A Systematic Review: Current and Future Directions of Dorsal Root Ganglion Therapeutics to Treat Chronic Pain

Pain Medicine (United States)

Volumn 14, Issue 10, 2013, Pages 1477-1496

  Pope, Jason E ^a   Deer, Timothy R ^a,b   Kramer, Jeffery ^c,d  

^a Center for Pain Relief   (United States)

^b WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Spinal Modulation Inc   (United States)

^d UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Chronic Pain; Dorsal Root Ganglion; DRG; Spinal Cord Stimulation

Indexed keywords

CAPSAICIN; GASTRODIN; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; INTERLEUKIN 10; IOHEXOL; MEPIVACAINE; NERVE GROWTH FACTOR; NITRIC OXIDE; RNA ANTIBODY;

ALLODYNIA; ANALGESIA; BACKACHE; BRACHIALGIA; CERVICOBRACHIAL NEURALGIA; CHRONIC PAIN; COMPLEX REGIONAL PAIN SYNDROME; CONSERVATIVE TREATMENT; DISEASE DURATION; ELECTROSTIMULATION; FAILED BACK SURGERY SYNDROME; GANGLIONECTOMY; GENE INDUCTION; GENE TRANSFER; HUMAN; INTRACTABLE PAIN; LEG PAIN; MEMBRANE CURRENT; MERALGIA PARESTHETICA; NERVE STIMULATION; NEURALGIA; NEUROMODULATION; NEUROPATHIC PAIN; NOCICEPTION; OUTCOME ASSESSMENT; PULSED RADIOFREQUENCY TREATMENT; RADICULAR PAIN; RADIOFREQUENCY; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SECONDARY HEADACHE; SPINAL CORD STIMULATION; SPINAL CORD STIMULATOR; SPINAL GANGLION; SYSTEMATIC REVIEW; UPREGULATION; VIRAL GENE DELIVERY SYSTEM; VISUAL ANALOG SCALE;

CHRONIC PAIN; DORSAL ROOT GANGLION; DRG; SPINAL CORD STIMULATION;

CHRONIC PAIN; ELECTRIC STIMULATION THERAPY; GANGLIA, SPINAL; GANGLIONECTOMY; HUMANS; PULSED RADIOFREQUENCY TREATMENT;

EID: 84885869153     PISSN: 15262375     EISSN: 15264637     Source Type: Journal    
DOI: 10.1111/pme.12171     Document Type: Review

References (74)

1. Westlund High KN. Chapter 7 Pain Pathways: Peripheral, Spinal, Ascending, and Descending Pathways, 4th edition. Benzon: Raj's Practical Management of Pain; 2008. Figure 7-3.
2. North RB, Kidd DH, Campbell JN, Long DM. Dorsal root ganglionectomy for failed back surgery syndrome: A 5-year follow-up study. J Neurosurg 1991;74:236-242.
3. Taub A, Robinson F, Taub E. Dorsal root ganglionectomy for intractable monoradicular sciatica. A series of 61 patients. Stereotact Funct Neurosurg 1995;65(1-4):106-110.
4. Wilkinson HA, Chan AS. Sensory ganglionectomy: Theory, technical aspects, and clinical experience. J Neurosurg 2001;95(1):61-66.
5. Weigel R, Capelle HH, Schmetz M, Krauss JK. Selective thoracic ganglionectomy for the treatment of segmental neuropathic pain. Eur J Pain 2012;16(10):1398-1402.
6. Lozano AM, Vanderlinded G, Bachoo R, Rothbart P. Microsurgical C-2 ganglionectomy for chronic intractable occipital pain. J Neurosurg 1998;89:359-365.
7. Acar F, Miller J, Golshani KJ, etal. Pain relief after cervical ganglionectomy (C2 and C3) for treatment of medically intractable occipital neuralgia. Stereotact Funct Neurosurg 2008;86:106-112.
8. Jansen J. Surgical treatment for non-responsive cervicogenic headache. Clin Exp Rheumatol 2000;18(suppl 19):s67-70.
9. Cetas J, Saedi T, Burchiel KJ. Destructive procedures for the treatment of nonmalignant pain: A structured literature review. J Neurosurg 2008;109:389-404.
10. Cosman ER, Cosman ER. Electric and thermal field effects in tissue around radiofrequency electrodes. Pain Med 2005;8(6):405-424.
11. Buijs E, van Wijk RMAW, Geurts JWM, etal. Radiofrequency lumbar facet denervation: A comparative study of the reproducibility of lesion size after 2 current radiofrequency techniques. Reg Anesth Pain Med 2004;29(5):400-407.
12. Hildebrandt B, Wust P, Ahlers O, etal. The cellular and molecular basis of hyperthermia. Crit Rev Oncol Hematol 2002;43(1):33-56.
13. Molina JAL, Rivera MJ, Trujillo M, Berjano EJ. Thermal modeling for pulsed radiofrequency ablation: Analytical study based on hyperbolic heat conduction. Med Phys 2009;36:1112-1119.
14. Hamann W, Abou-Sherif S, Thomson S, Hall S. Pulsed radiofrequency applied to dorsal root ganglia causes a selective increase in ATF3 in small neurons. Eur J Pain 2006;10(2):171-176.
15. Van Kleef M, Liem L, Lousberg R, etal. Radiofrequency lesion adjacent to the Dorsal root ganglion for cervicobrachial pain: A prospective double blind randomized study. Neurosurgery 1996;38:1127-1131.
16. Slappendel R, Crul BJ, Braak GJ, etal. The efficacy of radiofrequency lesioning of the cervical spinal dorsal root ganglion in a double-blinded, randomized study: No difference between 40 degrees C and 67 degrees C treatments. Pain 1997;73:159-163.
17. Geurts JW, Van Wijk RM, Wynne HJ, etal. Radiofrequency lesioning of the dorsal root ganglia for chronic lumbosacral radicular radicular pain: A randomized, double-blind, controlled trial. Lancet 2003;361:21-26.
18. Haspeslagh SR, Van Suijlekom HA, Lame IE, etal. Randomized controlled trial of cervical radiofrequency lesions as a treatment for cervicogenic headache. BMC Anesthesiol 2006;6:1-11.
19. Van Kleef M, Spaans F, Dingemans W, etal. Effects and side effects of a percutaneous thermal lesion of the dorsal root ganglion in patients with cervical pain syndrome. Pain 1993;52:49-53.
20. Stolker RJ, Vervest AC, Groen GJ. The treatment of chronic thoracic segmental pain by radiofrequency percutaneous partial rhizotomy. J Neurosurg 1994;80:986-992.
21. Niv D, Chayen MS. Reduction of localized cancer pain by percutaneous dorsal root ganglia lesions. Pain Clin 1992;5:229-234.
22. Sluijter ME, Koetsveld-Baart CC. Interruption of pain pathways in the treatment of the cervical syndrome. Anaesthesia 1980;35:302-307.
23. Sluijter ME. Percutaneous facet denervation and partial posterior rhizotomy. Acta Anaesthesiol Belg 1981;32:63-79.
24. Nash TP. Percutaneous radiofrequency lesioning of dorsal root ganglia for intractable pain. Pain 1986;24:67-73.
25. Vervest ACM, Stolker RJ. The treatment of cervical pain syndromes with radiofrequency procedures. Pain Clin 1991;4:103-112.
26. Van Kleef M, Barendse GA, Dingemans WA, etal. Effects of producing a radiofrequency lesion adjacent to the dorsal root ganglion in patient with thoracic segmental pain. Clin J Pain 1995;11:325-332.
27. Van Wijk RMAW, Geurts JW, Wynne HJ. Long-lasting analgesic effect of radiofrequency treatment of the lumbosacral dorsal root ganglion. J Neurosurg 2001;94:227-231.
28. Nagda JV, Davis CW, Bajwa ZH, Simopoulos TT. Retrospective review of the efficacy and safety of repeated pulsed and continuous radiofrequency lesioning of the dorsal root ganglion/segmental nerve for lumbar radicular pain. Pain Physician 2011;14:371-376.
29. Sluijter ME, Cosman ER, Rittman WB, Van Kleef M. The effects of pulsed radiofrequency fields applied to the dorsal root ganglion: A preliminary report. Pain Clin 1998;11:109-117.
30. Van Zundert J, Lame IE, De Louw A, etal. Percutaneous pulsed radiofrequency treatment of the cervical dorsal root ganglion in the treatment of chronic cervical pain syndromes: A clinical audit. Neuromodulation 2003;6:6-14.
31. Munglani R, Stauffer KA. Pulsed radiofrequency treatment of chronic neck, back, sympathetic, and peripheral neuroma-derived pain. In: Bountra C, Munglani R, Schmidt W, eds. Pain: Current Understanding, Emerging Therapies and Novel Approaches to Drug Discovery. New York: Marcel Dekker; 2003:213-222.
32. Erdine S. Techniques and results of pulsed RF treatment of the DRG in failed back surgery patients. In: Devor M, Erdine S, Ruiz-Lopez R, eds. 3rd World Congress of WIP. Barcelona: Blackwell Publishing; 2004:219.
33. Abejon D, Delgado C, Garcia del Valle S, Nieto C, Gomez-Arnau J. Effects of applied pulsed radiofrequency to the lumbar spinal dorsal root ganglion. Comparative study among three groups. In: Devor M, Erdine S, Ruiz-Lopez R, eds. 3rd World Congress of WIP. Barcelona: Blackwell Publishing; 2004:92.
34. Teixeira A, Grandinson M, Sluijter ME. Pulsed radiofrequency for radicular pain due to herniated intervertebral disc: An initial report. Pain Pract 2005;5:111-115.
35. Pevzner E, David R, Leitner Y, etal. Pulsed radiofrequency treatment of severe radicular pain. Harefuah 2005;144(3):178-180, 231.
36. Shabat S, Pevsner Y, Folman Y, Gepstein R. Pulsed radiofrequency in the treatment of patients with chronic neuropathic spinal pain. Minim Invasive Neurosurg 2006;49:147-149.
37. Cohen SP, Sireci A, Wu CL, etal. Pulsed radiofrequency of the dorsal root ganglia is superior to pharmacotherapy or pulsed radiofrequency of the intercostal nerves in the treatment of chronic postsurgical thoracic pain. Pain Physician 2006;9:227-235.
38. Van Zundert J, Patijn J, Kessels A, etal. Pulsed radiofrequency adjacent to the cervical dorsal root ganglion in chronic cervical radicular pain: A double-blind sham controlled clinical trial. Pain 2007;127:173-182.
39. Abejon D, Garcia-del-Valle S, Fuentes ML, etal. Pulsed radiofrequency in lumbar radicular pain: Clinical effects in various etiological groups. Pain Pract 2007;7(1):21-26.
40. Chao SC, Lee HT, Kao TH, etal. Percutaneous pulsed radiofrequency in the treatment of cervical and radicular pain. Surg Neurol 2008;70:59-65.
41. Simopoulos TT, Kraemer J, Nagda JV, Aner M, Bajwa ZH. Reponse to pulsed and continuous radiofrequency lesioning of the dorsal root ganglion and segmental nerves in patients with chronic lumbar radicular pain. Pain Physician 2008;11:1137-1144.
42. Tsou HK, Chao SC, Wang CJ, etal. Percutaneous pulsed radiofrequency applied to the L2 dorsal root ganglion for treatment of chronic low-back pain: 3-year experience. J Neurosurg Spine 2010;12:190-196.
43. Van Boxem K, van Bilsen J, de Meij N, etal. Pulsed radiofrequency treatment adjacent to the lumbar dorsal root ganglion for the management of lumbosacral radicular syndrome: A clinical audit. Pain Med 2011;12:1322-1330.
44. Choi GS, Ahn SH, Cho YW, Lee DG. Long-term effect of pulsed radiofrequency on chronic cervical radicular pain refractory to repeated transforaminal epidural injections. Pain Med 2012;13:368-375.
45. Gauchi C. Pulsed radiofrequency for the management of discogenic low back pain. Krames E, Reig E, eds. The Management of Acute and Chronic Pain: The Use of the Tools of the Trade. San Francisco, CA: Monduzzi; 2000:461-464.
46. Perret D, Kim DS, Li KW, Luo ZD. Exposure of the dorsal root ganglion to pulsed radiofrequency current in a neuropathic model of peripheral nerve injury. Methods Mol Biol 2012;851:275-284.
47. Cahana A, Van Zundert J, Macrea L, van Kleef M, Sluijter M. Pulsed radiofrequency: Current clinical and biological literature available. Pain Med 2006;7(5):411-423.
48. Ramanavarapu V, Simopoulos TT. Pulsed radiofrequency of lumbar dorsal root ganglia for chronic post-amputation stump pain. Pain Physician 2008;11:561-566.
49. Shanthanna H, Chan P, McChesney J, Paul J, Thabane L. Assessing the effectiveness of pulse radiofrequency treatment of the dorsal root ganglion in patients with chronic lumbar radicular pain: Study protocol for a randomized control trial. Trials 2012;13:52.
50. Malik K, Benzon HT. Radiofrequency applications to the dorsal root ganglia: A literature review. Anesthesiology 2008;109:527-542.
51. Geurts JW, Van Wijk RM, Stolker RJ, Groen GJ. Efficacy of radiofrequency procedures for the treatment of spinal pain: A systematic review of randomized clinical trials. Reg Anesth Pain Med 2001;26:394-400.
52. Wright RE, Collition JW. Neurostimulation of the L2 dorsal root ganglion for intractable disc pain: Description of a novel technique. Presented at 3rd Conference of International Functional Electrical Stimulation Society: September 17-20, 1998; Lucence, Switzerland. 1998.
53. Lynch PJ, McJunkin T, Eross E, Gooch S, Maloney J. Case report: Successful epiradicular peripheral nerve stimulation of the C2 dorsal root ganglion for postherpetic neuralgia. Neuromodulation 2011;14(1):58-61.
54. Slavin KV, Wess C. Trigeminal branch stimulation for intractable neuropathic pain: Technical note. Neuromodulation 2005;8(1):7-13.
55. Grigsby E, Deer T, Weiner R, Wilcosky B, Kramer J. Prospective, multicenter clinical trial studying dorsal root ganglion stimulation in the treatment of back pain. North American Neuromodulation Society Annual Meeting Proceedings, 2010.
56. Abstracts of the 6th World Congress of the World Institute for Pain, WIP 2012. Miami Beach, Florida, USA. Pain Pract 2012;12(suppl 1):1-199.
57. Deer TR, Grigsby E, Weiner RL, Wilcosky B, Kramer JM. A prospective study of dorsal root ganglion stimulation for the relief of chronic pain. Neuromodulation 2012;16(1):67-71.
58. Coffey RJ, Owens ML, Broste SK, etal. Mortality associated with implantation and management of intrathecal opioid drug infusion systems to treat noncancer pain. Anesthesiology 2009;111:881-891.
59. Lawson SN. Peptides and cutaneous polymodal nociceptor neurones. In: Kumazawa T, Kruger L, Mizumura K, eds. Progress in Brain Research. Amsterdam: Elsevier; 1996:369-385.
60. Waxman SG. The molecular pathophysiology of pain: Abnormal expression of sodium channels and its contributions to hyperexcitability of primary neurons. Pain 1999;(suppl 6):S133-140.
61. Wang H, Sun H, Della Penna K, etal. Chronic neuropathic pain is accompanied by global changes in gene expression and shares pathobiology with neurodegenrative diseases. Neuroscience 2002;114(3):529-546.
62. Wiltse LL. Anatomy of the extradural compartments of the lumbar spinal canal. Peridural membrane and circumneural sheath. Radiol Clin North Am 2000;38(6):1177-1206.
63. Aveill S, Michael GJ, Shortland PJ, etal. NGF and GDNF ameliorate the increase in ATF3 expression which occurs in dorsal root ganglion cells in response to peripheral injury. Eur J Neurosci 2004;19:1437-1445.
64. Holmes D. Anti-NGF painkillers back on track? Nat Rev Drug Discov 2012;11:337-338.
65. Wang R, Guo W, Ossipov MH, etal. Glial cell line-derived neurotrophic factor normalizes neurochemical changes in injured dorsal root ganglion neurons and prevents the expression of experimental neuropathic pain. Neuroscience 2003;121:815-824.
66. Jin Y, Kim J, Kwak J. Activation of the cGMP/protein kinase G pathway by nitric oxide can decrease TRPVI activity in cultured rat dorsal root ganglion neurons. Korean J Physiol Pharmacol 2012;16:211-217.
67. Kwak J. Capsaicin blocks the hyperpolarization-activated inward currents via TRPV1 in the rat dorsal root ganglion neurons. Exp Neurobiol 2012;21(2):75-82.
68. Sun W, Miao B, Wang XC, etal. Gastrodin inhibits allodynia and hyperalgesia in painful diabetic neuropathic rats by decreasing excitability of nociceptive priamry sensory neurons. PLoS One 2012;7(6):e39647.
69. Milligan E. Inflammatory mediators for pain. North American Neuromodulation Society Meeting. Las Vegas. December 3, 2011.
70. Yu H, Fischer G, Jia G, etal. Lentivirial gene transfer into the dorsal root ganglion of adults rats. Mol Pain 2011;7:63.
71. Samad OA, Tan AM, Cheng X, etal. Virus-mediated shRNA knockdown of Na1.3 in rat dorsal root ganglion attenuates nerve injury-induced neuropathic pain. Mol Ther 2012;21(1):49-56.
72. Xu Q, Chou B, Fitzsimmons B, etal. In vivo gene knockdown in rat dorsal root ganglio mediated by self-complementary adeno-associated virus serotype 5 following intrathecal delivery. PLoS One 2012;3(3):e32581.
73. Middleditch A, Oliver J. Functional Anatomy of the Spine, 2nd edition. Edinburgh: Butterworth-Heinemann; 2006:277.
74. Lin CR, Chen KH, Yang CH, etal. Sonoporation-mediated gene transfer into adult rat dorsal root ganglion cells. J Biomed Sci 2010;17:44.