Increased error-related brain activity in six-year-old children with clinical anxiety

Journal of Abnormal Child Psychology

Volumn 41, Issue 8, 2013, Pages 1257-1266

  Meyer, Alexandria ^a   Hajcak, Greg ^a   Torpey, Dana C ^b   Kujawa, Autumn ^a   Kim, Jiyon ^a   Bufferd, Sara ^a   Carlson, Gabrielle ^a   Klein, Daniel N ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Anxiety disorders; Biological marker; Children; Error related negativity; Event related potentials; Pediatric anxiety; Risk markers

Indexed keywords

ADOLESCENT; ADULT; ANALYSIS OF VARIANCE; ANXIETY DISORDER; ARTICLE; CASE CONTROL STUDY; CHILD; CINGULATE GYRUS; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; ELECTROENCEPHALOGRAPHY; EVOKED RESPONSE; FEMALE; HUMAN; INHIBITION (PSYCHOLOGY); MALE; METHODOLOGY; MOTHER; NEUROPSYCHOLOGICAL TEST; PATHOPHYSIOLOGY; PHYSIOLOGY; PRESCHOOL CHILD; PSYCHOLOGIC TEST; PSYCHOLOGICAL ASPECT; REACTION TIME; STATISTICAL MODEL;

ADOLESCENT; ADULT; ANALYSIS OF VARIANCE; ANXIETY DISORDERS; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; ELECTROENCEPHALOGRAPHY; EVOKED POTENTIALS; FEMALE; GYRUS CINGULI; HUMANS; INHIBITION (PSYCHOLOGY); INTERVIEW, PSYCHOLOGICAL; LINEAR MODELS; MALE; MOTHERS; NEUROPSYCHOLOGICAL TESTS; REACTION TIME;

EID: 84885954214     PISSN: 00910627     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10802-013-9762-8     Document Type: Article

References (73)

1. Achenbach, T. M.; McConaughy, S. H.; & Howell, C. T. (1987). Child/adolescent behavioral and emotional problems: implications of cross-informant correlations for situational specificity. Psychological Bulletin, 101, 213-232.
2. Adleman, N. E.; Menon, V.; Blasey, C. M.; White, C. D.; Warsofsky, I. S.; Glover, G. H.; et al. (2002). A Developmental fMRI study of the stroop color-word task. NeuroImage, 16, 61-75. doi: 10.1006/nimg.2001.1046.
3. Amodio, D. M.; Master, S. L.; Yee, C. M.; & Taylor, S. E. (2008). Neurocognitive components of the behavioral inhibition and activation systems: implications for theories of self-regulation. Psychophysiology, 45, 11-19. doi: 10.1111/j.1469-8986.2007.00609.x.
4. Anokhin, A. P.; Golosheykin, S.; & Heath, A. C. (2008). Heritability of frontal brain function related to action monitoring. Psychophysiology, 45, 524-534. doi: 10.1111/j.1469-8986.2008.00664.x.
5. Arbel, Y.; & Donchin, E. (2011). When a child errs: the ERN and the Pe complex in children. Psychophysiology, 48, 55-63. doi: 10.1111/j.1469-8986. 2010.01042.x.
6. Beesdo, K.; Knappe, S.; & Pine, D. S. (2009). Anxiety and anxiety disorders in children and adolescents: developmental issues and implications for DSM-V. Psychiatric Clinics of North America, 32, 483-524. doi: 10.1016/j.psc.2009.06.002.
7. Beesdo, K.; Pine, D. S.; Lieb, R.; & Wittchen, H. (2010). Incidence and risk patterns of anxiety and depressive disorders and categorization of generalized anxiety disorder. Archives of General Psychiatry, 67, 47-57. doi: 10.1001/archgenpsychiatry.2009.177.
8. Beidel, D. C.; & Turner, S. M. (1997). At risk for anxiety: I. Psychopathology in the offspring of anxious parents. Journal of the American Academy of Child and Adolescent Psychiatry, 36, 918-924. doi: 10.1097/00004583-199707000-00013.
9. Bijl, R. V.; Cuijpers, P.; & Smit, F. (2002). Psychiatric disorders in adult children of parents with a history of psychopathology. Social Psychiatry And Psychiatric Epidemiology, 37, 7-12.
10. Bird, H. R.; Gould, M. S.; & Staghezza, B. (1992). Aggregating data from multiple informants in child psychiatry epidemiological research. Journal of the American Academy of Child and Adolescent Psychiatry, 31, 78-85.
11. Bittner, A.; Egger, H. L.; Erkanli, A.; Jane Costello, E.; Foley, D. L.; & Angold, A. (2007). What do childhood anxiety disorders predict? Journal of Child Psychology and Psychiatry, 48, 1174-1183.
12. Boksem, M. A. S.; Tops, M.; Wester, A. E.; Meijman, T. F.; & Lorist, M. M. (2006). Error-related ERP components and individual differences in punishment and reward sensitivity. Brain Research, 1101, 92-101. doi: 10.1016/j.brainres.2006.05.004.
13. Brooker, R. J.; Buss, K. A.; & Dennis, T. A. (2011). Error-monitoring brain activity is associated with affective behaviors in young children. Developmental Cognitive Neuroscience, 1, 141-152. doi: 10.1016/j.dcn.2010.12. 002.
14. Carrasco, M.; Harbin, S. M.; Nienhuis, J. K.; Fitzgerald, K. D.; Gehring, W. J.; & Hanna, G. L. (2013). Increased error-related brain activity in youth with obsessive-compulsive disorder and unaffected siblingseased error-related brain activity in youth with obsessive-compulsive disorder and unaffected siblings. Depression and Anxiety, 30, 39-46.
15. Casey, B. J.; Tottenham, N.; Liston, C.; & Durston, S. (2005). Imaging the developing brain: what have we learned about cognitive development? Trends in Cognitive Sciences, 9, 104-110. doi: 10.1016/j.tics.2005.01.011.
16. Crozier, W. R.; & Burnham, M. (1990). Age-related differences in children's understanding of shyness. British Journal of Developmental Psychology, 8, 179-185. doi: 10.1111/j.2044-835X.1990.tb00832.x.
17. Cunningham, M. G.; Bhattacharyya, S.; & Benes, F. M. (2002). Amygdalo-cortical sprouting continues into early adulthood: Implications for the development of normal and abnormal function during adolescence. The Journal of Comparative Neurology, 453, 116-130. doi: 10.1002/cne.10376.
18. Davies, P. L.; Segalowitz, S. J.; & Gavin, W. J. (2004). Development of response-monitoring ERPs in 7- to 25-year-olds. Developmental Neuropsychology, 25, 355-376.
19. Debener, S.; Ullsperger, M.; Siegel, M.; Fiehler, K.; von Cramon, D. Y.; & Engel, A. K. (2005). Trial-by-trial coupling of concurrent electroencephalogram and functional magnetic resonance imaging identifies the dynamics of performance monitoring. The Journal of Neuroscience, 25, 11730-11737. doi: 10.1523/jneurosci.3286-05.2005.
20. Dehaene, S.; Posner, M. I.; & Don, M. T. (1994). Localization of a neural system for error detection and compensation. Psychological Science, 5, 303-305.
21. Egger, H. L.; Ascher, B. H.; & Angold, A. (1999). The preschool age psychiatric assessment: Version 1.1. Durham, NC: Center for Developmental Epidemiology, Department of Psychiatry and Behavioral Sciences, Duke University Medical Center.
22. Egger, Erkanli, A.; Keeler, G.; Potts, E.; Walter, B. K.; & Angold, A. (2006). Test-retest reliability of the Preschool Age Psychiatric Assessment (PAPA). Journal of the American Academy of Child and Adolescent Psychiatry, 45, 538-549.
23. Emmelkamp, P. M. G.; & Wittchen, H. U. (2009). Specific Phobias. In G. Andrews, D. S. Charney, & P. J. Sirovatka (Eds.), Stress-induced and fear circuitry disorders. Refining the research agenda for DSM-V (pp. 77-101). Arlington, VA: APA.
24. Endrass, T.; Klawohn, J.; Schuster, F.; & Kathmann, N. (2008). Overactive performance monitoring in obsessive-compulsive disorder: ERP evidence from correct and erroneous reactions. Neuropsychologia, 46, 1877-1887. doi: 10.1016/j.neuropsychologia.2007.12.001.
25. Etkin, A.; & Wager, T. D. (2007). Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. The American Journal of Psychiatry, 164, 1476-1488.
26. Falkenstein, M.; Hohnsbein, J.; Hoormann, J.; & Blanke, L. (1991). Effects of crossmodal divided attention on late ERP components. II. Error processing in choice reaction tasks. Electroencephalography and Clinical Neurophysiology, 78, 447-455. doi: 10.1016/0013-4694(91)90062-9.
27. First, M. B.; Spitzer, R. L.; Gibbon, M.; Williams, J. B. W.; Davies, M.; Borus, J.; et al. (1995). The structured clinical interview for DSM-III-R personality disorders (SCID-II). Part II: Multi-site test-retest reliability study. Journal of Personality Disorders, 9, 92-104.
28. Fitzgerald, K. D.; Welsh, R. C.; Gehring, W. J.; Abelson, J. L.; Himle, J. A.; Liberzon, I.; et al. (2005). Error-related hyperactivity of the anterior cingulate cortex in obsessive-compulsive disorder. Biological Psychiatry, 57, 287-294. doi: 10.1016/j.biopsych.2004.10.038.
29. Gehring, W. J.; Goss, B.; Coles, M. G. H.; Meyer, D. E.; & Donchin, E. (1993). A neural system for error detection and compensation. Psychological Science, 4, 385-390.
30. Gehring, W. J.; Himle, J.; & Nisenson, L. G. (2000). Action-monitoring dysfunction in obsessive-compulsive disorder. Psychological Science, 11, 1-6.
31. Gratton, G.; Coles, M. G. H.; & Donchin, E. (1983). A new method for off-line removal of ocular artifact. Electroencephalography and Clinical Neurophysiology, 55, 468-484. doi: 10.1016/0013-4694(83)90135-9.
32. Hajcak, G. (2012). What we've learned from mistakes. Current Directions in Psychological Science, 21, 101-106. doi: 10.1177/0963721412436809.
33. Hajcak, G.; McDonald, N.; & Simons, R. F. (2003). Anxiety and error-related brain activity. Biological Psychology, 64, 77-90. doi: 10.1016/s0301-0511(03)00103-0.
34. Hajcak, G.; McDonald, N.; & Simons, R. F. (2004). Error-related psychophysiology and negative affect. Brain and Cognition, 56, 189-197. doi: 10.1016/j.bandc.2003.11.001.
35. Hajcak, G.; Franklin, M. E.; Foa, E. B.; & Simons, R. F. (2008). Increased error-related brain activity in pediatric obsessive-compulsive disorder before and after treatment. Amercian Journal of Psychiatry, 165, 116-123. doi: 10.1176/appi.ajp.2007.07010143.
36. Hall, J. R.; Bernat, E. M.; & Patrick, C. J. (2007). Externalizing psychopathology and the error-related negativity. Psychological Science, 18, 326-333.
37. Hanna, G. L.; Carrasco, M.; Harbin, S. M.; Nienhuis, J. K.; LaRosa, C. E.; Chen, P.; Gehring, W. J. (2012). Error-related negativity and tic history in pediatric obsessive-compulsive disorder. Journal of the American Academy of Child & Adolescent Psychiatry, 51, 902-910. doi: 10.1016/j.jaac.2012.06.019.
38. Holroyd, C. B.; Dien, J.; & Coles, M. G. H. (1998). Error-related scalp potentials elicited by hand and foot movements: evidence for an output-independent error-processing system in humans. Neuroscience Letters, 242, 65-68. doi: 10.1016/s0304-3940(98)00035-4.
39. Kessler, R. C.; Berglund, P.; Demler, O.; Jin, R.; Merikangas, K. R.; & Walters, E. E. (2005). Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Archives of General Psychiatry, 62, 593-602.
40. Ladouceur, C. D.; Dahl, R. E.; Birmaher, B.; Axelson, D. A.; & Ryan, N. D. (2006). Increased error-related negativity (ERN) in childhood anxiety disorders: ERP and source localization. Journal of Child Psychology and Psychiatry, 47, 1073-1082.
41. Last, C. G.; Hersen, M.; Kazdin, A.; Orvaschel, H.; & Perrin, S. (1991). Anxiety disorders in children and their families. Archives of General Psychiatry, 48, 928-934.
42. Last, C. G.; Perrin, S.; Hersen, M.; & Kazdin, A. E. (1996). A prospective study of childhood anxiety disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 35, 1502-1510.
43. Mathalon, D. H.; Whitfield, S. L.; & Ford, J. M. (2003). Anatomy of an error: ERP and fMRI. Biological Psychology, 64, 119-141. doi: 10.1016/s0301-0511(03)00105-4.
44. McClure, E. B.; Monk, C. S.; & Nelson, E. E. (2007). Abnormal attention modulation of fear circuit function in pediatric generalized anxiety disorder. Archives of General Psychiatry, 64, 97-106. doi: 10.1001/archpsyc.64. 1.97.
45. McDermott, J. M.; Perez-Edgar, K.; Henderson, H. A.; Chronis-Tuscano, A.; Pine, D. S.; & Fox, N. A. (2009). A history of childhood behavioral inhibition and enhanced response monitoring in adolescence are linked to clinical anxiety. Biological Psychiatry, 65, 445-448. doi: 10.1016/j.biopsych. 2008.10.043.
46. Merikangas, K. R.; Dierker, L. C.; & Szatmari, P. (1998). Psychopathology among offspring of parents with substance abuse and/or anxiety disorders: a high-risk study. Journal of Child Psychology and Psychiatry, 39, 711-720.
47. Meyer, Klein, D. N.; Torpey, D. C.; Kujawa, A. J.; Hayden, E. P.; & Sheikh, H. I. (2012a). Additive effects of the dopamine D2 receptor and dopamine transporter genes on the error-related negativity in young children. Genes, Brain, and Behavior, 11, 695-703.
48. Meyer, Weinberg, A.; Klein, D. N.; & Hajcak, G. (2012b). The development of the error-related negativity (ERN) and its relationship with anxiety: Evidence from 8 to 13 year-olds. Developmental Cognitive Neuroscience, 2, 152-161. doi: 10.1016/j.dcn.2011.09.005.
49. Moser, J. S.; Moran, T. P.; & Jendrusina, A. A. (2012). Parsing relationships between dimensions of anxiety and action monitoring brain potentials in female undergraduates. Psychophysiology, 49, 3-10. doi: 10.1111/j.1469-8986.2011.01279.x.
50. Nieuwenhuis, S.; Ridderinkhof, K. R.; Blom, J.; Band, G. P.; & Kok, A. (2001). Error-related brain potentials are differentially related to awareness of response errors: evidence from an antisaccade task. Psychophysiology, 38, 752-760.
51. Pailing, P. E.; Segalowitz, S. J.; Dywan, J.; & Davies, P. L. (2002). Error negativity and response control. Psychophysiology, 39, 198-206.
52. Paulus, M. P.; Hozack, N.; Frank, L.; & Brown, G. G. (2002). Error rate and outcome predictability affect neural activation in prefrontal cortex and anterior cingulate during decision-making. NeuroImage, 15, 836-846. doi: 10.1006/nimg.2001.1031.
53. Pine, D. S. (2007). Research review: a neuroscience framework for pediatric anxiety disorders. Journal of Child Psychology and Psychiatry, 48, 631-648.
54. Pine, D. S.; Cohen, P.; Gurley, D.; Brook, J.; & Ma, Y. (1998). The risk for early-adulthood anxiety and depressive disorders in adolescents with anxiety and depressive disorders. Archives of General Psychiatry, 55, 56-64.
55. Potts, G. F.; George, M. R. M.; Martin, L. E.; & Barratt, E. S. (2006). Reduced punishment sensitivity in neural systems of behavior monitoring in impulsive individuals. Neuroscience Letters, 397, 130-134.
56. Riesel, A.; Endrass, T.; Kaufmann, C.; & Kathmann, N. (2011). Overactive error-related brain activity as a candidate endophenotype for Obsessive-Compulsive Disorder: Evidence from unaffected first-degree relatives. The American Journal of Psychiatry, 168, 317-324. doi: 10.1176/appi.ajp.2010. 10030416.
57. Santesso, D. L.; Segalowitz, S. J.; & Schmidt, L. A. (2006). Error-related electrocortical responses are enhanced in children with obsessive-compulsive behaviors. Developmental Neuropsychology, 29, 431-445.
58. Spence, S. H.; Rapee, R.; McDonald, C.; & Ingram, M. (2001). The structure of anxiety symptoms among preschoolers. Behaviour Research and Therapy, 39, 1293-1316. doi: 10.1016/s0005-7967(00)00098-x.
59. Torpey, D. C.; Hajcak, G.; Kim, J.; Kujawa, A.; & Klein, D. N. (2011). Electrocortical and behavioral measures of response monitoring in young children during a Go/No-Go task. Developmental Psychobiology, 54, 139-150. doi: 10.1002/dev.20590.
60. Torpey, D. C.; Hajcak, G.; Kim, J.; Kujawa, A. J.; Dyson, M. W.; Olino, T. M.; & Klein, D. N. (2013). Error-related brain activity in young children: associations with parental anxiety and child temperamental negative emotionality. Journal of Child Psychology and Psychiatry. doi: 10.1111/jcpp.12041.
61. Ursu, S.; Stenger, V. A.; Shear, M. K.; Jones, M. R.; & Cameron, S. C. (2003). Overactive action monitoring in obsessive-compulsive disorder: evidence from functional magnetic resonance imaging. Psychological Science, 14, 347-353.
62. Van Bogaert, P.; Wikler, D.; Damhaut, P.; Szliwowski, H. B.; & Goldman, S. (1998). Regional changes in glucose metabolism during brain development from the age of 6 years. NeuroImage, 8, 62-68. doi: 10.1006/nimg.1998.0346.
63. Van den Bergh, B. R.; & Marcoen, A. (2004). High antenatal maternal anxiety is related to ADHD symptoms, externalizing problems, and anxiety in 8-and 9-year-olds. Child Development, 75, 1085-1097.
64. Van den Bergh, B. R.; Mulder, E. J.; Mennes, M.; & Glover, V. (2005). Antenatal maternal anxiety and stress and the neurobehavioural development of the fetus and child: links and possible mechanisms. A review. Neuroscience and Biobehavioral Reviews, 29, 237-258.
65. Van Der Toorn, S. L. M.; Huizink, A. C.; Utens, E. M. W. J.; Verhulst, F. C.; Ormel, J.; & Ferdinand, R. F. (2010). Maternal depressive symptoms, and not anxiety symptoms, are associated with positive mother-child reporting discrepancies of internalizing problems in children: a report on the TRAILS Study. European Child & Adolescent Psychiatry, 19, 379-388.
66. Vasey, M.; Crnic, K.; & Carter, W. (1994). Worry in childhood: a developmental perspective. Cognitive Therapy and Research, 18, 529-549. doi: 10.1007/bf02355667.
67. Weinberg, A.; & Hajcak, G. (2011a). Electrocortical evidence for vigilance-avoidance in Generalized Anxiety Disorder. Psychophysiology, 48, 842-851. doi: 10.1111/j.1469-8986.2010.01149.x.
68. Weinberg, A.; & Hajcak, G. (2011b). Longer term test-retest reliability of error-related brain activity. Psychophysiology, 48, 1420-1425. doi: 10.1111/j.1469-8986.2011.01206.x.
69. Weinberg, A.; Olvet, D. M.; & Hajcak, G. (2010). Increased error-related brain activity in generalized anxiety disorder. Biological Psychology, 85, 472-480. doi: 10.1016/j.biopsycho.2010.09.011.
70. Weinberg, A.; Klein, D. N.; & Hajcak, G. (2012). Increased error-related brain activity distinguishes generalized anxiety disorder with and without comorbid major depressive disorder. Journal of Abnormal Psychology, 121, 885-896. doi: 10.1037/a0028270.
71. Wiersema, J. R.; van der Meere, J. J.; & Roeyers, H. (2007). Developmental changes in error monitoring: an event-related potential study. Neuropsychologia, 45, 1649-1657. doi: 10.1016/j.neuropsychologia.2007.01.004.
72. Wittchen, H. U.; Lieb, R.; Pfister, H.; & Schuster, P. (2000). The waxing and waning of mental disorders: evaluating the stability of syndromes of mental disorders in the population. Comprehensive Psychiatry, 41(2 Suppl 1), 122-132.
73. Xiao, Z.; Wang, J.; Zhang, M.; Li, H.; Tang, Y.; Wang, Y.; et al. (2011). Error-related negativity abnormalities in generalized anxiety disorder and obsessive-compulsive disorder. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 35, 265-272. doi: 10.1016/j.pnpbp.2010.11.022.