Glycyrrhizin protects spinal cord and reduces inflammation in spinal cord ischemia-reperfusion injury

International Journal of Neuroscience

Volumn 123, Issue 11, 2013, Pages 745-751

  Ni, Bin ^a   Cao, Zhenyu ^a   Liu, Yan ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Glycyrrhizin; HMGB 1; Ischemia reperfusion injury; Spinal cord

Indexed keywords

GLYCYRRHIZIC ACID; HIGH MOBILITY GROUP B1 PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MESSENGER RNA; PHOSPHATE BUFFERED SALINE; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; AORTA ARCH; APOPTOSIS; ARTICLE; COMMON CAROTID ARTERY; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; INFLAMMATION; MACROPHAGE; MOTONEURON; MOTOR PERFORMANCE; MOUSE; NEUROPROTECTION; NEUTROPHIL CHEMOTAXIS; NONHUMAN; POSITIVE FEEDBACK; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RECURRENT LARYNGEAL NERVE; REPERFUSION INJURY; SPINAL CORD; SPINAL CORD INJURY; SPINAL CORD ISCHEMIA; SPINAL CORD VENTRAL HORN; SUBCLAVIAN ARTERY; THORACIC AORTA; VAGUS NERVE; WESTERN BLOTTING;

ANIMALS; GLYCYRRHIZIC ACID; INFLAMMATION; INFLAMMATION MEDIATORS; MALE; MICE; MICE, INBRED C57BL; NEUROPROTECTIVE AGENTS; NF-KAPPA B; REPERFUSION INJURY; SPINAL CORD ISCHEMIA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84885924624     PISSN: 00207454     EISSN: 15635279     Source Type: Journal    
DOI: 10.3109/00207454.2013.796551     Document Type: Article

References (28)

1. Carmona P, Mateo E, Otero M, et al. Spinal cord protection during open and endovascular surgery in thoracic and thoracoabdominal aorta diseases. Rev Esp Anestesiol Reanim 2011;58:110-8.
2. ShimizuH, Yozu R.Current strategies for spinal cord protection during thoracic and thoracoabdominal aortic aneurysm repair. Gen Thorac Cardiovasc Surg 2011;59:155-63.
3. Rowland JW, Hawryluk GW, Kwon B, Fehlings MG. Current status of acute spinal cord injury pathophysiology and emerging therapies: Promise on the horizon. Neurosurg Focus 2008;25:E2.
4. Lu K, Cho CL, Liang CL, et al. Inhibition of the MEK/ERK pathway reduces microglial activation and interleukin-1-beta expression in spinal cord ischemia/reperfusion injury in rats. J Thorac Cardiovasc Surg 2007;133:934-41.
5. Matsumoto S, Matsumoto M, Yamashita A, et al. The temporal profile of the reaction of microglia, astrocytes, and macrophages in the delayed onset paraplegia after transient spinal cord ischemia in rabbits. Anesth Analg 2003;96:1777-84, table of contents.
6. Yamada S, Maruyama I. HMGB1, a novel inflammatory cytokine. Clin Chim Acta 2007;375:36-42.
7. Lotze MT, Tracey KJ. High-mobility group box 1 protein (HMGB1): Nuclear weapon in the immune arsenal. Nat Rev Immunol 2005;5:331-42.
8. Scaffidi P, Misteli T, Bianchi ME. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 2002;418:191-5.
9. Wang H, Bloom O, Zhang M, et al. HMG-1 as a late mediator of endotoxin lethality in mice. Science 1999;285:248-51.
10. Stern D, Yan SD, Yan SF, Schmidt AM. Receptor for advanced glycation end products: A multiligand receptor magnifying cell stress in diverse pathologic settings. Adv Drug Deliv Rev 2002;54:1615-25.
11. Park JS, Svetkauskaite D, He Q, et al. Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein. J Biol Chem 2004;279:7370-77.
12. Yang H,Wang H, Czura CJ, Tracey KJ. The cytokine activity of HMGB1. J Leukoc Biol 2005;78:1-8.
13. Davis EA, Morris DJ. Medicinal uses of licorice through the millennia: The good and plenty of it. Mol Cell Endocrinol 1991;78:1-6.
14. Mabuchi A,WakeK,MarliniM, et al. Protection by glycyrrhizin against warm ischemia-reperfusion-induced cellular injury and derangement of the microcirculatory blood flow in the rat liver. Microcirculation 2009;16:364-76.
15. Nagai T, Egashira T, Kudo Y, et al. Attenuation of dysfunction in the ischemia-reperfused liver by glycyrrhizin. Jpn J Pharmacol 1992;58:209-18.
16. Yi JH, Park SW, Kapadia R, Vemuganti R. Role of transcription factors in mediating post-ischemic cerebral inflammation and brain damage. Neurochem Int 2007;50:1014-27.
17. Chan CC. Inflammation: Beneficial or detrimental after spinal cord injury? Recent Pat CNS Drug Discov 2008;3:189-99.
18. Hasturk A, Atalay B, Calisaneller T, et al. Analysis of serum pro-inflammatory cytokine levels after rat spinal cord ischemia/reperfusion injury and correlation with tissue damage. Turk Neurosurg 2009;19:353-9.
19. Wang L, Zhang X, Liu L, et al. Tanshinone II A downregulates HMGB1, RAGE, TLR4, NF-kappaB expression, ameliorates BBB permeability and endothelial cell function, and protects rat brains against focal ischemia. Brain Res 2010;1321: 143-51.
20. Fan L,Wang K, Shi Z, et al. Tetramethylpyrazine protects spinal cord and reduces inflammation in a rat model of spinal cord ischemia-reperfusion injury. J Vasc Surg 2011;54:192-200.
21. Mollica L, De Marchis F, Spitaleri A, et al. Glycyrrhizin binds to high-mobility group box 1 protein and inhibits its cytokine activities. Chem Biol 2007;14:431-41.
22. Andersson U, Wang H, Palmblad K, et al. High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes. J Exp Med 2000;192:565-70.
23. Andersson U, Erlandsson-Harris H, Yang H, Tracey KJ. HMGB1 as a DNA-binding cytokine. J Leukoc Biol 2002;72:1084-91.
24. Baltimore D. Discovering NF-kappaB. Cold Spring Harbor Perspective in Biology 1: A000026. 2009. http://www.ncbi.nlm. nih.gov/entrez/query.fcgi?cmd= Retrieve&db=PubMed&dopt= Citation&list uids=20066072.
25. Lu K, Liang CL, Liliang PC, et al. Inhibition of extracellular signal-regulated kinases 1/2 provides neuroprotection in spinal cord ischemia/reperfusion injury in rats: Relationship with the nuclear factor-kappaB-regulated anti-Apoptotic mechanisms. J Neurochem 2010;114:237-46.
26. Malek R, Borowicz KK, Jargiello M, Czuczwar SJ. Role of nuclear factor kappaB in the central nervous system. Pharmacol Rep 2007;59:25-33.
27. Lang-Lazdunski L, Matsushita K, Hirt L, et al. Spinal cord ischemia. Development of a model in the mouse. Stroke 2000;31: 208-13.
28. Johnson SH, Kraimer JM, Graeber GM. Effects of flunarizine on neurological recovery and spinal cord blood flow in experimental spinal cord ischemia in rabbits. Stroke 1993;24:1547-53.