Wide-Scope Screening of Illicit Drugs in Urban Wastewater by UHPLC-QTOF MS

Illicit Drugs in the Environment: Occurrence, Analysis, and Fate Using Mass Spectrometry

Volumn , Issue , 2011, Pages 69-85

  Hernández, Félix ^a   Sancho, Juan V ^a   Bijlsma, Lubertus ^a  

^a UNIVERSITAT JAUME I   (Spain)

Author keywords

Illicit drug screening in urban wastewater by UHPLC QTOF MS and illicit drug presence; Post target approach, detecting unlimited number of compounds of interest; QTOF MS potential, and ultrahigh pressure liquid chromatography (UHPLC) screening and confirmation of illicit drugs in wastewater

Indexed keywords

EID: 84886039648     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781118000816.ch4     Document Type: Chapter

References (36)

1. Badoud, F., E. Grata, L. Perrenoud, L. Avois, M. Saugy, S. Rudaz, and J.-L. Veuthey. 2009. Fast analysis of doping agents in urine by ultra-high-pressure liquid chromatography-quadrupole time-of-flight mass spectrometry I. Screening analysis. J. Chromatogr. A 1216:4423-4433.
2. Barceló, D., and M. Petrovic. 2007. Pharmaceuticals and personal care products (PPCPs) in the environment. Anal. Bioanal. Chem. 387:1141-1142.
3. Bijlsma, L., J. V. Sancho, E. Pitarch, M. Ibáñez, F. Hernández 2009. Simultaneous ultra-highpressure liquid chromatography-tandem mass spectrometry determination of amphetamine and amphetamine-like stimulants, cocaine and its metabolites, and a cannabis metabolite in surface water and urban wastewater. J. Chromatogr. A 1216:3078-3089.
4. Castiglioni, S., E. Zuccato, E. Crisci, C. Chiabrando, R. Fanelli, and R. Bagnati. 2006. Identification and measurement of illicit drugs and their metabolites in urban wastewater by liquid chromatography-tandem mass spectrometry. Anal. Chem. 78:8421-8429.
5. Castiglioni, S., E. Zuccato,C. Chiabrando, R. Fanelli, andR. Bagnati. 2008. Mass spectrometric analysis of illicit drugs in wastewater and surface water. Mass Spectrom. Rev. 27:378-394.
6. Castro-Perez, J., J. Hoyes, H. Major, and S. Preece. 2002. Advances in MS-based approaches for drug and metabolism studies. Chromatographia 55:S59-S63.
7. Díaz,R., M. Ibáñez, J. V. Sancho, and F. Hernández. 2010. Building an empirical mass spectra library for screening of organic pollutants by UHPLC-QTOF MS. Rapid Commun. Mass Spectrom. under revision.
8. Ferrer, I., and E. M. Thurman. 2007. Multi-residue method for the analysis of 101 pesticides and their degradates in food and water samples by liquid chromatography/time-of-flight mass spectrometry. J. Chromatogr. A 1175:24-37.
9. García-Reyes, J. F., B. Gilbert-López, A. Molina-Díaz, and A. R. Fernández-Alba. 2008. Determination of pesticide residues in fruit-based soft drinks. Anal. Chem. 80:8966-8974.
10. Gheorghe, A., A. van Nuijs, B. Pecceu, L. Bervoets, P. G. Jorens, R. Blust, H. Neels, and A. Covaci. 2008. Analysis of cocaine and its principal metabolites in waste and surface water using solid-phase extraction and liquid chromatography-ion trap tandem mass spectrometry. Anal. Bioanal. Chem. 391:1309-1319.
11. Grimalt, S., O. J. Pozo, J. V. Sancho, and F. Hernández. 2007. Use of liquid chromatography coupled to quadrupole time-of-flight mass spectrometry to investigate pesticide residues in fruits. Anal. Chem. 79:2833-2843.
12. Grimalt, S., J. V. Sancho, O. J. Pozo, and F. Hernández. 2010. Quantification, confirmation and screening capability of UHPLC coupled to triple quadrupole and hybrid quadrupole timeof-flight mass spectrometry in pesticide residue analysis. J. Mass Spectrom. 45:421-436.
13. Hernández, F., O. J. Pozo, J. V. Sancho, F. J. López, J. M. Marín, and M. Ibáñez. 2005a. Strategies for quantification and confirmation of multi-class polar pesticides and transformation products in water by LC-MS2 using triple quarupole and hybrid quadrupole time-of-flight analyzers. Trends Anal. Chem. 24:596-612.
14. Hernández, F., J. V. Sancho, and O. J. Pozo. 2005b. Critical review of the application of liquid chromatography/mass spectrometry to the determination of pesticide residues in biological samples. Anal. Bioanal. Chem. 382:934-946.
15. Hogenboom, A. C., W. M. A. Niessen, D. Little, U. A. Th. Brinkman. 1999. Accurate mass determinations for the confirmation and identification of organic microcontaminants in surface water using on-line solid-phase extraction liquid chromatography electrospray orthogonal-acceleration time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom. 13:125-133.
16. Huerta-Fontela, M., M. T. Galceran, and F. Ventura. 2007. Ultraperformance liquid chromatography-tandem mass spectrometry analysis of stimulatory drugs of abuse in wastewater and surface waters. Anal. Chem. 79:3821-3829.
17. Ibáñez,M., J. V. Sancho, O. J. Pozo, W. Niessen, and F. Hernández. 2005. Use of quadrupole time-of-flight mass spectrometry in the elucidation of unknown compounds present in environmental water. Rapid Commun. Mass Spectrom. 19:169-178.
18. Ibáñez, M., J. V. Sancho, D. McMillan, R. Rao, and F. Hernández. 2008. Rapid non-target screening of organic pollutants in water by ultraperformance liquid chromatography coupled to time-of-flight mass spectrometry. Trends Anal. Chem. 27(5): 481-489.
19. Ibáñez, M., C. Guerrero, J. V. Sancho, and F. Hernández. 2009. Screening of antibiotics in surface and wastewater samples by ultra-high-pressure liquid chromatography coupled to hybrid quadrupole time-of-flight mass spectrometry. J. Chromatogr. A 1216:2529-2539.
20. Jones-Lepp, T. L., D. A. Alvarez, J. D. Petty, and J. N. Huckins. 2004. Polar organic chemical integrative sampling and liquid chromatography-electrospray/ion-trap mass spectrometry for assessing selected prescription and illicit drugs in treated sewage effluents. Arch. Environ. Contamination Toxicol. 47:427-439.
21. Kasprzyk-Hordern, B., R. M. Dinsdale, and A. J. Guwy. 2007. Multi-residue method for the determination of basic/neutral pharmaceuticals and illicit drugs in surface water by solid-phase extraction and ultra performance liquid chromatography-positive electrospray ionisation tandem mass spectrometry. J. Chromatogr. A 1161:132-145.
22. Kaufmann, A. 2009. Quantitative analysis of veterinary drug residues by sub 2-μm particulate high-perfromance liquid chromatography columns and time-of-flight mass spectrometry (UPLC-TOF). In: Liquid chromatography time-of-flight mass spectrometry: principles, tools, and applications for accurate mass analysis, edited by I. Ferrer and E. M. Thurman, pp. 133-150Wiley, Hoboken, New Jersey.
23. Laks, S., A. Pelander, E. Vuori, E. Ali-Tolppa, E. Sippola, and I. Ojanperä. 2004. Analysis of street drugs in seized material without primary reference standards. Anal. Chem. 76:7375-7379.
24. Mezcua,M., O. Malato, J. F. García-Reyes, A. Molina-Díaz, and A. R. Fernández-Alba. 2009. Accurate-mass databases for comprehensive screening of pesticide residues in food by fast liquid chromatography time-of-flight mass spectrometry. Anal. Chem. 81:913-929.
25. Niessen, W. M. A., P. Manini, and R. Anderoli. 2006. Matrix effects in quantitative pesticide analysis using liquid chromatography-mass spectrometry. Mass Spectrom. Rev. 25:881-899.
26. Ojanperä, S.,A. Pelander, M. Pelzing, I. Krebs, E. Vuori, and I. Ojanperä. 2006. Isotopic pattern and accurate mass determination in urine drug screening by liquid chromatography/timeof-flight mass spectrometry. Rapid Commun. Mass Spectrom. 20:1161-1167.
27. Pelander, A., I. Ojanperä, S. Laks, I. Rasanen, and E. Vuori. 2003. Toxicological screening with formula-based metabolite identification by liquid chromatography/time-of-flight mass spectrometry. Anal. Chem. 75:5710-5718.
28. Petrovic, M., M. Gros, and D. Barcelo. 2006. Multi-residue analysis of pharmaceuticals in wastewater by ultra-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry. J. Chromatogr. A 1124:68-81.
29. Plumb, R. S., K. A. Johnson, P. Rainville, B. W. Smith, I. D. Wilson, J. Castro-Perez, and J. K. Nicholson. 2006. UPLC/MSE; a new approach for generating molecular fragment information for biomarker structure elucidation. Rapid Commun. Mass Spectrom. 20:1989-1994.
30. Pozo, O. J., J. V. Sancho, M. Ibañez, F. Hernandez, and W. M. A. Niessen. 2006. Confirmation of organic micropollutants detected in environmental samples by liquid chromatography tandem mass spectrometry: achievements and pitfalls. Trends Anal. Chem. 25(10): 1030-1042.
31. Richardson, S. D. 2008. Environmental mass spectrometry: emerging contaminants and current issues. Anal. Chem. 80:4373-4402.
32. Richardson, S. D. 2009. Water analysis: emerging contaminants and current issues. Anal. Chem. 81:4645-4677.
33. Sancho, J. V., O. J. Pozo, M. Ibañez, and F. Hernández. 2006. Potential of liquid chromatography/time-of-flight mass spectrometry for the determination of pesticides and transformation products in water. Anal. Bioanal. Chem. 386:987-997.
34. Tiller, P. R., S. Yu, J. Castro-Perez, K. L. Fillgrove, and T. A. Baillie. 2008. High-throughput, accurate mass liquid chromatography/tandem mass spectrometry on a quadrupole time-offlight system as a 'first-line'approach for metabolite identification studies. Rapid Commun. Mass Spectrom. 22:1053-1061.
35. Weaver, P. J., A. Laures, and J.-C. Wolff. 2007. Investigation of the advanced functionalities of a hybrid quadrupole orthogonal acceleration time-of-flight mass spectrometer. Rapid Commun. Mass Spectrom. 21:2415-2421.
36. Zuccato, E., C. Chiabrando, S. Castiglioni, D. Calamari, R. Bagnati, S. Schiarea, R. Fanelli. 2005. Cocaine in surface waters: A new evidence-based tool to monitor community drug abuse. Environ. Health Global Access Sci. Source 4:14. Available at http://www.ehjournal.net/content/4/1/14.