Nanomaterials for Improved Orthopedic and Bone Tissue Engineering Applications

Advanced Biomaterials: Fundamentals, Processing, and Applications

Volumn , Issue , 2010, Pages 205-241

  Zhang, Lijie ^a   Sirivisoot, Sirinrath ^a   Balasundaram, Ganesh ^a   Webster, Thomas J ^a  

^a BROWN UNIVERSITY   (United States)

Author keywords

Nanomaterials for improved orthopedic and bone tissue engineering applications; Nanostructured ceramics biomimicing natural bone; Nanostructured metals examination with magnetic resonance imaging

Indexed keywords

EID: 84886168504     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470891315.ch7     Document Type: Chapter

References (144)

1. Joos, U., Wiesmann, H. P., Szuwart, T. and Meyer, U., Mineralization at the interface of implants, Int. J. Oral Maxillofac. Surg., volume: 35, 2006, pp. 783-790.
2. Charnley, J., Anchorage of the fermoral head prosthesis to the shaft of the femur, Journal of bone joint surgery, volume: 42B, 1960, pp. 28-30.
3. Charnley, J., Surgery of the hip-joint: present and future developments, Br. Me. J., volume: 5176, 1960, pp. 821-826.
4. Frankowski, J. J. and Watkins-Castillo, S., Primary total knee and hip arthroplasty pro jections for the U.S. population to the year 2030, American Academy of Orthopaedic Surgeons, Rosemont, IL, reviewed by T. P. Sculco and S. M. Sporer, August 23, 2002.
5. AAOS online, http://www.aaos.org/research/research.asp.
6. Bozic, K. J., Rubash, H. E., Berry, J., Saleh, K. J. and Durbhakula, S. M., Modes of failure in revision hip and knee replacement.
7. Revisions of Hip and Knee Replacements in Canada, Canadian Joint Replacement Registry Analytic Bulletin: Canadian Institute for Health Information, June 2004, pp. 1-20.
8. Branemark, P. I., Adell, R., Albrektsson, T., Lekholm, U., Lundkvist, S. and Rockler, B., Osseointegrated titanium fixtures in the treatment of edentulousness, Biomaterials, volume: 4, 1983, pp. 25-28.
9. Webster, T. J., Nanophase ceramics: the future orthopedic and dental implant material. Advances in Chemical Engineering, pp. 125-166, J. Y. Ying (eds.), Academic Press: A Harcourt Science and Technology company, 2001.
10. Esposito, M., Hirsh, J. M., Lekholm, U. and Thomsen, P., Biological factors contributing to failures of osseointegrated oral implants (I): Success criteria and epidemiology, European Journal of Oral Sciences, volume: 106, 1998, pp. 527-551.
11. Esposito, M., Hirsh, J. M., Lekholm, U. and Thomsen, P., Biological factors contributing to failures of osseointegrated oral implants (II): Etiopathogenesis, European Journal of Oral Sciences, volume: 106, 1998, pp. 721-764.
12. Cochran, D. L., Schenk, R. K., Lussi, A., Higginbottom, F. L. and Buser, D., Bone response to unloaded and loaded titanium implants with a sandblasted and acid-etched surface: a histometric study in the canine mandible, J. Biomed. Mater. Res., volume: 40, 1998, pp. 1-11.
13. Wennerberg, A., Hallgren, C., Johansson, C. and Danelli, S., A histomorphometric evaluation of screw-shaped implants each prepared with two surface roughnesses, Clin. Oral Implants Res., volume: 9, 1998, pp. 11-19.
14. Webster, T. J., Siegel, R. W. and Bizios, R., Osteoblast adhesion on nanophase ceramics, Biomaterials, volume: 20, 1999, pp. 1221-1227.
15. Webster, T. J., Siegel, R. W. and Bizios, R., Design and evaluation of nanophase alumina for orthopaedic/dental applications, Nanostructured Materials, volume: 12, 1999, pp. 983-986.
16. Webster, T. J., Siegel, R. W. and Bizios, R., Specific proteins mediate osteoblast adhesion on nanophase ceramics, J. Biomed. Mater. Res., volume: 51, 2000, pp. 475-483.
17. Webster, T. J. and Ejiofor, J. U., Increased osteoblast adhesion on nanophase metals: Ti, Ti6Al4V, and CoCrMo, Biomaterials, volume: 25, 2004, pp. 4731-4739.
18. Kaplan, F. S., Hayes, W. C., Keaveny, T. M., Boskey, A., Einhorn, T. A. and Iannotti, J. P., Form and function of bone. Orthopedic basic science, pp. 127-185, S. P. Sinmon, (eds.). American Academy of Orthopaedic Surgeons, 1994.
19. Castner, D. G. and Ratner, B. D., Biomedical surface science: Foundations to frontiers, Surface Science, volume: 500, 2002, pp. 28-60.
20. Chun, A. L., Helical Rosette Nanotubes: An investigation towards its application in orthopaedics, Purdue university (thesis), May 2006.
21. Hayakawa, T., Yoshinari, M., Kiba, H., Yamamoto, H., Nemoto, K. and Jansen, J. A., Trabecular bone response to surface roughened and calcium phosphate (Ca-P) coated titanium implants, Biomaterials, volume: 23, 2002, pp. 1025-1031.
22. Meyer, U., Wiesmann, H. P., Fillies, T. and Joos, U., Early tissue reaction at the interface of immediately loaded dental implants, Int. J. Oral Maxillofac Implants, volume: 18, 2003, pp. 489-499.
23. Gu'ehennec, L. L., Soueidan, A., Layrolle, P. and Amouriq, Y., Surface treatments of titanium dental implants for rapid osseointegration, Dental Materials, 2006, doi:10.1016/j.dental.
24. Loosening & Osteolysis: Osteolysis (Aseptic Loosening), AAOS online.
25. Hanson, S. R., Lalor, P. A., Niemi, S. M., Northup, S. J., Ratner, B. D. and Spector, M., et al., Testing biomaterials. pp. 221. Biomaterials science: An introduction to materials and medicine, B. D. Ratner, A. S. Hoffman, F. J. Schoen, J. E. Lemons, (eds.). New York: Academic Press.
26. Zhu, Y. H., Chiu, K. Y. and Tang, W. M., Review article: polyethylene wear and osteolysis in total hip arthroplasty, Journal of Orthopaedic Surgery, volume: 9, number: 1, 2001, pp. 91-99.
27. Harris, W. H., The problem is osteolysis, Clin. Orthop., volume: 311, 1995, pp. 46-53.
28. David, V., Jarka, N. and Olga, K., Periprosthetic osteolysis and its association with the molecule RANKL expression. Physiological research pre-press article.
29. Bronson, J. G., Breakthrough technology: searching for artificial articular cartilage, Orthopedic Technology Review, volume: 1, number: 1, 1999.
30. Anaheim and Calif. Rosemont, Polyethylene: the past, present and future. In: orthopaedic proceedings, 66th Annual Meeting, American Academy of Orthopaedic Surgeons. Academy of Orthopaedic Surgeons, 2001, 445-468.
31. Gutwein, L. G. and Webster, T. J., Increased viable osteoblast density in the presence of nanophase compared to conventional alumina and titania particles, Biomaterials, volume: 25, number: 18, 2004, pp. 4175-4183.
32. Gutwein, L. G. and Webster, T. J., Osteoblast and chrondrocyte proliferation in the presence of alumina and titania nanoparticles, Journal of Nanoparticle Research, volume: 4, 2002, pp. 231-238.
33. Tamura, K., Takashi, N. and Akasaka, T., et al., Effects of micro/nano particle size on cell function and morphology, Key Engr. Mat., 2004, 254-256, 919-922.
34. Warheit, D. B., Nanoparticles: health impacts? Materials Today, 2004, pp. 32-35.
35. Sato, M. and Webster, T. J., Nanobiotechnology: implications for the future of nanotechnology in orthopedic applications, Expert Rev. Medical Devices, volume: 1, number: 1, 2004, pp. 105-114.
36. Lindahl, H., Garellick, G., Regnér, H., Herberts, P. and Malchau, H., Three hundred and twenty-one periprosthetic femoral fractures, J. Bone Joint Surg. Am., volume: 88, 2006, pp. 1215-1222.
37. Implant wear in total joint replacement: clinical and biologic issues, material and design considerations, edited by T. M. Wright and S. B. Goodman. Chapter 22: what are the wear mechanisms and What control them? (2001) ISBN number 0-89203-261-8. Available online: http://www4.aaos.org/product/details_page.cfm?code=02522 &dlink=ImpWear.cfm.
38. Bethea, J. S., Deandrade, J. R., Fleming, L. L., Lindenbaum, S. D. and Welch, R. B., Proximal femoral fractures following total hip arthroplasty, Clin. Orthop. Relat. Res., volume: 170, 1982, pp. 95-106.
39. Beals, R. K. and Tower, S. S., Periprosthetic fractures of the femur. An analysis of 93 fractures. Clin. Orthop. Relat. Res., volume: 327, 1996, pp. 238-246.
40. Learmonth, I. D., The management of periprosthetic fractures around the femoral stem, J. Bone Joint Surg. Br., volume: 86, 2004, pp. 13-19.
41. Herberts, P. and Malchau, H., Long-term registration has improved the quality of hip replacement: a review of the Swedish THR Register comparing 160,000 cases, Acta Orthop Scand., volume: 71, 2000, pp. 111-121.
42. Siegel, R. W. and Fougere, G. E., Mechanical properties of nanophase metals, Nanostruct. Mater., volume: 6, 1995, pp. 205-216.
43. Lemons, J. E., Bioceramics: is there a difference? Clinical Orthopedics and Related Research, volume: 261, 1990, pp: 153-158.
44. Webster, T. J., Ergun, C., Doremus, R. H., Seigel, R.W. and Bizios, R., Enhanced functions of osteoblasts on nanophase ceramics, Biomaterials, volume: 21, 2000, pp. 1803-1810.
45. Webster, T. J., Siegel, R. W. and Bizios, R., Nanoceramic surface roughness enhances osteoblast and osteoclast functions for improved orthopedic/dental implant efficacy, Scripta Mater., volume: 44, 2001, pp. 1639-1642.
46. Webster, T. J., Ergun, C., Doremus, R. H., Seigel, R. W. and Bizios, R., Enhanced osteoclast-like functions on nanophase ceramics, Biomaterials, volume: 22, 2001, pp. 1327-1333.
47. Gutwein, L. G., Webster, T. J., Increased viable osteoblast density in the presence of nanophase compared to conventional alumina and titania particles, Biomaterials, volume: 25, 2004, pp. 4175-4183.
48. Webster, T. J., Hellenmeyer, E. L., Price, R. L., Increased osteoblast functions on theta+delta nanofiber alumina, Biomaterials, volume: 26, 2005, pp. 953-960.
49. Hamadouche, M., Sedel, L., Ceramics in oethopaedics, J. Bone Joint Surg. Br., volume: 82-B, 2000, pp. 1095-1099.
50. Willert, H. G., Bertram, H., Buchhorn, G. H., Osteolysis in alloarthroplasty of the hip: the role of bone cement fragmentation, Clin Orthop, volume: 258, 1990, pp. 108-121.
51. Hulbert, S. F., Hench, L. L., Forbers, D. and Bowman, L. S., History of bioceramics, Ceramics international, volume: 8, number: 4, 1982, pp. 131-140.
52. Chang, C. K., Wu, J. S., Mao, D. L. and Ding, C. X., Mechanical and histological evaluations of hydroxyapatite-coated and noncoated Ti-6Al-4V implants in tibia bone, J. Biomed. Mater. Res., volume: 56, number: 1, 2001, pp. 17-23.
53. Cook, S. D., Thomas, K. A., Kay, J. F. and Jarcho, M., Hydroxyapatite-coated porous titanium for use as an orthopedic biologic attachment system, Clin. Orthop. Relat. Res., volume: 230, 1988, pp. 303-312.
54. Catledge, S. A., Fries, M. D., Vohra, Y. K., Lacefield, W. R., Lemons, J. E., Woodard, S. and Venugopalan, R., Nanostructured Ceramics for Biomedical Implants, Journal of Nanoscience and Nanotechnology, volume: 2, 2002, pp. 293-312.
55. Chris Arts, J. J., Verdonschot, N., Schreurs, B. W., Buma, P., The use of a bioresorbable nano-crystalline hydroxyapatite paste in acetabular bone impaction grafting, Biomaterials, volume: 27, 2006, pp: 1110-1118.
56. Huber, F.-X., Belyaev, O., Hillmeier, J., Kock, H.-J., Huber, C., Meeder, P.-J. and Berger, I., First histological observations on the incorporation of a novel nanocrystalline hydroxyapatite paste OSTIM ® in human cancellous bone, BMC Musculoskeletal Disorders, 2006, 7: 50 doi:10.1186/1471-2474-7-50.
57. Colon, G., Ward, B. C., Webster, T. J., Increased osteoblast and decreased Staphylococcus epidermidis functions on nanophase ZnO and TiO2, J. Biomed. Mater. Res. A., volume: 78, number: 3, 2006, pp. 595-604.
58. Donlan, R. M. and Costerton, J. W., Biofilms: Survival mechanisms to clinically relevant microorganisms, Clinical Microbiol Rev., volume: 15, 2002, pp. 167-193.
59. Nieman, G. W., Processing and mechanical behavior of nanocrystalline Cu, Pd and Ag. (Ph. D thesis), Northwestern University, 1991.
60. Luck, M., Paulke, B. R., Schröder, W., Blunk, T., Müller, R. H., Analysis of plasma protein adsorption on polymeric nanoparticles with the different surface characteristics, J. Biomed. Mater. Res., volume: 39, 1998, pp. 478-485.
61. Lopes, M. A., J. Biomed. Mater. Res., volume: 45, number: 4, 1999, pp. 370-375.
62. Cooke, F. W., Ceramics in orthopedic surgery, Clinical orthopaedics and related research, volume: 276, 1992, pp. 135-146.
63. Weertman, J. R. and Averback, R. S., Mechanical properties, pp. 323. Nanomaterials: sythesis, properties and applications, A. S. Edelstein and R. C. Cammarata (eds.), London: Institue of Physics Publishing, 1998.
64. Wallbridge, N., Dowson, D., The walking activity of patients with artificial hip joints, Eng. Med., volume: 11, 1982, pp. 95-96.
65. Dogan, C. P., Hawk, J. A., Role of composition and microstructure in the abrasive wear of high-alumina ceramics, Wear, volume: 225-229, 1999, pp. 1050-1058.
66. Sedel, L., Kerboul, L., Christel, P., Meunier, A. and Witvoet, J., Alumina-on-alumina hip replacement, J. Bone Joint Surg. Br., volume: 72B, 1990, pp. 658-663.
67. Xu, H. H. K., Wei, L. and Jahanmir, S., Influence of grain size on the grinding response of alumina, J. Am. Ceram. Soc., volume: 79, 1996, pp. 1307-1313.
68. Xu, H. H. K., Jahanmir, S. and Wang, Y., Effect of grain size on scratch interactions and material removal in alumina, J. Am. Ceram. Soc., volume: 78, 1995, pp. 881-891.
69. Xiong, F., Manory, R. R., Ward, L., Terheci, M. and Lathabai, S., Effect of grain size and test configuration on the wear behavior of alumina. J. Am. Ceram. Soc., volume: 80, 1997, pp. 1310-1312.
70. Mukhopadhyay, A. K. and Mai, Y-W., Grain size effect on abrasive wear mechanisms in alumina ceramics, Wear, volume: 162-164, 1993, pp. 258-268.
71. He, Y., Winnubst, L., Burggraaf, A. J. and Verweij, H., Influence of porosity on friction and wear of tetragonal zirconia polycrystal, J. Am. Ceram. Soc., volume: 80, number: 2, 1997, pp. 377-380.
72. Park, J. B. and Lakes, R. S., Biomaterials: An Introduction, New York: Plenum Press, 1992.
73. Streicher, R. M., Senlitsch, M. and Schon, R., Articulation of ceramic surfaces against polyethylene, pp. 118-123. Bioceramics and the Human Body. A. Ravaglioli and A. Krajewsk (eds.), New York: Elsevier Applied Science, 1992.
74. Grim, M. J., Orthopedic biomaterials, in: Standard handbook of biomedical engineering and design. 15.1-15.22.
75. Nieman, G. W., Weertman, J. R. and Siegel, R. W., Microhardness of Nanocrystalline Palladium and Copper Produced by Inert-Gas Condensation, Scr. Metall., volume: 23, 1989, pp. 2013-2018.
76. Nieman, G. W., Weertman, J. R. and Siegel, R. W., Mechanical behavior of nanocrystalline Cu and Pd, J. Mater. Res., volume: 6, 1991, pp. 1012-1027.
77. Vanzillotta, P. S., Soares, G. A., Bastos, I. N., Simão, R. A. and Kuromoto, N. K., Potentialities of some surface characterization techniques for the development of titanium biomedical alloys, Materials Research, volume: 7, number: 3, 2004, pp. 437-444.
78. Tengvall, P., Textor, M. and Brunette, D. M., Titanium in medicine, Springer, 2001.
79. Steinemann, S. G., Titanium: the material of choice? Periodontol, volume: 7, 2000, pp. 7-21.
80. Rompen, E., Domken, O., Degidi, M., Farias Pontes, A. E. and Piattelli, A., The effect of material characteristics, of surface topography and of implant components and connections on soft tissue integration: a literature review, Clinical oral implants research, volume: 17, number: 2, 2006, pp. 55-67.
81. Thomas, T., Rough Surfaces, Imperial College Press, 2nd edition London, 1999.
82. Wennerberg, A. and Albrektsson, T., Suggested guidelines for the topographic evaluation of implants surfaces, The International Journal of Oral & Maxillofacial Implants, volume: 15, number: 3, 2000, pp. 331-344.
83. Hong, J., andersson, J., Ekdahl, K. N., Elgue, G., Axen, N., Larsson, R. and Nilsson, B., Titanium is a highly thrombogenic biomaterial: Possible implications for osteogenesis, Thrombosis Haemostasis, volume: 82, number: 1, 1999, pp. 58-64.
84. Eisenbarth E., Meyle. J., Nachtigall, W. and Breme, J., Influence of the surface structure of titanium materials on the adhesion of fibroblasts, Biomaterials, volume: 17, 1996, pp. 1399-1403.
85. Laurencin, C. T., Ambrosio, A. M. A., Borden, M. D. and Cooper, J. A. Jr., Tissue Engineering: Orthopedic Applications. Annu. Rev. Biomed. Eng., volume: 1, 1999, pp. 19-46.
86. Unwin, P. S., The recent advantages in bone and joint implant technology. Cost-effective titanium component technology for leading-edge performance, M. Ward-Close (ed.), Bury St. Edmunds & London: Professional engineers publishing limited for the institution of mechanical engineers, 2000.
87. Dunn, M. G. and Maxian, S. H., Biomaterials used in orthopedic surgery, pp. 229 Implantation biology. The host response and biomedical devices, Greco, R. S. (ed.), Boca Paton: CRC Press, Inc., 1994.
88. Davidson, J. A., Poggie, R. A., Mishra, A. K., Abrasive wear of ceramic, metal and UHMPE bearing surfaces from third-body bone, PMMA bone cement and titanium debris. Biomed. Mater. Eng., volume: 4, 1994, pp. 213-229.
89. Coombes, A. D. and Heckman, J. D., Gel casting of resorbable polymers, Biomaterials, volume: 13, 1992, pp. 217-224.
90. Devin, J. E., Attawia, M. A. and Laurencin, C. T., Three-dimensional degradable porous polymer-ceramic matrices for use in bone repair, J. Biomater. Sci. Polymer Ed., volume: 7, 1996, pp. 661-669.
91. Mikos, A. G., Thorsen, A. J., Czerwonka, L. A., Bao, Y. and Langer, R., Preparation and characterization of poly (l-lactic acid) foams, Polymer, volume: 35, 1994, pp. 1068-1077.
92. Thompson, R. C., Yaszemski, M. J., Powers, J. M. and Mikos, A. G., Fabrication of biodegradable polymer scaffolds to engineer trabecular bone, J. Biomater. Sci. Polymer Ed., volume: 7, 1995, pp. 23-38.
93. Chen, V. J. and Ma, P. X., Nano-fibrous poly(l-lactic acid) scaffolds with interconnected spherical macropores, Biomaterials, volume: 25, 2004, pp. 2065-2073.
94. Miller, D. C., Thapa, A., Haberstroh, K. M. and Webster, T. J., Enhanced functions of vascular and bladder cells on poly-lactic-co-glycolic acid polymers with nanostructured surfaces, IEEE Trans Nanobioscience, volume: 1, number: 2, 2002, pp. 61-66.
95. Thapa, A., Miller, D. C., Webster, T. J. and Haberstroh, K. M., Nano-structured polymers enhance bladder smooth muscle cell function, Biomaterials, volume: 24, 2003, pp. 2915-2926.
96. Miller, D. C., Haberstroh, K. M. and Webster, T. J., Mechanism(s) of increased vascular cell adhesion on nanostructured poly(lactic-co-glycolic acid) films, J. Biomed. Mater. Res. A., volume: 73, number: 4, 2005, pp. 476-484.
97. Park, G. E., Pattison, M. A., Park, K. and Webster, T. J., Accelerated chondrocyte functions on NaOH-treated PLGA scaffolds, Biomaterials, volume: 26, number: 16, 2005, pp. 3075-3082.
98. Liu, H., Slamovich, E. B. and Webster, T. J., Increased osteoblast functions among nanophase titania/poly(lactide-co-glycolide) composites of the highest nanometer surface roughness, J. Biomed. Mater. Res. A., volume: 78, number: 4, 2006, pp. 798-807.
99. Vance, R. J., Miller, D. C., Thapa. A., Haberstroh, K. M. and Webster, T. J., Decreased fibroblast cell density on chemically degraded poly(lactic-co-glycolic acid), polyurethane, and polycaprolactone, Biomaterials, volume: 25, 2004, pp. 2095-2103.
100. Li, J., Polymeric hydrogels. In Engineering materials for biomedical applications, pp. 7.1-7.18, T. S. Hin (ed.), World Scientific, 2004.
101. Lee, K. Y. and Mooney, D. J., Hydrogels for tissue engineering, Chemical Reviews, volume: 101, number: 7, 2001, pp. 1869-1879.
102. Stevens, M. M. and George, J. H., Exploring and engineering the cell surface interface, Science, volume: 310, 2005, pp. 1135-1138.
103. Bonzani, I. C., George, J. H. and Stevens, M. M., Novel materials for bone and cartilage regeneration, Current Opinion in Chemical Biology, volume: 10, 2006, pp. 1-8.
104. Lia, M., Guob, Y., Weib, Y., MacDiarmidc, A. G. and Lelkes, P. I., Electrospinning polyaniline-contained gelatin nanofibers for tissue engineering applications, Biomaterials, volume: 27, 2006, pp. 2705-2715.
105. Kisiday, J., Jin, M., Kurz, B., Hung, H., Semino, C. and Zhang, S., et al., Self-assembling peptide hydrogel fosters chondrocyte extracellular matrix production and cell division: implications for cartilage tissue repair. Proc. Natl. Acad. Sci., volume: 99, 2002, pp. 9996-10001.
106. Zhang, L., Ramsaywack, S., Fenniri, H. and Webster, T. J., Enhanced osteoblast adhesion on self-assembled nanostructured hydrogel scaffolds, Tissue engineering, in press, 2007.
107. Yamada, S., Heymann, D., Bouler, J. N. and Daculsi, G.D., Osteoclastic resorption of calcium phosphate ceramics with different hydroxyapatite/tricalcium phosphate ratios, Biomaterials, volume: 18, pp. 1037-1041.
108. Ramachandra, R. R., Roopa, H. N. and Kannan, T. S., Solid state synthesis and thermal stability of HAP and HAP-ß-TCP composite ceramic powders, Journal of materials science Materials in medicine, volume: 8, 1997, pp. 511-518.
109. Tampieri, A., Celloti, G., Szontagh, F. and Landi, E., Sintering and characterization of HA and TCP bioceramics with control of their strength and phase purity, Journal of materials science, Materials in Medicine, volume: 8, 1997, pp. 29-37.
110. Cuneyt, A. T., Korkusuz, F., Timucin, M. and Akkas, N., An investigation of the chemical synthesis and high-temperature sintering behavior of calcium hydroxyapatite (HA) and Tricalcium phosphate (TCP) bioceramic, Journal of materials science, Materials in medicine, volume: 8, 1997, pp. 91-96.
111. Hench, L. L., Bioceramics, Journal of the American Ceramic Society, volume: 81, 1998, pp. 705-1728.
112. Homaeigohar, S. SH., Shokrgozar, M. A., Sadi, A. Y., Khavandi, A., Javadpour, J. and Hosseinalipour, M., In vitro evaluation of biocompatibility of beta-tricalcium phosphate-reinforced high-density polyethylene; an orthopedic composite, Wiley Periodicals Inc., 2005.
113. Murugan, R. and Ramakrishna, S., Bioresorbable composite bone paste using polysaccharide based nano hydroxyapatite, Biomaterials, volume: 25, number: 17, 2004, pp. 3829-3835.
114. Esmaiel, J., Aqueous Based Hydrogel/Apatite Nanocomposite Scaffolds for Guided Bone Regeneration, Topical H #256d (TH014) - Biomedical Applications of Nanotechnology (Bionanotechnology), AIChE Annual Meeting, Cincinnati, OH, Oct. 30- Nov 4, 2005.
115. Quan, R., Yang, D. and Miao, X., Biocompatibility of graded zirconia-hydroxyapatite composite, Chinese journal of reparative and reconstructive surgery, volume: 20, number: 5, 2006, pp. 569-573.
116. Kim, H. W., Georgiou, G., Knowles, J. C., Koh, Y. H. and Kim, H. E., Calcium phosphates and glass composite coatings on zirconia for enhanced biocompatibility, Biomaterials, volume: 25, number: 18, 2004, pp. 4203-4213.
117. Kong, Y. M., Bae, C. J., Lee, S. H., Kim, H. W. and Kim, H. E., Improvement in biocompatibility of ZrO 2-Al 2 O 3 nano-composite by addition of HA, Biomaterials, volume: 26, number: 5, 2005, pp. 509-517.
118. Mistry, A. S. and Mikos, A. G., Tissue engineering strategies for bone regeneration, advances in biochemical engineering/biotechnology 2005, pp. 94, 1-22.
119. Webster, T. J., Waid, M. C., McKenzie, J. L., Price, R. L. and Ejiofor, J. U., Nano-biotechnology: carbon nanofibres as improved neural and orthopaedic implants, Nanotechnology, volume: 15, 2004, pp. 48-54.
120. Shi, X., Hudson, J. L., Spicer, P. P., Tour, J. M., Krishnamoorti, R. and Mikos, A.G., Injectable nanocomposites of single-walled carbon nanotubes and biodegradable polymers for bone tissue engineering, Biomacromolecules, volume: 7, number: 7, 2006, pp. 2237-4.
121. Supronowicz, P. R., Ajayan, P. M., Ullmann, K. R., Arulanandam, B. P., Metzger, D. W. and Bizios, R., Novel current-conducting composite substrates for exposing osteoblasts to alternating current stimulation, Journal of biomedical materials research, volume: 59, volume: 3, 2002, pp. 499-506.
122. Tsuchiya, H., Macak, J. M., Muller, L., Kunze, J., Muller, F., Greil, P., Virtanen, S. and Schmuki, P., Hydroxyapatite growth on anodic TiO2 nanotubes, Journal of biomedical materials research A., volume: 77, 2006, pp. 534-541.
123. Serro, A. P. and Saramago, B., Influence of sterilization on the mineralization of titanium implants induced by incubation in various biological model fluids, Biomaterials, volume: 24, 2003, pp. 4749-4760.
124. Barber, T. A., Golledge, S. L., Castner, D. G. and Healy, K. E., Peptide modified p (AAm-co-EG/AAc) IPNs grafted to bulk titanium modulate osteoblast behavior in vitro, J. Biomed. Mater. Res., volume: 64, 2003, pp. 38-47.
125. Lu, X., Leng, Y., Zhang, X., Xu, J., Qin, L. and Chan, C. W., Comparative study of osteoconduction on micromachined and alkalitreated titanium alloy surfaces in vitro and in vivo, Biomaterials, volume: 26, 2005, pp. 1793-1801.
126. Macak, J. M., Tsuchiya, H., Taveira, L., Ghicov, A. and Schmuki, P., Self-organized nanotubular oxide layers on Ti-6Al-7Nb and Ti-6Al-4V formed by anodization in NH4F solutions, J. Biomed. Mater. Res., 2005, volume: 75, pp. 928-933.
127. Winkelmann, M., Gold, J. and Hauert, R., Chemically patterned, metal oxide based surfaces produced by photolithographic techniques for studying protein-and cell-surface interactions I: Microfabrication and surface characterization, Biomaterials, volume: 24, 2003, pp. 1133-1145.
128. Balasundaram, G. and Webster, T. J., A perspective on nanophase materials for orthopedic implant applications, J. Mater. Chem., volume: 16, 2006, pp. 3737-3745.
129. Hoet, P. H., Bruske-Hohlfeld, I. and Salata, O.V., Nanoparticles - known and unknown health risks, J. Nanobiotechnology., volume: 2, 2004, pp. 2-12.
130. Tamura, K., Takashi, N. and Akasaka, T., Effects of micro/nano particle size on cell. function and morphology, Key Engr. Mat., volume: 254, 2004, pp. 919-922.
131. Sato, M., Nanophase hydroxyapatite coatings for dental and orthopedic applications [Ph.D. thesis]. School of Materials Engineering, Purdue University, West Lafayette, IN, 2006.
132. Park, J. B. and Lakes, R. S., Biomaterials: An Introduction, New York: Plenum Press, 1992.
133. Streicher, R. M., Senlitsch, M. and Schon, R., Articulation of ceramic surfaces against polyethylene, pp. 118-123. Bioceramics and the human body. Ravaglioli, A. and Krajewsk, A. (eds.), New York: Elsevier Applied Science, 1992.
134. Reising, A., Yao, C., Storey, D. and Webster, T. J., Greater osteoblast long-term functions on ionic plasma deposited nanostructured orthopedic implant coatings, J. Biomed. Mater. Res. A., volume: 87A, number 1, 2008, pp. 78-83. Epub ahead of print.
135. Spencer, N. D. and Textor, M., Surface modification, surface analysis, and biomaterials. http://www.textorgroup.ch/pdf/publications/journals/22/Spencer_MatDay_1998. pdf.
136. Bronzino, J. D., Biomedical Engineering Handbook. CRC Press, 1995, pp. 274.706.
137. Vincent, J., Materials technology from nature. Metals and Materials, Institute of Materials, 1990.
138. Learmonth, I. D., Young, C. and Rorabeck, C., The operation of the century: total hip replacement, Lancet, volume: 370, 2007, pp. 1508-1519.
139. D' ntonio, J., Capello, W., Manley, M., Naughton, M. and Sutton, K., Alumina ceramic bearings for total hip arthroplasty, Clinical orthopaedics and related research, number: 436, 2005, pp. 164-171.
140. Affatato, S., Torrecillas, R., Taddei, P., Rocchi, M., Fagnano, C., Ciapetti, G. and Toni, A., Advanced nanocomposite materials for orthopaedic applications, a long-term in vitro wear study of zirconia-toughened alumina, J. Biomed. Mater. Res. Part B (Appl. Biomater.), volume: 78B, 2006, pp. 76-82.
141. Tanaka, K., Tamura, J., Kawanabe, K., Nawa, M., Oka, M., Uchida, M., Kokubo, T. and Nakamura, T., Ce-TZP/Al 2 O 3 nanocomposite as a bearing material in total joint replacement, J. Biomed. Mater. Res. (Appl. Biomater.), volume: 63, 2002, pp. 262-270.
142. Takemoto, M., Fujibayashi, S., Neo, M., Suzuki, J., Kokubo, T. and Nakamura, T., Bone-bonding ability of a hydroxyapatite coated zirconia-alumina nanocomposite with a microporous surface. J. Biomed. Mater. Res., volume: 78A, 2006, pp. 693-701.
143. Österle, W., Klaffke, D., Griepentrog, M., Gross, U., Kranz, I. and Knabe, CH., Potential of wear resistant coatings on Ti6Al4V for artificial hip joint bearing surfaces, Wear, volume: 264, 2008, pp. 505-517.
144. Sokolowska, A., Rudnicki, J., Niedzielski, P., Boczkowska, A., Boguslawski, G., Wierzchon, T. and Mitura, S., TiN-NCD composite coating produced on the Ti6Al4V alloy for medical applications, Surf. Coat. Technol., volume: 200, 2005, pp. 87-89.