PHF1 rearrangements in ossifying fibromyxoid tumors of soft parts: A fluorescence in situ hybridization study of 41 cases with emphasis on the malignant variant

American Journal of Surgical Pathology

Volumn 37, Issue 11, 2013, Pages 1751-1755

  Graham, Rondell P ^a   Weiss, Sharon W ^b   Sukov, William R ^a   Goldblum, John R ^c   Billings, Steven D ^c   Dotlic, Snjezana ^d   Folpe, Andrew L ^a  

^a MAYO CLINIC   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c LERNER RESEARCH INSTITUTE   (United States)

^d KBC Zagreb   (Croatia)

Author keywords

FISH; ossifying fibromyxoid tumor; PHF1; soft tissue tumors

Indexed keywords

DNA BINDING PROTEIN; PHF1 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ARTICLE; BIOPSY; BONE TUMOR; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE REARRANGEMENT; GENETICS; HUMAN; MALE; MIDDLE AGED; OSSIFYING FIBROMA; PATHOLOGY; SOFT TISSUE TUMOR;

BIOPSY; BONE NEOPLASMS; DNA-BINDING PROTEINS; FEMALE; FIBROMA, OSSIFYING; GENE REARRANGEMENT; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; MIDDLE AGED; SOFT TISSUE NEOPLASMS; TRANSCRIPTION FACTORS;

EID: 84886389174     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e31829644b4     Document Type: Article

References (22)

1. Enzinger FM, Weiss SW, Liang CY. Ossifying fibromyxoid tumor of soft parts. A clinicopathological analysis of 59 cases. Am J Surg Pathol. 1989;13:817-827.
2. Folpe AL, Weiss SW. Ossifying fibromyxoid tumor of soft parts: a clinicopathologic study of 70 cases with emphasis on atypical and malignant variants. Am J Surg Pathol. 2003;27:421-431.
3. Graham RP, Dry S, Li X, et al. Ossifying fibromyxoid tumor of soft parts: a clinicopathologic, proteomic, and genomic study. Am J Surg Pathol. 2011;35:1615-1625.
4. Miettinen M. Ossifying fibromyxoid tumor of soft parts. Additional observations of a distinctive soft tissue tumor. Am J Clin Pathol. 1991;95:142-149.
5. Donner LR. Ossifying fibromyxoid tumor of soft parts: evidence supporting Schwann cell origin. Hum Pathol. 1992;23:200-202.
6. Schofield JB, Krausz T, Stamp GW, et al. Ossifying fibromyxoid tumour of soft parts: immunohistochemical and ultrastructural analysis. Histopathology. 1993;22:101-112.
7. Hanski W, Lewicki Z. New observations on three cases of ossifying fibromyxoid tumor of soft parts. Pol J Pathol. 1994;45:231-238.
8. Yang P, Hirose T, Hasegawa T, et al. Ossifying fibromyxoid tumor of soft parts: a morphological and immunohistochemical study. Pathol Int. 1994;44:448-453.
9. Kilpatrick SE, Ward WG, Mozes M, et al. Atypical and malignant variants of ossifying fibromyxoid tumor: clinicopathologic analysis of six cases. Am J Surg Pathol. 1995;19:1039-1046.
10. Zamecnik M, Michal M, Simpson RH, et al. Ossifying fibromyxoid tumor of soft parts: a report of 17 cases with emphasis on unusual histological features. Ann Diagn Pathol. 1997;1:73-81.
11. Matsumoto K, Yamamoto T, Min W, et al. Ossifying fibromyxoid tumor of soft parts: clinicopathologic, immunohistochemical and ultrastructural study of four cases. Pathol Int. 1999;49:742-746.
12. Gebre-Medhin S, Nord KH, Moller E, et al. Recurrent rearrangement of the PHF1 gene in ossifying fibromyxoid tumors. Am J Pathol. 2012;181:1069-1077.
13. Boulay G, Rosnoblet C, Guerardel C, et al. Functional characterization of human polycomb-like 3 isoforms identifies them as components of distinct EZH2 protein complexes. Biochem J. 2011;434:333-342.
14. Endoh M, Endo TA, Endoh T, et al. Histone H2A monoubiquitination is a crucial step to mediate PRC1-dependent repression of developmental genes to maintain ES cell identity. PLoS Genet. 2012;8:e1002774.
15. Sarma K, Margueron R, Ivanov A, et al. Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo. Mol Cell Biol. 2008;28:2718-2731.
16. Cao R, Zhang Y. The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3. Curr Opin Genet Dev. 2004;14: 155-164.
17. Schuettengruber B, Chourrout D, Vervoort M, et al. Genome regulation by polycomb and trithorax proteins. Cell. 2007;128: 735-745.
18. Walker E, Chang WY, Hunkapiller J, et al. Polycomb-like 2 associates with PRC2 and regulates transcriptional networks during mouse embryonic stem cell self-renewal and differentiation. Cell Stem Cell. 2010;6:153-166.
19. Hong Z, Jiang J, Lan L, et al. A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell. Nucleic Acids Res. 2008;36:2939-2947.
20. Micci F, Panagopoulos I, Bjerkehagen B, et al. Consistent rearrangement of chromosomal band 6p21 with generation of fusion genes JAZF1/PHF1 and EPC1/PHF1 in endometrial stromal sarcoma. Cancer Res. 2006;66:107-112.
21. Chiang S, Ali R, Melnyk N, et al. Frequency of known gene rearrangements in endometrial stromal tumors. Am J Surg Pathol. 2011;35:1364-1372.
22. Lee CH, Ou WB, Marino-Enriquez A, et al. 14-3-3 fusion oncogenes in high-grade endometrial stromal sarcoma. Proc Natl Acad Sci USA. 2012;109:929-934.