A diagnostic score for the prediction of spontaneous resolution of acute hepatitis C virus infection

Journal of Hepatology

Volumn 59, Issue 5, 2013, Pages 972-977

  Beinhardt, Sandra ^a   Payer, Berit Anna ^a   Datz, Christian ^b   Strasser, Michael ^c   Maieron, Andreas ^d   Dorn, Livia ^e   Grilnberger Franz, Evelyn ^f   Dulic Lakovic, Emina ^g   Stauber, Rudolf ^h   Laferl, Hermann ^a   Aberle, Judith H ^a   Holzmann, Heidemarie ^a   Krall, Christoph ^a   Vogel, Wolfgang ^e   Ferenci, Peter ^a   Hofer, Harald ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b Hospital Oberndorf   (Austria)

^c PARACELSUS MEDICAL UNIVERSITY   (Austria)

^d Hospital of Elisabethinen   (Austria)

^e INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^f Otto Wagner Spital   (Austria)

^g WILHELMINEN HOSPITAL   (Austria)

^h MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

IL28B; IP 10; Newly acquired HCV; Score; Spontaneous clearance

Indexed keywords

ALANINE AMINOTRANSFERASE; BILIRUBIN; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 28B; VIRUS RNA;

ACUTE HEPATITIS; ADOLESCENT; ADULT; AGE DISTRIBUTION; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANTIVIRAL THERAPY; AREA UNDER THE CURVE; ARTICLE; BILIRUBIN BLOOD LEVEL; DIAGNOSTIC VALUE; FEMALE; GENOTYPE; HEPATITIS C; HUMAN; MAJOR CLINICAL STUDY; MALE; PREDICTION; PREDICTIVE VALUE; PRIORITY JOURNAL; PROBABILITY; RECEIVER OPERATING CHARACTERISTIC; RETROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; TH1 CELL; VIRAL CLEARANCE; WATCHFUL WAITING;

ACUTE HEPATITIS C; AHC; ALANINE AMINOTRANSFERASE; ALT; AREA UNDER THE RECEIVER OPERATING CURVE; AUROC; DAA; DIRECT ACTING ANTIVIRALS; GENOTYPE; GT; HCV; HEPATITIS C VIRUS; HIV; HUMAN IMMUNODEFICIENCY VIRUS; IL28B; INTERFERON-GAMMA INDUCIBLE PROTEIN; IP-10; NEGATIVE PREDICTIVE VALUE; NEWLY ACQUIRED HCV; NPV; POSITIVE PREDICTIVE VALUE; PPV; SC; SCORE; SINGLE NUCLEOTIDE POLYMORPHISM; SNP; SPONTANEOUS CLEARANCE;

ACUTE DISEASE; ADOLESCENT; ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; ANTIVIRAL AGENTS; BILIRUBIN; CHEMOKINE CXCL10; FEMALE; HEPACIVIRUS; HEPATITIS C; HUMANS; INTERLEUKINS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; PREDICTIVE VALUE OF TESTS; REMISSION, SPONTANEOUS; RETROSPECTIVE STUDIES; RNA, VIRAL; SENSITIVITY AND SPECIFICITY; WATCHFUL WAITING; YOUNG ADULT;

EID: 84885951403     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2013.06.028     Document Type: Article

References (30)

1. D.L. Thomas, and L.B. Seeff Natural history of hepatitis C Clin Liver Dis 9 2005 383 398
2. M.U. Mondelli, A. Cerino, and A. Cividini Acute hepatitis C: diagnosis and management J Hepatol 42 2005 S108 S114
3. L.B. Seeff, and J.H. Hoofnagle Appendix: the National Institutes of Health consensus development conference management of hepatitis C 2002 Clin Liver Dis 7 2003 261 287
4. A.L. Cox, D.M. Netski, T. Mosbruger, S.G. Sherman, S. Strathdee, and D. Ompad Prospective evaluation of community-acquired acute-phase hepatitis C virus infection Clin Infect Dis 40 2005 951 958
5. J.T. Gerlach, H.M. Diepolder, R. Zachoval, N.H. Gruener, M.C. Jung, and A. Ulsenheimer Acute hepatitis C: high rate of both spontaneous and treatment-induced viral clearance Gastroenterology 125 2003 80 88
6. K.E. Corey, A.S. Ross, A. Wurcel, J. Schulze zur Wiesch, A.Y. Kim, and G.M. Lauer Outcomes and treatment of acute hepatitis C virus infection in a United States population Clin Gastroenterol Hepatol 4 2006 1278 1282
7. C. Wang, E. Krantz, J. Klarquist, M. Krows, L. McBride, and E.P. Scott Acute hepatitis C in a contemporary US cohort: modes of acquisition and factors influencing viral clearance J Infect Dis 196 2007 1474 1482
8. S. Beinhardt, J.H. Aberle, M. Strasser, E. Dulic-Lakovic, A. Maieron, and A. Kreil Serum IP-10 improves predictive value of IL28B-polymorphisms in spontaneous clearance of acute hepatitis C virus infection Gastroenterology 142 2012 78 85
9. H. Hofer, T. Watkins-Riedel, O. Janata, E. Penner, H. Holzmann, and P. Steindl-Munda Spontaneous viral clearance in patients with acute hepatitis C can be predicted by repeated measurements of serum viral load Hepatology 37 2003 60 64
10. H.L. Tillmann, A.J. Thompson, K. Patel, M. Wiese, H. Tenckhoff, and H.D. Nischalke A Polymorphism near IL28B is associated with spontaneous clearance of acute hepatitis C virus and jaundice Gastroenterology 139 2011 1586 1592
11. D.L. Thomas, C.L. Thio, and M.P. Martin Genetic variation in IL28B and spontaneous clearance of hepatitis C virus Nature 461 2009 798 801
12. J. Grebely, K. Peoumenos, M. Hellard, G.V. Matthews, V. Suppiah, and T. Applegate Potential role for interleukin-28B genotype in treatment decision-making in recent hepatitis c virus infection Hepatology 52 2010 1216 1224
13. J.H. Aberle, E. Formann, P. Steindl-Munda, L. Weseslindtner, C. Gurguta, and G. Perstinger Prospective study of viral clearance and CD4+ T-cell response in acute hepatitis C primary infection and reinfection J Clin Virol 36 2006 24 31
14. J. Grebely, J.J. Feld, T. Applegate, G.V. Matthews, M. Hellard, and A. Sherker Plasma interferon-gamma-inducible protein-10 (IP-10) levels during acute hepatitis C infection Hepatology 57 6 2013 2124 2134
15. A. Riva, M. Laird, A. Casrouge, A. Ambrozaitis, M.L. Albert, and N.V. Naoumov The soluble antagonistic form of IFN-inducible protein-10 (IP-10) is a predictor of clinical outcome during acute hepatitis C J Hepatol 56 2012 Abstract-#: 808
16. H.M. Diepolder New insights into the immunopathogenesis of chronic hepatitis C Antiviral Res 82 2009 103 109
17. J. Post, S. Ratnarajah, and A.R. Lloyd Immunological determinants of the outcomes from primary hepatitis C infection Cell Mol Life Sci 66 2009 733 756
18. B. Rehermann, and C. Hepatitis Virus versus innate and adaptive immune responses: a tale of coevolution and coexistence J Clin Invest 119 2009 1745 1754
19. J.T. Blackard, M.T. Shata, N.J. Shire, and K.E. Sherman Acute hepatitis C virus infection: a chronic problem Hepatology 47 2008 321 331
20. B. Maasoumy, and H. Wedemeyer Natural history of acute and chronic hepatitis C Best Pract Res Clin Gastroenterol 26 2012 401 412
21. E. Jaeckel, M. Cornberg, H. Wedemeyer, T. Santantonio, J. Mayer, and M. Zankel Treatment of acute hepatitis C with interferon alfa-2b N Engl J Med 345 2001 1452 1457
22. A. Mangia, R. Santoro, M. Copetti, M. Massari, V. Piazolla, and E. Spada Treatment optimization of and prediction of HCV clearance in patients with acute HCV infection J Hepatol 2013 10.1016/j.jhep.2013.04.007 [epub ahead of print]
23. K. Deterding, N. Grüner, P. Buggisch, J. Wiegand, P. Galle, and U. Spengler Early versus delayed treatment of acute hepatitis C: final results of the randomized controlled German HEP-NET acute HCV-III study J Hepatol 56 2012 21 Abstract-#: 48
24. E.R. DeLong, D.M. DeLong, and D.L. Clarke-Pearson Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach Biometrics 44 1988 837 845
25. T. Santantonio, J. Wiegand, and J.T. Gerlach Acute hepatitis C: current status and remaining challenges J Hepatol 49 2008 625 633
26. H. Nomura, S. Sou, H. Tanimoto, T. Nagahama, Y. Kimura, and J. Hayashi Short-term interferon-alpha therapy for acute heatitis C: a randomized controlled trial Hepatology 39 2004 1213 1219
27. J. Delwaide, N. Bourgeois, C. Gerad, S. DeMaeght, F. Mokaddem, and E. Wain Treatment of acute hepatitis C with interferon alpha-2b: early initiation of treatment is the most effective predictive factor of sustained viral response Aliment Pharmacol Ther 20 2004 15 22
28. K.E. Corey, J. Mendez-Navarro, E.C. Gorospe, H. Zheng, and R.T. Chung Early treatment improves outcomes in acute hepatitis C virus: a meta-analysis J Viral Hepat 17 2010 201 207
29. T. Santantonio, M. Fasano, E. Sinisi, A. Guastadisegni, C. Casalino, and M. Mazzola Efficacy of a 24-week course of PEG-interferon alpha-2b monotherapy in patients with acute hepatitis C after failure of spontaneous clearance J Hepatol 42 2005 329 333
30. S. Deuffic-Burban, H. Castel, J. Wiegand, M.P. Manns, H. Wedemeyer, and P. Mathurin Immediate vs. delayed treatment in patients with acute hepatitis C based on IL28B polymorphism: a model-based analysis J Hepatol 57 2012 260 266