Loss of the desmosomal cadherin desmoglein-2 suppresses colon cancer cell proliferation through EGFR signaling

Oncogene

Volumn 33, Issue 36, 2014, Pages 4531-4536

  Kamekura, R ^a   Kolegraff, K N ^a   Nava, P ^b   Hilgarth, R S ^a   Feng, M ^a   Parkos, C A ^a   Nusrat, A ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DEPARTAMENTO DE FÍSICA   (Mexico)

Author keywords

cancer; desmocollin; desmoglein; Desmosome; EGFR; intestinal epithelium

Indexed keywords

DESMOCOLLIN; DESMOGLEIN; EPIDERMAL GROWTH FACTOR RECEPTOR;

ADENOCARCINOMA; ANIMAL; ARTICLE; CELL PROLIFERATION; COLON TUMOR; EXPERIMENTAL NEOPLASM; GENE EXPRESSION REGULATION; GENETICS; HELA CELL LINE; HUMAN; MALE; METABOLISM; MOUSE; PATHOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ADENOCARCINOMA; ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; COLONIC NEOPLASMS; DESMOCOLLINS; DESMOGLEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; HELA CELLS; HUMANS; MALE; MICE; NEOPLASMS, EXPERIMENTAL; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION;

EID: 84886205238     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2013.442     Document Type: Article

References (22)

1. Holthofer B, Windoffer R, Troyanovsky S, Leube RE. Structure and function of desmosomes. Int Rev Cytol 2007; 264: 65-163.
2. Getsios S, Amargo EV, Dusek RL, Ishii K, Sheu L, Godsel LM et al. Coordinated expression of desmoglein 1 and desmocollin 1 regulates intercellular adhesion. Differentiation 2004; 72: 419-433.
3. Tselepis C, Chidgey M, North A, Garrod D. Desmosomal adhesion inhibits invasive behavior. Proc Natl Acad Sci USA 1998; 95: 8064-8069.
4. Schlegel N, Meir M, Heupel WM, Holthofer B, Leube RE, Waschke J. Desmoglein 2- mediated adhesion is required for intestinal epithelial barrier integrity. Am J Physiol Gastrointest Liver Physiol 2010; 298: G774-G783.
5. Brennan D, Hu Y, Joubeh S, Choi YW, Whitaker-Menezes D, O'Brien T et al. Suprabasal Dsg2 expression in transgenic mouse skin confers a hyperproliferative and apoptosis-resistant phenotype to keratinocytes. J Cell Sci 2007; 120: 758-771.
6. Mannan T, Jing S, Foroushania SH, Fortune F, Wan H. RNAi-mediated inhibition of the desmosomal cadherin (desmoglein 3) impairs epithelial cell proliferation. Cell Prolif 2011; 44: 301-310.
7. Kolegraff K, Nava P, Helms MN, Parkos CA, Nusrat A. Loss of desmocollin-2 confers a tumorigenic phenotype to colonic epithelial cells through activation of Akt/bcatenin signaling. Mol Biol Cell 2011; 22: 1121-1134.
8. Biedermann K, Vogelsang H, Becker I, Plaschke S, Siewert JR, Hofler H et al. Desmoglein 2 is expressed abnormally rather than mutated in familial and sporadic gastric cancer. J Pathol 2005; 207: 199-206.
9. Brennan D, Mahoney MG. Increased expression of Dsg2 in malignant skin carcinomas: a tissue-microarray based study. Cell Adh Migr 2009; 3: 148-154.
10. Wex T, Kuester D, Monkemuller K, Stahr A, Fry LC, Kandulski A et al. Assessment of desmosomal components (desmoglein 1-3, plakoglobin) in cardia mucosa in relation to gastroesophageal reflux disease and Helicobacter pylori infection. Hum Pathol 2012; 43: 1745-1754.
11. Baron S, Hoang A, Vogel H, Attardi LD. Unimpaired skin carcinogenesis in Desmoglein 3 knockout mice. PLoS One 2012; 7: e50024.
12. Lock JG, Stow JL. Rab11 in recycling endosomes regulates the sorting and basolateral transport of E-cadherin. Mol Biol Cell 2005; 16: 1744-1755.
13. Getsios S, Simpson CL, Kojima S, Harmon R, Sheu LJ, Dusek RL et al. Desmoglein 1- dependent suppression of EGFR signaling promotes epidermal differentiation and morphogenesis. J Cell Biol 2009; 185: 1243-1258.
14. Biscardi JS, Maa MC, Tice DA, Cox ME, Leu TH, Parsons SJ. c-Src-mediated phosphorylation of the epidermal growth factor receptor on Tyr845 and Tyr1101 is associated with modulation of receptor function. J Biol Chem 1999; 274: 8335-8343.
15. Oksvold MP, Thien CB, Widerberg J, Chantry A, Huitfeldt HS, Langdon WY. Serine mutations that abrogate ligand-induced ubiquitination and internalization of the EGF receptor do not affect c-Cbl association with the receptor. Oncogene 2003; 22: 8509-8518.
16. Hynes NE, Lane HA. ERBB receptors and cancer: the complexity of targeted inhibitors. Nat Rev Cancer 2005; 5: 341-354.
17. Ishii K, Norvell SM, Bannon LJ, Amargo EV, Pascoe LT, Green KJ. Assembly of desmosomal cadherins into desmosomes is isoform dependent. J Invest Dermatol 2001; 117: 26-35.
18. Nava P, Laukoetter MG, Hopkins AM, Laur O, Gerner-Smidt K, Green KJ et al. Desmoglein-2: a novel regulator of apoptosis in the intestinal epithelium. Mol Biol Cell 2007; 18: 4565-4578.
19. Resnik N, Sepcic K, Plemenitas A, Windoffer R, Leube R, Veranic P. Desmosome assembly and cell-cell adhesion are membrane raft-dependent processes. J Biol Chem 2011; 286: 1499-1507.
20. Chen YJ, Chang JT, Lee L, Wang HM, Liao CT, Chiu CC et al. DSG3 is overexpressed in head neck cancer and is a potential molecular target for inhibition of oncogenesis. Oncogene 2007; 26: 467-476.
21. Kolegraff K, Nava P, Laur O, Parkos CA, Nusrat A. Characterization of full-length and proteolytic cleavage fragments of desmoglein-2 in native human colon and colonic epithelial cell lines. Cell Adh Migr 2011; 5: 306-314.
22. Shimoyama Y, Hirohashi S, Hirano S, Noguchi M, Shimosato Y, Takeichi M et al. Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas. Cancer Res 1989; 49: 2128-2133.