메뉴 건너뛰기




Volumn 7, Issue , 2013, Pages 401-409

Ambrisentan for the treatment of pulmonary arterial hypertension: Improving outcomes

Author keywords

Ambrisentan; Endothelin; Endothelin receptor antagonist; Letairis education and access program; Pulmonary arterial hypertension

Indexed keywords

AMBRISENTAN; BOSENTAN; BRAIN NATRIURETIC PEPTIDE; CYCLOSPORIN; CYTOCHROME P450; CYTOCHROME P450 2C; CYTOCHROME P450 3A4; ENDOTHELIN 1; ENDOTHELIN 2; ENDOTHELIN 3; ENDOTHELIN A RECEPTOR ANTAGONIST; LIVER ENZYME; NIFEDIPINE; PROSTACYCLIN; SILDENAFIL; TADALAFIL; WARFARIN;

EID: 84886518672     PISSN: None     EISSN: 1177889X     Source Type: Journal    
DOI: 10.2147/PPA.S30949     Document Type: Review
Times cited : (11)

References (31)
  • 1
    • 0025837793 scopus 로고
    • Survival in patients with primary pulmonary hypertension: Results from a national prospective registry
    • D'Alonzo GE, Barst RJ, Ayres SM, et al. Survival in patients with primary pulmonary hypertension: results from a national prospective registry. Ann Intern Med. 1991;115:343-349.
    • (1991) Ann Intern Med , vol.115 , pp. 343-349
    • D'alonzo, G.E.1    Barst, R.J.2    Ayres, S.M.3
  • 2
    • 3142692425 scopus 로고    scopus 로고
    • Screening, early detection, and diagnosis of pulmonary arterial hypertension: ACCP evidence-based clinical practice guidelines
    • McGoon M, Gutterman D, Steen V, et al. Screening, early detection, and diagnosis of pulmonary arterial hypertension: ACCP evidence-based clinical practice guidelines. Chest. 2004;126:14S-34S.
    • (2004) Chest , vol.126
    • McGoon, M.1    Gutterman, D.2    Steen, V.3
  • 3
    • 2942522878 scopus 로고    scopus 로고
    • Clinical classification of pulmonary hypertension
    • Simonneau G, Galiè N, Rubin LJ, et al. Clinical classification of pulmonary hypertension. J Am Coll Cardiol. 2004;43(12 Suppl S):5S-12S.
    • (2004) J Am Coll Cardiol , vol.43 , Issue.12 SUPPL. S
    • Simonneau, G.1    Galiè, N.2    Rubin, L.J.3
  • 4
    • 70049112901 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and treatment of pulmonary hypertension: The Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS)
    • Galie N, Hoeper MM, Humbert M, et al. Guidelines for the diagnosis and treatment of pulmonary hypertension: the Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS). Eur Heart J. 2009;30:2493-2537.
    • (2009) Eur Heart J , vol.30 , pp. 2493-2537
    • Galie, N.1    Hoeper, M.M.2    Humbert, M.3
  • 5
    • 5344233478 scopus 로고    scopus 로고
    • Pulmonary arterial hypertension
    • Farber HW, Loscalzo J. Pulmonary arterial hypertension. N Engl J Med. 2004;351:1655-1665.
    • (2004) N Engl J Med , vol.351 , pp. 1655-1665
    • Farber, H.W.1    Loscalzo, J.2
  • 6
    • 0027324745 scopus 로고
    • Expression of endothelin-1 in the lungs of patients with pulmonary hypertension
    • Giaid A, Yanagisawa M, Langleben D, et al. Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. N Engl J Med. 1993;328:1732-1739.
    • (1993) N Engl J Med , vol.328 , pp. 1732-1739
    • Giaid, A.1    Yanagisawa, M.2    Langleben, D.3
  • 7
    • 0013543367 scopus 로고
    • The human endothelin family: Three structurally and pharmacologically distinct isopeptides predicted by three separate genes
    • Inoue AM, Yanagisawa S, Kimura Y, et al. The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc Natl Acad Sci U S A. 1989;86:2863-2867.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 2863-2867
    • Inoue, A.M.1    Yanagisawa, S.2    Kimura, Y.3
  • 8
    • 0023859136 scopus 로고
    • A novel potent vasoconstrictor peptide produced by vascular endothelial cells
    • Yanagisawa M, Kurihara H, Kimura S, et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature. 1988;332:411-415.
    • (1988) Nature , vol.332 , pp. 411-415
    • Yanagisawa, M.1    Kurihara, H.2    Kimura, S.3
  • 9
    • 0027984808 scopus 로고
    • Endothelins: Molecular biology, biochemistry, pharmacology, physiology, and pathophysiology
    • Rubanyi GM, Polokoff PM. Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology. Pharmacol Rev. 1994;46:325-415.
    • (1994) Pharmacol Rev , vol.46 , pp. 325-415
    • Rubanyi, G.M.1    Polokoff, P.M.2
  • 10
    • 0036468709 scopus 로고    scopus 로고
    • ET(A) and ET(B) receptors modulate the proliferation of human pulmonary artery smooth muscle cells
    • Davie N, Haleen SJ, Upton PD, et al. ET(A) and ET(B) receptors modulate the proliferation of human pulmonary artery smooth muscle cells. Am J Respir Crit Care Med. 2002;165:398-405.
    • (2002) Am J Respir Crit Care Med , vol.165 , pp. 398-405
    • Davie, N.1    Haleen, S.J.2    Upton, P.D.3
  • 11
    • 0028307066 scopus 로고
    • Constitutive endothelin-1 overexpression promotes smooth muscle cell proliferation via an external autocrine loop
    • Alberts GF, Peifley KA, Johns A, Kleha JF, Winkles JA. Constitutive endothelin-1 overexpression promotes smooth muscle cell proliferation via an external autocrine loop. J Biol Chem. 1994;269:10112-10118.
    • (1994) J Biol Chem , vol.269 , pp. 10112-10118
    • Alberts, G.F.1    Peifley, K.A.2    Johns, A.3    Kleha, J.F.4    Winkles, J.A.5
  • 12
    • 0028333046 scopus 로고
    • Clearance of circulating endothelin-1 by ETB receptors in rats
    • Fukuroda T, Fujikawa T, Ozaki S, et al. Clearance of circulating endothelin-1 by ETB receptors in rats. Biochem Biophys Res Commun. 1994;199:1461-1465.
    • (1994) Biochem Biophys Res Commun , vol.199 , pp. 1461-1465
    • Fukuroda, T.1    Fujikawa, T.2    Ozaki, S.3
  • 13
    • 0028361235 scopus 로고
    • Endothelin receptor subtypes in human versus rabbit pulmonary arteries
    • Fukuroda T, Kobayashi M, Ozaki S, et al. Endothelin receptor subtypes in human versus rabbit pulmonary arteries. J Appl Physiol. 1994;76:1976-1982.
    • (1994) J Appl Physiol , vol.76 , pp. 1976-1982
    • Fukuroda, T.1    Kobayashi, M.2    Ozaki, S.3
  • 14
    • 84886452605 scopus 로고    scopus 로고
    • Pfizer initiates product withdrawal of THELIN® (sitaxsentan sodium) worldwide. Available from, Accessed February 26
    • Pfizer initiates product withdrawal of THELIN® (sitaxsentan sodium) worldwide. Available from: http://www.hc-sc.gc.ca/dhp-mps/alt_ formats/pdf/medeff/advisories-avis/prof/2010/thelin_2_hpc-cps-eng.pdf. Accessed February 26, 2013.
    • (2013)
  • 15
    • 77951443168 scopus 로고    scopus 로고
    • Pharmacotherapeutic management of pulmonary arterial hypertension
    • Anderson JR, Nawarskas JJ. Pharmacotherapeutic management of pulmonary arterial hypertension. Cardiol Rev. 2010;18:148-162.
    • (2010) Cardiol Rev , vol.18 , pp. 148-162
    • Anderson, J.R.1    Nawarskas, J.J.2
  • 16
    • 84886469456 scopus 로고    scopus 로고
    • Letairis [package insert]. Foster City, CA: Gilead Sciences Inc; Oct 2012. Available from, Accessed November 24
    • Letairis [package insert]. Foster City, CA: Gilead Sciences Inc; Oct 2012. Available from: http://www.gilead.com/pdf/letairis_pi.pdf. Accessed November 24, 2012.
  • 17
    • 84886521542 scopus 로고    scopus 로고
    • US Food and Drug Administration. Drug approval package: Letairis (ambrisentan NDA #022081). Medical Review, Part 1. Available from, Accessed November 11
    • US Food and Drug Administration. Drug approval package: Letairis (ambrisentan NDA #022081). Medical Review, Part 1. Available from: http://www.accessdata.fda.gov/drugsatfda_docs/nda/2007/022081s000_MedR_P1.pdf. Accessed November 11, 2012.
    • (2012)
  • 18
    • 22844436819 scopus 로고    scopus 로고
    • Ambrisentan therapy for pulmonary arterial hypertension
    • Galie N, Badesch D, Oudiz R, et al. Ambrisentan therapy for pulmonary arterial hypertension. J Am Coll Cardiol. 2005;46:529-535.
    • (2005) J Am Coll Cardiol , vol.46 , pp. 529-535
    • Galie, N.1    Badesch, D.2    Oudiz, R.3
  • 19
    • 84886521713 scopus 로고    scopus 로고
    • Gilead Sciences Inc, Foster City, CA: Gilead Sciences Inc
    • Gilead Sciences Inc. Prescriber Guide: Letairis and the LEAP program. Foster City, CA: Gilead Sciences Inc; Feb 2012.
    • (2012) Prescriber Guide: Letairis and The LEAP Program
  • 20
    • 78650240029 scopus 로고    scopus 로고
    • Availability of and access to orphan drugs: An international comparison of pharmaceutical treatments for pulmonary arterial hypertension, Fabry disease, hereditary angioedema and chronic myeloid leukaemia
    • Blankart CR, Stargardt T, Schreyögg J. Availability of and access to orphan drugs: an international comparison of pharmaceutical treatments for pulmonary arterial hypertension, Fabry disease, hereditary angioedema and chronic myeloid leukaemia. Pharmacoeconomics. 2011;29:63-82.
    • (2011) Pharmacoeconomics , vol.29 , pp. 63-82
    • Blankart, C.R.1    Stargardt, T.2    Schreyögg, J.3
  • 21
    • 46449124591 scopus 로고    scopus 로고
    • Ambrisentan for the treatment of pulmonary arterial hypertension: Results of the ambrisentan in pulmonary arterial hypertension, randomized, double-blind, placebo-controlled, multicenter, efficacy (ARIES) study 1 and 2
    • Galiè N, Olschewski H, Oudiz RJ, et al. Ambrisentan for the treatment of pulmonary arterial hypertension: results of the ambrisentan in pulmonary arterial hypertension, randomized, double-blind, placebo-controlled, multicenter, efficacy (ARIES) study 1 and 2. Circulation. 2008;117:3010-3019.
    • (2008) Circulation , vol.117 , pp. 3010-3019
    • Galiè, N.1    Olschewski, H.2    Oudiz, R.J.3
  • 22
    • 65949117012 scopus 로고    scopus 로고
    • The 6-min walk test: Clinical and research role, technique, coding, and reimbursement
    • Salzman SH. The 6-min walk test: clinical and research role, technique, coding, and reimbursement. Chest. 2009;135:1345-1352.
    • (2009) Chest , vol.135 , pp. 1345-1352
    • Salzman, S.H.1
  • 23
    • 20144364111 scopus 로고    scopus 로고
    • Minimal clinically important differences in the six-minute walk test and the incremental shuttle walking test
    • Wise RA, Brown CD. Minimal clinically important differences in the six-minute walk test and the incremental shuttle walking test. COPD. 2005;2:125-129.
    • (2005) COPD , vol.2 , pp. 125-129
    • Wise, R.A.1    Brown, C.D.2
  • 24
    • 0034702908 scopus 로고    scopus 로고
    • Plasma brain natriuretic peptide as a prognostic indicator in patients with primary pulmonary hypertension
    • Nagaya N, Nishikimi T, Uematsu M, et al. Plasma brain natriuretic peptide as a prognostic indicator in patients with primary pulmonary hypertension. Circulation. 2000;102:865-870.
    • (2000) Circulation , vol.102 , pp. 865-870
    • Nagaya, N.1    Nishikimi, T.2    Uematsu, M.3
  • 25
    • 70350708667 scopus 로고    scopus 로고
    • Long-term ambrisentan therapy for the treatment of pulmonary arterial hypertension
    • Oudiz RJ, Galiè N, Olschewski H, et al. Long-term ambrisentan therapy for the treatment of pulmonary arterial hypertension. J Am Coll Cardiol. 2009;54:1971-1981.
    • (2009) J Am Coll Cardiol , vol.54 , pp. 1971-1981
    • Oudiz, R.J.1    Galiè, N.2    Olschewski, H.3
  • 26
    • 75149115729 scopus 로고    scopus 로고
    • Long-term outcomes with ambrisentan monotherapy in pulmonary arterial hypertension
    • Blalock SE, Matulevicius S, Mitchell LC, et al. Long-term outcomes with ambrisentan monotherapy in pulmonary arterial hypertension. J Card Fail. 2010;16:121-127.
    • (2010) J Card Fail , vol.16 , pp. 121-127
    • Blalock, S.E.1    Matulevicius, S.2    Mitchell, L.C.3
  • 27
    • 84858279164 scopus 로고    scopus 로고
    • ARIES-3: Ambrisentan therapy in a diverse population of patients with pulmonary hypertension
    • Badesch DB, Feldman J, Keogh A, et al. ARIES-3: ambrisentan therapy in a diverse population of patients with pulmonary hypertension. Cardiovasc Ther. 2012;30:93-99.
    • (2012) Cardiovasc Ther , vol.30 , pp. 93-99
    • Badesch, D.B.1    Feldman, J.2    Keogh, A.3
  • 28
    • 84867734437 scopus 로고    scopus 로고
    • Dosing frequency and medication adherence in chronic disease
    • Coleman CI, Limone B, Sobieraj DM, et al. Dosing frequency and medication adherence in chronic disease. J Manag Care Pharm. 2012;18:527-539.
    • (2012) J Manag Care Pharm , vol.18 , pp. 527-539
    • Coleman, C.I.1    Limone, B.2    Sobieraj, D.M.3
  • 29
    • 58249107821 scopus 로고    scopus 로고
    • Ambrisentan therapy in patients with pulmonary arterial hypertension who discontinued bosentan or sitaxsentan due to liver function test abnormalities
    • McGoon MD, Frost AE, Oudiz RJ, et al. Ambrisentan therapy in patients with pulmonary arterial hypertension who discontinued bosentan or sitaxsentan due to liver function test abnormalities. Chest. 2009;135:122-129.
    • (2009) Chest , vol.135 , pp. 122-129
    • McGoon, M.D.1    Frost, A.E.2    Oudiz, R.J.3
  • 30
    • 84886503734 scopus 로고    scopus 로고
    • US Food and Drug Administration. FDA drug safety communication: liver injury warning to be removed from Letairis (ambrisentan) tablets. Available from, Updated 01/10/2012. Accessed September 26
    • US Food and Drug Administration. FDA drug safety communication: liver injury warning to be removed from Letairis (ambrisentan) tablets. Available from: http://www.fda.gov/Drugs/DrugSafety/ucm245852.htm. Updated 01/10/2012. Accessed September 26, 2012.
    • (2012)
  • 31
    • 84886533290 scopus 로고    scopus 로고
    • Tracleer [package insert]. South San Francisco, CA: Actelion Pharmaceuticals US Inc; October 2012. Available from, Accessed December 11
    • Tracleer [package insert]. South San Francisco, CA: Actelion Pharmaceuticals US Inc; October 2012. Available from: http://www.tracleer.com/docs/Tracleer_Full_Prescribing_Information.pdf. Accessed December 11, 2012.
    • (2012)


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.