Experimental design in formulation of diazepam nanoemulsions: Physicochemical and pharmacokinetic performances

Journal of Pharmaceutical Sciences

Volumn 102, Issue 11, 2013, Pages 4159-4172

  Dordević, Sanela M ^a   Radulović, Tamara S ^a   Cekić, Nebojša D ^b,c   Randelović, Danijela V ^d   Savić, Miroslav M ^a   Krajišnik, Danina R ^a   Milić, Jela R ^a   Savić, Snežana D ^a  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b UNIVERSITY OF NI   (Serbia)

^c DCP Hemigal ^*  (Serbia)

^d UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

Atomic force microscopy; Diazepam; Drug excipient interaction; FTIR; Full factorial design; Nanoemulsion; Particle size; Pharmacokinetics; Stability

Indexed keywords

DIAZEPAM; DRUG VEHICLE; EXCIPIENT; OIL; PHOSPHATIDYLCHOLINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; ATOMIC FORCE MICROSCOPY; BRAIN; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CLEARANCE; DRUG FORMULATION; DRUG HALF LIFE; DRUG SOLUBILITY; DRUG STABILITY; DRUG SYNTHESIS; ELECTRIC CONDUCTIVITY; EXPERIMENTAL DESIGN; INFRARED SPECTROSCOPY; LETHAL DOSE; MALE; MAXIMUM PLASMA CONCENTRATION; MORPHOLOGY; NANOEMULSION; NONHUMAN; PH; PHYSICAL CHEMISTRY; PLASMA CONCENTRATION-TIME CURVE; RAT; SURFACE CHARGE; VISCOSITY; ZETA POTENTIAL;

ATOMIC FORCE MICROSCOPY; DIAZEPAM; DRUG-EXCIPIENT INTERACTION; FTIR; FULL FACTORIAL DESIGN; NANOEMULSION; PARTICLE SIZE; PHARMACOKINETICS; STABILITY;

ADJUVANTS, ANESTHESIA; ANIMALS; BRAIN; DIAZEPAM; EMULSIFYING AGENTS; EMULSIONS; LECITHINS; MALE; PHARMACEUTICAL VEHICLES; POLYSORBATES; RATS; RATS, WISTAR; SOLUBILITY; SOYBEAN OIL; TRIGLYCERIDES;

EID: 84885846550     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23734     Document Type: Article

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