14-3-3 fusion oncogenes in high-grade endometrial stromal sarcoma

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 3, 2012, Pages 929-934

  Lee, Cheng Han ^a,b   Ou, Wen Bin ^a   Mariño Enriquez, Adrian ^a   Zhu, Meijun ^a   Mayeda, Mark ^a   Wang, Yuexiang ^a   Guo, Xiangqian ^c   Brunner, Alayne L ^c   Amant, Frédéric ^d   French, Christopher A ^a   West, Robert B ^c   McAlpine, Jessica N ^e   Gilks, C Blake ^b   Yaffe, Michael B ^f   Prenticeg, Leah M ^g   McPherson, Andrew ^g   Jones, Steven J M ^g   Marra, Marco A ^g   Shah, Sohrab P ^g   Van De Rijn, Matt ^c   Huntsman, David G ^g   Dal Cin, Paola ^a   Debiec Rychter, Maria ^d   Nucci, Marisa R ^a   Fletcher, Jonathan A ^a   more..

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b VANCOUVER GENERAL HOSPITAL   (Canada)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF LEUVEN   (Belgium)

^e UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^f MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^g BRITISH COLUMBIA CANCER AGENCY   (Canada)

Author keywords

Cytogenetic aberration; Leiomyosarcoma; NUT; Translocation; Uterine neoplasm

Indexed keywords

HYBRID PROTEIN; MATRIX METALLOPROTEINASE 15; ONCOPROTEIN; PROTEIN 14 3 3; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSCRIPTOME; UNCLASSIFIED DRUG; YWHAE FAM22 PROTEIN;

ARTICLE; CANCER CELL CULTURE; CANCER GRADING; CELL GROWTH; CELL MIGRATION; CELL NUCLEUS; CELL PROLIFERATION; CELL VIABILITY; CYTOGENETICS; ENDOMETRIUM SARCOMA; EXON; FLUORESCENCE IN SITU HYBRIDIZATION; FUSION GENE; GENE EXPRESSION PROFILING; GENE FUSION; GENE REARRANGEMENT; GENE SILENCING; IMMUNOBLOTTING; NUCLEAR LOCALIZATION SIGNAL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; SEQUENCE ANALYSIS;

14-3-3 PROTEINS; CELL NUCLEUS; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOMES, HUMAN, PAIR 10; CHROMOSOMES, HUMAN, PAIR 17; CYTOGENETIC ANALYSIS; DISEASE PROGRESSION; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE REARRANGEMENT; GENOME, HUMAN; HUMANS; MOLECULAR SEQUENCE DATA; NEOPLASM GRADING; NEOPLASM PROTEINS; ONCOGENE PROTEINS, FUSION; PROTEIN BINDING; PROTEIN TRANSPORT; SARCOMA, ENDOMETRIAL STROMAL; SEQUENCE ANALYSIS, DNA; TRANSCRIPTOME; TRANSLOCATION, GENETIC;

EID: 84863038132     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1115528109     Document Type: Article

References (28)

1. Aitken A (2006) 14-3-3 proteins: A historic overview. Semin Cancer Biol 16:162-172.
2. Mackintosh C (2004) Dynamic interactions between 14-3-3 proteins and phosphoproteins regulate diverse cellular processes. Biochem J 381:329-342.
3. Hermeking H (2003) The 14-3-3 cancer connection. Nat Rev Cancer 3:931-943.
4. Morrison DK (2009) The 14-3-3 proteins: Integrators of diverse signaling cues that impact cell fate and cancer development. Trends Cell Biol 19:16-23.
5. Lodygin D, Hermeking H (2006) Epigenetic silencing of 14-3-3σ in cancer. Semin Cancer Biol 16:214-224.
6. Chan TA, Hermeking H, Lengauer C, Kinzler KW, Vogelstein B (1999) 14-3-3σ is required to prevent mitotic catastrophe after DNA damage. Nature 401:616-620.
7. Wilker EW, et al. (2007) 14-3-3σ controls mitotic translation to facilitate cytokinesis. Nature 446:329-332. (Pubitemid 46426148)
8. Neal CL, et al. (2009) 14-3-3ζ overexpression defines high risk for breast cancer recurrence and promotes cancer cell survival. Cancer Res 69:3425-3432.
9. Li Z, et al. (2008) Down-regulation of 14-3-3ζ suppresses anchorage-independent growth of lung cancer cells through anoikis activation. Proc Natl Acad Sci USA 105:162-167.
10. Lu J, et al. (2009) 14-3-3ζ cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition. Cancer Cell 16:195-207.
11. Koontz JI, et al. (2001) Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors. Proc Natl Acad Sci USA 98:6348-6353. (Pubitemid 32488241)
12. Micci F, Panagopoulos I, Bjerkehagen B, Heim S (2006) Consistent rearrangement of chromosomal band 6p21 with generation of fusion genes JAZF1/PHF1 and EPC1/PHF1 in endometrial stromal sarcoma. Cancer Res 66:107-112. (Pubitemid 43166015)
13. McPherson A, et al. (2011) deFuse: An algorithm for gene fusion discovery in tumor RNA-Seq data. PLOS Comput Biol 7:e1001138.
14. French CA, et al. (2003) BRD4-NUT fusion oncogene: A novel mechanism in aggressive carcinoma. Cancer Res 63:304-307. (Pubitemid 36152484)
15. French CA, et al. (2008) BRD-NUT oncoproteins: A family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells. Oncogene 27:2237-2242. (Pubitemid 351483375)
16. Gardino AK, Smerdon SJ, Yaffe MB (2006) Structural determinants of 14-3-3 binding specificities and regulation of subcellular localization of 14-3-3-ligand complexes: A comparison of the X-ray crystal structures of all human 14-3-3 isoforms. Semin Cancer Biol 16:173-182. (Pubitemid 43796126)
17. Brunet A, et al. (2002) 14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport. J Cell Biol 156:817-828. (Pubitemid 34839865)
18. Brameier M, Krings A, MacCallum RM(2007) NucPred-predicting nuclear localization of proteins. Bioinformatics 23:1159-1160.
19. Briesemeister S, Rahnenführer J, Kohlbacher O (2010) Going from where to why-interpretable prediction of protein subcellular localization. Bioinformatics 26: 1232-1238.
20. Nakai K, Horton P (1999) PSORT: A program for detecting sorting signals in proteins and predicting their subcellular localization. Trends Biochem Sci 24:34-36.
21. Fletcher JA, et al. (1991) Diagnostic relevance of clonal cytogenetic aberrations in malignant soft-tissue tumors. N Engl J Med 324:436-442.
22. Shah SP, et al. (2009) Mutation of FOXL2 in granulosa-cell tumors of the ovary. N Engl J Med 360:2719-2729.
23. Shah SP, et al. (2009) Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution. Nature 461:809-813.
24. Wiegand KC, et al. (2010) ARID1A mutations in endometriosis-associated ovarian carcinomas. N Engl J Med 363:1532-1543.
25. Rubin BP, et al. (2001) KIT activation is a ubiquitous feature of gastrointestinal stromal tumors. Cancer Res 61:8118-8121. (Pubitemid 33091601)
26. Shaw RJ, et al. (2001) The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling. Dev Cell 1:63-72. (Pubitemid 33586069)
27. Beck AH, et al. (2010) 3′-end sequencing for expression quantification (3SEQ) from archival tumor samples. PLoS ONE 5:e8768.
28. Li R, et al. (2009) SOAP2: An improved ultrafast tool for short read alignment. Bioinformatics 25:1966-1967.