Cynaropicrin targets the trypanothione redox system in Trypanosoma brucei

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 22, 2013, Pages 7202-7209

  Zimmermann, Stefanie ^a,b   Oufir, Mouhssin ^a   Leroux, Alejandro ^c   Krauth Siegel, R Luise ^c   Becker, Katja ^d   Kaiser, Marcel ^b   Brun, Reto ^b   Hamburger, Matthias ^a   Adams, Michael ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Drug target; HPLC MS MS; Sesquiterpene lactone; Trypanosoma brucei; Trypanothione

Indexed keywords

CYNAROPICRIN; EFLORNITHINE; GLUTATHIONE TRANSFERASE; ORNITHINE DECARBOXYLASE; SYNTHETASE; TRYPANOTHIONE; TRYPANOTHIONE REDUCTASE; TRYPANOTHIONE SYNTHETASE; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ANTITRYPANOSOMAL ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG EXPOSURE; DRUG MECHANISM; DRUG STRUCTURE; ENZYME INHIBITION; MASS SPECTROMETRY; NONHUMAN; OXIDATION REDUCTION REACTION; TRYPANOSOMA BRUCEI; TRYPANOSOMA RHODESIENSE; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

MUS; TRYPANOSOMA BRUCEI;

CYN; CYNAROPICRIN; DITHIOTHREITOL; DMFO; DRUG TARGET; DTT; EFLORNITHINE; FA; FORMIC ACID; GLUTATHIONE; GSH; HAT; HPLC-MS/MS; HUMAN AFRICAN TRYPANOSOMIASIS; INTERNAL STANDARD; IS; LLOD; LLOQ; LOWER LIMIT OF DETECTION; LOWER LIMIT OF QUANTIFICATION; ODC; ORNITHINE DECARBOXYLASE; SAR; SESQUITERPENE LACTONE; SPERMIDINE SYNTHASE; SPS; SS; STL; STOCK SOLUTION; STRUCTURE ACTIVITY RELATIONSHIP; T(SH)(2); TR; TRYPANOSOMA BRUCEI; TRYPANOTHIONE; TRYPANOTHIONE REDUCTASE; TRYPANOTHIONE SYNTHETASE; TRYS;

AMIDE SYNTHASES; ENZYME ACTIVATION; HUMANS; LACTONES; NADH, NADPH OXIDOREDUCTASES; ORNITHINE DECARBOXYLASE; OXIDATION-REDUCTION; PROTOZOAN PROTEINS; SESQUITERPENES; SULFHYDRYL COMPOUNDS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMIASIS, AFRICAN;

EID: 84885843677     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.08.052     Document Type: Article

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