Urinary cystatin C as a renal biomarker and its immunohistochemical localization in anti-GBM glomerulonephritis rats

Experimental and Toxicologic Pathology

Volumn 65, Issue 7-8, 2013, Pages 1137-1143

  Togashi, Yuko ^a   Imura, Naoko ^a   Miyamoto, Yohei ^a  

^a TORAY INDUSTRIES INC   (Japan)

Author keywords

Anti glomerular basement membrane (GBM) glomerulonephritis rats; Cystatin C; Immunohistochemistry; Renal biomarker

Indexed keywords

BETA 2 MICROGLOBULIN; BIOLOGICAL MARKER; CALBINDIN; CLUSTERIN; CREATININE; CYSTATIN C; EPIDERMAL GROWTH FACTOR; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE ALPHA; GLUTATHIONE TRANSFERASE MU; KIDNEY INJURY MOLECULE 1; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; NITROGEN; OSTEOPONTIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; UNCLASSIFIED DRUG; UREA; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE MARKER; EARLY DIAGNOSIS; GLOMERULONEPHRITIS; IMMUNOHISTOCHEMISTRY; INTERMETHOD COMPARISON; KIDNEY CORTEX; KIDNEY INJURY; KIDNEY MEDULLA; KIDNEY PROXIMAL TUBULE; MALE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN URINE LEVEL; RAT; UREA NITROGEN BLOOD LEVEL;

RATTUS;

ANTI-GLOMERULAR BASEMENT MEMBRANE (GBM) GLOMERULONEPHRITIS RATS; CYSTATIN C; IMMUNOHISTOCHEMISTRY; RENAL BIOMARKER;

ANIMALS; AUTOANTIBODIES; BIOLOGICAL MARKERS; CYSTATIN C; DISEASE MODELS, ANIMAL; GLOMERULONEPHRITIS; IMMUNOASSAY; IMMUNOHISTOCHEMISTRY; MALE; RATS; RATS, INBRED WKY;

EID: 84885854764     PISSN: 09402993     EISSN: 16181433     Source Type: Journal    
DOI: 10.1016/j.etp.2013.05.005     Document Type: Article

References (41)

1. Abrahamson M., Olafsson I., Palsdottir A., Ulvsbäck M., Lundwall A., Jensson O., Grubb A. Structure and expression of the human cystatin C gene. The Biochemical Journal 1990, 268:287-294.
2. Adiyanti S.S., Loho T. Acute Kidney Injury (AKI) biomarker. Acta Medica Indonesiana 2012, 44:246-255.
3. Aki K., Shimizu A., Masuda Y., Kuwahara N., Arai T., Ishikawa A., Fujita E., Mii A., Natori Y., Fukunaga Y., Fukuda Y. ANG II receptor blockade enhances anti-inflammatory macrophages in anti-glomerular basement membrane glomerulonephritis. American Journal of Physiology. Renal Physiology 2010, 298:F870-F882.
4. Baran D., Tenstad O., Aukland K. Localization of tubular uptake segment of filtered cystatin C and aprotinin in the rat kidney. Acta Physiologica (Oxford, England) 2006, 186:209-221.
5. Bonventre J.V., Vaidya V.S., Schmouder R., Feig P., Dieterle F. Next-generation biomarkers for detecting kidney toxicity. Nature Biotechnology 2010, 28:436-440.
6. Coll E., Botey A., Alvarez L., Poch E., Quintó L., Saurina A., Vera M., Piera C., Darnell A. Serum cystatin C as a new marker for noninvasive estimation of glomerular filtration rate and as a marker for early renal impairment. American Journal of Kidney Diseases 2000, 36:29-34.
7. Dieterle F., Sistare F., Goodsaid F., Papaluca M., Ozer J.S., Webb C.P., Baer W., Senagore A., Schipper M.J., Vonderscher J., Sultana S., Gerhold D.L., Phillips J.A., Maurer G., Carl K., Laurie D., Harpur E., Sonee M., Ennulat D., Holder D., Andrews-Cleavenger D., Gu Y.Z., Thompson K.L., Goering P.L., Vidal J.M., Abadie E., Maciulaitis R., Jacobson-Kram D., Defelice A.F., Hausner E.A., Blank M., Thompson A., Harlow P., Throckmorton D., Xiao S., Xu N., Taylor W., Vamvakas S., Flamion B., Lima B.S., Kasper P., Pasanen M., Prasad K., Troth S., Bounous D., Robinson-Gravatt D., Betton G., Davis M.A., Akunda J., McDuffie J.E., Suter L., Obert L., Guffroy M., Pinches M., Jayadev S., Blomme E.A., Beushausen S.A., Barlow V.G., Collins N., Waring J., Honor D., Snook S., Lee J., Rossi P., Walker E., Mattes W. Renal biomarker qualification submission: a dialog between the FDA-EMEA and Predictive Safety Testing Consortium. Nature Biotechnology 2010, 28:455-462.
8. Dieterle F., Perentes E., Cordier A., Roth D.R., Verdes P., Grenet O., Pantano S., Moulin P., Wahl D., Mahl A., End P., Staedtler F., Legay F., Carl K., Laurie D., Chibout S.D., Vonderscher J., Maurer G. Urinary clusterin, cystatin C, beta2-microglobulin and total protein as markers to detect drug-induced kidney injury. Nature Biotechnology 2010, 28:463-469.
9. Ferguson M.A., Vaidya V.S., Bonventre J.V. Biomarkers of nephrotoxic acute kidney injury. Toxicology 2008, 245:182-193.
10. Fuchs T.C., Hewitt P. Preclinical perspective of urinary biomarkers for the detection of nephrotoxicity: what we know and what we need to know. Biomarkers in Medicine 2011, 5:763-779.
11. Gatanaga H., Tachikawa N., Kikuchi Y., Teruya K., Genka I., Honda M., Tanuma J., Yazaki H., Ueda A., Kimura S., Oka S. Urinary beta2-microglobulin as a possible sensitive marker for renal injury caused by tenofovir disoproxil fumarate. AIDS Research and Human Retroviruses 2006, 22:744-748.
12. Gautier J.C., Riefke B., Walter J., Kurth P., Mylecraine L., Guilpin V., Barlow N., Gury T., Hoffman D., Ennulat D., Schuster K., Harpur E., Pettit S. Evaluation of novel biomarkers of nephrotoxicity in two strains of rat treated with Cisplatin. Toxicologic Pathology 2010, 38:943-956.
13. Grubb A. Diagnostic value of analysis of cystatin C and protein HC in biological fluids. Clinical Nephrology 1992, 38(Suppl. 1):S20-S27.
14. Hall I.E., Koyner J.L., Doshi M.D., Marcus R.J., Parikh C.R. Urine cystatin C as a biomarker of proximal tubular function immediately after kidney transplantation. American Journal of Nephrology 2011, 33:407-413.
15. Harpur E., Ennulat D., Hoffman D., Betton G., Gautier J.C., Riefke B., Bounous D., Schuster K., Beushausen S., Guffroy M., Shaw M., Lock E., Pettit S. HESI Committee on Biomarkers of Nephrotoxicity. Biological qualification of biomarkers of chemical-induced renal toxicity in two strains of male rat. Toxicological Sciences 2011, 122:235-252.
16. Herrera R., Almaguer M., Chipi J., Martínez O., Bacallao J., Rodríguez N., Abreu Mde L., Fariña O., Roche Mdel C. Albuminuria as a marker of kidney and cardio-cerebral vascular damage. Isle of Youth Study (ISYS), Cuba. MEDICC Review 2010, 12:20-26.
17. Heuer J.G., Sharma G.R., Gerlitz B., Zhang T., Bailey D.L., Ding C., Berg D.T., Perkins D., Stephens E.J., Holmes K.C., Grubbs R.L., Fynboe K.A., Chen Y.F., Grinnell B., Jakubowski J.A. Evaluation of protein C and other biomarkers as predictors of mortality in a rat cecal ligation and puncture model of sepsis. Critical Care Medicine 2004, 32:1570-1578.
18. Hewitt S.M., Dear J., Star R.A. Discovery of protein biomarkers for renal diseases. Journal of the American Society of Nephrology 2004, 15:1677-1689.
19. Hoffmann D., Adler M., Vaidya V.S., Rached E., Mulrane L., Gallagher W.M., Callanan J.J., Gautier J.C., Matheis K., Staedtler F., Dieterle F., Brandenburg A., Sposny A., Hewitt P., Ellinger-Ziegelbauer H., Bonventre J.V., Dekant W., Mally A. Performance of novel kidney biomarkers in preclinical toxicity studies. Toxicological Sciences 2010, 116:8-22.
20. Hoffmann D., Fuchs T.C., Henzler T., Matheis K.A., Herget T., Dekant W., Hewitt P., Mally A. Evaluation of a urinary kidney biomarker panel in rat models of acute and subchronic nephrotoxicity. Toxicology 2010, 277:49-58.
21. Inker L.A., Okparavero A. Cystatin C as a marker of glomerular filtration rate: prospects and limitations. Current Opinion in Nephrology and Hypertension 2011, 20:631-639.
22. Jacobsson B., Lignelid H., Bergerheim U.S. Transthyretin and cystatin C are catabolized in proximal tubular epithelial cells and the proteins are not useful as markers for renal cell carcinomas. Histopathology 1995, 26:559-564.
23. Kanaguchi Y., Suzuki Y., Osaki K., Sugaya T., Horikoshi S., Tomino Y. Protective effects of L-type fatty acid-binding protein (L-FABP) in proximal tubular cells against glomerular injury in anti-GBM antibody-mediated glomerulonephritis. Nephrology, Dialysis, Transplantation 2011, 26:3465-3473.
24. Kaseda R., Iino N., Hosojima M., Takeda T., Hosaka K., Kobayashi A., Yamamoto K., Suzuki A., Kasai A., Suzuki Y., Gejyo F., Saito A. Megalin-mediated endocytosis of cystatin C in proximal tubule cells. Biochemical and Biophysical Research Communications 2007, 357:1130-1134.
25. Kohda T., Okada S., Hayashi A., Kanzaki S., Ninomiya Y., Taki M., Sado Y. High nephritogenicity of monoclonal antibodies belonging to IgG2a and IgG2b subclasses in rat anti-GBM nephritis. Kidney International 2004, 66:177-186.
26. Ma Y., Li Q., Wang J., Xu Z., Song C., Zhuang R., Yang K., Yang A., Jin B., Cystatin C. A novel urinary biomarker for sensitive detection of acute kidney injury during haemorrhagic fever with renal syndrome. Biomarkers 2010, 15:410-417.
27. Madero M., Sarnak M.J. Association of cystatin C with adverse outcomes. Current Opinion in Nephrology and Hypertension 2009, 18:258-263.
28. Marrer E., Dieterle F. Impact of biomarker development on drug safety assessment. Toxicology and Applied Pharmacology 2010, 243:167-179.
29. Martin H. Laboratory measurement of urine albumin and urine total protein in screening for proteinuria in chronic kidney disease. The Clinical Biochemist Reviews 2011, 32:97-102.
30. Nejat M., Pickering J.W., Walker R.J., Endre Z.H. Rapid detection of acute kidney injury by plasma cystatin C in the intensive care unit. Nephrology, Dialysis, Transplantation 2010, 25:3283-3289.
31. Ozer J.S., Dieterle F., Troth S., Perentes E., Cordier A., Verdes P., Staedtler F., Mahl A., Grenet O., Roth D.R., Wahl D., Legay F., Holder D., Erdos Z., Vlasakova K., Jin H., Yu Y., Muniappa N., Forest T., Clouse H.K., Reynolds S., Bailey W.J., Thudium D.T., Topper M.J., Skopek T.R., Sina J.F., Glaab W.E., Vonderscher J., Maurer G., Chibout S.D., Sistare F.D., Gerhold D.L. A panel of urinary biomarkers to monitor reversibility of renal injury and a serum marker with improved potential to assess renal function. Nature Biotechnology 2010, 28:486-494.
32. Pusey C.D. Anti-glomerular basement membrane disease. Kidney International 2003, 64:1535-1550.
33. Salama A.D., Pusey C.D. Immunology of anti-glomerular basement membrane disease. Current Opinion in Nephrology and Hypertension 2002, 11:279-286.
34. Tenstad O., Roald A.B., Grubb A., Aukland K. Renal handling of radiolabelled human cystatin C in the rat. Scandinavian Journal of Clinical and Laboratory Investigation 1996, 56:409-414.
35. Thielemans N., Lauwerys R., Bernard A. Competition between albumin and low-molecular-weight proteins for renal tubular uptake in experimental nephropathies. Nephron 1994, 66:453-458.
36. Togashi Y., Miyamoto Y. Urinary cystatin C as a biomarker for diabetic nephropathy and its immunohistochemical localization in kidney in Zucker diabetic fatty (ZDF) rats. Experimental and Toxicologic Pathology 2013, 65:615-622.
37. Togashi Y., Sakaguchi Y., Miyamoto M., Miyamoto Y. Urinary cystatin C as a biomarker for acute kidney injury and its immunohistochemical localization in kidney in the CDDP-treated rats. Experimental and Toxicologic Pathology 2012, 64:797-805.
38. Tonomura Y., Tsuchiya N., Torii M., Uehara T. Evaluation of the usefulness of urinary biomarkers for nephrotoxicity in rats. Toxicology 2010, 273:53-59.
39. Urbschat A., Obermüller N., Haferkamp A. Biomarkers of kidney injury. Biomarkers 2011, 16(Suppl. 1):S22-S30.
40. Vaidya V.S., Ramirez V., Ichimura T., Bobadilla N.A., Bonventre J.V. Urinary kidney injury molecule-1: a sensitive quantitative biomarker for early detection of kidney tubular injury. American Journal of Physiology. Renal Physiology 2006, 290:F517-F529.
41. Zhou C.L., Lv J.Q., Lu R., Chen L.J., Li H.Q., Cao H.L., Li Q.L., Wang S., Fu Z., Yao Z. A new pentapeptide compound, PLNPK, ameliorates anti-glomerular basement membrane nephritis in Wistar rats. Peptides 2008, 29:1789-1797.