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Volumn 46, Issue 10-11, 2013, Pages 842-845

MiRNAs: Their discovery, biogenesis and mechanism of action

Author keywords

Biogenesis; History; Mechanism of action; MiRNA; Translation inhibition

Indexed keywords

DOUBLE STRANDED RNA; EXPORTIN 5; MICRORNA; RIBONUCLEASE III; RNA BINDING PROTEIN; RNA POLYMERASE II; SINGLE STRANDED RNA;

EID: 84886095617     PISSN: 00099120     EISSN: 18732933     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2013.02.009     Document Type: Review
Times cited : (102)

References (56)
  • 3
    • 29644432901 scopus 로고    scopus 로고
    • MicroRNAs and endocrine biology
    • Cuellar T.L., McManus M.T. MicroRNAs and endocrine biology. J Endocrinol 2005, 187:327-332.
    • (2005) J Endocrinol , vol.187 , pp. 327-332
    • Cuellar, T.L.1    McManus, M.T.2
  • 4
    • 22444432179 scopus 로고    scopus 로고
    • Developmental biology: tiny brakes for a growing heart
    • Bruneau B.G. Developmental biology: tiny brakes for a growing heart. Nature 2005, 436:181-182.
    • (2005) Nature , vol.436 , pp. 181-182
    • Bruneau, B.G.1
  • 5
    • 11844278458 scopus 로고    scopus 로고
    • Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
    • Lewis B.P., Burge C.B., Bartel D.P. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 2005, 120:15-20.
    • (2005) Cell , vol.120 , pp. 15-20
    • Lewis, B.P.1    Burge, C.B.2    Bartel, D.P.3
  • 6
    • 0027751663 scopus 로고
    • The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    • Lee R.C., Feinbaum R.L., Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 1993, 75:843-854.
    • (1993) Cell , vol.75 , pp. 843-854
    • Lee, R.C.1    Feinbaum, R.L.2    Ambros, V.3
  • 7
    • 0021771445 scopus 로고
    • Heterochronic mutants of the nematode Caenorhabditis elegans
    • Ambros V., Horvitz H.R. Heterochronic mutants of the nematode Caenorhabditis elegans. Science 1984, 226:409-416.
    • (1984) Science , vol.226 , pp. 409-416
    • Ambros, V.1    Horvitz, H.R.2
  • 8
    • 0027730383 scopus 로고
    • Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans
    • Wightman B., Ha I., Ruvkun G. Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell 1993, 75:855-862.
    • (1993) Cell , vol.75 , pp. 855-862
    • Wightman, B.1    Ha, I.2    Ruvkun, G.3
  • 9
    • 0035955366 scopus 로고    scopus 로고
    • An extensive class of small RNAs in Caenorhabditis elegans
    • Lee R.C., Ambros V. An extensive class of small RNAs in Caenorhabditis elegans. Science 2001, 294:862-864.
    • (2001) Science , vol.294 , pp. 862-864
    • Lee, R.C.1    Ambros, V.2
  • 11
    • 0038708326 scopus 로고    scopus 로고
    • The Caenorhabditis elegans hunchback-like gene lin-57/hbl-1 controls developmental time and is regulated by microRNAs
    • Abrahante J.E., Daul A.L., Li M., Volk M.L., Tennessen J.M., Miller E.A., et al. The Caenorhabditis elegans hunchback-like gene lin-57/hbl-1 controls developmental time and is regulated by microRNAs. Dev Cell 2003, 4:625-637.
    • (2003) Dev Cell , vol.4 , pp. 625-637
    • Abrahante, J.E.1    Daul, A.L.2    Li, M.3    Volk, M.L.4    Tennessen, J.M.5    Miller, E.A.6
  • 12
    • 0942301280 scopus 로고    scopus 로고
    • The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3'utr
    • Vella M.C., Choi E.Y., Lin S.Y., Reinert K., Slack F.J. The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3'utr. Genes Dev 2004, 18:132-137.
    • (2004) Genes Dev , vol.18 , pp. 132-137
    • Vella, M.C.1    Choi, E.Y.2    Lin, S.Y.3    Reinert, K.4    Slack, F.J.5
  • 13
    • 0034597777 scopus 로고    scopus 로고
    • Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA
    • Pasquinelli A.E., Reinhart B.J., Slack F., Martindale M.Q., Kuroda M.I., Maller B., et al. Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature 2000, 408:86-89.
    • (2000) Nature , vol.408 , pp. 86-89
    • Pasquinelli, A.E.1    Reinhart, B.J.2    Slack, F.3    Martindale, M.Q.4    Kuroda, M.I.5    Maller, B.6
  • 14
    • 1942494040 scopus 로고    scopus 로고
    • Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation
    • Sempere L.F., Freemantle S., Pitha-Rowe I., Moss E., Dmitrovsky E., Ambros V. Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation. Genome Biol 2004, 5:R13.
    • (2004) Genome Biol , vol.5
    • Sempere, L.F.1    Freemantle, S.2    Pitha-Rowe, I.3    Moss, E.4    Dmitrovsky, E.5    Ambros, V.6
  • 15
    • 22844440427 scopus 로고    scopus 로고
    • Identification of hundreds of conserved and nonconserved human microRNAs
    • Bentwich I., Avniel A., Karov Y., Aharonov R., Gilad S., Barad O., et al. Identification of hundreds of conserved and nonconserved human microRNAs. Nat Genet 2005, 37:766-770.
    • (2005) Nat Genet , vol.37 , pp. 766-770
    • Bentwich, I.1    Avniel, A.2    Karov, Y.3    Aharonov, R.4    Gilad, S.5    Barad, O.6
  • 17
    • 0035955361 scopus 로고    scopus 로고
    • An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans
    • Lau N.C., Lim L.P., Weinstein E.G., Bartel D.P. An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science 2001, 294:858-862.
    • (2001) Science , vol.294 , pp. 858-862
    • Lau, N.C.1    Lim, L.P.2    Weinstein, E.G.3    Bartel, D.P.4
  • 18
    • 42949093218 scopus 로고    scopus 로고
    • Mir-17-92 cluster accelerates adipocyte differentiation by negatively regulating tumor-suppressor rb2/p130
    • Wang Q., Li Y.C., Wang J., Kong J., Qi Y., Quigg R.J., et al. Mir-17-92 cluster accelerates adipocyte differentiation by negatively regulating tumor-suppressor rb2/p130. Proc Natl Acad Sci U S A 2008, 105:2889-2894.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 2889-2894
    • Wang, Q.1    Li, Y.C.2    Wang, J.3    Kong, J.4    Qi, Y.5    Quigg, R.J.6
  • 22
    • 78651293534 scopus 로고    scopus 로고
    • Mirbase: integrating microRNA annotation and deep-sequencing data
    • Kozomara A., Griffiths-Jones S. Mirbase: integrating microRNA annotation and deep-sequencing data. Nucleic Acids Res 2011, 39:D152-7.
    • (2011) Nucleic Acids Res , vol.39
    • Kozomara, A.1    Griffiths-Jones, S.2
  • 23
    • 18344369543 scopus 로고    scopus 로고
    • MicroRNA biogenesis: coordinated cropping and dicing
    • Kim V.N. MicroRNA biogenesis: coordinated cropping and dicing. Nat Rev Mol Cell Biol 2005, 6:376-385.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 376-385
    • Kim, V.N.1
  • 24
    • 9344235449 scopus 로고    scopus 로고
    • Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs
    • Cai X., Hagedorn C.H., Cullen B.R. Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs. RNA 2004, 10:1957-1966.
    • (2004) RNA , vol.10 , pp. 1957-1966
    • Cai, X.1    Hagedorn, C.H.2    Cullen, B.R.3
  • 27
    • 0037009364 scopus 로고    scopus 로고
    • MicroRNA maturation: stepwise processing and subcellular localization
    • Lee Y., Jeon K., Lee J.T., Kim S., Kim V.N. MicroRNA maturation: stepwise processing and subcellular localization. EMBO J 2002, 21:4663-4670.
    • (2002) EMBO J , vol.21 , pp. 4663-4670
    • Lee, Y.1    Jeon, K.2    Lee, J.T.3    Kim, S.4    Kim, V.N.5
  • 28
    • 0141843656 scopus 로고    scopus 로고
    • The nuclear RNAse III Drosha initiates microRNA processing
    • Lee Y., Ahn C., Han J., Choi H., Kim J., Yim J., et al. The nuclear RNAse III Drosha initiates microRNA processing. Nature 2003, 425:415-419.
    • (2003) Nature , vol.425 , pp. 415-419
    • Lee, Y.1    Ahn, C.2    Han, J.3    Choi, H.4    Kim, J.5    Yim, J.6
  • 29
    • 10644234841 scopus 로고    scopus 로고
    • The Drosha-DGCR8 complex in primary microRNA processing
    • Han J., Lee Y., Yeom K.H., Kim Y.K., Jin H., Kim V.N. The Drosha-DGCR8 complex in primary microRNA processing. Genes Dev 2004, 18:3016-3027.
    • (2004) Genes Dev , vol.18 , pp. 3016-3027
    • Han, J.1    Lee, Y.2    Yeom, K.H.3    Kim, Y.K.4    Jin, H.5    Kim, V.N.6
  • 31
    • 0037273432 scopus 로고    scopus 로고
    • Sequence requirements for micro RNA processing and function in human cells
    • Zeng Y., Cullen B.R. Sequence requirements for micro RNA processing and function in human cells. RNA 2003, 9:112-123.
    • (2003) RNA , vol.9 , pp. 112-123
    • Zeng, Y.1    Cullen, B.R.2
  • 34
  • 38
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    • Fire A., Xu S., Montgomery M.K., Kostas S.A., Driver S.E., Mello C.C. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998, 391:806-811.
    • (1998) Nature , vol.391 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6
  • 39
    • 37648998629 scopus 로고    scopus 로고
    • Getting to the root of miRNA-mediated gene silencing
    • Eulalio A., Huntzinger E., Izaurralde E. Getting to the root of miRNA-mediated gene silencing. Cell 2008, 132:9-14.
    • (2008) Cell , vol.132 , pp. 9-14
    • Eulalio, A.1    Huntzinger, E.2    Izaurralde, E.3
  • 40
    • 33750318273 scopus 로고    scopus 로고
    • A guide through present computational approaches for the identification of mammalian microRNA targets
    • Sethupathy P., Megraw M., Hatzigeorgiou A.G. A guide through present computational approaches for the identification of mammalian microRNA targets. Nat Methods 2006, 3:881-886.
    • (2006) Nat Methods , vol.3 , pp. 881-886
    • Sethupathy, P.1    Megraw, M.2    Hatzigeorgiou, A.G.3
  • 41
    • 13944282215 scopus 로고    scopus 로고
    • Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
    • Lim L.P., Lau N.C., Garrett-Engele P., Grimson A., Schelter J.M., Castle J., et al. Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature 2005, 433:769-773.
    • (2005) Nature , vol.433 , pp. 769-773
    • Lim, L.P.1    Lau, N.C.2    Garrett-Engele, P.3    Grimson, A.4    Schelter, J.M.5    Castle, J.6
  • 44
    • 54149095553 scopus 로고    scopus 로고
    • Biological principles of microRNA-mediated regulation: shared themes amid diversity
    • Flynt A.S., Lai E.C. Biological principles of microRNA-mediated regulation: shared themes amid diversity. Nat Rev Genet 2008, 9:831-842.
    • (2008) Nat Rev Genet , vol.9 , pp. 831-842
    • Flynt, A.S.1    Lai, E.C.2
  • 45
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: target recognition and regulatory functions
    • Bartel D.P. MicroRNAs: target recognition and regulatory functions. Cell 2009, 136:215-233.
    • (2009) Cell , vol.136 , pp. 215-233
    • Bartel, D.P.1
  • 46
    • 43449102192 scopus 로고    scopus 로고
    • Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large b-cell lymphoma
    • Lawrie C.H., Gal S., Dunlop H.M., Pushkaran B., Liggins A.P., Pulford K., et al. Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large b-cell lymphoma. Br J Haematol 2008, 141:672-675.
    • (2008) Br J Haematol , vol.141 , pp. 672-675
    • Lawrie, C.H.1    Gal, S.2    Dunlop, H.M.3    Pushkaran, B.4    Liggins, A.P.5    Pulford, K.6
  • 49
    • 84859480864 scopus 로고    scopus 로고
    • Clinical outcome prediction by microRNAs in human cancer: a systematic review
    • Nair V.S., Maeda L.S., Ioannidis J.P. Clinical outcome prediction by microRNAs in human cancer: a systematic review. J Natl Cancer Inst 2012, 104:528-540.
    • (2012) J Natl Cancer Inst , vol.104 , pp. 528-540
    • Nair, V.S.1    Maeda, L.S.2    Ioannidis, J.P.3
  • 50
    • 79960096964 scopus 로고    scopus 로고
    • Exosomes: secreted vesicles and intercellular communications
    • Thery C. Exosomes: secreted vesicles and intercellular communications. F1000 Biol Rep 2011, 3:15.
    • (2011) F1000 Biol Rep , vol.3 , pp. 15
    • Thery, C.1
  • 51
    • 79953202200 scopus 로고    scopus 로고
    • Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma
    • Arroyo J.D., Chevillet J.R., Kroh E.M., Ruf I.K., Pritchard C.C., Gibson D.F., et al. Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma. Proc Natl Acad Sci U S A 2011, 108:5003-5008.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 5003-5008
    • Arroyo, J.D.1    Chevillet, J.R.2    Kroh, E.M.3    Ruf, I.K.4    Pritchard, C.C.5    Gibson, D.F.6
  • 52
    • 79953301730 scopus 로고    scopus 로고
    • MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins
    • Vickers K.C., Palmisano B.T., Shoucri B.M., Shamburek R.D., Remaley A.T. MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins. Nat Cell Biol 2011, 13:423-433.
    • (2011) Nat Cell Biol , vol.13 , pp. 423-433
    • Vickers, K.C.1    Palmisano, B.T.2    Shoucri, B.M.3    Shamburek, R.D.4    Remaley, A.T.5
  • 53
    • 84869212180 scopus 로고    scopus 로고
    • Exosomal miRNAs: biological properties and therapeutic potential
    • Hu G., Drescher K.M., Chen X.M. Exosomal miRNAs: biological properties and therapeutic potential. Front Genet 2012, 3:56.
    • (2012) Front Genet , vol.3 , pp. 56
    • Hu, G.1    Drescher, K.M.2    Chen, X.M.3
  • 54
    • 54849408182 scopus 로고    scopus 로고
    • An analysis of human microRNA and disease associations
    • Lu M., Zhang Q., Deng M., Miao J., Guo Y., Gao W., et al. An analysis of human microRNA and disease associations. PLoS One 2008, 3:e3420.
    • (2008) PLoS One , vol.3
    • Lu, M.1    Zhang, Q.2    Deng, M.3    Miao, J.4    Guo, Y.5    Gao, W.6
  • 55
    • 84886100468 scopus 로고    scopus 로고
    • Circulating miRNAs as sensitive and specific biomarkers for the diagnosis and monitoring of human diseases: Promises and challenges
    • (this issue)
    • De Guire V., Robitaille R., Tétreault N., Guérin R., Ménard C., Bambace N., et al. Circulating miRNAs as sensitive and specific biomarkers for the diagnosis and monitoring of human diseases: Promises and challenges. Clinical Biochemistry 2013, 46:845-859. (this issue).
    • (2013) Clinical Biochemistry , vol.46 , pp. 845-859
    • De Guire, V.1    Robitaille, R.2    Tétreault, N.3    Guérin, R.4    Ménard, C.5    Bambace, N.6
  • 56
    • 84886096517 scopus 로고    scopus 로고
    • Online resources for miRNA analysis
    • (this issue)
    • Vlachos I.S., Hatzigeorgiou A.G. Online resources for miRNA analysis. Clinical Biochemistry 2013, 46:878-899. (this issue).
    • (2013) Clinical Biochemistry , vol.46 , pp. 878-899
    • Vlachos, I.S.1    Hatzigeorgiou, A.G.2


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