The role of the pharmacist in optimizing pharmacotherapy in older people

Drugs and Aging

Volumn 29, Issue 6, 2012, Pages 495-510

  Spinewine, Anne ^a   Fialová, Daniela ^b,c   Byrne, Stephen ^d  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b CHARLES UNIVERSITY   (Czech Republic)

^c Charles University in Prague Faculty of Pharmacy   (Czech Republic)

^d UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

Elderly; Medication errors; Prescribing

Indexed keywords

ANTIDEPRESSANT AGENT; HYPNOTIC AGENT; NEUROLEPTIC AGENT; PSYCHOTROPIC AGENT;

AGING; AMBULATORY CARE; ANALYTIC METHOD; COST BENEFIT ANALYSIS; COST EFFECTIVENESS ANALYSIS; DRUG EFFICACY; DRUG INDUSTRY; DRUG SAFETY; EMERGENCY CARE; EUROPE; EVIDENCE BASED MEDICINE; FLEETWOOD MODEL; GENERAL PRACTICE; GENERAL PRACTITIONER; HEALTH CARE PERSONNEL; HEALTH EDUCATION; HOME CARE; HOSPITALIZATION; HUMAN; INTERVENTION STUDY; LONG TERM CARE; MEDICAL CARE; MEDICATION THERAPY MANAGEMENT; MEDICINE; MULTICENTER STUDY (TOPIC); NURSING HOME; OUTCOME ASSESSMENT; PEER REVIEW; PHARMACIST; PRESCRIPTION; PRIMARY MEDICAL CARE; PRIORITY JOURNAL; PROCESS OPTIMIZATION; PUBLICATION; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SKILL; SYSTEMATIC REVIEW;

AGED; AMBULATORY CARE; CONTINUITY OF PATIENT CARE; DRUG THERAPY; HUMANS; NURSING HOMES; PHARMACISTS;

EID: 84861699226     PISSN: 1170229X     EISSN: 11791969     Source Type: Journal    
DOI: 10.2165/11631720-000000000-00000     Document Type: Review

References (60)

1. Spinewine A, Schmader KE, Barber N, et al. Appropriate prescribing in elderly people: How well can it be measured and optimised? Lancet 2007 Jul; 370 (9582): 173-84
2. Hanlon JT, Lindblad CI, Gray SL. Can clinical pharmacy services have a positive impact on drug-related problems and health outcomes in community-based older adults? Am J Geriatr Pharmacother 2004 Mar; 2 (1): 3-13
3. Kongkaew C, Noyce PR, Ashcroft DM. Hospital admissions associated with adverse drug reactions: A systematic review of prospective observational studies. Ann Pharmacother 2008 Jul; 42 (7): 1017-1025
4. Mannesse CK, Derkx FH, De Ridder MA, et al. Contribution of adverse drug reactions to hospital admission of older patients. Age Ageing 2000 Jan; 29 (1): 35-39
5. Col N, Fanale JE, Kronholm P. The role of medication noncompliance and adverse drug reactions in hospitalizations of the elderly. Arch Intern Med 1990 Apr; 150 (4): 841-5
6. Steinman MA, Hanlon JT. Managing medications in clinically complex elders: 'There's got to be a happy medium'. JAMA 2010 Oct; 304 (14): 1592-1601
7. Sorensen L, Stokes JA, Purdie DM, et al. Medication reviews in the community: Results of a randomized, controlled effectiveness trial. Br J Clin Pharmacol 2004 Dec; 58 (6): 648-64
8. Hepler CD, Strand LM. Opportunities and responsibilities in pharmaceutical care. Am J Hosp Pharm 1990 Mar; 47 (3): 533-43
9. Hughes CM, Lapane KL. Pharmacy interventions on prescribing in nursing homes: From evidence to practice. Ther Adv Drug Safety 2011; 2: 103-12
10. Zermansky AG, Alldred DP, Petty DR, et al. Clinical medication review by a pharmacist of elderly people living in care homes: Randomised controlled trial. Age Ageing 2006 Nov; 35 (6): 586-91
11. Patterson SM, Hughes CM, Crealey G, et al. An evaluation of an adapted US model of pharmaceutical care to improve psychoactive prescribing for nursing home residents in Northern Ireland (Fleetwood Northern Ireland study). J Am Geriatr Soc 2010 Jan; 58 (1): 44-53
12. Bernsten C, Bjorkman I, Caramona M, et al. Improving the well-being of elderly patients via community pharmacy-based provision of pharmaceutical care: A multicentre study in seven European countries. Drugs Aging 2001; 18 (1): 63-77
13. Sturgess IK, McElnay JC, Hughes CM, et al. Community pharmacy based provision of pharmaceutical care to older patients. Pharm World Sci 2003 Oct; 25 (5): 218-26
14. Denneboom W, Dautzenberg MG, Grol R, et al. Treatment reviews of older people on polypharmacy in primary care: Cluster controlled trial comparing two approaches. Br J Gen Pract 2007 Sep; 57 (542): 723-31
15. Richmond S, Morton V, Cross B. Effectiveness of shared pharmaceutical care for older patients: RESPECT trial findings. Br J Gen Pract 2010 Jan; 60 (570): E10-19
16. Bojke C, Philips Z, Sculpher M. Cost-effectiveness of shared pharmaceutical care for older patients: RESPECT trial findings. Br J Gen Pract 2010 Jan; 60 (570): E20-7
17. Krska J, Cromarty JA, Arris F, et al. Pharmacist-led medication review in patients over 65: A randomized, controlled trial in primary care. Age Ageing 2001 May; 30 (3): 205-11
18. Holland R, Lenaghan E, Harvey I, et al. Does home based medication review keep older people out of hospital? The HOMER randomised controlled trial. BMJ 2005 Feb; 330 (7486): 293
19. Lenaghan E, Holland R, BrooksA. Home-based medication review in a high risk elderly population in primary care: The POLYMED randomised controlled trial. Age Ageing 2007 May; 36 (3): 292-7
20. Zermansky AG, Petty DR, Raynor DK, et al. Randomised controlled trial of clinical medication review by a pharmacist of elderly patients receiving repeat prescriptions in general practice. BMJ 2001 Dec; 323 (7325): 1340-3
21. Spinewine A, Swine C, Dhillon S, et al. Effect of a collaborative approach on the quality of prescribing for geriatric inpatients: A randomized, controlled trial. J Am Geriatr Soc 2007 May; 55 (5): 658-65
22. Gillespie U, Alassaad A, Henrohn D, et al. A comprehensive pharmacist intervention to reduce morbidity in patients 80 years or older: A randomized controlled trial. Arch Intern Med 2009 May; 169 (9): 894-900
23. Hellstrom LM, Bondesson A, Hoglund P, et al. Impact of the Lund Integrated Medicines Management (LIMM) model on medication appropriateness and drug-related hospital revisits. Eur J Clin Pharmacol 2011 Jul; 67 (7): 741-52
24. Lisby M, Thomsen A, Nielsen LP, et al. The effect of systematic medication review in elderly patients admitted to an acute ward of internal medicine. Basic Clin Pharmacol Toxicol 2010 May; 106 (5): 422-7
25. Nazareth I, Burton A, Shulman S, et al. A pharmacy discharge plan for hospitalized elderly patients: A randomized controlled trial. Age Ageing 2001 Jan; 30 (1): 33-40
26. Al Rashed SA, Wright DJ, Roebuck N, et al. The value of inpatient pharmaceutical counselling to elderly patients prior to discharge. Br J Clin Pharmacol 2002 Dec; 54 (6): 657-64
27. HollandR,Desborough J,Goodyer L, et al.Does pharmacistledmedication review help to reduce hospital admissions and deaths in older people? A systematic review and metaanalysis. Br J Clin Pharmacol 2008Mar; 65 (3): 303-16
28. Castelino RL, Bajorek BV, Chen TF. Targeting suboptimal prescribing in the elderly: A review of the impact of pharmacy services. Ann Pharmacother 2009 Jun; 43 (6): 1096-1106
29. Verrue CL, Petrovic M, Mehuys E, et al. Pharmacists' interventions for optimization of medication use in nursing homes: A systematic review. Drugs Aging 2009; 26 (1): 37-49
30. Zermansky AG, Silcock J. Is medication review by primarycare pharmacists for older people cost effective? a narrative review of the literature, focusing on costs and benefits. Pharmacoeconomics 2009; 27 (1): 11-24
31. da Silva DT, Santos AP, Aguiar PM, et al. Analysis of research quality regarding pharmaceutical intervention in elderly residents of long-term care facilities: A systematic review. J Am Geriatr Soc 2010 Jul; 58 (7): 1404-6
32. Kaur S, Mitchell G, Vitetta L, et al. Interventions that can reduce inappropriate prescribing in the elderly: A systematic review. Drugs Aging 2009; 26 (12): 1013-1028
33. Marcum ZA, Handler SM, Wright R, et al. Interventions to improve suboptimal prescribing in nursing homes: A narrative review. Am J Geriatr Pharmacother 2010 Jun; 8 (3): 183-200
34. Forsetlund L, Eike MC, Gjerberg E, et al. Effect of interventions to reduce potentially inappropriate use of drugs in nursing homes: A systematic review of randomised controlled trials. BMC Geriatr 2011; 11: 16
35. Loganathan M, Singh S, Franklin BD, et al. Interventions to optimise prescribing in care homes: Systematic review. Age Ageing 2011 Mar; 40 (2): 150-62
36. Stuijt CC, Franssen EJ, Egberts AC, et al. Appropriateness of prescribing among elderly patients in a Dutch residential home: Observational study of outcomes after a pharmacistled medication review. Drugs Aging 2008; 25 (11): 947-54
37. Furniss L, Burns A, Craig SK, et al. Effects of a pharmacist's medication review in nursing homes: Randomised controlled trial. Br J Psychiatry 2000 Jun; 176: 563-7
38. Schmidt I, Claesson CB, Westerholm B, et al. The impact of regular multidisciplinary team interventions on psychotropic prescribing in Swedish nursing homes. J Am Geriatr Soc 1998 Jan; 46 (1): 77-82
39. Schmidt IK, Claesson CB, Westerholm B, et al. Physician and staff assessments of drug interventions and outcomes in Swedish nursing homes. Ann Pharmacother 1998 Jan; 32 (1): 27-32
40. Halvorsen KH, Ruths S, Granas AG, et al. Multidisciplinary intervention to identify and resolve drug-related problems in Norwegian nursing homes. Scand J Prim Health Care 2010 Jun; 28 (2): 82-88
41. Brulhart MI, Wermeille JP. Multidisciplinary medication review: Evaluation of a pharmaceutical care model for nursing homes. Int J Clin Pharm 2011 Jun; 33 (3): 549-57
42. Daschner M, Brownstein S, Cameron KA, et al. Fleetwood phase II: Tests a new model of long-term care pharmacy. Consult Pharm 2000; 15: 989-1005
43. Bootman JL, Harrison DL, Cox E. The health care cost of drug-related morbidity and mortality in nursing facilities. Arch Intern Med 1997 Oct; 157 (18): 2089-2096
44. Lapane KL, Hughes CM. Pharmacotherapy interventions undertaken by pharmacists in the Fleetwood phase III study: The role of process control. Ann Pharmacother 2006 Sep; 40 (9): 1522-6
45. Patterson SM, Hughes CM, Lapane KL. Assessment of a United States pharmaceutical care model for nursing homes in the United Kingdom. Pharm World Sci 2007 Oct; 29 (5): 517-25
46. Patterson SM, Hughes CM, Cardwell C, et al. A cluster randomized controlled trial of an adapted US model of pharmaceutical care for nursing home residents in Northern Ireland (Fleetwood Northern Ireland study): A costeffectiveness analysis. J Am Geriatr Soc 2011 Apr; 59 (4): 586-93
47. Eide E, Schjott J. Assessing the effects of an intervention by a pharmacist on prescribing and administration of hypnotics in nursing homes. PharmWorld Sci 2001 Dec; 23 (6): 227-31
48. Nishtala PS, McLachlan AJ, Bell JS, et al. Psychotropic prescribing in long-term care facilities: Impact of medication reviews and educational interventions. Am J Geriatr Psychiatry 2008 Aug; 16 (8): 621-32
49. Department of Health. National service framework for older people. London: Department of Health, 2001
50. Department of Health. Medicines and older people: Implementing medicines-related aspects of the NSF for older people. London: Department of Health, 2001
51. Kucukarslan SN, Hagan AM, Shimp LA, et al. Integrating medication therapy management in the primary care medical home: A review of randomized controlled trials. Am J Health Syst Pharm 2011 Feb; 68 (4): 335-45
52. Rosenthal TC. The medical home: Growing evidence to support a new approach to primary care. J Am Board Fam Med 2008 Sep; 21 (5): 427-40
53. Bates DW. Role of pharmacists in the medical home. Am J Health Syst Pharm 2009 Jun; 66 (12): 1116-8
54. Castelino RL, Bajorek BV, Chen TF. Retrospective evaluation of home medicines review by pharmacists in older Australian patients using the medication appropriateness index. Ann Pharmacother 2010 Dec; 44 (12): 1922-9
55. Bradley CP. The future role of pharmacists in primary care. Br J Gen Pract 2009 Dec; 59 (569): 891-2
56. Kaboli PJ, Hoth AB, McClimon BJ, et al. Clinical pharmacists and inpatient medical care: A systematic review. Arch Intern Med 2006 May; 166 (9): 955-64
57. LeBlanc JM, Seoane-Vazquez E, Dasta JF. Survey of hospital pharmacist activities outside of the United States. Am J Health Syst Pharm 2007 Aug; 64 (16): 1748-1755
58. Spinewine A, Dhillon S, Mallet L, et al. Implementation of ward-based clinical pharmacy services in Belgium: Description of the impact on a geriatric unit. Ann Pharmacother 2006 Apr; 40 (4): 720-8
59. Garcia-Caballos M, Ramos-Diaz F, Jimenez-Moleon JJ, et al. Drug-related problems in older people after hospital discharge and interventions to reduce them. Age Ageing 2010 Jul; 39 (4): 430-8
60. Hanlon JT. Perspective: Is pharmacy ready for the baby boomers? Am J Geriatr Pharmacother 2010 Feb; 8 (1): 1-3