TGF-β1 Up-Regulates the Expression of PDGF-β Receptor mRNA and Induces a Delayed PI3K-, AKT-, and p70S6K-Dependent Proliferative Response in Activated Hepatic Stellate Cells

Alcoholism: Clinical and Experimental Research

Volumn 37, Issue 11, 2013, Pages 1838-1848

  Shah, Ruchi ^a,b   Reyes Gordillo, Karina ^a,b   Arellanes Robledo, Jaime ^a,b   Lechuga, Carmen G ^c,d   Hernández Nazara, Zamira ^b,c,e   Cotty, Adam ^c   Rojkind, Marcos ^b,c,f   Lakshman, M Raj ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d Centro Nacional de Investigaciones Oncológicas   (Spain)

^e UNIVERSITY OF GUADALAJARA   (Mexico)

^f WALTER REED ARMY MEDICAL CENTER   (United States)

Author keywords

Hepatic Stellate Cells; Liver Fibrosis; PDGF Receptor; Proliferation; TGF 1

Indexed keywords

CATALASE; CELL DNA; COLLAGEN TYPE 1; HYDROGEN PEROXIDE; MESSENGER RNA; MYOSIN; NEUTRALIZING ANTIBODY; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; PROTEIN SERINE THREONINE KINASE INHIBITOR; REACTIVE OXYGEN METABOLITE; S6 KINASE; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

ACTIN FILAMENT; ANIMAL CELL; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CELL ACTIVATION; CELL PROLIFERATION; CELL SIZE; CELL STRUCTURE; CELL TRANSDIFFERENTIATION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; LIVER FIBROSIS; LIVER INJURY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCAR; SIGNAL TRANSDUCTION; STELLATE CELL; WESTERN BLOTTING;

RATTUS;

HEPATIC STELLATE CELLS; LIVER FIBROSIS; PDGF-Β RECEPTOR; PROLIFERATION; TGF-Β1;

ANIMALS; CELL PROLIFERATION; CELL SIZE; CELLS, CULTURED; HEPATIC STELLATE CELLS; HYDROGEN PEROXIDE; MICE; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-SIS; RATS; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84886380249     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/acer.12167     Document Type: Article

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