Antifibrinolytic therapy in intracranial hemorrhage

Drug Development Research

Volumn 74, Issue 7, 2013, Pages 478-484

  Meier, Kevin ^a   Hoesch, Robert ^a  

^a UNIVERSITY OF UTAH   (United States)

Author keywords

antifibrinolytic; epsilon aminocaproic acid; intracranial hemorrhage; tranexamic acid

Indexed keywords

AMINOCAPROIC ACID; ANTIFIBRINOLYTIC AGENT; HEMOSTATIC AGENT; TRANEXAMIC ACID;

BLOOD PRESSURE REGULATION; BRAIN HEMORRHAGE; BRAIN VASOSPASM; CEREBROVASCULAR ACCIDENT; DRUG INDICATION; DRUG USE; EPIDURAL HEMATOMA; HEART SURGERY; HEMOSTASIS; HUMAN; INJURY; MENORRHAGIA; NONHUMAN; REVIEW; SUBARACHNOID HEMORRHAGE; SUBDURAL HEMATOMA; TRAUMATIC BRAIN INJURY; TREATMENT DURATION;

EID: 84886433584     PISSN: 02724391     EISSN: 10982299     Source Type: Journal    
DOI: 10.1002/ddr.21105     Document Type: Review

References (63)

1. Adams HP Jr,. 1990. Calcium antagonists in the management of patients with aneurysmal subarachnoid hemorrhage: a review. Angiology 41: 1010-1016.
2. Adams HP Jr, Nibbelink DW, Torner JC, Sahs AL,. 1981. Antifibrinolytic therapy in patients with aneurysmal subarachnoid hemorrhage A report of the cooperative aneurysm study. Arch Neurol 38: 25-29.
3. Baumann Kreuziger LM, Morton CT, Dries DJ,. 2012. New anticoagulants: A concise review. J Trauma Acute Care Surg 4: 983-992.
4. Beck DW, Adams HP, Flamm ES, Godersky JC, Loftus CM,. 1988. Combination of aminocaproic acid and nicardipine in treatment of aneurysmal subarachnoid hemorrhage. Stroke 19: 63-67.
5. Beynon C, Hoffmann T, Wick W, Unterberg AW, Kiening KL,. 2011. Stereotactic brainstem biopsy in a patient with coagulopathy of unclear etiology: case report. Minim Invasive Neurosurg 54: 268-270.
6. Brott T, Broderick J, Kothari R, Barsan W, Tomsick T, Sauerbeck L, Spilker J, Duldner J, Khoury J,. 1997. Early hemorrhage growth in patients with intracerebral hemorrhage. Stroke 28: 1-5.
7. Cap AP, Baer DG, Orman JA, Aden J, Ryan K, Blackbourne LH,. 2011. Tranexamic acid for trauma patients: a critical review of the literature. J Trauma 71: S9-14.
8. Clavé A, Fazilleau F, Dumser D, Lacroix J,. 2012. Efficacy of tranexamic acid on blood loss after primary cementless total hip replacement with rivaroxaban thromboprophylaxis: A case-control study in 70 patients. Orthop Traumatol Surg Res 5: 484-490.
9. Connolly ES Jr, Rabinstein AA, Carhuapoma JR, Derdeyn CP, Dion J, Higashida RT, Hoh BL, Kirkness CJ, Naidech AM, Ogilvy CS, et al., American Heart Association Stroke Council, Council on Cardiovascular Radiology and Intervention, Council on Cardiovascular Nursing, Council on Cardiovascular Surgery and Anesthesia, Council on Clinical Cardiology. 2012. Guidelines for the management of aneurysmal subarachnoid hemorrhage: a guideline for healthcare professionals from the American Heart Association/american Stroke Association. Stroke 43: 1711-1737.
10. CRASH-2 trial collaborators, Shakur H, Roberts I, Bautista R, Caballero J, Coats T, Dewan Y, El-Sayed H, Gogichaishvili T, Gupta S, Herrera J, et al. 2010. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet 376: 23-32.
11. Deanda A Jr, Spiess BD,. 2012. Aprotinin revisited. J Thorac Cardiovasc Surg 144: 998-1002.
12. Dorhout Mees SM, Rinkel GJ, Feigin VL, Algra A, van den Bergh WM, Vermeulen M, van Gijn J,. 2007. Calcium antagonists for aneurysmal subarachnoid haemorrhage. Cochrane Database Syst Rev (3): CD000277.
13. Elliott J, Smith M,. 2010. The acute management of intracerebral hemorrhage: a clinical review. Anesth Analg 5: 1419-1427.
14. Feigin VL, Rinkel GJ, Algra A, Vermeulen M, van Gijn J,. 2000. Calcium antagonists for aneurysmal subarachnoid haemorrhage. Cochrane Database Syst Rev (2): CD000277.
15. Fergusson DA, Hébert PC, Mazer CD, Fremes S, MacAdams C, Murkin JM, Teoh K, Duke PC, Arellano R, Blajchman MA, et al. 2008. A comparison of aprotinin and lysine analogues in high-risk cardiac surgery. N Engl J Med 358: 2319-2331.
16. Fogelholm R, Murros K, Rissanen A, Avikainen S,. 2005. Long term survival after primary intracerebral haemorrhage: a retrospective population based study. J Neurol Neurosurg Psychiatry 76: 1534-1538.
17. French KF, White J, Hoesch RE,. 2012. Treatment of intracerebral hemorrhage with tranexamic acid after thrombolysis with tissue plasminogen activator. Neurocrit Care 17: 107-111.
18. Fujii Y, Takeuchi S, Sasaki O, Minakawa T, Koike T, Tanaka R,. 1996. Ultra-early rebleeding in spontaneous subarachnoid hemorrhage. J Neurosurg 84: 35-42.
19. Furtmüller R, Schlag MG, Berger M, Hopf R, Huck S, Sieghart W, Redl H,. 2002. Tranexamic acid, a widely used antifibrinolytic agent, causes convulsions by a gamma-aminobutyric acid(A) receptor antagonistic effect. J Pharmacol Exp Ther 301: 168-173.
20. Gaberel T, Magheru C, Emery E, Derlon JM,. 2012. Antifibrinolytic therapy in the management of aneurismal subarachnoid hemorrhage revisited A meta-analysis. Acta Neurochir 154: 1-9.
21. Germans MR, Post R, Coert BA, Rinkel GJ, Vandertop WP, Verbaan D,. 2013. Ultra-early tranexamic acid after subarachnoid hemorrhage (ULTRA): study protocol for a randomized controlled trial. Trials 14: 143.
22. Harrigan MR, Rajneesh KF, Ardelt AA, Fisher WS 3rd,. 2010. Short-term antifibrinolytic therapy before early aneurysm treatment in subarachnoid hemorrhage: effects on rehemorrhage, cerebral ischemia, and hydrocephalus. Neurosurgery 67: 935-939.
23. Henry DA, Moxey AJ, Carless PA, O'Connell D, McClelland B, Henderson KM, Sly K, Laupacis A, Fergusson D,. 2001. Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion. Cochrane Database Syst Rev (1): CD001886.
24. Hillman J, Fridriksson S, Nilsson O, Yu Z, Saveland H, Jakobsson KE,. 2002. Immediate administration of tranexamic acid and reduced incidence of early rebleeding after aneurysmal subarachnoid hemorrhage: a prospective randomized study. J Neurosurg 97: 771-778.
25. Hongo K, Kobayashi S,. 1993. Calcium antagonists for the treatment of vasospasm following subarachnoid haemorrhage. Neurol Res 15: 218-224.
26. Kageyama H, Toyooka T, Tsuzuki N, Oka K,. 2013. Nonsurgical treatment of chronic subdural hematoma with tranexamic acid. J Neurosurg 2: 332-337.
27. Kassell NF, Torner JC, Adams HP Jr,. 1984. Antifibrinolytic therapy in the acute period following aneurysmal subarachnoid hemorrhage Preliminary observations from the Cooperative Aneurysm Study. J Neurosurg 61: 225-230.
28. Ker K, Edwards P, Perel P, Shakur H, Roberts I,. 2012. Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis. BMJ 344: e3054.
29. Kissela BM, Sauerbeck L, Woo D, Khoury J, Carrozzella J, Pancioli A, Jauch E, Moomaw CJ, Shukla R, Gebel J, et al. 2002. Subarachnoid hemorrhage: a preventable disease with a heritable component. Stroke 33: 1321-1326.
30. Kitamura H, Matsui I, Itoh N, Fujii T, Aizawa M, Yamamoto R, Okuno A, Okazaki Y, Fujita Y, Kuwayama Y, et al. 2003. Tranexamic acid-induced visual impairment in a hemodialysis patient. Clin Exp Nephrol 7: 311-314.
31. Lee KH, Lukovits T, Friedman JA,. 2006. "Triple-H" therapy for cerebral vasospasm following subarachnoid hemorrhage. Neurocrit Care 4: 68-76.
32. Leipzig TJ, Redelman K, Horner TG,. 1997. Reducing the risk of rebleeding before early aneurysm surgery: a possible role for antifibrinolytic therapy. J Neurosurg 86: 220-225.
33. Leminen H, Hurskainen R,. 2012. Tranexamic acid for the treatment of heavy menstrual bleeding: efficacy and safety. Int J Womens Health. 4: 413-421.
34. Lukes AS, Moore KA, Muse KN, Gersten JK, Hecht BR, Edlund M, Richter HE, Eder SE, Attia GR, Patrick DL, et al. 2010. Tranexamic acid treatment for heavy menstrual bleeding: a randomized controlled trial. Obstet Gynecol 116: 865-875.
35. Mangano DT, Rieves RD, Weiss KD,. 2006. Judging the safety of aprotinin. N Engl J Med 21: 2261-2262.
36. Mangano DT, Miao Y, Vuylsteke A, Tudor IC, Juneja R, Filiescu D, Hoeft A, Fontes ML, Hillel Z, Ott E, Titov T, Dietzel C, Levin J, Investigators of the Multicenter Study of Perioperative Ischemia Research Group, Ischemia Research and Education Foundation. 2007. Mortality associated with aprotinin during 5 years following coronary artery bypass graft surgery. JAMA 5: 471-479.
37. Mayer SA, Rincon F,. 2006. Ultra-early hemostatic therapy for acute intracerebral hemorrhage. Semin Hematol 43 (Suppl 1): S70-S76.
38. McCormack PL,. 2012. Tranexamic acid: a review of its use in the treatment of hyperfibrinolysis. Drugs 72: 585-617.
39. Meyer R, Deem S, Yanez ND, Souter M, Lam A, Treggiari MM,. 2011. Current practices of triple-H prophylaxis and therapy in patients with subarachnoid hemorrhage. Neurocrit Care 14: 24-36.
40. Morgenstern LB, Hemphill JC 3rd, Anderson C, Becker K, Broderick JP, Connolly ES Jr, Greenberg SM, Huang JN, MacDonald RL, Messé SR, et al., American Heart Association Stroke Council and Council on Cardiovascular Nursing. 2010. Guidelines for the management of spontaneous intracerebral hemorrhage: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 41: 2108-2129.
41. Morris CD, Jacobs P, Berman PA, Rutherfoord GS,. 1983. Epsilon-aminocaproic acid-induced myopathy A case report. S Afr Med J 64: 363-366.
42. Murkin JM, Falter F, Granton J, Young B, Burt C, Chu M,. 2010. High-dose tranexamic Acid is associated with nonischemic clinical seizures in cardiac surgical patients. Anesth Analg 110: 350-353.
43. Naidech AM, Janjua N, Kreiter KT, Ostapkovich ND, Fitzsimmons BF, Parra A, Commichau C, Connolly ES, Mayer SA,. 2005. Predictors and impact of aneurysm rebleeding after subarachnoid hemorrhage. Arch Neurol 62: 410-416.
44. Nilsson IM,. 1980. Clinical pharmacology of aminocaproic and tranexamic acids. J Clin Pathol Suppl (R Coll Pathol) 14: 41-47.
45. Ohkuma H, Tsurutani H, Suzuki S,. 2001. Incidence and significance of early aneurysmal rebleeding before neurosurgical or neurological management. Stroke 32: 1176-1180.
46. Origitano TC, Wascher TM, Reichman OH, Anderson DE,. 1990. Sustained increased cerebral blood flow with prophylactic hypertensive hypervolemic hemodilution ("triple-H" therapy) after subarachnoid hemorrhage. Neurosurgery 27: 729-739.
47. Perel P, Al-Shahi Salman R, Kawahara T, Morris Z, Prieto-Merino D, Roberts I, Sandercock P, Shakur H, Wardlaw J,. 2012. CRASH-2 (Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage) intracranial bleeding study: the effect of tranexamic acid in traumatic brain injury-a nested randomised, placebo-controlled trial. Health Technol Assess 16: 1-54.
48. Piriyawat P, Morgenstern LB, Yawn DH, Hall CE, Grotta JC,. 2004. Treatment of acute intracerebral hemorrhage with epsilon-aminocaproic acid: a pilot study. Neurocrit Care 1: 47-51.
49. Rivas JJ, Lobato RD, Sarabia R, Cordobés F, Cabrera A, Gomez P,. 1988. Extradural hematoma: analysis of factors influencing the courses of 161 patients. Neurosurgery 23: 44-51.
50. Roberts I, Shakur H, Ker K, Coats T, CRASH-2 Trial collaborators. 2012. Antifibrinolytic drugs for acute traumatic injury. Cochrane Database Syst Rev (12): CD004896.
51. Roos Y,. 2000. Antifibrinolytic treatment in subarachnoid hemorrhage: a randomized placebo-controlled trial STAR Study Group. Neurology 54: 77-82.
52. Roos YB, Vermeulen M, Rinkel GJ, Algra A, Van Gijn J, Algra A,. 1998. Systematic review of antifibrinolytic treatment in aneurysmal subarachnoid haemorrhage. J Neurol Neurosurg Psychiatry 65: 942-943.
53. Ross J, Al-Shahi Salman R,. 2012. The frequency of thrombotic events among adults given antifibrinolytic drugs for spontaneous bleeding: systematic review and meta-analysis of observational studies and randomized trials. Curr Drug Saf 7: 44-54.
54. Samra SK, Giordani B, Caveney AF, Clarke WR, Scott PA, Anderson S, Thompson BG, Todd MM,. 2007. Recovery of cognitive function after surgery for aneurysmal subarachnoid hemorrhage. Stroke 38: 1864-1872.
55. Sauaia A, Moore FA, Moore EE, Moser KS, Brennan R, Read RA, Pons PT,. 1995. Epidemiology of trauma deaths: a reassessment. J Trauma 38: 185-193.
56. Seelig JM, Becker DP, Miller JD, Greenberg RP, Ward JD, Choi SC,. 1981. Traumatic acute subdural hematoma: major mortality reduction in comatose patients treated within four hours. N Engl J Med 304: 1511-1518.
57. Sorimachi T, Fujii Y, Morita K, Tanaka R,. 2005. Rapid administration of antifibrinolytics and strict blood pressure control for intracerebral hemorrhage. Neurosurgery 57: 837-844.
58. Starke RM, Kim GH, Fernandez A, Komotar RJ, Hickman ZL, Otten ML, Ducruet AF, Kellner CP, Hahn DK, Chwajol M, et al. 2008. Impact of a protocol for acute antifibrinolytic therapy on aneurysm rebleeding after subarachnoid hemorrhage. Stroke 39: 2617-2621.
59. Tovi D, Nilsson IM,. 1972. Increased fibrinolytic activity and fibrin degradation products after experimental intracerebral haemorrhage. Acta Neurol Scand 48: 403-415.
60. Triplett DA,. 2000. Coagulation and bleeding disorders: review and update. Clin Chem 46: 1260-1269.
61. Verstraete M,. 1985. Clinical application of inhibitors of fibrinolysis. Drugs 29: 236-261.
62. Vujkovac B, Sabovic M,. 2000. Treatment of subdural and intracerebral haematomas in a haemodialysis patient with tranexamic acid. Nephrol Dial Transplant 15: 107-109.
63. Wysenbeek AJ, Sella A, Blum I, Yeshurun D,. 1979. Acute delirious state after epsilon-amino caproic acid administration. Clin Toxicol 14: 93-95.