Substance P acting via the neurokinin-1 receptor regulates adverse myocardial remodeling in a rat model of hypertension

International Journal of Cardiology

Volumn 168, Issue 5, 2013, Pages 4643-4651

  Dehlin, Heather M ^a   Manteufel, Edward J ^a   Monroe, Andrew L ^a   Reimer, Michael H ^a   Levick, Scott P ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Cardiac fibroblast; Fetal genes; Fibrosis; Hypertrophy; Substance P

Indexed keywords

COLLAGEN; ENDOTHELIN 1; N ACETYLTRYPTOPHAN 3,5 BIS(TRIFLUOROMETHYL)BENZYL ESTER; NEUROKININ 1 RECEPTOR; NEUROKININ 1 RECEPTOR ANTAGONIST; SUBSTANCE P; UNCLASSIFIED DRUG;

ADVERSE MYOCARDIAL REMODELING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ADHESION; CELL FUNCTION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; ELEVATED BLOOD PRESSURE; EXTRACELLULAR MATRIX; FIBROBLAST; GENE; GENE CONTROL; GENE EXPRESSION; GENE INDUCTION; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HEART VENTRICLE HYPERTROPHY; HYPERTENSION; HYPERTROPHY; MOLECULAR MECHANICS; MYOCARDIAL DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INDUCTION; RAT; RECEPTOR BLOCKING; REGULATORY MECHANISM; SPONTANEOUSLY HYPERTENSIVE RAT; TAC1 GENE; UPREGULATION;

CARDIAC FIBROBLAST; FETAL GENES; FIBROSIS; HYPERTROPHY; SUBSTANCE P;

ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEART VENTRICLES; HYPERTENSION; MYOCYTES, CARDIAC; POLYMERASE CHAIN REACTION; PREGNANCY; PREGNANCY, ANIMAL; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RECEPTORS, NEUROKININ-1; RNA, MESSENGER; SUBSTANCE P; VENTRICULAR FUNCTION, LEFT; VENTRICULAR REMODELING;

EID: 84886395013     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2013.07.190     Document Type: Article

References (38)

1. S. Nakanishi Mammalian tachykinin receptors Annu Rev Neurosci 14 1991 123 136
2. M. Reinecke, E. Weihe, and W.G. Forssmann Substance P-immunoreactive nerve fibers in the heart Neurosci Lett 20 1980 265 269
3. J. Wharton, J.M. Polak, G.P. McGregor, A.E. Bishop, and S.R. Bloom The distribution of substrate P-like immunoreactive nerves in the guinea-pig heart Neuroscience 6 1981 2193 2204
4. C.J. Dalsgaard, A. Franco-Cereceda, and A. Saria Distribution and origin of substance P- and neuropeptide Y-immunoreactive nerves in the guinea-pig heart Cell Tissue Res 243 1986 477 485
5. P. Milner, V. Ralevic, and A.M. Hopwood Ultrastructural localisation of substance P and choline acetyltransferase in endothelial cells of rat coronary artery and release of substance P and acetylcholine during hypoxia Experientia 15 45 1989 121 125
6. M. D'Souza, M.A. Garza, and M. Xie Substance P is associated with heart enlargement and apoptosis in murine dilated cardiomyopathy induced by Taenia crassiceps infection J Parasitol 93 2007 1121 1127
7. P. Robinson, A. Garza, and J. Moore Substance P is required for the pathogenesis of EMCV infection in mice Int J Clin Exp Med 2 2009 76 86
8. G.C. Melendez, J. Li, and B.A. Law Substance P induces adverse myocardial remodeling via a mechanism involving cardiac mast cells Cardiovasc Res 92 2011 420 429
9. I.T. Mak, J.J. Chmielinska, J.H. Kramer, C.F. Spurney, and W.B. Weglicki Loss of neutral endopeptidase activity contributes to neutrophil activation and cardiac dysfunction during chronic hypomagnesemia: protection by substance P receptor blockade Exp Clin Cardiol 16 2011 121 124
10. J.H. Kramer, T.M. Phillips, and W.B. Weglicki Magnesium-deficiency- enhanced post-ischemic myocardial injury is reduced by substance P receptor blockade J Mol Cell Cardiol 29 1997 97 110
11. W.B. Weglicki, I.T. Mak, and T.M. Phillips Blockade of cardiac inflammation in Mg2 + deficiency by substance P receptor inhibition Circ Res 74 1994 1009 1013
12. M.O. Boluyt, and O.H. Bing Matrix gene expression and decompensated heart failure: the aged SHR model Cardiovasc Res 46 2000 239 249
13. B.J. Wilkins, Y.S. Dai, and O.F. Bueno Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy Circ Res 94 2004 110 118
14. D.J. Church, S.J. Arkinstall, and M.B. Vallotton Stimulation of atrial natriuretic peptide release by neurokinins in neonatal rat ventricular cardiomyocytes Am J Physiol 270 1996 H935 H944
15. H. Ehmke, J. Faulhaber, K. Munter, M. Kirchengast, and R.J. Wiesner Chronic ETA receptor blockade attenuates cardiac hypertrophy independently of blood pressure effects in renovascular hypertensive rats Hypertension 33 1999 954 960
16. V. Polyakova, S. Hein, S. Kostin, T. Ziegelhoeffer, and J. Schaper Matrix metalloproteinases and their tissue inhibitors in pressure-overloaded human myocardium during heart failure progression J Am Coll Cardiol 44 2004 1609 1618
17. M.R. Zile, C.F. Baicu, and R.E. Stroud Pressure overload-dependent membrane type 1-matrix metalloproteinase induction: relationship to LV remodeling and fibrosis Am J Physiol Heart Circ Physiol 302 2012 H1429 H1437
18. W.M. Yarbrough, R. Mukherjee, and R.E. Stroud Progressive induction of left ventricular pressure overload in a large animal model elicits myocardial remodeling and a unique matrix signature J Thorac Cardiovasc Surg 143 2012 215 223
19. K. Koli, J. Saharinen, M. Hyytiainen, C. Penttinen, and J. Keski-Oja Latency, activation, and binding proteins of TGF-beta Microsc Res Tech 52 2001 354 362
20. S.L. Dallas, P. Sivakumar, and C.J. Jones Fibronectin regulates latent transforming growth factor-beta (TGF beta) by controlling matrix assembly of latent TGF beta-binding protein-1 J Biol Chem 280 2005 18871 18880
21. E.R. Neptune, P.A. Frischmeyer, and D.E. Arking Dysregulation of TGF-beta activation contributes to pathogenesis in Marfan syndrome Nat Genet 33 2003 407 411
22. D.B. Rifkin Latent transforming growth factor-beta (TGF-beta) binding proteins: orchestrators of TGF-beta availability J Biol Chem 280 2005 7409 7412
23. X.H. Feng, and R. Derynck Specificity and versatility in TGF-beta signaling through Smads Annu Rev Cell Dev Biol 21 2005 659 693
24. A. Bobik Transforming growth factor-betas and vascular disorders Arterioscler Thromb Vasc Biol 26 2006 1712 1720
25. A.K. Ghosh Factors involved in the regulation of type I collagen gene expression: implication in fibrosis Exp Biol Med (Maywood) 227 2002 301 314
26. H. Matsusaka, T. Ide, and S. Matsushima Targeted deletion of matrix metalloproteinase 2 ameliorates myocardial remodeling in mice with chronic pressure overload Hypertension 47 2006 711 717
27. F.G. Spinale, J.S. Janicki, and M.R. Zile Membrane-associated matrix proteolysis and heart failure Circ Res 112 2013 195 208
28. G. Fong, L.J. Backman, and D.A. Hart Substance P enhances collagen remodeling and MMP-3 expression by human tenocytes J Orthop Res 31 2013 91 98
29. C. Kumaran, and K. Shivakumar Calcium- and superoxide anion-mediated mitogenic action of substance P on cardiac fibroblasts Am J Physiol Heart Circ Physiol 282 2002 H1855 H1862
30. N. Yamada, R. Yanai, M. Inui, and T. Nishida Sensitizing effect of substance P on corneal epithelial migration induced by IGF-1, fibronectin, or interleukin-6 Invest Ophthalmol Vis Sci 46 2005 833 839
31. A.H.Y. Lau, S.S.M. Chow, and Y.S. Ng Immunologically induced histamine release from rat peritoneal mast cells is enhanced by low levels of substance P Eur J Pharmacol 414 2001 295 303
32. P. Kong, P. Christia, and N.G. Frangogiannis The pathogenesis of cardiac fibrosis Cell Mol Life Sci 2013 10.1007/s00018-013-1349-6
33. D.B. Hoover Effects of substance P on rate and perfusion pressure in the isolated guinea pig heart J Pharmacol Exp Ther 252 1990 179 184
34. E.E. Ustinova, D. Bergren, and H.D. Schultz Neuropeptide depletion impairs postischemic recovery of the isolated rat heart: role of substance P Cardiovasc Res 30 1995 55 63
35. L. Wang, and D.H. Wang TRPV1 gene knockout impairs postischemic recovery in isolated perfused heart in mice Circulation 112 2005 3617 3623
36. B. Zhong, and D.H. Wang TRPV1 gene knockout impairs preconditioning protection against myocardial injury in isolated perfused hearts in mice Am J Physiol Heart Circ Physiol 293 2007 H1791 H1798
37. P.W. Mantyh, C.J. Allen, and J.R. Ghilardi Rapid endocytosis of a G protein-coupled receptor: substance P evoked internalization of its receptor in the rat striatum in vivo Proc Natl Acad Sci U S A 92 1995 2622 2626
38. S. Valdemarsson, L. Edvinsson, R. Ekman, P. Hedner, and A. Sjoholm Increased plasma level of substance P in patients with severe congestive heart failure treated with ACE inhibitors J Intern Med 230 1991 325 331