Potentially inappropriate prescribing and drug-drug interactions among elderly Chinese nursing home residents in Macao

International Journal of Clinical Pharmacy

Volumn 35, Issue 5, 2013, Pages 805-812

  Lao, Cheng Kin ^a   Ho, Sao Chan ^a   Chan, Ka Kit ^a   Tou, Chon Fai ^a   Tong, Henry Hoi Yee ^a   Chan, Alexandre ^b  

^a MACAO POLYTECHNIC INSTITUTE   (Macao)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Drug interactions; Elderly; Macao; Nursing home; Potentially inappropriate medication; STOPP

Indexed keywords

ACETYLSALICYLIC ACID; ALLOPURINOL; AMLODIPINE; ANTIHISTAMINIC AGENT; BENZODIAZEPINE DERIVATIVE; CAPTOPRIL; CELECOXIB; CILOSTAZOL; CLOPIDOGREL; DIGOXIN; DILTIAZEM; DIPYRIDAMOLE; ENALAPRIL; ESOMEPRAZOLE; FUROSEMIDE; LEVODOPA; NEUROLEPTIC AGENT; NIFEDIPINE; NONSTEROID ANTIINFLAMMATORY AGENT; PHENYTOIN; PROTON PUMP INHIBITOR; PSYCHOTROPIC AGENT; SIMVASTATIN; THEOPHYLLINE;

AGED; ARTICLE; CEREBROVASCULAR ACCIDENT; CROSS-SECTIONAL STUDY; DIABETES MELLITUS; DRUG INTERACTION; ESOPHAGITIS; FALLING; FEMALE; GASTROESOPHAGEAL REFLUX; HEART FAILURE; HUMAN; HYPERTENSION; INAPPROPRIATE PRESCRIBING; MACAO; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; NURSING HOME PATIENT; PEPTIC ULCER; PREVALENCE; PRIORITY JOURNAL;

AGED; AGED, 80 AND OVER; AGING; CHINA; CROSS-SECTIONAL STUDIES; DRUG INTERACTIONS; DRUG MONITORING; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; FEMALE; GERIATRIC ASSESSMENT; HOMES FOR THE AGED; HUMANS; IATROGENIC DISEASE; INAPPROPRIATE PRESCRIBING; MALE; NURSING HOMES; POLYPHARMACY; PREVALENCE; RISK; SEVERITY OF ILLNESS INDEX;

EID: 84886095423     PISSN: 22107703     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11096-013-9811-y     Document Type: Article

References (38)

1. Statistics and Census Service of Macao S.A.R. Macao Population Projection 2011-2036 [Internet]. Macao: Statistics and Census Service of Macao S.A.R.; 2012. [Updated Oct 2012; cited 6 Dec 2012]. Available from http://www.dsec.gov. mo/Statistic.aspx?lang=en-US&NodeGuid=ec391696-f920-49ed-b539-e1cfabff1d84.
2. Wolff JL, Starfield B, Anderson G. Prevalence, expenditures, and complications of multiple chronic conditions in the elderly. Arch Intern Med. 2002;162(20):2269-76.
3. Mizokami F, Koide Y, Noro T, Furuta K. Polypharmacy with common diseases in hospitalized elderly patients. Am J Geriatr Pharmacother. 2012;10(2):123-8.
4. Linjakumpu T, Hartikainen S, Klaukka T, Veijola J, Kivela SL, Isoaho R. Use of medications and polypharmacy are increasing among the elderly. J Clin Epidemiol. 2002;55(8):809-17.
5. Mamun K, Lien CT, Goh-Tan CY, Ang WS. Polypharmacy and inappropriate medication use in Singapore nursing homes. Ann Acad Med Singap. 2004;33(1):49-52.
6. Hosia-Randell HM, Muurinen SM, Pitkala KH. Exposure to potentially inappropriate drugs and drug-drug interactions in elderly nursing home residents in Helsinki, Finland: a cross-sectional study. Drugs Aging. 2008;25(8):683-92.
7. Chen LL, Tangiisuran B, Shafie AA, Hassali MA. Evaluation of potentially inappropriate medications among older residents of Malaysian nursing homes. Int J Clin Pharm. 2012;34(4):596-603.
8. Ryan C, O'Mahony D, Kennedy J, Weedle P, Cottrell E, Heffernan M, et al. Potentially inappropriate prescribing in older residents in Irish nursing homes. Age Ageing. 2013;42(1):116-20.
9. Liao HL, Chen JT, Ma TC, Chang YS. Analysis of drug-drug interactions (DDIs) in nursing homes in Central Taiwan. Arch Gerontol Geriatr. 2008;47(1):99-107.
10. Obreli-Neto PR, Nobili A, de Oliveira Baldoni A, Guidoni CM, de Lyra Junior DP, Pilger D, et al. Adverse drug reactions caused by drug-drug interactions in elderly outpatients: a prospective cohort study. Eur J Clin Pharmacol. 2012;68(12):1667-76.
11. Macao Yearbook Editorial Team. Macao yearbook 2012. Macao: Government Information Bureau of Macao S.A.R.; 2012. ISBN 978-99937-56-25-5.
12. Social Welfare Bureau of Macao S.A.R. Social service facilities - home for the elderly [Internet]. Macao: Social Welfare Bureau of Macao S.A.R.; cited 17 May 2012]. Available from http://www.ias.gov.mo/en/.
13. Levenson SA, Saffel DA. The consultant pharmacist and the physician in the nursing home: roles, relationships, and a recipe for success. J Am Med Dir Assoc. 2007;8(1):55-64.
14. World Health Organization Collaborating Centre for Drug Statistics Methodology. Anatomical therapeutic chemical (ATC) classification index with defined daily doses (DDDs) [Internet]. Oslo: WHO Collaborating Centre for Drug Statistics Methodology; 2011. [Updated 2011; cited 6 Dec 2012]. Available from http://www.whocc.no/atc-ddd-index/.
15. Gallagher P, Ryan C, Byrne S, Kennedy J, O'Mahony D. STOPP (screening tool of older person's prescriptions) and START (screening tool to alert doctors to right treatment). Consensus validation. Int J Clin Pharmacol Ther. 2008;46(2):72-83.
16. Gallagher P, Baeyens JP, Topinkova E, Madlova P, Cherubini A, Gasperini B, et al. Inter-rater reliability of STOPP (screening tool of older persons' prescriptions) and START (screening tool to alert doctors to right treatment) criteria amongst physicians in six European countries. Age Ageing. 2009;38(5):603-6.
17. Ryan C, O'Mahony D, Byrne S. Application of STOPP and START criteria: interrater reliability among pharmacists. Ann Pharmacother. 2009;43(7):1239-44.
18. Micromedex Healthcare Series. Drug-reax system [Internet]. Greenwood Village, CO: Thomson Reuters (Healthcare) Inc. [Updated periodically; cited 9 May 2012]. Available from http://www.micromedexsolutions.com/home/dispatch.
19. Lexi-Comp Online. Drug-Interact [Internet]. Hudson, OH: Lexi-Comp, Inc. [Updated periodically; cited 9 Mar 2012]. Available from https://online.lexi. com/lco/action/home;jsessionid=b1361afd49266aa5522b1821947b.
20. Vonbach P, Dubied A, Krahenbuhl S, Beer JH. Evaluation of frequently used drug interaction screening programs. Pharm World Sci. 2008;30(4):367-74.
21. Wong CM, Ko Y, Chan A. Clinically significant drug-drug interactions between oral anticancer agents and nonanticancer agents: profiling and comparison of two drug compendia. Ann Pharmacother. 2008;42(12):1737-48.
22. Hanlon JT, Schmader KE, Ruby CM, Weinberger M. Suboptimal prescribing in older inpatients and outpatients. J Am Geriatr Soc. 2001;49(2):200-9.
23. van der Hooft CS, Schoofs MW, Ziere G, Hofman A, Pols HA, Sturkenboom MC, et al. Inappropriate benzodiazepine use in older adults and the risk of fracture. Br J Clin Pharmacol. 2008;66(2):276-82.
24. Dalleur O, Spinewine A, Henrard S, Losseau C, Speybroeck N, Boland B. Inappropriate prescribing and related hospital admissions in frail older persons according to the STOPP and START criteria. Drugs Aging. 2012;29(10):829-37.
25. Vitry AI. Comparative assessment of four drug interaction compendia. Br J Clin Pharmacol. 2007;63(6):709-14.
26. Rodriguez-Terol A, Caraballo MO, Palma D, Santos-Ramos B, Molina T, Desongles T, et al. Quality of interaction database management systems. Farm Hosp. 2009;33(3):134-46.
27. Secoli SR, Figueras A, Lebrao ML, de Lima FD, Santos JL. Risk of potential drug-drug interactions among Brazilian elderly: a population-based, cross-sectional study. Drugs Aging. 2010;27(9):759-70.
28. Carter BL, Lund BC, Hayase N, Chrischilles E. The extent of potential antihypertensive drug interactions in a Medicaid population. Am J Hypertens. 2002;15(11):953-7.
29. Niwata S, Yamada Y, Ikegami N. Prevalence of inappropriate medication using Beers criteria in Japanese long-term care facilities. BMC Geriatr. 2006;6:1.
30. Stafford AC, Alswayan MS, Tenni PC. Inappropriate prescribing in older residents of Australian care homes. J Clin Pharm Ther. 2011;36(1):33-44.
31. Cannon KT, Choi MM, Zuniga MA. Potentially inappropriate medication use in elderly patients receiving home health care: a retrospective data analysis. Am J Geriatr Pharmacother. 2006;4(2):134-43.
32. Nobili A, Pasina L, Tettamanti M, Lucca U, Riva E, Marzona I, et al. Potentially severe drug interactions in elderly outpatients: results of an observational study of an administrative prescription database. J Clin Pharm Ther. 2009;34(4):377-86.
33. Gallagher P, O'Mahony D. STOPP (screening tool of older persons' potentially inappropriate prescriptions): application to acutely ill elderly patients and comparison with Beers' criteria. Age Ageing. 2008;37(6):673-9.
34. Brulhart MI, Wermeille JP. Multidisciplinary medication review: evaluation of a pharmaceutical care model for nursing homes. Int J Clin Pharm. 2011;33(3):549-57.
35. Bootman JL, Harrison DL, Cox E. The health care cost of drug-related morbidity and mortality in nursing facilities. Arch Intern Med. 1997;157(18):2089-96.
36. Halvorsen KH, Stensland P, Granas AG. A qualitative study of physicians' and nurses' experiences of multidisciplinary collaboration with pharmacists participating at case conferences. Int J Pharm Pract. 2011;19(5):350-7.
37. Spinewine A, Fialova D, Byrne S. The role of the pharmacist in optimizing pharmacotherapy in older people. Drugs Aging. 2012;29(6):495-510.
38. Page RL II, Linnebur SA, Bryant LL, Ruscin JM. Inappropriate prescribing in the hospitalized elderly patient: defining the problem, evaluation tools, and possible solutions. Clin Interv Aging. 2010;5:75-87.