Diabetes impairs an interleukin-1β-dependent pathway that enhances neurite outgrowth through JAK/STAT3 modulation of mitochondrial bioenergetics in adult sensory neurons

Molecular Brain

Volumn 6, Issue 1, 2013, Pages

  Saleh, Ali ^a   Roy Chowdhury, Subir K ^a   Smith, Darrell R ^a   Balakrishnan, Savitha ^a   Tessler, Lori ^a   Schartner, Emily ^a   Bilodeau, Andre ^a   Van Der Ploeg, Randy ^a   Fernyhough, Paul ^a,b  

^a ST BONIFACE GENERAL HOSPITAL   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

Author keywords

Axon regeneration; Bioenergetics; Dorsal root ganglia; Neuropathy; Neurotrophic factor

Indexed keywords

CYTOKINE; INTERLEUKIN 10; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 2; JANUS KINASE; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; SHORT HAIRPIN RNA; STAT3 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOENERGY; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC NEUROPATHY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; INSULIN DEPENDENT DIABETES MELLITUS; NERVE; NERVE CELL; NERVE CELL CULTURE; NERVE CELL PLASTICITY; NERVE FIBER GROWTH; NERVE FIBER REGENERATION; NERVOUS TISSUE; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SENSORY NERVE CELL; STREPTOZOCIN DIABETES; SYNTHESIS;

MUS; RATTUS; RODENTIA;

AGING; ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; ENERGY METABOLISM; GANGLIA, SPINAL; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-1ALPHA; INTERLEUKIN-1BETA; JANUS KINASES; MALE; MICE; MITOCHONDRIA; NEURITES; PHOSPHORYLATION; PHOSPHOTYROSINE; RATS; RATS, SPRAGUE-DAWLEY; SCIATIC NERVE; SENSORY RECEPTOR CELLS; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; STREPTOZOCIN; TYRPHOSTINS;

EID: 84885993309     PISSN: None     EISSN: 17566606     Source Type: Journal    
DOI: 10.1186/1756-6606-6-45     Document Type: Article

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