메뉴 건너뛰기




Volumn 14, Issue 10, 2013, Pages 20386-20398

Molecular study of a Hoxa2 gain-of-function in chondrogenesis: A model of idiopathic proportionate short stature

Author keywords

Chondrogenesis; Endochondral ossification; Hoxa2; Proportionate short stature

Indexed keywords

BONE MORPHOGENETIC PROTEIN RECEPTOR 1A; GROWTH DIFFERENTIATION FACTOR 10; GROWTH DIFFERENTIATION FACTOR 5; OSTEOGENIC PROTEIN 1; PARATHYROID HORMONE RELATED PROTEIN; PROTEIN BAPX1; PROTEIN HOXA2; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR MSX1; TRANSCRIPTION FACTOR PAX9; TRANSCRIPTION FACTOR SOX6; TRANSCRIPTION FACTOR SOX9; UNCLASSIFIED DRUG; WNT5A PROTEIN;

EID: 84885902332     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms141020386     Document Type: Article
Times cited : (5)

References (67)
  • 1
    • 84885921937 scopus 로고    scopus 로고
    • Available online:, (accessed on 3 February 2013)
    • POSNA, Short Stature. Available online: http://www.posna.org/ (accessed on 3 February 2013).
    • POSNA, Short Stature
  • 5
    • 79955034448 scopus 로고    scopus 로고
    • Transcriptional regulation of bone formation
    • Baek, W.Y.; Kim, J.E. Transcriptional regulation of bone formation. Front. Biosci. 2011, 3, 126-135.
    • (2011) Front. Biosci. , vol.3 , pp. 126-135
    • Baek, W.Y.1    Kim, J.E.2
  • 6
    • 42749092987 scopus 로고    scopus 로고
    • Transcription factors controlling osteoblastogenesis
    • Marie, P.J. Transcription factors controlling osteoblastogenesis. Arch. Biochem. Biophys. 2008, 473, 98-105.
    • (2008) Arch. Biochem. Biophys. , vol.473 , pp. 98-105
    • Marie, P.J.1
  • 9
    • 26844502418 scopus 로고    scopus 로고
    • Transcriptional control of chondrocyte fate and differentiation
    • Lefebvre, V.; Smits, P. Transcriptional control of chondrocyte fate and differentiation. Birth Defects Res. C Embryo Today 2005, 75, 200-212.
    • (2005) Birth Defects Res. C Embryo Today , vol.75 , pp. 200-212
    • Lefebvre, V.1    Smits, P.2
  • 10
    • 0037323850 scopus 로고    scopus 로고
    • Pax1 and Pax9 activate Bapx1 to induce chondrogenic differentiation in the sclerotome
    • Rodrigo, I.; Hill, R.E.; Balling, R.; Munsterberg, A.; Imai, K. Pax1 and Pax9 activate Bapx1 to induce chondrogenic differentiation in the sclerotome. Development 2003, 130, 473-482.
    • (2003) Development , vol.130 , pp. 473-482
    • Rodrigo, I.1    Hill, R.E.2    Balling, R.3    Munsterberg, A.4    Imai, K.5
  • 12
    • 84885925000 scopus 로고    scopus 로고
    • Comparison the effects of BMP-4 and BMP-7 on articular cartilage repair with bone marrow mesenchymal stem cells
    • Jiang, Y.Z.; Qi, Y.Y.; Zou, X.H.; Wang, L.L.; Ouyang, H.W. Comparison the effects of BMP-4 and BMP-7 on articular cartilage repair with bone marrow mesenchymal stem cells. IFMBE Proc. 2009, 23, 1285-1288.
    • (2009) IFMBE Proc. , vol.23 , pp. 1285-1288
    • Jiang, Y.Z.1    Qi, Y.Y.2    Zou, X.H.3    Wang, L.L.4    Ouyang, H.W.5
  • 15
    • 0036683426 scopus 로고    scopus 로고
    • Shh establishes an Nkx3.2/Sox9 autoregulatory loop that is maintained by BMP signals to induce somitic chondrogenesis
    • Zeng, L.; Kempf, H.; Murtaugh, L.C.; Sato, M.E.; Lassar, A.B. Shh establishes an Nkx3.2/Sox9 autoregulatory loop that is maintained by BMP signals to induce somitic chondrogenesis. Genes Dev. 2002, 16, 1990-2005.
    • (2002) Genes Dev. , vol.16 , pp. 1990-2005
    • Zeng, L.1    Kempf, H.2    Murtaugh, L.C.3    Sato, M.E.4    Lassar, A.B.5
  • 16
    • 0034747252 scopus 로고    scopus 로고
    • BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation
    • Minina, E.; Wenzel, H.M.; Kreschel, C.; Karp, S.; Gaffield, W.; McMahon, A.P.; Vortkamp, A. BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation. Development 2001, 128, 4523-4534.
    • (2001) Development , vol.128 , pp. 4523-4534
    • Minina, E.1    Wenzel, H.M.2    Kreschel, C.3    Karp, S.4    Gaffield, W.5    McMahon, A.P.6    Vortkamp, A.7
  • 18
    • 0037347909 scopus 로고    scopus 로고
    • Wnt5a and Wnt5b exhibit distinct activities in coordinating chondrocyte proliferation and differentiation
    • Yang, Y.; Topol, L.; Lee, H.; Wu, J. Wnt5a and Wnt5b exhibit distinct activities in coordinating chondrocyte proliferation and differentiation. Development 2003, 130, 1003-1015.
    • (2003) Development , vol.130 , pp. 1003-1015
    • Yang, Y.1    Topol, L.2    Lee, H.3    Wu, J.4
  • 19
    • 33846067098 scopus 로고    scopus 로고
    • BMPs regulate multiple aspects of growth-plate chondrogenesis through opposing actions on FGF pathways
    • Yoon, B.S.; Pogue, R.; Ovchinnikov, D.A.; Yoshii, I.; Mishina, Y.; Behringer, R.R.; Lyons, K.M. BMPs regulate multiple aspects of growth-plate chondrogenesis through opposing actions on FGF pathways. Development 2006, 133, 4667-4678.
    • (2006) Development , vol.133 , pp. 4667-4678
    • Yoon, B.S.1    Pogue, R.2    Ovchinnikov, D.A.3    Yoshii, I.4    Mishina, Y.5    Behringer, R.R.6    Lyons, K.M.7
  • 20
    • 22644447278 scopus 로고    scopus 로고
    • Regulation of skeletal development by the Runx family of transcription factors
    • Komori, T. Regulation of skeletal development by the Runx family of transcription factors. J. Cell Biochem. 2005, 95, 445-453.
    • (2005) J. Cell Biochem. , vol.95 , pp. 445-453
    • Komori, T.1
  • 22
    • 34447506565 scopus 로고    scopus 로고
    • Prochondrogenic signals induce a competence for Runx2 to activate hypertrophic chondrocyte gene expression
    • Kempf, H.; Ionescu, A.; Udager, A.M.; Lassar, A.B. Prochondrogenic signals induce a competence for Runx2 to activate hypertrophic chondrocyte gene expression. Dev. Dyn. 2007, 236, 1954-1962.
    • (2007) Dev. Dyn. , vol.236 , pp. 1954-1962
    • Kempf, H.1    Ionescu, A.2    Udager, A.M.3    Lassar, A.B.4
  • 23
    • 67349120238 scopus 로고    scopus 로고
    • Sox9 directly promotes Bapx1 gene expression to repress Runx2 in chondrocytes
    • Yamashita, S.; Andoh, M.; Ueno-Kudoh, H.; Sato, T.; Miyaki, S.; Asahara, H. Sox9 directly promotes Bapx1 gene expression to repress Runx2 in chondrocytes. Exp. Cell Res. 2009, 315, 2231-2240.
    • (2009) Exp. Cell Res. , vol.315 , pp. 2231-2240
    • Yamashita, S.1    Andoh, M.2    Ueno-Kudoh, H.3    Sato, T.4    Miyaki, S.5    Asahara, H.6
  • 24
    • 12944265540 scopus 로고    scopus 로고
    • Col2a1-directed expression of Cre recombinase in differentiating chondrocytes in transgenic mice
    • Ovchinnikov, D.A.; Deng, J.M.; Ogunrinu, G.; Behringer, R.R. Col2a1-directed expression of Cre recombinase in differentiating chondrocytes in transgenic mice. Genesis 2000, 26, 145-146.
    • (2000) Genesis , vol.26 , pp. 145-146
    • Ovchinnikov, D.A.1    Deng, J.M.2    Ogunrinu, G.3    Behringer, R.R.4
  • 25
    • 0031858666 scopus 로고    scopus 로고
    • Hoxa-2 restricts the chondrogenic domain and inhibits bone formation during development of the branchial area
    • Kanzler, B.; Kuschert, S.J.; Liu, Y.H.; Mallo, M. Hoxa-2 restricts the chondrogenic domain and inhibits bone formation during development of the branchial area. Development 1998, 125, 2587-2597.
    • (1998) Development , vol.125 , pp. 2587-2597
    • Kanzler, B.1    Kuschert, S.J.2    Liu, Y.H.3    Mallo, M.4
  • 27
    • 0031561724 scopus 로고    scopus 로고
    • BMP7 null mutation in mice: Developmental defects in skeleton, kidney, and eye
    • Jena, N.; Martin-Seisdedos, C.; McCue, P.; Croce, C.M. BMP7 null mutation in mice: Developmental defects in skeleton, kidney, and eye. Exp. Cell Res. 1997, 230, 28-37.
    • (1997) Exp. Cell Res. , vol.230 , pp. 28-37
    • Jena, N.1    Martin-Seisdedos, C.2    McCue, P.3    Croce, C.M.4
  • 28
    • 0033379122 scopus 로고    scopus 로고
    • The murine Bapx1 homeobox gene plays a critical role in embryonic development of the axial skeleton and spleen
    • Tribioli, C.; Lufkin, T. The murine Bapx1 homeobox gene plays a critical role in embryonic development of the axial skeleton and spleen. Development 1999, 126, 5699-5711.
    • (1999) Development , vol.126 , pp. 5699-5711
    • Tribioli, C.1    Lufkin, T.2
  • 29
    • 0036237950 scopus 로고    scopus 로고
    • Differential effects of osteogenic protein-1 (BMP-7) on gene expression of BMP and GDF family members during differentiation of the mouse MC615 chondrocyte cells
    • Yeh, L.C.; Mallein-Gerin, F.; Lee, J.C. Differential effects of osteogenic protein-1 (BMP-7) on gene expression of BMP and GDF family members during differentiation of the mouse MC615 chondrocyte cells. J. Cell Physiol. 2002, 191, 298-309.
    • (2002) J. Cell Physiol. , vol.191 , pp. 298-309
    • Yeh, L.C.1    Mallein-Gerin, F.2    Lee, J.C.3
  • 30
    • 13444296903 scopus 로고    scopus 로고
    • Multiple functions of BMPs in chondrogenesis
    • Yoon, B.S.; Lyons, K.M. Multiple functions of BMPs in chondrogenesis. J. Cell Biochem. 2004, 93, 93-103.
    • (2004) J. Cell Biochem. , vol.93 , pp. 93-103
    • Yoon, B.S.1    Lyons, K.M.2
  • 31
    • 0034682072 scopus 로고    scopus 로고
    • Roles for Msx and Dlx homeoproteins in vertebrate development
    • Bendall, A.J.; Abate-Shen, C. Roles for Msx and Dlx homeoproteins in vertebrate development. Gene 2000, 247, 17-31.
    • (2000) Gene , vol.247 , pp. 17-31
    • Bendall, A.J.1    Abate-Shen, C.2
  • 32
    • 0345575645 scopus 로고    scopus 로고
    • Upstream and downstream targets of RUNX proteins
    • Otto, F.; Lubbert, M.; Stock, M. Upstream and downstream targets of RUNX proteins. J. Cell Biochem. 2003, 89, 9-18.
    • (2003) J. Cell Biochem. , vol.89 , pp. 9-18
    • Otto, F.1    Lubbert, M.2    Stock, M.3
  • 33
    • 4644358680 scopus 로고    scopus 로고
    • Distinct functions of BMP4 and GDF5 in the regulation of chondrogenesis
    • Hatakeyama, Y.; Tuan, R.S.; Shum, L. Distinct functions of BMP4 and GDF5 in the regulation of chondrogenesis. J. Cell Biochem. 2004, 91, 1204-1217.
    • (2004) J. Cell Biochem. , vol.91 , pp. 1204-1217
    • Hatakeyama, Y.1    Tuan, R.S.2    Shum, L.3
  • 35
    • 77956023094 scopus 로고    scopus 로고
    • The role of endogenous bone morphogenetic proteins in normal skeletal repair
    • Marsell, R.; Einhorn, T.A. The role of endogenous bone morphogenetic proteins in normal skeletal repair. Injury 2009, 40, S4-S7.
    • (2009) Injury , vol.40
    • Marsell, R.1    Einhorn, T.A.2
  • 36
    • 19744378342 scopus 로고    scopus 로고
    • The homeobox transcription factor Barx2 regulates chondrogenesis during limb development
    • Meech, R.; Edelman, D.B.; Jones, F.S.; Makarenkova, H.P. The homeobox transcription factor Barx2 regulates chondrogenesis during limb development. Development 2005, 132, 2135-2146.
    • (2005) Development , vol.132 , pp. 2135-2146
    • Meech, R.1    Edelman, D.B.2    Jones, F.S.3    Makarenkova, H.P.4
  • 37
    • 0038687536 scopus 로고    scopus 로고
    • Developmental regulation of the growth plate
    • Kronenberg, H.M. Developmental regulation of the growth plate. Nature 2003, 423, 332-336.
    • (2003) Nature , vol.423 , pp. 332-336
    • Kronenberg, H.M.1
  • 38
    • 46549083928 scopus 로고    scopus 로고
    • Control of chondrogenesis by the transcription factor Sox9
    • Akiyama, H. Control of chondrogenesis by the transcription factor Sox9. Mod. Rheumatol. 2008, 18, 213-219.
    • (2008) Mod. Rheumatol. , vol.18 , pp. 213-219
    • Akiyama, H.1
  • 40
    • 77954978666 scopus 로고    scopus 로고
    • WNT5A regulates chondrocyte differentiation through differential use of the CaN/NFAT and IKK/NF-kappaB pathways
    • Bradley, E.W.; Drissi, M.H. WNT5A regulates chondrocyte differentiation through differential use of the CaN/NFAT and IKK/NF-kappaB pathways. Mol. Endocrinol. 2010, 24, 1581-1593.
    • (2010) Mol. Endocrinol. , vol.24 , pp. 1581-1593
    • Bradley, E.W.1    Drissi, M.H.2
  • 41
    • 0032717355 scopus 로고    scopus 로고
    • Ablation of the PTHrP gene or the PTH/PTHrP receptor gene leads to distinct abnormalities in bone development
    • Lanske, B.; Amling, M.; Neff, L.; Guiducci, J.; Baron, R.; Kronenberg, H.M. Ablation of the PTHrP gene or the PTH/PTHrP receptor gene leads to distinct abnormalities in bone development. J. Clin. Invest. 1999, 104, 399-407.
    • (1999) J. Clin. Invest. , vol.104 , pp. 399-407
    • Lanske, B.1    Amling, M.2    Neff, L.3    Guiducci, J.4    Baron, R.5    Kronenberg, H.M.6
  • 44
    • 0032938813 scopus 로고    scopus 로고
    • A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo
    • Yamaguchi, T.P.; Bradley, A.; McMahon, A.P.; Jones, S. A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo. Development 1999, 126, 1211-1223.
    • (1999) Development , vol.126 , pp. 1211-1223
    • Yamaguchi, T.P.1    Bradley, A.2    McMahon, A.P.3    Jones, S.4
  • 45
    • 0033917762 scopus 로고    scopus 로고
    • Targeted disruption of the homeobox transcription factor Bapx1 results in lethal skeletal dysplasia with asplenia and gastroduodenal malformation
    • Akazawa, H.; Komuro, I.; Sugitani, Y.; Yazaki, Y.; Nagai, R.; Noda, T. Targeted disruption of the homeobox transcription factor Bapx1 results in lethal skeletal dysplasia with asplenia and gastroduodenal malformation. Genes Cells 2000, 5, 499-513.
    • (2000) Genes Cells , vol.5 , pp. 499-513
    • Akazawa, H.1    Komuro, I.2    Sugitani, Y.3    Yazaki, Y.4    Nagai, R.5    Noda, T.6
  • 47
    • 0033567213 scopus 로고    scopus 로고
    • Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation
    • St-Jacques, B.; Hammerschmidt, M.; McMahon, A.P. Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev. 1999, 13, 2072-2086.
    • (1999) Genes Dev. , vol.13 , pp. 2072-2086
    • St-Jacques, B.1    Hammerschmidt, M.2    McMahon, A.P.3
  • 49
    • 0032169255 scopus 로고    scopus 로고
    • Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities
    • Peters, H.; Neubuser, A.; Kratochwil, K.; Balling, R. Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities. Genes Dev. 1998, 12, 2735-2747.
    • (1998) Genes Dev. , vol.12 , pp. 2735-2747
    • Peters, H.1    Neubuser, A.2    Kratochwil, K.3    Balling, R.4
  • 51
    • 0033377614 scopus 로고    scopus 로고
    • Pax1 and Pax9 synergistically regulate vertebral column development
    • Peters, H.; Wilm, B.; Sakai, N.; Imai, K.; Maas, R.; Balling, R. Pax1 and Pax9 synergistically regulate vertebral column development. Development 1999, 126, 5399-5408.
    • (1999) Development , vol.126 , pp. 5399-5408
    • Peters, H.1    Wilm, B.2    Sakai, N.3    Imai, K.4    Maas, R.5    Balling, R.6
  • 52
    • 1442358788 scopus 로고    scopus 로고
    • Sox5 and Sox6 are needed to develop and maintain source, columnar, and hypertrophic chondrocytes in the cartilage growth plate
    • Smits, P.; Dy, P.; Mitra, S.; Lefebvre, V. Sox5 and Sox6 are needed to develop and maintain source, columnar, and hypertrophic chondrocytes in the cartilage growth plate. J. Cell Biol. 2004, 164, 747-758.
    • (2004) J. Cell Biol. , vol.164 , pp. 747-758
    • Smits, P.1    Dy, P.2    Mitra, S.3    Lefebvre, V.4
  • 53
    • 34848818790 scopus 로고    scopus 로고
    • Regulation of skeletogenic differentiation in cranial dermal bone
    • Abzhanov, A.; Rodda, S.J.; McMahon, A.P.; Tabin, C.J. Regulation of skeletogenic differentiation in cranial dermal bone. Development 2007, 134, 3133-3144.
    • (2007) Development , vol.134 , pp. 3133-3144
    • Abzhanov, A.1    Rodda, S.J.2    McMahon, A.P.3    Tabin, C.J.4
  • 54
    • 80053342514 scopus 로고    scopus 로고
    • Induction and patterning of intramembranous bone
    • Franz-Odendaal, T.A. Induction and patterning of intramembranous bone. Front. Biosci. 2012, 17, 3734-3746.
    • (2012) Front. Biosci. , vol.17 , pp. 3734-3746
    • Franz-Odendaal, T.A.1
  • 55
    • 0035865852 scopus 로고    scopus 로고
    • Development of the clavicles in birds and mammals
    • Hall, B.K. Development of the clavicles in birds and mammals. J. Exp. Zool. 2001, 289, 153-161.
    • (2001) J. Exp. Zool. , vol.289 , pp. 153-161
    • Hall, B.K.1
  • 56
    • 0030866935 scopus 로고    scopus 로고
    • Mouse clavicular development: Analysis of wild-type and cleidocranial dysplasia mutant mice
    • Huang, L.F.; Fukai, N.; Selby, P.B.; Olsen, B.R.; Mundlos, S. Mouse clavicular development: Analysis of wild-type and cleidocranial dysplasia mutant mice. Dev. Dyn. 1997, 210, 33-40.
    • (1997) Dev. Dyn. , vol.210 , pp. 33-40
    • Huang, L.F.1    Fukai, N.2    Selby, P.B.3    Olsen, B.R.4    Mundlos, S.5
  • 57
    • 26944485817 scopus 로고    scopus 로고
    • Ultrastructural analysis of mouse embryonic stem cell-derived chondrocytes
    • Kramer, J.; Klinger, M.; Kruse, C.; Faza, M.; Hargus, G.; Rohwedel, J. Ultrastructural analysis of mouse embryonic stem cell-derived chondrocytes. Anat. Embryol. 2005, 210, 175-185.
    • (2005) Anat. Embryol. , vol.210 , pp. 175-185
    • Kramer, J.1    Klinger, M.2    Kruse, C.3    Faza, M.4    Hargus, G.5    Rohwedel, J.6
  • 59
    • 0036181393 scopus 로고    scopus 로고
    • Differential temporal expression of members of the transforming growth factor beta superfamily during murine fracture healing
    • Cho, T.J.; Gerstenfeld, L.C.; Einhorn, T.A. Differential temporal expression of members of the transforming growth factor beta superfamily during murine fracture healing. J. Bone Miner Res. 2002, 17, 513-520.
    • (2002) J. Bone Miner Res. , vol.17 , pp. 513-520
    • Cho, T.J.1    Gerstenfeld, L.C.2    Einhorn, T.A.3
  • 60
    • 77954143899 scopus 로고    scopus 로고
    • Gene expression profiling of primary human articular chondrocytes in high-density micromasses reveals patterns of recovery, maintenance, re-and dedifferentiation
    • Dehne, T.; Schenk, R.; Perka, C.; Morawietz, L.; Pruss, A.; Sittinger, M.; Kaps, C.; Ringe, J. Gene expression profiling of primary human articular chondrocytes in high-density micromasses reveals patterns of recovery, maintenance, re-and dedifferentiation. Gene 2010, 462, 8-17.
    • (2010) Gene , vol.462 , pp. 8-17
    • Dehne, T.1    Schenk, R.2    Perka, C.3    Morawietz, L.4    Pruss, A.5    Sittinger, M.6    Kaps, C.7    Ringe, J.8
  • 61
    • 0036830491 scopus 로고    scopus 로고
    • The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6
    • Akiyama, H.; Chaboissier, M.C.; Martin, J.F.; Schedl, A.; de Crombrugghe, B. The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes Dev. 2002, 16, 2813-2828.
    • (2002) Genes Dev. , vol.16 , pp. 2813-2828
    • Akiyama, H.1    Chaboissier, M.C.2    Martin, J.F.3    Schedl, A.4    de Crombrugghe, B.5
  • 62
    • 84255184901 scopus 로고    scopus 로고
    • Indian hedgehog requires additional effectors besides Runx2 to induce osteoblast differentiation
    • Tu, X.; Joeng, K.S.; Long, F. Indian hedgehog requires additional effectors besides Runx2 to induce osteoblast differentiation. Dev. Biol. 2012, 362, 76-82.
    • (2012) Dev. Biol. , vol.362 , pp. 76-82
    • Tu, X.1    Joeng, K.S.2    Long, F.3
  • 63
    • 0032543986 scopus 로고    scopus 로고
    • Evidence for regulation of cartilage differentiation by the homeobox gene Hoxc-8
    • Yueh, Y.G.; Gardner, D.P.; Kappen, C. Evidence for regulation of cartilage differentiation by the homeobox gene Hoxc-8. Proc. Natl. Acad. Sci. USA 1998, 95, 9956-9961.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 9956-9961
    • Yueh, Y.G.1    Gardner, D.P.2    Kappen, C.3
  • 64
    • 77749324021 scopus 로고    scopus 로고
    • Expression of cartilage developmental genes in Hoxc8-and Hoxd4-transgenic mice
    • Kruger, C.; Kappen, C. Expression of cartilage developmental genes in Hoxc8-and Hoxd4-transgenic mice. PLoS One 2010, 5, e8978.
    • (2010) PLoS One , vol.5
    • Kruger, C.1    Kappen, C.2
  • 65
    • 0036964935 scopus 로고    scopus 로고
    • Structural changes in the angiofollicular units between active and hypofunctioning follicles align with differences in the epithelial expression of newly discovered proteins involved in iodine transport and organification
    • Gerard, A.C.; Many, M.C.; Daumerie, C.; Costagliola, S.; Miot, F.; DeVijlder, J.J.; Colin, I.M.; Denef, J.F. Structural changes in the angiofollicular units between active and hypofunctioning follicles align with differences in the epithelial expression of newly discovered proteins involved in iodine transport and organification. J. Clin. Endocrinol. Metab. 2002, 87, 1291-1299.
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 1291-1299
    • Gerard, A.C.1    Many, M.C.2    Daumerie, C.3    Costagliola, S.4    Miot, F.5    DeVijlder, J.J.6    Colin, I.M.7    Denef, J.F.8
  • 66
    • 0029382434 scopus 로고
    • Antisera and cDNA probes to human and certain animal model bone matrix noncollagenous proteins
    • Fisher, L.W.; Stubbs, J.T., 3rd; Young, M.F. Antisera and cDNA probes to human and certain animal model bone matrix noncollagenous proteins. Acta Orthop. Scand. Suppl. 1995, 266, 61-65.
    • (1995) Acta Orthop. Scand. Suppl. , vol.266 , pp. 61-65
    • Fisher, L.W.1    Stubbs III, J.T.2    Young, M.F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.