메뉴 건너뛰기




Volumn 13, Issue 10, 2013, Pages 1207-1218

Advanced non-small-cell lung cancer with epidermal growth factor receptor mutations: Current evidence and future perspectives

Author keywords

afatinib; clinical trials; dacomitinib; EGFR; erlotinib; gefitinib; neratinib; NSCLC

Indexed keywords

AFATINIB; ANTINEOPLASTIC AGENT; B RAF KINASE; BRCA1 PROTEIN; CARBOPLATIN; CISPLATIN; DACOMITINIB; DOCETAXEL; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ERLOTINIB; GEFITINIB; GEMCITABINE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; NERATINIB; PACLITAXEL; PEMETREXED; PHOSPHATIDYLINOSITOL 3 KINASE; PLATINUM COMPLEX; PROTEIN TYROSINE KINASE INHIBITOR;

EID: 84886390038     PISSN: 14737140     EISSN: 17448328     Source Type: Journal    
DOI: 10.1586/14737140.2013.845092     Document Type: Review
Times cited : (12)

References (75)
  • 1
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch TJ, Bell DW, Sordella R et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N. Med. 350(21), 2129-2139 (2004).
    • (2004) N. Med. , vol.350 , Issue.21 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3
  • 2
    • 4444344330 scopus 로고    scopus 로고
    • EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
    • Pao W, Miller V, Zakowski M et al. EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc. Natl Acad. Sci. USA 101(36), 13306-13311 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , Issue.36 , pp. 13306-13311
    • Pao, W.1    Miller, V.2    Zakowski, M.3
  • 3
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
    • Paez JG, Janne PA, Lee JC et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 304(5676), 1497-1500 (2004).
    • (2004) Science , vol.304 , Issue.5676 , pp. 1497-1500
    • Paez, J.G.1    Janne, P.A.2    Lee, J.C.3
  • 4
    • 0041629450 scopus 로고    scopus 로고
    • Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer
    • Mendelsohn J, Baselga J. Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer. J. Clin. Oncol. 21(14), 2787-2799 (2003).
    • (2003) J. Clin. Oncol. , vol.21 , Issue.14 , pp. 2787-2799
    • Mendelsohn, J.1    Baselga, J.2
  • 5
    • 40849147041 scopus 로고    scopus 로고
    • EGFR antagonist in cancer treatment
    • Ciardiello F, Tortora G. EGFR Antagonist in Cancer Treatment. N. Engl. J. Med. 358, 1160-1174 (2008).
    • (2008) N. Engl. J. Med. , vol.358 , pp. 1160-1174
    • Ciardiello, F.1    Tortora, G.2
  • 6
    • 84856928052 scopus 로고    scopus 로고
    • The role of epidermal growth factor receptor tyrosine kinase inhibitors in the treatment of advanced stage non-small cell lung cancer
    • Voon PJ, Cho BC, Yeo WL, Soo RA. The role of epidermal growth factor receptor tyrosine kinase inhibitors in the treatment of advanced stage non-small cell lung cancer. J. Thorac. Dis. 2(3), 144-153 (2010).
    • (2010) J. Thorac. Dis. , vol.2 , Issue.3 , pp. 144-153
    • Voon, P.J.1    Cho, B.C.2    Yeo, W.L.3    Soo, R.A.4
  • 7
    • 36949005161 scopus 로고    scopus 로고
    • Methodological issues of clinical research with EGFR inhibitors
    • Morabito A, Piccirillo MC, Monaco K et al. Methodological issues of clinical research with EGFR inhibitors. Curr. Cancer Ther. Rev. 3, 292-302 (2007).
    • (2007) Curr. Cancer Ther. Rev. , vol.3 , pp. 292-302
    • Morabito, A.1    Piccirillo, M.C.2    Monaco, K.3
  • 8
    • 20044364940 scopus 로고    scopus 로고
    • Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancer
    • Shigematsu H, Lin L, Takahashi T et al. Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancer. J. Natl Cancer Inst. 97(5), 339-346 (2005).
    • (2005) J. Natl Cancer Inst. , vol.97 , Issue.5 , pp. 339-346
    • Shigematsu, H.1    Lin, L.2    Takahashi, T.3
  • 9
    • 33947498978 scopus 로고    scopus 로고
    • Molecular predictors of response to epidermal growth factor receptor antagonists in non-small-cell lung cancer
    • Sequist LV, Bell DW, Lynch TJ, Haber DA. Molecular predictors of response to epidermal growth factor receptor antagonists in non-small-cell lung cancer. J. Clin. Oncol. 25(5), 587-595 (2007).
    • (2007) J. Clin. Oncol. , vol.25 , Issue.5 , pp. 587-595
    • Sequist, L.V.1    Bell, D.W.2    Lynch, T.J.3    Haber, D.A.4
  • 10
    • 77958478674 scopus 로고    scopus 로고
    • Rational, biologically based treatment of EGFR mutant non-small-cell lung cancer
    • Pao W, Chmielecki J. Rational, biologically based treatment of EGFR mutant non-small-cell lung cancer. Nat. Rev. Cancer 10(11), 760-774 (2010).
    • (2010) Nat. Rev. Cancer , vol.10 , Issue.11 , pp. 760-774
    • Pao, W.1    Chmielecki, J.2
  • 11
    • 68949201629 scopus 로고    scopus 로고
    • Activating and resistance mutations of EGFR in non-small-cell lung cancer: Role in clinical response to EGFR tyrosine kinase inhibitors
    • Gazdar AF. Activating and resistance mutations of EGFR in non-small-cell lung cancer: role in clinical response to EGFR tyrosine kinase inhibitors. Oncogene 28 (Suppl. 1), S24-S31 (2009).
    • (2009) Oncogene , vol.28 , Issue.SUPPL. 1
    • Gazdar, A.F.1
  • 12
    • 33847406095 scopus 로고    scopus 로고
    • Structures of lung cancer-derived EGFR mutants and inhibitor complexes: Mechanism of activation and insights into differential inhibitor sensitivity
    • Yun CH, Boggon TJ, Li Y et al. Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity. Cancer Cell. 11(3), 217-227 (2007).
    • (2007) Cancer Cell. , vol.11 , Issue.3 , pp. 217-227
    • Yun, C.H.1    Boggon, T.J.2    Li, Y.3
  • 13
    • 33847323129 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mutations in lung cancer
    • Sharma SV, Bell DW, Settleman J, Haber DA. Epidermal growth factor receptor mutations in lung cancer. Nat. Rev. Cancer 7(3), 169-181 (2007).
    • (2007) Nat. Rev. Cancer , vol.7 , Issue.3 , pp. 169-181
    • Sharma, S.V.1    Bell, D.W.2    Settleman, J.3    Haber, D.A.4
  • 15
    • 45149084723 scopus 로고    scopus 로고
    • First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations
    • Sequist LV, Martins RG, Spigel D et al First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations. J. Clin. Oncol. 26(15), 2442-2449 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.15 , pp. 2442-2449
    • Sequist, L.V.1    Martins, R.G.2    Spigel, D.3
  • 16
    • 69949162760 scopus 로고    scopus 로고
    • Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
    • Mok TS, Wu YL, Thongprasert S et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N. Engl. J. Med. 361(10), 947-957 (2009).
    • (2009) N. Engl. J. Med. , vol.361 , Issue.10 , pp. 947-957
    • Mok, T.S.1    Wu, Y.L.2    Thongprasert, S.3
  • 17
    • 84861976809 scopus 로고    scopus 로고
    • First-SIGNAL: First-line single-agent iressa versus gemcitabine and cisplatin trial in never-smokers with adenocarcinoma of the lung
    • Han JY, Park K, Kim SW et al. First-SIGNAL: first-line single-agent iressa versus gemcitabine and cisplatin trial in never-smokers with adenocarcinoma of the lung. J. Clin. Oncol. 30(10), 1122-1128 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , Issue.10 , pp. 1122-1128
    • Han, J.Y.1    Park, K.2    Kim, S.W.3
  • 18
    • 75249087060 scopus 로고    scopus 로고
    • Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): An open label, randomized phase 3 trial
    • Mitsudomi T, Morita S, Negoro S et al Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomized phase 3 trial. Lancet Oncol. 11(2), 121-128 (2010).
    • (2010) Lancet Oncol. , vol.11 , Issue.2 , pp. 121-128
    • Mitsudomi, T.1    Morita, S.2    Negoro, S.3
  • 19
    • 77953930730 scopus 로고    scopus 로고
    • Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR
    • Maemondo M, Inoue A, Kobayashi K et al. Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N. Engl. J. Med. 362(25), 2380-2388 (2010)
    • (2010) N. Engl. J. Med. , vol.362 , Issue.25 , pp. 2380-2388
    • Maemondo, M.1    Inoue, A.2    Kobayashi, K.3
  • 20
    • 79960702788 scopus 로고    scopus 로고
    • Biomarker analyses and final overall survival results from a phase III, randomized, open-label, first-line study of gefitinib versus carboplatin/paclitaxel in clinically selected patients with advanced non-small-cell lung cancer in Asia (IPASS)
    • Fukuoka M, Wu YL, Thongprasert S et al. Biomarker analyses and final overall survival results from a phase III, randomized, open-label, first-line study of gefitinib versus carboplatin/paclitaxel in clinically selected patients with advanced non-small-cell lung cancer in Asia (IPASS). J. Clin. Oncol. 29(21), 2866-2874 (2012).
    • (2012) J. Clin. Oncol. , vol.29 , Issue.21 , pp. 2866-2874
    • Fukuoka, M.1    Wu, Y.L.2    Thongprasert, S.3
  • 21
    • 80054882063 scopus 로고    scopus 로고
    • Health-related quality-of-life in a randomized phase III first-line study of gefitinib versus carboplatin/paclitaxel in clinically selected patients from Asia with advanced NSCLC (IPASS)
    • Thongprasert S, Duffield E, Saijo N et al Health-related quality-of-life in a randomized phase III first-line study of gefitinib versus carboplatin/paclitaxel in clinically selected patients from Asia with advanced NSCLC (IPASS). J. Thorac. Oncol 6(11), 1872-1880 (2011).
    • (2011) J. Thorac. Oncol , vol.6 , Issue.11 , pp. 1872-1880
    • Thongprasert, S.1    Duffield, E.2    Saijo, N.3
  • 22
    • 84886407696 scopus 로고    scopus 로고
    • Efficacy, safety and tolerability results from a phase IV, open-label, single arm study of 1st-line gefitinib in Caucasian patients (pts) with epidermal growth factor receptor (EGFR) mutation-positive non-small-cell lung cancer (NSCLC)
    • Douillard JY, Ostoros G, Cobo M et al. Efficacy, safety and tolerability results from a phase IV, open-label, single arm study of 1st-line gefitinib in Caucasian patients (pts) with epidermal growth factor receptor (EGFR) mutation-positive non-small-cell lung cancer (NSCLC). Lung Cancer. 80 (Suppl. 1), S31 (2013).
    • (2013) Lung Cancer. , vol.80 , Issue.SUPPL. 1
    • Douillard, J.Y.1    Ostoros, G.2    Cobo, M.3
  • 23
    • 69949186250 scopus 로고    scopus 로고
    • Screening for epidermal growth factor receptor mutations in lung cancer
    • Rosell R, Moran T, Queralt C et al. Screening for epidermal growth factor receptor mutations in lung cancer. N. Engl. J. Med. 361(10), 958-967 (2009).
    • (2009) N. Engl. J. Med. , vol.361 , Issue.10 , pp. 958-967
    • Rosell, R.1    Moran, T.2    Queralt, C.3
  • 24
    • 79960889662 scopus 로고    scopus 로고
    • Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): A multicenter, open-label, randomized, phase 3 study
    • Zhou C, Wu YL, Chen G et al. Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicenter, open-label, randomized, phase 3 study. Lancet Oncol. 12(8), 735-742 (2011).
    • (2011) Lancet Oncol. , vol.12 , Issue.8 , pp. 735-742
    • Zhou, C.1    Wu, Y.L.2    Chen, G.3
  • 25
    • 84857502654 scopus 로고    scopus 로고
    • Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): A multicenter, open-label, randomised phase 3 trial
    • Rosell R, Carcereny E, Gervais R et al. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicenter, open-label, randomised phase 3 trial. Lancet Oncol. 13(3), 239-246 (2012).
    • (2012) Lancet Oncol. , vol.13 , Issue.3 , pp. 239-246
    • Rosell, R.1    Carcereny, E.2    Gervais, R.3
  • 26
    • 84878471164 scopus 로고    scopus 로고
    • Quality of life (QoL) analyses from OPTIMAL (CTONG-0802), a phase III, randomised, open-label study of first-line erlotinib versus chemotherapy in patients with advanced EGFR mutation-positive non-small-cell lung cancer (NSCLC)
    • Chen G, Feng J, Zhou C, et al. Quality of life (QoL) analyses from OPTIMAL (CTONG-0802), a phase III, randomised, open-label study of first-line erlotinib versus chemotherapy in patients with advanced EGFR mutation-positive non-small-cell lung cancer (NSCLC). Ann. Oncol. 24(6), 1615-1622 (2013).
    • (2013) Ann. Oncol. , vol.24 , Issue.6 , pp. 1615-1622
    • Chen, G.1    Feng, J.2    Zhou, C.3
  • 27
    • 84886441762 scopus 로고    scopus 로고
    • Overall survival (OS) results from OPTIMAL (CTONG0802), a phase III trial of erlotinib (E) versus carboplatin plus gemcitabine (GC) as first-line treatment for Chinese patients with EGFR mutation-positive advanced non-small cell lung cancer (NSCLC)
    • Chicago, IL, USA, 1-5 June 2012 (Abstract 7520
    • Zhou C, Wu YL, Liu X et al. Overall survival (OS) results from OPTIMAL (CTONG0802), a phase III trial of erlotinib (E) versus carboplatin plus gemcitabine (GC) as first-line treatment for Chinese patients with EGFR mutation-positive advanced non-small cell lung cancer (NSCLC). 2012 ASCO Annual Meeting. Chicago, IL, USA, 1-5 June 2012 (Abstract 7520).
    • 2012 ASCO Annual Meeting
    • Zhou, C.1    Wu, Y.L.2    Liu, X.3
  • 28
    • 83555166254 scopus 로고    scopus 로고
    • Randomized phase II study of gefitinib versus erlotinib in patients with advanced non-small cell lung cancer who failed previous chemotherapy
    • Kim ST, Uhm JE, Lee J et al. Randomized phase II study of gefitinib versus erlotinib in patients with advanced non-small cell lung cancer who failed previous chemotherapy. Lung Cancer 75(1), 82-88 (2012).
    • (2012) Lung Cancer , vol.75 , Issue.1 , pp. 82-88
    • Kim, S.T.1    Uhm, J.E.2    Lee, J.3
  • 29
    • 58149333768 scopus 로고    scopus 로고
    • Acquired resistance to epidermal growth factor receptor kinase inhibitors associated with a novel T854A mutation in a patient with EGFR-mutant lung adenocarcinoma
    • Bean J, Riely GJ, Balak M et al. Acquired resistance to epidermal growth factor receptor kinase inhibitors associated with a novel T854A mutation in a patient with EGFR-mutant lung adenocarcinoma. Clin. Cancer Res. 14(22), 7519-7525 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , Issue.22 , pp. 7519-7525
    • Bean, J.1    Riely, G.J.2    Balak, M.3
  • 30
    • 49149118719 scopus 로고    scopus 로고
    • BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models
    • Li D, Ambrogio L, Shimamura T et al. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene 27(34), 4702-4711 (2008).
    • (2008) Oncogene , vol.27 , Issue.34 , pp. 4702-4711
    • Li, D.1    Ambrogio, L.2    Shimamura, T.3
  • 31
    • 21144439000 scopus 로고    scopus 로고
    • Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib
    • Kwak EL, Sordella R, Bell DW et al. Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib. Proc. Natl Acad. Sci. USA 102(21), 7665-7670 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , Issue.21 , pp. 7665-7670
    • Kwak, E.L.1    Sordella, R.2    Bell, D.W.3
  • 32
    • 84862819699 scopus 로고    scopus 로고
    • Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): A phase 2 trial
    • Yang JC, Shih JY, Su WC et al. Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): a phase 2 trial. Lancet Oncol. 13(5), 539-548 (2012).
    • (2012) Lancet Oncol. , vol.13 , Issue.5 , pp. 539-548
    • Yang, J.C.1    Shih, J.Y.2    Su, W.C.3
  • 33
    • 84884736973 scopus 로고    scopus 로고
    • Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations
    • Sequist LV, Yang J-CH, Yamamoto N et al. Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations. J. Clin. Oncol. 31(27), 3327-3334 (2013).
    • (2013) J. Clin. Oncol. , vol.31 , Issue.27 , pp. 3327-3334
    • Sequist, L.V.1    J-Ch, Y.2    Yamamoto, N.3
  • 34
    • 84884659258 scopus 로고    scopus 로고
    • LUX-Lung 6: A randomized, open-label, phase III study of afatinib (A) versus gemcitabine/cisplatin (GC) as first-line treatment for Asian patients (pts) with EGFR mutation-positive (EGFR M+) advanced adenocarcinoma of the lung
    • Abstract 8016
    • Wu YL, Zhou C, Hu CP et al. LUX-Lung 6: a randomized, open-label, phase III study of afatinib (A) versus gemcitabine/cisplatin (GC) as first-line treatment for Asian patients (pts) with EGFR mutation-positive (EGFR M+) advanced adenocarcinoma of the lung. J. Clin. Oncol. 31(Suppl.), Abstract 8016 (2013).
    • (2013) J. Clin. Oncol. , vol.31 , Issue.SUPPL.
    • Wu, Y.L.1    Zhou, C.2    Hu, C.P.3
  • 35
    • 84884658724 scopus 로고    scopus 로고
    • LUX-Lung 6: Patient-reported outcomes (PROs) from a randomized open-label phase III study in first-line advanced NSCLC patients (pts) harboring epidermal growth factor receptor (EGFR) mutations
    • Abstract 8061
    • Greater SL, Zhou C, Hu CP et al. LUX-Lung 6: Patient-reported outcomes (PROs) from a randomized open-label, phase III study in first-line advanced NSCLC patients (pts) harboring epidermal growth factor receptor (EGFR) mutations. J. Clin. Oncol. 31(Suppl.), Abstract 8061 (2013).
    • (2013) J. Clin. Oncol. , vol.31 , Issue.SUPPL.
    • Greater, S.L.1    Zhou, C.2    Hu, C.P.3
  • 36
    • 71649091295 scopus 로고    scopus 로고
    • Efficacy and safety of PF-00299804 (PF299) in patients (pt) with advanced NSCLC after failure of at least one prior chemotherapy regimen and prior treatment with erlotinib (E): A two-arm, phase II trial
    • Abstract 8063
    • Janne P, Reckamp K, Koczywas M et al. Efficacy and safety of PF-00299804 (PF299) in patients (pt) with advanced NSCLC after failure of at least one prior chemotherapy regimen and prior treatment with erlotinib (E): A two-arm, phase II trial. J. Clin. Oncol. 27 (Suppl.), 15s, Abstract 8063 (2009)
    • (2009) J. Clin. Oncol. , vol.27 , Issue.SUPPL.
    • Janne, P.1    Reckamp, K.2    Koczywas, M.3
  • 37
    • 84866255620 scopus 로고    scopus 로고
    • Randomized phase II study of dacomitinib (PF-00299804), an irreversible pan-human epidermal growth factor receptor inhibitor, versus erlotinib in patients with advanced non-small-cell lung cancer
    • Ramalingam SS, Blackhall F, Krzakowski M et al. Randomized phase II study of dacomitinib (PF-00299804), an irreversible pan-human epidermal growth factor receptor inhibitor, versus erlotinib in patients with advanced non-small-cell lung cancer. J. Clin. Oncol. 30(27), 3337-3344 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , Issue.27 , pp. 3337-3344
    • Ramalingam, S.S.1    Blackhall, F.2    Krzakowski, M.3
  • 38
    • 77954584507 scopus 로고    scopus 로고
    • Neratinib, an irreversible pan-ErbB receptor tyrosine kinase inhibitor: Results of a phase II in patients with advanced non-small-cell lung cancer
    • Sequist LV, Beese B, Lynch TJ et al. Neratinib, an irreversible pan-ErbB receptor tyrosine kinase inhibitor: results of a phase II in patients with advanced non-small-cell lung cancer. J. Clin. Oncol. 28(18), 3076-3083 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.18 , pp. 3076-3083
    • Sequist, L.V.1    Beese, B.2    Lynch, T.J.3
  • 39
    • 35648965243 scopus 로고    scopus 로고
    • Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas
    • Gong Y, Somwar R, Politi K et al. Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas. PLoS Med. 4(10), e294 (2007).
    • (2007) PLoS Med. , vol.4 , Issue.10
    • Gong, Y.1    Somwar, R.2    Politi, K.3
  • 40
    • 79952264325 scopus 로고    scopus 로고
    • Pretreatment EGFR T790M mutation and BRAC1 mRNA expression in erlotinib-treated advanced non-small-cell lung cancer patients with EGFR mutations
    • Rosell R, Molina MA, Costa C et al. Pretreatment EGFR T790M mutation and BRAC1 mRNA expression in erlotinib-treated advanced non-small-cell lung cancer patients with EGFR mutations. Clin. Cancer Res. 17(5), 1160-1168 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , Issue.5 , pp. 1160-1168
    • Rosell, R.1    Molina, M.A.2    Costa, C.3
  • 41
    • 79953046542 scopus 로고    scopus 로고
    • FAS and NF-kappaB signalling modulate dependence of lung cancers on mutant EGFR
    • Bivona TG, Hieronymus H, Parker J et al. FAS and NF-kappaB signalling modulate dependence of lung cancers on mutant EGFR. Nature 471(7339), 523-526, (2011).
    • (2011) Nature , vol.471 , Issue.7339 , pp. 523-526
    • Bivona, T.G.1    Hieronymus, H.2    Parker, J.3
  • 42
    • 74949110711 scopus 로고    scopus 로고
    • Clinical definition of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer
    • Jackman D, Pao W, Riely GJ et al. Clinical definition of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer. J. Clin. Oncol. 28(2), 357-360 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.2 , pp. 357-360
    • Jackman, D.1    Pao, W.2    Riely, G.J.3
  • 43
    • 18244371651 scopus 로고    scopus 로고
    • Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
    • Pao W, Miller VA, Politi KA et al. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med. 2(3), e73 (2005).
    • (2005) PLoS Med. , vol.2 , Issue.3
    • Pao, W.1    Miller, V.A.2    Politi, K.A.3
  • 44
    • 33750302365 scopus 로고    scopus 로고
    • Analysis of epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer and acquired resistance to gefitinib
    • Kosaka T, Yatabe Y, Endoh H et al. Analysis of epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer and acquired resistance to gefitinib. Clin. Cancer Res. 12(19), 5764-5769 (2006).
    • (2006) Clin. Cancer Res. , vol.12 , Issue.19 , pp. 5764-5769
    • Kosaka, T.1    Yatabe, Y.2    Endoh, H.3
  • 45
    • 40049099220 scopus 로고    scopus 로고
    • The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP
    • Yun CH, Mengwasser KE, Toms AV et al. The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP. Proc. Natl. Acad. Sci. USA 105(6), 2070-2075 (2008).
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , Issue.6 , pp. 2070-2075
    • Yun, C.H.1    Mengwasser, K.E.2    Toms, A.V.3
  • 46
    • 51049116207 scopus 로고    scopus 로고
    • Lung cancer with epidermal growth factor receptor exon 20 mutations is associated with poor gefitinib treatment response
    • Wu JY, Wu SG, Yang CH et al. Lung cancer with epidermal growth factor receptor exon 20 mutations is associated with poor gefitinib treatment response. Clin. Cancer Res. 14(15), 4877-4882 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , Issue.15 , pp. 4877-4882
    • Wu, J.Y.1    Wu, S.G.2    Yang, C.H.3
  • 47
    • 84880887864 scopus 로고    scopus 로고
    • Activity of Gefitinib in a non-small-cell lung cancer patient with both activating and resistance EGFR mutations
    • Morabito A, Costanzo R, Rachiglio AM, et al. Activity of Gefitinib in a non-small-cell lung cancer patient with both activating and resistance EGFR mutations. J. Thorac. Oncol. 8(7), e59-e60 (2013).
    • (2013) J. Thorac. Oncol. , vol.8 , Issue.7
    • Morabito, A.1    Costanzo, R.2    Rachiglio, A.M.3
  • 48
    • 34249075147 scopus 로고    scopus 로고
    • MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
    • Engelman JA, Zejnullahu K, Mitsudomi T et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 316(5827), 1039-1043 (2007).
    • (2007) Science , vol.316 , Issue.5827 , pp. 1039-1043
    • Engelman, J.A.1    Zejnullahu, K.2    Mitsudomi, T.3
  • 49
    • 84867760241 scopus 로고    scopus 로고
    • HER2 amplification: A potential mechanism of acquired resistance to EGFR inhibition in EGFR-mutant lung cancers that lack the second-site EGFRT790M mutation
    • Takezawa K, Pirazzoli V, Arcila ME et al. HER2 amplification: a potential mechanism of acquired resistance to EGFR inhibition in EGFR-mutant lung cancers that lack the second-site EGFRT790M mutation. Cancer Discov. 2(10), 922-933 (2012).
    • (2012) Cancer Discov. , vol.2 , Issue.10 , pp. 922-933
    • Takezawa, K.1    Pirazzoli, V.2    Arcila, M.E.3
  • 50
    • 79953118839 scopus 로고    scopus 로고
    • Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors
    • Sequist LV, Waltman BA, Dias-Santagata D et al. Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors. Sci. Transl. Med. 3(75), 75ra26 (2011).
    • (2011) Sci. Transl. Med. , vol.3 , Issue.75
    • Sequist, L.V.1    Waltman, B.A.2    Dias-Santagata, D.3
  • 51
    • 84864524696 scopus 로고    scopus 로고
    • Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1
    • Ohashi K, Sequist LV, Arcila ME et al. Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1. Proc. Natl Acad. Sci. USA 109(31), E2127-E2133 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , Issue.31
    • Ohashi, K.1    Sequist, L.V.2    Arcila, M.E.3
  • 52
    • 84864402225 scopus 로고    scopus 로고
    • Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer
    • Zhang Z, Lee JC, Lin L, et al. Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer. Nat. Genet. 44(8), 852-860 (2012).
    • (2012) Nat. Genet. , vol.44 , Issue.8 , pp. 852-860
    • Zhang, Z.1    Lee, J.C.2    Lin, L.3
  • 53
    • 84868010326 scopus 로고    scopus 로고
    • Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors
    • Ercan D, Xu C, Yanagita M, et al. Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors. Cancer Discov. 2(10), 934-947 (2012).
    • (2012) Cancer Discov. , vol.2 , Issue.10 , pp. 934-947
    • Ercan, D.1    Xu, C.2    Yanagita, M.3
  • 54
    • 84875950992 scopus 로고    scopus 로고
    • Epidermal growth factor receptor tyrosine kinase inhibitor-resistant disease
    • Ohashi K, Maruvka YE, Michor F, Pao W. Epidermal growth factor receptor tyrosine kinase inhibitor-resistant disease. J. Clin. Oncol. 31(8), 1070-1080 (2013).
    • (2013) J. Clin. Oncol. , vol.31 , Issue.8 , pp. 1070-1080
    • Ohashi, K.1    Maruvka, Y.E.2    Michor, F.3    Pao, W.4
  • 55
    • 80054730405 scopus 로고    scopus 로고
    • Efficacy of increased-dose erlotinib for central nervous system metastases in non-small cell lung cancer patients with epidermal growth factor receptor mutation
    • Togashi Y, Masago K, Fukudo M et al. Efficacy of increased-dose erlotinib for central nervous system metastases in non-small cell lung cancer patients with epidermal growth factor receptor mutation. Cancer Chemother. Pharmacol. 68(4), 1089-1092 (2011).
    • (2011) Cancer Chemother. Pharmacol. , vol.68 , Issue.4 , pp. 1089-1092
    • Togashi, Y.1    Masago, K.2    Fukudo, M.3
  • 56
    • 78650390328 scopus 로고    scopus 로고
    • Development of central nervous system metastases in patients with advanced non-small cell lung cancer and somatic EGFR mutations treated with gefitinib or erlotinib
    • Heon S, Yeap BY, Britt GJ et al. Development of central nervous system metastases in patients with advanced non-small cell lung cancer and somatic EGFR mutations treated with gefitinib or erlotinib. Clin. Cancer Res. 16(23), 5873-5882 (2010).
    • (2010) Clin. Cancer Res. , vol.16 , Issue.23 , pp. 5873-5882
    • Heon, S.1    Yeap, B.Y.2    Britt, G.J.3
  • 57
    • 84871087595 scopus 로고    scopus 로고
    • Clinical modes of EGFR tyrosine kinase inhibitor failure and subsequent management in advanced non-small cell lung cancer
    • Yang JJ, Chen HJ, Yan HH, et al. Clinical modes of EGFR tyrosine kinase inhibitor failure and subsequent management in advanced non-small cell lung cancer. Lung Cancer 79(1), 33-39 (2013).
    • (2013) Lung Cancer , vol.79 , Issue.1 , pp. 33-39
    • Yang, J.J.1    Chen, H.J.2    Yan, H.H.3
  • 58
    • 84946240088 scopus 로고    scopus 로고
    • Acquired resistance to targeted therapies in advanced non-small cell lung cancer: New strategies and new agents
    • West H, Oxnard GR, Doebele RC. Acquired resistance to targeted therapies in advanced non-small cell lung cancer: new strategies and new agents. ASCO Educational Book. Am. Soc. Clin. Oncol. e272-e278 (2013).
    • (2013) ASCO Educational Book. Am. Soc. Clin. Oncol.
    • West, H.1    Oxnard, G.R.2    Doebele, R.C.3
  • 59
    • 84877291745 scopus 로고    scopus 로고
    • Impact of EGFR inhibitor in non-small cell lung cancer on progression-free and overall survival: A meta-analysis
    • Lee CK, Brown C, Gralla RJ et al. Impact of EGFR inhibitor in non-small cell lung cancer on progression-free and overall survival: a meta-analysis. J. Natl Cancer Inst. 105(9), 595-605 (2013).
    • (2013) J. Natl Cancer Inst. , vol.105 , Issue.9 , pp. 595-605
    • Lee, C.K.1    Brown, C.2    Gralla, R.J.3
  • 60
    • 84871540705 scopus 로고    scopus 로고
    • Treating patients with EGFR-sensitizing mutations: First line or second line-is there a difference?
    • Mok T, Yang JJ, Lam KC. Treating patients with EGFR-sensitizing mutations: first line or second line-is there a difference? J. Clin. Oncol. 31(8), 1081-1088 (2013).
    • (2013) J. Clin. Oncol. , vol.31 , Issue.8 , pp. 1081-1088
    • Mok, T.1    Yang, J.J.2    Lam, K.C.3
  • 61
    • 84865154870 scopus 로고    scopus 로고
    • First-line erlotinib followed by second-line cisplatin-gemcitabine chemotherapy in advanced non-small-cell lung cancer: The TORCH randomized trial
    • Gridelli C, Ciardiello F, Gallo C et al. First-line erlotinib followed by second-line cisplatin-gemcitabine chemotherapy in advanced non-small-cell lung cancer: the TORCH randomized trial. J. Clin. Oncol. 30(24), 3002-3011 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , Issue.24 , pp. 3002-3011
    • Gridelli, C.1    Ciardiello, F.2    Gallo, C.3
  • 62
    • 84873166606 scopus 로고    scopus 로고
    • Radiographic assessment and therapeutic decisions at RECIST progression in EGFR-mutant NSCLC treated with EGFR tyrosine kinase inhibitors
    • Nishino M, Cardarella S, Dahlberg SE et al. Radiographic assessment and therapeutic decisions at RECIST progression in EGFR-mutant NSCLC treated with EGFR tyrosine kinase inhibitors. Lung Cancer 79(3), 283-288 (2013).
    • (2013) Lung Cancer , vol.79 , Issue.3 , pp. 283-288
    • Nishino, M.1    Cardarella, S.2    Dahlberg, S.E.3
  • 63
    • 79960085862 scopus 로고    scopus 로고
    • Optimization of dosing for EGFR-mutant non-small cell lung cancer with evolutionary cancer modelling
    • Chmielecki J, Foo J, Oxnard GR et al. Optimization of dosing for EGFR-mutant non-small cell lung cancer with evolutionary cancer modelling. Sci. Transl. Med. 3(90), 90ra59 (2011).
    • (2011) Sci. Transl. Med. , vol.3 , Issue.90
    • Chmielecki, J.1    Foo, J.2    Oxnard, G.R.3
  • 64
    • 79953688277 scopus 로고    scopus 로고
    • Phase II study of gefitinib readministration in patients with advanced non-small cell lung cancer and previous response to gefitinib
    • 5
    • Asahina H, Oizumi S, Inoue A et al. Phase II study of gefitinib readministration in patients with advanced non-small cell lung cancer and previous response to gefitinib. Oncology 79(5-6), 423-429 (2010).
    • (2010) Oncology , vol.79 , Issue.6 , pp. 423-429
    • Asahina, H.1    Oizumi, S.2    Inoue, A.3
  • 65
    • 80755128256 scopus 로고    scopus 로고
    • Retreatment with erlotinib: Regain of TKI sensitivity following a drug holiday for patients with NSCLC who initially responded to EGFR-TKI treatment
    • Becker A, Crombag L, Heideman DA et al. Retreatment with erlotinib: Regain of TKI sensitivity following a drug holiday for patients with NSCLC who initially responded to EGFR-TKI treatment. Eur. J. Cancer. 47(17), 2603-2606 (2011).
    • (2011) Eur. J. Cancer. , vol.47 , Issue.17 , pp. 2603-2606
    • Becker, A.1    Crombag, L.2    Heideman, D.A.3
  • 66
    • 77951643141 scopus 로고    scopus 로고
    • Amplification of EGFR T790M causes resistance to an irreversible EGFR inhibitor
    • Ercan D, Zejnullahu K, Yonesaka K et al. Amplification of EGFR T790M causes resistance to an irreversible EGFR inhibitor. Oncogene 29(16), 2346-2356 (2010).
    • (2010) Oncogene , vol.29 , Issue.16 , pp. 2346-2356
    • Ercan, D.1    Zejnullahu, K.2    Yonesaka, K.3
  • 67
    • 72949092456 scopus 로고    scopus 로고
    • Novel mutant-selective EGFR kinase inhibitors against EGFR T790M
    • Zhou W, Ercan D, Chen L et al. Novel mutant-selective EGFR kinase inhibitors against EGFR T790M. Nature 462(7276), 1070-1074 (2009).
    • (2009) Nature , vol.462 , Issue.7276 , pp. 1070-1074
    • Zhou, W.1    Ercan, D.2    Chen, L.3
  • 68
    • 84868451429 scopus 로고    scopus 로고
    • CO-1686, an orally available, mutant-selective inhibitor of the epidermal growth factor receptor (EGFR), causes tumor shrinkage in non-small cell lung cancer (NSCLC) with T790M mutations
    • Walter AO, Tjin R, Haringsma H et al. CO-1686, an orally available, mutant-selective inhibitor of the epidermal growth factor receptor (EGFR), causes tumor shrinkage in non-small cell lung cancer (NSCLC) with T790M mutations. Mol. Cancer Ther. 10 (11 Suppl. 1), C189 (2011).
    • (2011) Mol. Cancer Ther. , vol.10 , Issue.11 SUPPL. 1
    • Walter, A.O.1    Tjin, R.2    Haringsma, H.3
  • 69
    • 84875948814 scopus 로고    scopus 로고
    • AP26113 is a dual ALK/EGFR inhibitor: Characterization against EGFR T790M in cell and mouse models of NSCLC
    • Rivera VM, Wang F, Anjum R et al. AP26113 is a dual ALK/EGFR inhibitor: Characterization against EGFR T790M in cell and mouse models of NSCLC. Cancer Res. 72(Suppl. 72), 1794 (2012).
    • (2012) Cancer Res. , vol.72 , Issue.SUPPL. 72 , pp. 1794
    • Rivera, V.M.1    Wang, F.2    Anjum, R.3
  • 70
    • 80052437758 scopus 로고    scopus 로고
    • New strategies in overcoming acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in lung cancer
    • Oxnard GR, Arcila ME, Chmielecki J, Ladanyi M, Miller VA, Pao W. New strategies in overcoming acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in lung cancer. Clin. Cancer Res. 17(17), 5530-5537 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , Issue.17 , pp. 5530-5537
    • Oxnard, G.R.1    Arcila, M.E.2    Chmielecki, J.3    Ladanyi, M.4    Miller, V.A.5    Pao, W.6
  • 71
    • 84856813666 scopus 로고    scopus 로고
    • Activity and tolerability of combined EGFR targeting with afatinib (BIBW 2992) and cetuximab in T790M+ NSCLC patients
    • Amsterdam, NL, 3-7 July 2011
    • Groen HJ, Horn L, Smit EF et al. Activity and tolerability of combined EGFR targeting with afatinib (BIBW 2992) and cetuximab in T790M+ NSCLC patients. Presented at: 14th World Conference on Lung Cancer. Amsterdam, NL, 3-7 July 2011.
    • 14th World Conference on Lung Cancer
    • Groen, H.J.1    Horn, L.2    Smit, E.F.3
  • 72
    • 63049132774 scopus 로고    scopus 로고
    • First-line gefitinib for patients with advanced non-small-cell lung cancer harboring epidermal growth factor receptor mutations without indication for chemotherapy
    • Inoue A, Kobayashi K, Usui K et al. First-line gefitinib for patients with advanced non-small-cell lung cancer harboring epidermal growth factor receptor mutations without indication for chemotherapy. J. Clin. Oncol. 27(9), 1394-1400 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.9 , pp. 1394-1400
    • Inoue, A.1    Kobayashi, K.2    Usui, K.3
  • 73
    • 84867879786 scopus 로고    scopus 로고
    • Positron emission tomography and circulating tumor cells to monitor a dramatic response to gefitinib
    • Morabito A, Sandomenico C, Costanzo R et al. Positron emission tomography and circulating tumor cells to monitor a dramatic response to gefitinib. J. Thorac. Oncol. 7(11), e27-e28 (2012).
    • (2012) J. Thorac. Oncol. , vol.7 , Issue.11
    • Morabito, A.1    Sandomenico, C.2    Costanzo, R.3
  • 74
    • 79952268212 scopus 로고    scopus 로고
    • Brain metastases from lung cancer responding to erlotinib: The importance of EGFR mutation
    • Porta R, Sánchez-Torres JM, Paz-Ares L et al. Brain metastases from lung cancer responding to erlotinib: the importance of EGFR mutation. Eur. Respir. J. 37(3), 624-631 (2011).
    • (2011) Eur. Respir. J. , vol.37 , Issue.3 , pp. 624-631
    • Porta, R.1    Sánchez-Torres, J.M.2    Paz-Ares, L.3
  • 75
    • 84865197331 scopus 로고    scopus 로고
    • Efficacy of epidermal growth factor receptor tyrosine kinase inhibitors for brain metastasis in non-small cell lung cancer patients harboring either exon 19 or 21 mutation
    • Park SJ, Kim HT, Lee DH et al. Efficacy of epidermal growth factor receptor tyrosine kinase inhibitors for brain metastasis in non-small cell lung cancer patients harboring either exon 19 or 21 mutation. Lung Cancer 77(3), 556-560 (2012).
    • (2012) Lung Cancer , vol.77 , Issue.3 , pp. 556-560
    • Park, S.J.1    Kim, H.T.2    Lee, D.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.