A modeled dynamic regulatory network of NF-κB and IL-6 mediated by miRNA

BioSystems

Volumn 114, Issue 3, 2013, Pages 214-218

  Xue, Xu ^a,b   Xia, Wang ^b   Wenzhong, Hu ^a  

^a DALIAN NATIONALITIES UNIVERSITY   (China)

^b HEFEI UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

Dynamics; Inflammation; MiRNA; Oscillation

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MICRORNA; MICRORNA 146; MICRORNA 21; UNCLASSIFIED DRUG; MIRN146 MICRORNA, HUMAN; MIRN21 MICRORNA, HUMAN;

CANCER; GENE EXPRESSION; IMMUNE RESPONSE; INFECTIVITY; NUMERICAL MODEL; PATHOGEN; PHYSIOLOGY; RNA; SIGNALING;

ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; GENE REGULATORY NETWORK; INFLAMMATION; MATHEMATICAL MODEL; MOLECULAR DYNAMICS; NEGATIVE FEEDBACK; OSCILLATION; BIOLOGICAL MODEL; COMPUTER SIMULATION; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; SIGNAL TRANSDUCTION;

COMPUTER SIMULATION; GENE REGULATORY NETWORKS; HUMANS; INFLAMMATION; INTERLEUKIN-6; MICRORNAS; MODELS, IMMUNOLOGICAL; NF-KAPPA B; SIGNAL TRANSDUCTION;

EID: 84886232637     PISSN: 03032647     EISSN: 18728324     Source Type: Journal    
DOI: 10.1016/j.biosystems.2013.09.001     Document Type: Article

References (23)

1. Beinke S., Ley S.C. Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology. Biochem. J. 2004, 382:393-409.
2. Bhaumik D., Scott G.K., Schokrpur S., Patil C.K., Orjalo A.V., Rodier F., Lithgow G.J., Campisi J. MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8. Aging (Albany NY) 2009, 1:402-411.
3. Brasier A.R. The nuclear factor-kappaB-interleukin-6 signalling pathway mediating vascular inflammation. Cardiovasc. Res. 2010, 86:211-218.
4. Gabay C. Interleukin-6 and chronic inflammation. Arthritis Res. Ther. 2006, 8(Suppl. (2)):S3.
5. Gantier M.P., McCoy C.E., Rusinova I., Saulep D., Wang D., Xu D., Irving A.T., Behlke M.A., Hertzog P.J., Mackay F., Williams B.R. Analysis of microRNA turnover in mammalian cells following Dicer1 ablation. Nucleic Acids Res. 2011, 39:5692-5703.
6. Gong C., Yao Y., Wang Y., Liu B., Wu W., Chen J., Su F., Yao H., Song E. Up-regulation of miR-21 mediates resistance to trastuzumab therapy for breast cancer. J. Biol. Chem. 2011, 286:19127-19137.
7. Iliopoulos D., Jaeger S.A., Hirsch H.A., Bulyk M.L., Struhl K. STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer. Mol. Cell 2010, 39:493-506.
8. Kearns J.D., Basak S., Werner S.L., Huang C.S., Hoffmann A. IκBe provides negative feedback to control NF-kappaB oscillations, signaling dynamics, and inflammatory gene expression. J. Cell Biol. 2006, 173:659-664.
9. Lawrence T. The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harb. Perspect. Biol. 2009, 1:a001651.
10. Li G., Luna C., Qiu J., Epstein D.L., Gonzalez P. Modulation of inflammatory markers by miR-146a during replicative senescence in trabecular meshwork cells. Invest. Ophthalmol. Vis. Sci. 2010, 51:2976-2985.
11. Li W., Tan D., Zenali M.J., Brown R.E. Constitutive activation of nuclear factor-kappa B (NF-κB) signaling pathway in fibrolamellar hepatocellular carcinoma. Int. J. Clin. Exp. Pathol. 2010, 3:238-243.
12. Lu Z.Y., Brailly H., Wijdenes J., Bataille R., Rossi J.F., Klein B. Measurement of whole body interleukin-6 (IL-6) production: prediction of the efficacy of anti-IL-6 treatments. Blood 1995, 86:3123-3131.
13. Maiellaro K., Taylor W.R. The role of the adventitia in vascular inflammation. Cardiovasc. Res. 2007, 75:640-648.
14. Marquez R.T., Wendlandt E., Galle C.S., Keck K., McCaffrey A.P. MicroRNA-21 is upregulated during the proliferative phase of liver regeneration, targets Pellino-1, and inhibits NF-kappaB signaling. Am. J. Physiol. Gastrointest. Liver Physiol. 2010, 298:G535-G541.
15. Moldoveanu A.I., Shephard R.J., Shek P.N. Exercise elevates plasma levels but not gene expression of IL-1beta, IL-6, and TNF-alpha in blood mononuclear cells. J. Appl. Physiol. 2000, 89:1499-1504.
16. O'Connell R.M., Rao D.S., Baltimore D. microRNA regulation of inflammatory responses. Annu. Rev. Immunol. 2012, 30:295-312.
17. O'Connell R.M., Taganov K.D., Boldin M.P., Cheng G., Baltimore D. MicroRNA-155 is induced during the macrophage inflammatory response. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:1604-1609.
18. Surh Y.J., Chun K.S., Cha H.H., Han S.S., Keum Y.S., Park K.K., Lee S.S. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation. Mutat. Res. 2001, 480/481:243-268.
19. Tieu B.C., Lee C., Sun H., Lejeune W., Recinos A., Ju X., Spratt H., Guo D.C., Milewicz D., Tilton R.G., Brasier A.R. An adventitial IL-6/MCP1 amplification loop accelerates macrophage-mediated vascular inflammation leading to aortic dissection in mice. J. Clin. Invest. 2009, 119:3637-3651.
20. Valencia-Sanchez M.A., Liu J., Hannon G.J., Parker R. Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev. 2006, 20:515-524.
21. Wang X., Li Y., Xu X., Wang Y.H. Toward a system-level understanding of microRNA pathway via mathematical modeling. Biosystems 2010, 100:31-38.
22. Werner S.L., Barken D., Hoffmann A. Stimulus specificity of gene expression programs determined by temporal control of IKK activity. Science 2005, 309:1857-1861.
23. Zhou W., Li Y., Wang X., Wu L., Wang Y. MiR-206-mediated dynamic mechanism of the mammalian circadian clock. BMC Syst. Biol. 2011, 5:141.