Saikosaponin A of Bupleurum chinense (Chaihu) elevates bone morphogenetic protein 4 (BMP-4) during hepatic stellate cell activation

Phytomedicine

Volumn 20, Issue 14, 2013, Pages 1330-1335

  Wang, Xiaotong ^a,b   Wang, Qingguo ^b   Burczynski, Frank J ^a   Kong, Weisi ^a   Gong, Yuewen ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

^b BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Bone morphogenetic protein; Bupleurum chinense; Hepatic fibrogenesis; Hepatic stellate cells; Saikosaponins and gene regulation

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BONE MORPHOGENETIC PROTEIN 4; MESSENGER RNA; PROTEIN BAX; SAIKOSAPONIN A;

ARTICLE; BUPLEURUM CHINENSE; CELL ACTIVATION; CELL POPULATION; CELL PROLIFERATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STELLATE CELL; WESTERN BLOTTING;

BOVINAE; BUPLEURUM CHINENSE;

ACTIVIN RECEPTOR-LIKE KINASE; ALK; BMP-4; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN-4; BUPLEURUM CHINENSE; CARBON TETRACHLORIDE; CCL-4; DMEM/F12; DULBECCO'S MODIFIED EAGLE MEDIUM/F12; ECL; ECM; ENHANCED CHEMILUMINESCENCE; EXTRACELLULAR MATRIX; FBS; FETAL BOVINE SERUM; GDFS; GROWTH DIFFERENTIATION FACTORS; HEPATIC FIBROGENESIS; HEPATIC STELLATE CELLS; HSCS; MAPKS; MITOGEN-ACTIVATED PROTEIN KINASES; NARINGIN; NG; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RT-PCR; SAIKOSAPONIN A; SAIKOSAPONIN D; SAIKOSAPONINS AND GENE REGULATION; SDS; SMOOTH MUSCLE ALPHA ACTIN; SODIUM DODECYL SULFATE; SSA; SSD; TBS; TGF-Β; TRANSFORMING GROWTH FACTOR-Β; TRIS-BUFFERED-SALINE; Α-SMA;

ACTINS; ANIMALS; BCL-2-ASSOCIATED X PROTEIN; BONE MORPHOGENETIC PROTEIN 4; BUPLEURUM; CATTLE; CELL LINE; CELL PROLIFERATION; CELLS, CULTURED; DRUGS, CHINESE HERBAL; HEPATIC STELLATE CELLS; HUMANS; LIVER; LIVER CIRRHOSIS; OLEANOLIC ACID; PHYTOTHERAPY; RNA, MESSENGER; SAPONINS;

EID: 84886086953     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2013.07.010     Document Type: Article

References (45)

1. G. Aldinger, G. Herr, W. Kusswetter, H.J. Reis, F.W. Thielemann, and U. Holz Bone morphogenetic protein: a review International Orthopaedics 15 1991 169 177
2. M.G. Bachem, D. Meyer, W. Schafer, U. Riess, R. Melchior, K.M. Sell, and A.M. Gressner The response of rat liver perisinusoidal lipocytes to polypeptide growth regulator changes with their transdifferentiation into myofibroblast-like cells in culture Journal of Hepatology 18 1993 40 52
3. R. Bataller, and D.A. Brenner Liver fibrosis Journal of Clinical Investigation 115 2005 209 218
4. R. Bataller, R.F. Schwabe, Y.H. Choi, L. Yang, Y.H. Paik, J. Lindquist, T. Qian, R. Schoonhoven, C.H. Hagedorn, J.J. Lemasters, and D.A. Brenner NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis Journal of Clinical Investigation 112 2003 1383 1394
5. A. Blouin, R.P. Bolender, and E.R. Weibel Distribution of organelles and membranes between hepatocytes and nonhepatocytes in the rat liver parenchyma. A stereological study Journal of Cell Biology 72 1977 441 455
6. D.A. Brenner, T. Waterboer, S.K. Choi, J.N. Lindquist, B. Stefanovic, E. Burchardt, M. Yamauchi, A. Gillan, and R.A. Rippe New aspects of hepatic fibrosis Journal of Hepatology 32 2000 32 38
7. G. Buniatian, R. Gebhardt, D. Schrenk, and B. Hamprecht Colocalization of three types of intermediate filament proteins in perisinusoidal stellate cells: glial fibrillary acidic protein as a new cellular marker European Journal of Cell Biology 70 1996 23 32
8. A.D. Burt, J.L. Robertson, J. Heir, and R.N. MacSween Desmin-containing stellate cells in rat liver; distribution in normal animals and response to experimental acute liver injury Journal of Pathology 150 1986 29 35
9. J.C. Chen, N.W. Chang, J.G. Chung, and K.C. Chen Saikosaponin-A induces apoptotic mechanism in human breast MDA-MB-231 and MCF-7 cancer cells American Journal of Chinese Medicine 31 2003 363 377
10. C.Y. Chiu, K.K. Kuo, T.L. Kuo, K.T. Lee, and K.H. Cheng The activation of MEK/ERK signaling pathway by bone morphogenetic protein 4 to increase hepatocellular carcinoma cell proliferation and migration Molecular Cancer Research 10 2012 415 427
11. B.H. Davis, and T.F. Kresina Hepatic fibrogenesis Clinics in Laboratory Medicine 16 1996 361 375
12. S.A. Duncan, and A.J. Watt BMPs on the road to hepatogenesis Genes and Development 15 2001 1879 1884
13. J. Fan, X. Li, P. Li, N. Li, T. Wang, H. Shen, Y. Siow, P. Choy, and Y. Gong Saikosaponin-d attenuates the development of liver fibrosis by preventing hepatocyte injury Biochemistry and Cell Biology Biochimie et biologie cellulaire 85 2007 189 195
14. J. Fan, H. Shen, Y. Sun, P. Li, F. Burczynski, M. Namaka, and Y. Gong Bone morphogenetic protein 4 mediates bile duct ligation induced liver fibrosis through activation of Smad1 and ERK1/2 in rat hepatic stellate cells Journal of Cellular Physiology 207 2006 499 505
15. S.L. Friedman Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies New England Journal of Medicine 328 1993 1828 1835
16. S.L. Friedman, D.C. Rockey, R.F. McGuire, J.J. Maher, J.K. Boyles, and G. Yamasaki Isolated hepatic lipocytes and Kupffer cells from normal human liver: morphological and functional characteristics in primary culture Hepatology 15 1992 234 243
17. H.F. Hendriks, W.A. Verhoofstad, A. Brouwer, A.M. de Leeuw, and D.L. Knook Perisinusoidal fat-storing cells are the main vitamin A storage sites in rat liver Experimental Cell Research 160 1985 138 149
18. M.J. Hsu, J.S. Cheng, and H.C. Huang Effect of saikosaponin, a triterpene saponin, on apoptosis in lymphocytes: association with c-myc, p53, and bcl-2 mRNA British Journal of Pharmacology 131 2000 1285 1293
19. K. Imai, and H. Senoo Morphology of sites of adhesion between hepatic stellate cells (vitamin A-storing cells) and a three-dimensional extracellular matrix Anatomical Record 250 1998 430 437
20. B.M. Kim, and S.H. Hong Sequential caspase-2 and caspase-8 activation is essential for saikosaponin a-induced apoptosis of human colon carcinoma cell lines Apoptosis 16 2011 184 197
21. W. Klinger, T. Devereux, and J.R. Fouts Functional and structural zonal hepatocyte heterogeneity - dynamics and ontogenic development Experimental Pathology 35 1988 69 91
22. Z. Kmiec Cooperation of liver cells in health and disease Advances in Anatomy, Embryology and Cell Biology 161 2001 1 151 III-XIII
23. C.N. Lu, Z.G. Yuan, X.L. Zhang, R. Yan, Y.Q. Zhao, M. Liao, and J.X. Chen Saikosaponin a and its epimer saikosaponin d exhibit anti-inflammatory activity by suppressing activation of NF-kappaB signaling pathway International Immunopharmacology 14 2012 121 126
24. U. Maegdefrau, T. Amann, A. Winklmeier, S. Braig, T. Schubert, T.S. Weiss, K. Schardt, C. Warnecke, C. Hellerbrand, and A.K. Bosserhoff Bone morphogenetic protein 4 is induced in hepatocellular carcinoma by hypoxia and promotes tumour progression Journal of Pathology 218 2009 520 529
25. F. Marra Chemokines in liver inflammation and fibrosis Frontiers in Bioscience 7 2002 d1899 d1914
26. F. Marra, W. Delogu, I. Petrai, S. Pastacaldi, A. Bonacchi, E. Efsen, S. Aleffi, C. Bertolani, M. Pinzani, and P. Gentilini Differential requirement of members of the MAPK family for CCL2 expression by hepatic stellate cells American Journal of Physiology Gastrointestinal and Liver Physiology 287 2004 G18 G26
27. Y. Nakajima, T. Yamagishi, S. Hokari, and H. Nakamura Mechanisms involved in valvuloseptal endocardial cushion formation in early cardiogenesis: roles of transforming growth factor (TGF)-beta and bone morphogenetic protein (BMP) The Anatomical Record 258 2000 119 127
28. K. Neubauer, T. Knittel, S. Aurisch, P. Fellmer, and G. Ramadori Glial fibrillary acidic protein - a cell type specific marker for Ito cells in vivo and in vitro Journal of Hepatology 24 1996 719 730
29. M. Pinzani Novel insights into the biology and physiology of the Ito cell Clinical Pharmacology and Therapeutics 66 1995 387 412
30. M. Pinzani, and P. Gentilini Biology of hepatic stellate cells and their possible relevance in the pathogenesis of portal hypertension in cirrhosis Seminars in Liver Disease 19 1999 397 410
31. L. Qian, T. Murakami, Y. Kimura, M. Takahashi, and K. Okita Saikosaponin A-induced cell death of a human hepatoma cell line (HuH-7): the significance of the 'sub-G1 peak' in a DNA histogram Pathology International 45 1995 207 214
32. H. Shen, G. Huang, M. Hadi, P. Choy, M. Zhang, G.Y. Minuk, Y. Chen, and Y. Gong Transforming growth factor-beta1 downregulation of Smad1 gene expression in rat hepatic stellate cells American Journal of Physiology Gastrointestinal and Liver Physiology 285 2003 G539 G546
33. H. Shen, G.J. Huang, and Y.W. Gong Effect of transforming growth factor beta and bone morphogenetic proteins on rat hepatic stellate cell proliferation and trans-differentiation World Journal of Gastroenterology 9 2003 784 787
34. H. Shen, M. Zhang, G.Y. Minuk, and Y. Gong Different effects of rat interferon alpha, beta and gamma on rat hepatic stellate cell proliferation and activation BMC Cell Biology 3 2002 9
35. Y. Sun, T.T. Cai, X.B. Zhou, and Q. Xu Saikosaponin a inhibits the proliferation and activation of T cells through cell cycle arrest and induction of apoptosis International Immunopharmacology 9 2009 978 983
36. W. Wen-Sheng ERK signaling pathway is involved in p15INK4b/p16INK4a expression and HepG2 growth inhibition triggered by TPA and Saikosaponin a Oncogene 22 2003 955 963
37. G. Winnier, M. Blessing, P.A. Labosky, and B.L. Hogan Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse Genes and Development 9 1995 2105 2116
38. J.M. Wozney The bone morphogenetic protein family: multifunctional cellular regulators in the embryo and adult European Journal of Oral Sciences 106 Suppl 1 1998 160 166
39. J.M. Wozney, and V. Rosen Bone morphogenetic protein and bone morphogenetic protein gene family in bone formation and repair Clinical Orthopaedics and Related Research 1998 26 37
40. S.J. Wu, L.Y. C.C. Chu, Y.H. Tsai, and J.C. Chao Curcumin or saikosaponin a improves hepatic antioxidant capacity and protects against CCl4-induced liver injury in rats Journal of Medicinal Food 11 2008 224 229
41. S.J.T.K. Wu, Y.H. Tsai, C.C. Chang, and J.C. Chao Curcumin and saikosaponin a inhibit chemical-induced liver inflammation and fibrosis in rats American Journal of Chinese Medicine 38 2010 99 111
42. W. Wu ERK signaling pathway is involved in p15INK4b/p16INK4a expression and HepG2 growth inhibition triggered by TPA and Saikosaponin a Oncogene 22 2003 955 963
43. T. Yamagishi, Y. Nakajima, K. Miyazono, and H. Nakamura Bone morphogenetic protein-2 acts synergistically with transforming growth factor-beta3 during endothelial-mesenchymal transformation in the developing chick heart Journal of Cellular Physiology 180 1999 35 45
44. H. Yamashita, P. Ten Dijke, C.H. Heldin, and K. Miyazono Bone morphogenetic protein receptors Bone 19 1996 569 574
45. C. Yang, M. Zeisberg, B. Mosterman, A. Sudhakar, U. Yerramalla, K. Holthaus, L. Xu, F. Eng, N. Afdhal, and R. Kalluri Liver fibrosis: insights into migration of hepatic stellate cells in response to extracellular matrix and growth factors Gastroenterology 124 2003 147 159 of Canada