Lack of association of IL-6 polymorphism with rheumatoid arthritis/type 1 diabetes: A meta-analysis

Joint Bone Spine

Volumn 80, Issue 5, 2013, Pages 477-481

  Xu, Wang Dong ^a   Zhou, Mo ^a   Peng, Hui ^a   Pan, Hai Feng ^a   Ye, Dong Qing ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

IL 6; Meta analysis; Polymorphism; Rheumatoid arthritis; Type 1 diabetes

Indexed keywords

INTERLEUKIN 6;

ARTICLE; ASIA; AUTOIMMUNE DISEASE; CASE CONTROL STUDY; DISEASE PREDISPOSITION; ETHNIC GROUP; ETHNICITY; EUROPE; GENOTYPE; HUMAN; IMMUNE SYSTEM; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; RHEUMATOID ARTHRITIS; SINGLE NUCLEOTIDE POLYMORPHISM; SOUTH AMERICA;

IL-6; META-ANALYSIS; POLYMORPHISM; RHEUMATOID ARTHRITIS; TYPE 1 DIABETES;

ARTHRITIS, RHEUMATOID; DIABETES MELLITUS, TYPE 1; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INTERLEUKIN-6; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84885930424     PISSN: 1297319X     EISSN: 17787254     Source Type: Journal    
DOI: 10.1016/j.jbspin.2012.11.005     Document Type: Article

References (37)

1. Mathis D., Vence L., Benoist C. Beta-cell death during progression to diabetes. Nature 2001, 414:792-798.
2. Javor J., Ferencik S., Bucova M., et al. Polymorphisms in the genes encoding TGF-beta1, TNF-alpha, and IL-6 show association with type 1 diabetes mellitus in the Slovak population. Arch Immunol Ther Exp (Warsz) 2010, 58:385-393.
3. Boissier M.C. Cell and cytokine imbalances in rheumatoid synovitis. Joint Bone Spine 2011, 78:230-234.
4. Gonzalez-Juanatey C., Llorca J., Miranda-Filloy J.A., et al. Endothelial dysfunction in psoriatic arthritis patients without clinically evident cardiovascular disease or classic atherosclerosis risk factors. Arthritis Rheum 2007, 57:287-293.
5. Ichinose K., Kawasaki E., Eguchi K. Recent advancement of understanding pathogenesis of type 1 diabetes mellitus and potential relevance to diabetic nephropathy. Am J Nephrol 2007, 27:554-564.
6. Kristiansen O.P., Mandrup-Poulsen T. Interleukin-6 and diabetes: the good, the bad, or the indifferent?. Diabetes 2005, 54:S114-S1124.
7. Hoffmann S.C., Stanley E.M., Cox E.D., et al. Ethnicity greatly influences cytokine gene polymorphism distribution. Am J Transplant 2002, 2:560-567.
8. Fishman D., Faulds G., Jeffery R., et al. Effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest 1998, 102:1369-1376.
9. Arman A., Coker A., Sarioz O., et al. Lack of association between IL-6 gene polymorphisms and rheumatoid arthritis in Turkish population. Rheumatol Int 2012, 32:2199-2201.
10. Palomino-Morales R., Gonzalez-Juanatey C., Vazquez-Rodriguez T.R., et al. Interleukin-6 gene -174 promoter polymorphism is associated with endothelial dysfunction but not with disease susceptibility in patients with rheumatoid arthritis. Clin Exp Rheumatol 2009, 27:964-970.
11. Trajkov D., Mishevska-Perchinkova S., Karadzova-Stojanoska A., et al. Association of 22 cytokine gene polymorphisms with rheumatoid arthritis in population of ethnic Macedonians. Clin Rheumatol 2009, 28:1291-1300.
12. Panoulas V.F., Douglas K.M., Smith J.P., et al. Transforming growth factor-β1 869T/C, but not interleukin-6 -174G/C, polymorphism associates with hypertension in rheumatoid arthritis. Rheumatology (Oxford) 2009, 48:113-118.
13. Huang X.Z., Zhuang J.H., Ren Y.G., et al. Association of interleukin-6 and interleukin-18 gene polymorphism with rheumatoid arthritis in Guangdong Han population. Nan Fang Yi Ke Da Xue Xue Bao 2007, 27:1661-1664.
14. Pawlik A., Wrzesniewska J., Florczak M., et al. IL-6 promoter polymorphism in patients with rheumatoid arthritis. Scand J Rheumatol 2005, 34:109-113.
15. Pascual M., Nieto A., Matarán L., et al. IL-6 promoter polymorphisms in rheumatoid arthritis. Genes Immun 2000, 1:338-340.
16. Pérez-Bravo F., Soto M.F., López A.P., et al. -174 G/C polymorphism of interleukin 6 gene in women with type 1 diabetes. Rev Med Chil 2011, 139:158-164.
17. Myśliwska J., Zorena K., Myśliwiec M., et al. The -174 GG interleukin-6 genotype is protective from retinopathy and nephropathy in juvenile onset type 1 diabetes mellitus. Pediatr Res 2009, 66:341-345.
18. Myśliwiec M., Myśliwska J., Zorena K., et al. Interleukin-6 -174 (G>C) gene polymorphism is related to celiac disease and autoimmune thyroiditis coincidence in diabetes type 1 children. Diabetes Res Clin Pract 2008, 82:108-112.
19. Jahromi M.M., Millward B.A., Demaine A.G. A polymorphism in the promoter region of the gene for interleukin-6 is associated with susceptibility to type 1 diabetes mellitus. J Interferon Cytokine Res 2000, 20:885-888.
20. Siekiera U., Jarosz-Chobot P., Janusz J., et al. Polymorphism of TNF-alpha (308 A/G), IL-10 (1082 A/G, 819C/T 592 A/C), IL-6 (-174 G/C), and IFN-gamma (874 A/T); genetically conditioned cytokine synthesis level in children with diabetes type 1. Endokrynol Diabetol Chor Przemiany Materii Wieku Rozw 2002, 8:29-34.
21. Rudofsky G., Schlotterer A., Reismann P., et al. The -174G>C IL-6 gene promoter polymorphism and diabetic microvascular complications. Horm Metab Res 2009, 41:308-313.
22. Tao J.H., Zou Y.F., Feng X.L., et al. Meta-analysis of TYK2 gene polymorphisms association with susceptibility to autoimmune and inflammatory diseases. Mol Biol Rep 2011, 38:4663-4672.
23. Egger M., Davey Smith G., Schneider M., et al. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997, 315:629-634.
24. Lee Y.H., Nath S.K. Systemic lupus erythematosus susceptibility loci defined by genome scan meta-analysis. Hum Gene 2005, 118:434-443.
25. Hom G., Graham R.R., Modrek B., et al. Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. N Engl J Med 2008, 358:900-909.
26. Honda K., Yanai H., Takaoka A., et al. Regulation of the type I IFN induction: a current view. Int Immunol 2005, 17:1367-1378.
27. Lee Y.H., Rho Y.H., Choi S.J., et al. The PTPN22 C1858T functional polymorphism and autoimmune diseases: a meta-analysis. Rheumatology (Oxford) 2007, 46:49-56.
28. Pan H.F., Leng R.X., Ye D.Q. Lack of association of Interleukin-18 gene promoter -607A/C polymorphism with susceptibility to polymorphism with susceptibility to autoimmune diseases: a meta-analysis. Lupus 2011, 20:945-951.
29. Nishimoto N., Kishimoto T. Interleukin 6: from bench to bedside. Nat Clin Pract Rheu Matol 2006, 2:619-626.
30. Lipsky P.E. Interleukin-6 and rheumatic diseases. Arthritis Res Ther 2006, 8:S4.
31. Wong P.K., Campbell I.K., Egan P.J., et al. The role of the interleukin-6 family of cytokines in inflammatory arthritis and bone turnover. Arthritis Rheum 2003, 48:1177-1189.
32. Dessein P.H., Joffe B.I., Singh S. Biomarkers of endothelial dysfunction, cardiovascular risk factors and atherosclerosis in rheumatoid arthritis. Arthritis Res Ther 2005, 7:R634-R643.
33. Dessein P.H., Joffe B.I. Suppression of circulating interleukin-6 concentrations is associated with decreased endothelial activation in rheumatoid arthritis. Clin Exp Rheumatol 2006, 24:161-167.
34. Chae C.U., Lee R.T., Rifai N., et al. Blood pressure and inflammation in apparently healthy men. Hypertension 2001, 38:399-403.
35. Ridker P.M., Rifai N., Stampfer M.J., et al. Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation 2000, 101:1767-1772.
36. Cooper J.D., Smyth D.J., Bailey R., et al. The candidate genes TAF5L, TCF7, PDCD1, IL6 and ICAM1 cannot be excluded from having effects in type 1 diabetes. BMC Med Genet 2007, 8:71.
37. Settin A., Ismail A., El-Magd M.A., et al. Gene polymorphisms of TNF-alpha-308 (G/A), IL-10(-1082) (G/A), IL-6(-174) (G/C) and IL-1Ra (VNTR) in Egyptian cases with type 1 diabetes mellitus. Autoimmunity 2009, 42:50-55.