest. 2003;112: 1603-1618.
    • (2003) J Clin Invest , vol.112 , pp. 1603-1618
    • Melmed, S.1
  • 31
    • 0030868551 scopus 로고    scopus 로고
    • Magnetic resonance images of 91 children with different causes of short stature: Pituitary size reflects growth hormone secretion
    • Nagel BH, Palmbach M, Petersen D, Ranke MB. Magnetic resonance images of 91 children with different causes of short stature: pituitary size reflects growth hormone secretion. Eur J pediatr. 1997;156: 758-763.
    • (1997) Eur J Pediatr , vol.156 , pp. 758-763
    • Nagel, B.H.1    Palmbach, M.2    Petersen, D.3    Ranke, M.B.4
  • 32
    • 0021828930 scopus 로고
    • Independent effects of growth hormone releasing factor on growth hormone release and gene transcription
    • Barinaga M, Bilezikjian LM, Vale WW, Rosenfeld MG, Evans RM. Independent effects of growth hormone releasing factor on growth hormone release and gene transcription. Nature. 1985;314: 279-281.
    • (1985) Nature , vol.314 , pp. 279-281
    • Barinaga, M.1    Bilezikjian, L.M.2    Vale, W.W.3    Rosenfeld, M.G.4    Evans, R.M.5
  • 33
    • 0022389890 scopus 로고
    • Effects of rat growth hormone (rGH)-releasing factor and somatostatin on the release and synthesis of rGH in dispersed pituitary cells
    • Fukata J, Diamond DJ, Martin JB. Effects of rat growth hormone (rGH)-releasing factor and somatostatin on the release and synthesis of rGH in dispersed pituitary cells. Endocrinology. 1985;117: 457-467.
    • (1985) Endocrinology , vol.117 , pp. 457-467
    • Fukata, J.1    Diamond, D.J.2    Martin, J.B.3
  • 34
    • 0025266882 scopus 로고
    • Modulation of growth hormone (GH) secretion and GH mRNA levels by GH-releasing factor, somatostatin and secretagogues in cultured bovine adenohypophysial cells
    • Tanner JW, Davis SK, McArthur NH, French JT, Welsh TH Jr. Modulation of growth hormone (GH) secretion and GH mRNA levels by GH-releasing factor, somatostatin and secretagogues in cultured bovine adenohypophysial cells. J Endocrinol. 1990;125: 109-115.
    • (1990) J Endocrinol , vol.125 , pp. 109-115
    • Tanner, J.W.1    Davis, S.K.2    McArthur, N.H.3    French, J.T.4    Welsh Jr., T.H.5
  • 35
    • 77949314882 scopus 로고    scopus 로고
    • Pituitary somatostatin receptor signaling
    • Ben-Shlomo A, Melmed S. Pituitary somatostatin receptor signaling. Trends Endocrinol Metab. 2010;21: 123-133.
    • (2010) Trends Endocrinol Metab , vol.21 , pp. 123-133
    • Ben-Shlomo, A.1    Melmed, S.2
  • 36
    • 0019466004 scopus 로고
    • Effects of growth hormone excess and deficiency on hypothalamic somatostatin content and release and on tissue somatostatin distribution
    • Berelowitz M, Firestone SL, Frohman LA. Effects of growth hormone excess and deficiency on hypothalamic somatostatin content and release and on tissue somatostatin distribution. Endocrinology. 1981;109: 714-719.
    • (1981) Endocrinology , vol.109 , pp. 714-719
    • Berelowitz, M.1    Firestone, S.L.2    Frohman, L.A.3
  • 37
    • 0019504036 scopus 로고
    • Somatomedin-C mediates growth hormone negative feedback by effects on both the hypothalamus and the pituitary
    • BerelowitzM,SzaboM,Frohman LA, Firestone S, Chu L, Hintz RL. Somatomedin-C mediates growth hormone negative feedback by effects on both the hypothalamus and the pituitary. Science. 1981; 212: 1279-1281.
    • (1981) Science , vol.212 , pp. 1279-1281
    • Berelowitz, M.1    Szabo, M.2    Frohman, L.A.3    Firestone, S.4    Chu, L.5    Hintz, R.L.6
  • 38
    • 84864871710 scopus 로고    scopus 로고
    • Inhibitory effects of GHRH antagonists on human GH-secreting adenoma tissue
    • Szalontay L, Benveniste RJ, Schally AV, et al. Inhibitory effects of GHRH antagonists on human GH-secreting adenoma tissue. Neuroendocrinology. 2012;96: 81-88.
    • (2012) Neuroendocrinology , vol.96 , pp. 81-88
    • Szalontay, L.1    Benveniste, R.J.2    Schally, A.V.3
  • 39
    • 0025289864 scopus 로고
    • Pubertal development and testicular function in the male growth hormonedeficient rat
    • Bartlett JM, Charlton HM, Robinson IC, Nieschlag E. Pubertal development and testicular function in the male growth hormonedeficient rat. J Endocrinol. 1990;126: 193-201.
    • (1990) J Endocrinol , vol.126 , pp. 193-201
    • Bartlett, J.M.1    Charlton, H.M.2    Robinson, I.C.3    Nieschlag, E.4
  • 40
    • 0033061196 scopus 로고    scopus 로고
    • Differential regulation of hypothalamic tuberoinfundibular dopamine neurones in two dwarf rat models with contrasting changes in pituitary prolactin
    • Thomas GB, Phelps CJ, Robinson IC. Differential regulation of hypothalamic tuberoinfundibular dopamine neurones in two dwarf rat models with contrasting changes in pituitary prolactin. J Neuroendocrinol. 1999;11: 229-236.
    • (1999) J Neuroendocrinol , vol.11 , pp. 229-236
    • Thomas, G.B.1    Phelps, C.J.2    Robinson, I.C.3
  • 41
    • 0032958139 scopus 로고    scopus 로고
    • Pituitary and testicular function in growth hormone receptor gene knockout mice
    • Chandrashekar V, Bartke A, Coschigano KT, Kopchick JJ. Pituitary and testicular function in growth hormone receptor gene knockout mice. Endocrinology. 1999;140: 1082-1088.
    • (1999) Endocrinology , vol.140 , pp. 1082-1088
    • Chandrashekar, V.1    Bartke, A.2    Coschigano, K.T.3    Kopchick, J.J.4
  • 42
    • 17144415263 scopus 로고    scopus 로고
    • Role of insulin-like growth factor-I in diagnosis and management of acromegaly
    • Clemmons DR. Role of insulin-like growth factor-I in diagnosis and management of acromegaly. Endocr Pract. 2004;10: 362-371.
    • (2004) Endocr Pract , vol.10 , pp. 362-371
    • Clemmons, D.R.1
  • 43
    • 33747079921 scopus 로고    scopus 로고
    • Clinical utility of measurements of insulin-like growth factor 1
    • Clemmons DR. Clinical utility of measurements of insulin-like growth factor 1. Nat Clin Pract Endocrinol Metab. 2006;2: 436-446.
    • (2006) Nat Clin Pract Endocrinol Metab , vol.2 , pp. 436-446
    • Clemmons, D.R.1
  • 44
    • 4043058143 scopus 로고    scopus 로고
    • Central and peripheral actions of somatostatin on the growth hormone- IGF-I axis
    • Murray RD, Kim K, Ren SG, Chelly M, Umehara Y, Melmed S. Central and peripheral actions of somatostatin on the growth hormone- IGF-I axis. J Clin Invest. 2004;114: 349-356.
    • (2004) J Clin Invest , vol.114 , pp. 349-356
    • Murray, R.D.1    Kim, K.2    Ren, S.G.3    Chelly, M.4    Umehara, Y.5    Melmed, S.6
  • 45
    • 0029946671 scopus 로고    scopus 로고
    • The effects of octreotide onGHreceptor and IGF-I expression in the GH-deficient rat
    • Ambler GR, Butler AA, Padmanabhan J, Breier BH, Gluckman PD. The effects of octreotide onGHreceptor and IGF-I expression in the GH-deficient rat. J Endocrinol. 1996;149: 223-231.
    • (1996) J Endocrinol , vol.149 , pp. 223-231
    • Ambler, G.R.1    Butler, A.A.2    Padmanabhan, J.3    Breier, B.H.4    Gluckman, P.D.5
  • 46
    • 0033388419 scopus 로고    scopus 로고
    • Effects of a 7-day continuous infusion of octreotide on circulating levels of growth factors and binding proteins in growth hormone (GH)- treated GH-deficient patients
    • Laursen T, Møller J, Fisker S, Jorgensen JO, Christiansen JS. Effects of a 7-day continuous infusion of octreotide on circulating levels of growth factors and binding proteins in growth hormone (GH)- treated GH-deficient patients. GrowthHormIGF Res. 1999;9: 451-457.
    • (1999) GrowthHormIGF Res , vol.9 , pp. 451-457
    • Laursen, T.1    Møller, J.2    Fisker, S.3    Jorgensen, J.O.4    Christiansen, J.S.5
  • 47
    • 0025876689 scopus 로고
    • Inhibitory effect of octreotide on growth hormone-induced IGF-I generation and organ growth in hypophysectomized rats
    • Flyvbjerg A, Jørgensen KD, Marshall SM, Orskov H. Inhibitory effect of octreotide on growth hormone-induced IGF-I generation and organ growth in hypophysectomized rats. Am J Physiol. 1991; 260:E568-E574.
    • (1991) Am J Physiol , vol.260
    • Flyvbjerg, A.1    Jørgensen, K.D.2    Marshall, S.M.3    Orskov, H.4
  • 48
    • 0034690311 scopus 로고    scopus 로고
    • Treatment of acromegaly with the growth hormone-receptor antagonist pegvisomant
    • Trainer PJ, Drake WM, Katznelson L, et al. Treatment of acromegaly with the growth hormone-receptor antagonist pegvisomant. N Engl J Med. 2000;342: 1171-1177.
    • (2000) N Engl J Med , vol.342 , pp. 1171-1177
    • Trainer, P.J.1    Drake, W.M.2    Katznelson, L.3
  • 49
    • 21344474829 scopus 로고    scopus 로고
    • Regulation of ghrelin secretion by somatostatin analogs in rats
    • Silva AP, Bethmann K, Raulf F, Schmid HA. Regulation of ghrelin secretion by somatostatin analogs in rats. Eur J Endocrinol. 2005; 152: 887-894.
    • (2005) Eur J Endocrinol , vol.152 , pp. 887-894
    • Silva, A.P.1    Bethmann, K.2    Raulf, F.3    Schmid, H.A.4
  • 51
    • 0020566560 scopus 로고
    • Effects of in vivo administration of antiserum to rat growth hormone on body growth and insulin responsiveness in adipose tissue
    • Gause I, Eden S, Jansson JO, Isaksson O. Effects of in vivo administration of antiserum to rat growth hormone on body growth and insulin responsiveness in adipose tissue. Endocrinology. 1983;112: 1559-1566.
    • (1983) Endocrinology , vol.112 , pp. 1559-1566
    • Gause, I.1    Eden, S.2    Jansson, J.O.3    Isaksson, O.4
  • 52
    • 0027455584 scopus 로고
    • Growth hormone deficiency in 'little' mice results in aberrant body composition, reduced insulin-like growth factor-I and insulin-like growth factor-binding protein-3 (IGFBP-3), but does not affect IGFBP-2, -1 or -4
    • Donahue LR, Beamer WG. Growth hormone deficiency in 'little' mice results in aberrant body composition, reduced insulin-like growth factor-I and insulin-like growth factor-binding protein-3 (IGFBP-3), but does not affect IGFBP-2, -1 or -4. J Endocrinol. 1993;136: 91-104.
    • (1993) J Endocrinol , vol.136 , pp. 91-104
    • Donahue, L.R.1    Beamer, W.G.2
  • 53
    • 0033780069 scopus 로고    scopus 로고
    • Development of obesity in transgenic rats with low circulating growth hormone levels: Involvement of leptin resistance
    • Furuhata Y, Kagaya R, Hirabayashi K, et al. Development of obesity in transgenic rats with low circulating growth hormone levels: involvement of leptin resistance. Eur J Endocrinol. 2000;143: 535-541.
    • (2000) Eur J Endocrinol , vol.143 , pp. 535-541
    • Furuhata, Y.1    Kagaya, R.2    Hirabayashi, K.3
  • 54
    • 0027425918 scopus 로고
    • Body fat in GH-deficient children and the effect of treatment
    • Wabitsch M, Heinze E. Body fat in GH-deficient children and the effect of treatment. Horm Res. 1993;40: 5-9.
    • (1993) Horm Res , vol.40 , pp. 5-9
    • Wabitsch, M.1    Heinze, E.2
  • 55
    • 84874507612 scopus 로고    scopus 로고
    • The Role of GH in adipose tissue: Lessons from adipose-specific GH receptor gene-disrupted mice
    • List EO, Berryman DE, Funk K, et al. The Role of GH in adipose tissue: lessons from adipose-specific GH receptor gene-disrupted mice. Mol Endocrinol. 2013;27: 524-535.
    • (2013) Mol Endocrinol , vol.27 , pp. 524-535
    • List, E.O.1    Berryman, D.E.2    Funk, K.3
  • 56
    • 0025021511 scopus 로고
    • Identification and characterization of somatostatin receptors in neonatal rat long bones
    • Bruns C, Dietl MM, Palacios JM, Pless J. Identification and characterization of somatostatin receptors in neonatal rat long bones. Biochem J. 1990;265: 39-44.
    • (1990) Biochem J , vol.265 , pp. 39-44
    • Bruns, C.1    Dietl, M.M.2    Palacios, J.M.3    Pless, J.4
  • 57
    • 0025604379 scopus 로고
    • Somatostatin receptors are restricted to a subpopulation of osteoblast-like cells during endochondral bone formation
    • Mackie EJ, Trechsel U, Bruns C. Somatostatin receptors are restricted to a subpopulation of osteoblast-like cells during endochondral bone formation. Development. 1990;110: 1233-1239.
    • (1990) Development , vol.110 , pp. 1233-1239
    • Mackie, E.J.1    Trechsel, U.2    Bruns, C.3
  • 58
    • 0036320816 scopus 로고    scopus 로고
    • The somatostatin analog octreotide inhibits GH-stimulated, but not IGF-I-stimulated, bone growth in hypophysectomized rats
    • Zapf J, Gosteli-Peter M, Weckbecker G, Hunziker EB, Reinecke M. The somatostatin analog octreotide inhibits GH-stimulated, but not IGF-I-stimulated, bone growth in hypophysectomized rats. Endocrinology. 2002;143: 2944-2952.
    • (2002) Endocrinology , vol.143 , pp. 2944-2952
    • Zapf, J.1    Gosteli-Peter, M.2    Weckbecker, G.3    Hunziker, E.B.4    Reinecke, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.