De-peptidising protein-protein interactions - Big jobs for small molecules

Drug Discovery Today: Technologies

Volumn 10, Issue 4, 2013, Pages

  Fayne, Darren ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; ALPHA 1 ANTITRYPSIN; AMINO ACID; ANTINEOPLASTIC AGENT; BENZODIAZEPINE; COLCHICINE; GDC 0152; GLUCOCORTICOID RECEPTOR; INTERLEUKIN 2; MARAVIROC; NAVITOCLAX; PEPTIDE DERIVATIVE; PEPTIDOMIMETIC AGENT; PROTEIN; PROTEIN KINASE INHIBITOR; PROTEINASE INHIBITOR; RO 26 4550; RO 264550; TETRAPEPTIDE; TIROFIBAN; TRYPSIN INHIBITOR; UNCLASSIFIED DRUG; VINBLASTINE;

ALLOSTERISM; AMINO ACID SEQUENCE; APOPTOSIS; ARTICLE; BINDING SITE; CLINICAL TRIAL (TOPIC); COMBINATORIAL LIBRARY; COMPUTATIONAL FLUID DYNAMICS; CRYSTAL STRUCTURE; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG PROTEIN BINDING; FOOD AND DRUG ADMINISTRATION; HUMAN; HYDROPHOBICITY; LIGAND BINDING; MOLECULAR BIOLOGY; MOLECULAR DOCKING; MOLECULAR WEIGHT; MOLECULE; PHYSICAL CHEMISTRY; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; PUBLICATION; X RAY CRYSTALLOGRAPHY;

DRUG DESIGN; MODELS, MOLECULAR; PEPTIDES; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; SMALL MOLECULE LIBRARIES;

EID: 84886304492     PISSN: None     EISSN: 17406749     Source Type: Journal    
DOI: 10.1016/j.ddtec.2013.08.002     Document Type: Review

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